ES2065273A1 - Procedimiento para la purificacion de ciclosporina a. - Google Patents
Procedimiento para la purificacion de ciclosporina a.Info
- Publication number
- ES2065273A1 ES2065273A1 ES09301128A ES9301128A ES2065273A1 ES 2065273 A1 ES2065273 A1 ES 2065273A1 ES 09301128 A ES09301128 A ES 09301128A ES 9301128 A ES9301128 A ES 9301128A ES 2065273 A1 ES2065273 A1 ES 2065273A1
- Authority
- ES
- Spain
- Prior art keywords
- cyclosporin
- chromatography
- purification
- procedure
- chloroform
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 title abstract 4
- 229930105110 Cyclosporin A Natural products 0.000 title abstract 4
- 108010036949 Cyclosporine Proteins 0.000 title abstract 4
- 229960001265 ciclosporin Drugs 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 3
- 238000000746 purification Methods 0.000 title abstract 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 abstract 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 4
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 abstract 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 abstract 3
- 238000004587 chromatography analysis Methods 0.000 abstract 2
- 229930182912 cyclosporin Natural products 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 108010036941 Cyclosporins Proteins 0.000 abstract 1
- 238000004440 column chromatography Methods 0.000 abstract 1
- 239000000356 contaminant Substances 0.000 abstract 1
- 238000001704 evaporation Methods 0.000 abstract 1
- 230000008020 evaporation Effects 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 230000008018 melting Effects 0.000 abstract 1
- 238000002844 melting Methods 0.000 abstract 1
- 239000011877 solvent mixture Substances 0.000 abstract 1
Landscapes
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
PROCEDIMIENTO PARA LA PURIFICACION DE CICLOSPORINA A DE MEZCLAS QUE CONTIENEN ESPECIALMENTE CICLOSPORINAS A, B, C Y OTROS COMPONENTES DE CICLOSPORINA MAS POLARES O MAS APOLARES QUE LA CICLOSPORINA A O CONTAMINACIONES SIMILARES A ELLOS, QUE COMPRENDE CALENTAR LA MEZCLA O UN RESIDUO DE EVAPORACION DE ELLA A UNA TEMPERATURA ENTRE 80GC Y 115GC ANTES DE LA CROMATOGRAFIA DE COLUMNA, FUNDIRLA Y SOMETER LA MASA FUNDIDA A CROMATOGRAFIA MEDIANTE METODOS CONOCIDOS PER SE. LA CROMATOGRAFIA SE LLEVA A CABO CON LA UTILIZACION SUCESIVA DE LAS SIGUIENTES MEZCLAS DE DISOLVENTES: CLOROFORMO : DICLOROMETANO : ETANOL = 48:50:2 Y CLOROFORMO : ACETATO DE ETILO : ETANOL = 48:50
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES9301128A ES2065273B1 (es) | 1993-05-25 | 1993-05-25 | Procedimiento para la purificacion de ciclosporina a. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES9301128A ES2065273B1 (es) | 1993-05-25 | 1993-05-25 | Procedimiento para la purificacion de ciclosporina a. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES2065273A1 true ES2065273A1 (es) | 1995-02-01 |
| ES2065273B1 ES2065273B1 (es) | 1995-09-16 |
Family
ID=8281939
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES9301128A Expired - Fee Related ES2065273B1 (es) | 1993-05-25 | 1993-05-25 | Procedimiento para la purificacion de ciclosporina a. |
Country Status (1)
| Country | Link |
|---|---|
| ES (1) | ES2065273B1 (es) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES452942A1 (es) * | 1975-11-04 | 1978-01-16 | Sandoz Ag | Procedimiento para la produccion de dihidrociclosporina c. |
| ES485104A1 (es) * | 1978-10-18 | 1980-05-16 | Sandoz Ag | Procedimiento para preparar derivados de ciclosporina |
| EP0484281A2 (en) * | 1990-11-02 | 1992-05-06 | Sandoz Ltd. | Cyclosporins |
-
1993
- 1993-05-25 ES ES9301128A patent/ES2065273B1/es not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES452942A1 (es) * | 1975-11-04 | 1978-01-16 | Sandoz Ag | Procedimiento para la produccion de dihidrociclosporina c. |
| ES485104A1 (es) * | 1978-10-18 | 1980-05-16 | Sandoz Ag | Procedimiento para preparar derivados de ciclosporina |
| EP0484281A2 (en) * | 1990-11-02 | 1992-05-06 | Sandoz Ltd. | Cyclosporins |
Also Published As
| Publication number | Publication date |
|---|---|
| ES2065273B1 (es) | 1995-09-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD2A | Announcement of lapse in spain |
Effective date: 20180806 |