ES2065525T3 - Mejoras relacionadas con el radiomarcado de las proteinas. - Google Patents

Mejoras relacionadas con el radiomarcado de las proteinas.

Info

Publication number
ES2065525T3
ES2065525T3 ES90905248T ES90905248T ES2065525T3 ES 2065525 T3 ES2065525 T3 ES 2065525T3 ES 90905248 T ES90905248 T ES 90905248T ES 90905248 T ES90905248 T ES 90905248T ES 2065525 T3 ES2065525 T3 ES 2065525T3
Authority
ES
Spain
Prior art keywords
labelled
thiotriphosphates
proteins
antibody
tumour
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90905248T
Other languages
English (en)
Inventor
Brian Maurice John Foxwell
Peter Parker
Andrew Malcolm Creighton
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BTG International Ltd
Original Assignee
British Technology Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by British Technology Group Ltd filed Critical British Technology Group Ltd
Application granted granted Critical
Publication of ES2065525T3 publication Critical patent/ES2065525T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0491—Sugars, nucleosides, nucleotides, oligonucleotides, nucleic acids, e.g. DNA, RNA, nucleic acid aptamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Optics & Photonics (AREA)
  • Epidemiology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Labeling Devices (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

TRIFOSFATOS DE NUCLEOSIDOS PORTANDO ELEVADO 32P EN EL GRUPO GAMMA-TRIFOSFATO, PREPARADOS MEDIANTE REACCION ENTRE UN DIFOSFATO NUCLEOSIDO Y UNA SAL DE TRIFOSFATO ELEVADO 32P MARCADA, SE USAN COMO AGENTES TIOFOSFORILANTES PARA ANTICUERPOS QUE SE UNEN A ANTIGENOS ASOCIADOS A TUMORES. LOS TIOTRIFOSFATOS MARCADOS PUEDEN USARSE PARA INTRODUCIR UN ATOMO ELEVADO 32P USADO TERAPEUTICAMENTE EN UN ANTICUERPO QUE HA SIDO MODIFICADO MEDIANTE LA INCORPORACION EN SU ESTRUCTURA DE UNA REGION DE UN PEPTIDO CAPAZ DE ACTUAR COMO UN SUSTRATO PARA UNA FOSFOKINASA. EL ANTICUERPO MARCADO RESULTANTE PUEDE USARSE ENTONCES PARA UNA INYECTARSE EN UNA TERAPIA ANTITUMOR Y TIENE VENTAJAS CLINICAS SOBRE EL CORRESPONDIENTE ANALOGO FOSFORILATADO.
ES90905248T 1989-03-23 1990-03-23 Mejoras relacionadas con el radiomarcado de las proteinas. Expired - Lifetime ES2065525T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB898906708A GB8906708D0 (en) 1989-03-23 1989-03-23 Improvements relating to the radiolabelling of proteins

Publications (1)

Publication Number Publication Date
ES2065525T3 true ES2065525T3 (es) 1995-02-16

Family

ID=10653894

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90905248T Expired - Lifetime ES2065525T3 (es) 1989-03-23 1990-03-23 Mejoras relacionadas con el radiomarcado de las proteinas.

Country Status (8)

Country Link
EP (1) EP0464101B1 (es)
JP (1) JP2942776B2 (es)
AT (1) ATE114315T1 (es)
DE (1) DE69014300T2 (es)
DK (1) DK0464101T3 (es)
ES (1) ES2065525T3 (es)
GB (2) GB8906708D0 (es)
WO (1) WO1990011289A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5583212A (en) * 1989-03-23 1996-12-10 British Technology Group Limited (gamma)-[32 p](gamma) -thioribonucleoside-51 -triphosphates
GB9103886D0 (en) * 1991-02-25 1991-04-10 Creighton Andrew 32p-thiophosphate preparation
GB9126650D0 (en) * 1991-12-16 1992-02-12 Creighton Andrew M Further improvements relating to the radiolabelling of proteins
IL115177A0 (en) * 1994-09-16 1995-12-31 Immunomedics Inc Phosphorus-32 labeling of antibodies for cancer therapy
US5728369A (en) * 1994-10-05 1998-03-17 Immunomedics, Inc. Radioactive phosphorus labeling of proteins for targeted radiotherapy
WO1996023816A1 (en) * 1995-02-01 1996-08-08 British Technology Group Limited Radiolabelled proteins
US6187286B1 (en) * 1996-12-27 2001-02-13 The General Hospital Corporation Tumor imaging agents, methods and kits

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5087565A (en) * 1984-07-02 1992-02-11 Du Pont Merck Pharmaceutical Company Synthetic process for preparation of 32 P-labeled nucleotides
FR2585724B1 (fr) * 1985-08-01 1988-10-14 Centre Nat Rech Scient Kit de marquage enzymatique de nucleosides triphosphates et procede de preparation de nucleotides triphosphates marques au 32p ou 35s
GB2186579B (en) * 1986-01-21 1990-07-25 Brian Maurice John Foxwell Improvements relating to the radio-labelling of proteins

Also Published As

Publication number Publication date
EP0464101B1 (en) 1994-11-23
GB2248619A (en) 1992-04-15
DK0464101T3 (da) 1994-12-19
ATE114315T1 (de) 1994-12-15
JPH04503809A (ja) 1992-07-09
GB2248619B (en) 1993-02-24
DE69014300T2 (de) 1995-04-13
JP2942776B2 (ja) 1999-08-30
EP0464101A1 (en) 1992-01-08
GB8906708D0 (en) 1989-05-10
WO1990011289A1 (en) 1990-10-04
GB9119528D0 (en) 1991-12-04
DE69014300D1 (de) 1995-01-05

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