ES2066066T3 - Procedimiento para la purificacion del inhibidor de activadores de plasminogeno 2 (pai-2). - Google Patents

Procedimiento para la purificacion del inhibidor de activadores de plasminogeno 2 (pai-2).

Info

Publication number
ES2066066T3
ES2066066T3 ES90117038T ES90117038T ES2066066T3 ES 2066066 T3 ES2066066 T3 ES 2066066T3 ES 90117038 T ES90117038 T ES 90117038T ES 90117038 T ES90117038 T ES 90117038T ES 2066066 T3 ES2066066 T3 ES 2066066T3
Authority
ES
Spain
Prior art keywords
pref
soln
purification
satn
ppte
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90117038T
Other languages
English (en)
Inventor
Klaus-Peter Dr Radtke
Norbert Prof Dr Heimburger
Karlheinz Wenz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Siemens Healthcare Diagnostics GmbH Germany
Original Assignee
Behringwerke AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Behringwerke AG filed Critical Behringwerke AG
Application granted granted Critical
Publication of ES2066066T3 publication Critical patent/ES2066066T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8121—Serpins
    • C07K14/8132—Plasminogen activator inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Analytical Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

SE DESCRIBE UN PROCEDIMIENTO PARA LA PURIFICACION DEL INHIBIDOR DEL ACTIVADOR DE PLASMINOGENO, SEGUN EL CUAL SE PRECIPITAN LAS IMPUREZAS MEDIANTE UNA BASE DE ACRIDINA O DE QUINOLEINA
ES90117038T 1989-09-06 1990-09-05 Procedimiento para la purificacion del inhibidor de activadores de plasminogeno 2 (pai-2). Expired - Lifetime ES2066066T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3929504A DE3929504A1 (de) 1989-09-06 1989-09-06 Verfahren zur reinigung von plasminogen-aktivator-inhibitor 2 (pai-2)

Publications (1)

Publication Number Publication Date
ES2066066T3 true ES2066066T3 (es) 1995-03-01

Family

ID=6388683

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90117038T Expired - Lifetime ES2066066T3 (es) 1989-09-06 1990-09-05 Procedimiento para la purificacion del inhibidor de activadores de plasminogeno 2 (pai-2).

Country Status (11)

Country Link
EP (1) EP0418647B1 (es)
JP (1) JPH0393798A (es)
KR (1) KR910006477A (es)
AT (1) ATE115589T1 (es)
AU (1) AU642661B2 (es)
CA (1) CA2024701A1 (es)
DE (2) DE3929504A1 (es)
DK (1) DK0418647T3 (es)
ES (1) ES2066066T3 (es)
IE (1) IE65590B1 (es)
PT (1) PT95205A (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4214999C2 (de) * 1992-05-06 1994-07-14 Behringwerke Ag Reinigung von Plasminogen-Aktivator-Inhibitor 2 durch Immunaffinitätschromatographie
EP1581644B1 (en) 2003-01-09 2007-06-06 Genentech, Inc. Purification of polypeptides

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3713272A1 (de) * 1987-04-18 1988-11-03 Behringwerke Ag Plasminogenaktivator-inhibitor, typ 2 (pai-2)

Also Published As

Publication number Publication date
IE65590B1 (en) 1995-11-01
JPH0393798A (ja) 1991-04-18
DK0418647T3 (da) 1995-05-15
EP0418647A1 (de) 1991-03-27
ATE115589T1 (de) 1994-12-15
AU642661B2 (en) 1993-10-28
AU6217590A (en) 1991-03-14
KR910006477A (ko) 1991-04-29
DE59008002D1 (de) 1995-01-26
IE903230A1 (en) 1991-03-13
EP0418647B1 (de) 1994-12-14
DE3929504A1 (de) 1991-03-07
PT95205A (pt) 1991-05-22
CA2024701A1 (en) 1991-03-07

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