ES2068041T3 - Inhalador. - Google Patents

Inhalador.

Info

Publication number
ES2068041T3
ES2068041T3 ES93202365T ES93202365T ES2068041T3 ES 2068041 T3 ES2068041 T3 ES 2068041T3 ES 93202365 T ES93202365 T ES 93202365T ES 93202365 T ES93202365 T ES 93202365T ES 2068041 T3 ES2068041 T3 ES 2068041T3
Authority
ES
Spain
Prior art keywords
inhaler
substance
dose
storage chamber
frustoconic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93202365T
Other languages
English (en)
Inventor
Philip Wilson Braithwaite
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Innovata Biomed Ltd
Original Assignee
Innovata Biomed Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Innovata Biomed Ltd filed Critical Innovata Biomed Ltd
Application granted granted Critical
Publication of ES2068041T3 publication Critical patent/ES2068041T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A61M15/0068—Indicating or counting the number of dispensed doses or of remaining doses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A61M15/0068—Indicating or counting the number of dispensed doses or of remaining doses
    • A61M15/007—Mechanical counters
    • A61M15/0071—Mechanical counters having a display or indicator
    • A61M15/0075—Mechanical counters having a display or indicator on a disc
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06M—COUNTING MECHANISMS; COUNTING OF OBJECTS NOT OTHERWISE PROVIDED FOR
    • G06M1/00—Design features of general application
    • G06M1/22—Design features of general application for visual indication of the result of count on counting mechanisms, e.g. by window with magnifying lens
    • G06M1/24—Drums; Dials; Pointers
    • G06M1/246—Bands; Sheets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/06—Solids
    • A61M2202/062—Desiccants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/06—Solids
    • A61M2202/064—Powder

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Anesthesiology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Theoretical Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Medicinal Preparation (AREA)
  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
  • External Artificial Organs (AREA)
  • Steroid Compounds (AREA)

Abstract

LA INVENCION PROPORCIONA UN INHALADOR PARA ENTREGA DE UNA SUSTANCIA EN FORMA FINAMENTE DIVIDIDA, PROCEDENTE DE UNA CAMARA DE ALMACENAMIENTO, DENTRO DEL INHALADOR. EL INHALADOR COMPRENDE UN ELEMENTO DE MEDICION, OPERABLE PARA TRANSFERIR UNA DOSIS DE LA SUSTANCIA DESDE UNA CAMARA DE ALMACENAMIENTO A UN PASO DE INHALACION, TENIENDO EL ELEMENTO DE MEDICION UNA SUPERFICIE DE MEDICION FRUSTOCONICA QUE ESTA INDENTADA, PARA PROPORCIONAR POR LO MENOS UNA COPA DE DISPENSACION, Y SIENDO MOVIL ENTRE UNA PRIMERA POSICION, EN LA QUE SE PRESENTA UNA COPA DE DISPENSACION A LA CAMARA DE ALMACENAMIENTO PARA RECIBIR UNA DOSIS DE LA SUSTANCIA, Y UNA SEGUNDA POSICION, EN LA QUE UNA DOSIS DE LA SUSTANCIA SE PRESENTA AL PASO DE INHALACION, EN UNA COPA DE DISPENSACION ABIERTA HACIA ARRIBA. EL CUERPO DEL INHALADOR COMPRENDE UN ASIENTO QUE TIENE UNA SUPERFICIE DE CONTACTO ANULAR, FRUSTOCONICA, QUE HACE CONTACTO DESLIZANTE CON LA SUPERFICIE DE MEDICION, Y QUE DEFINE UN RECEPTACULO DENTRO DEL CUAL SE ARTICULA EL ELEMENTO DE MEDICION PARA ROTACION ENTRE SUS POSICIONES PRIMERA Y SEGUNDA. EL USO DE UN ELEMENTO DE MEDICION FRUSTOCONICO PERMITE UNA BUENA HERMETICIDAD ENTRE EL Y EL ASIENTO, Y TAMBIEN HACE EL INHALADOR RELATIVAMENTE COMPACTO.
ES93202365T 1990-07-13 1991-07-11 Inhalador. Expired - Lifetime ES2068041T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB909015522A GB9015522D0 (en) 1990-07-13 1990-07-13 Inhaler

Publications (1)

Publication Number Publication Date
ES2068041T3 true ES2068041T3 (es) 1995-04-01

Family

ID=10679104

Family Applications (2)

Application Number Title Priority Date Filing Date
ES93202365T Expired - Lifetime ES2068041T3 (es) 1990-07-13 1991-07-11 Inhalador.
ES91913462T Expired - Lifetime ES2072006T3 (es) 1990-07-13 1991-07-11 Inhalador.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES91913462T Expired - Lifetime ES2072006T3 (es) 1990-07-13 1991-07-11 Inhalador.

Country Status (18)

Country Link
US (2) US5437270A (es)
EP (2) EP0539469B1 (es)
JP (1) JP2891541B2 (es)
KR (1) KR0184288B1 (es)
AT (2) ATE120970T1 (es)
AU (1) AU657914B2 (es)
BR (1) BR9106693A (es)
CA (1) CA2086415C (es)
DE (2) DE69108912T2 (es)
DK (2) DK0539469T3 (es)
ES (2) ES2068041T3 (es)
FI (1) FI104236B (es)
GB (3) GB9015522D0 (es)
GR (2) GR3015317T3 (es)
NO (2) NO304218B1 (es)
NZ (2) NZ238958A (es)
WO (1) WO1992000771A1 (es)
ZA (1) ZA915437B (es)

Families Citing this family (234)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6536427B2 (en) 1990-03-02 2003-03-25 Glaxo Group Limited Inhalation device
SK280968B6 (sk) 1990-03-02 2000-10-09 Glaxo Group Limited Balenie medikamentu na použite v inhalačnom prístroji
GB9004781D0 (en) * 1990-03-02 1990-04-25 Glaxo Group Ltd Device
MY105368A (en) * 1990-03-02 1994-09-30 Glaxo Group Ltd Inhalation device.
GB9015522D0 (en) * 1990-07-13 1990-08-29 Braithwaite Philip W Inhaler
JPH06504223A (ja) * 1991-08-15 1994-05-19 デル・ボン・フランコ 吸入器
US6029661A (en) * 1991-08-26 2000-02-29 3M Innovative Properties Company Powder dispenser
EP0601071B1 (en) * 1991-08-26 1999-10-20 Minnesota Mining And Manufacturing Company Powder dispenser
GB9203761D0 (en) 1992-02-21 1992-04-08 Innovata Biomed Ltd Inhaler
SE9201411D0 (sv) * 1992-05-05 1992-05-05 Astra Ab Dosage inhalator with indicating/interupting means
WO1994006497A1 (en) * 1992-09-11 1994-03-31 Glaxo Group Limited Inhalation device
DE4239402A1 (de) * 1992-11-24 1994-05-26 Bayer Ag Pulverinhalator
AT398277B (de) * 1992-12-11 1994-11-25 Hurka Wilhelm Inhalationsgerät
DE4340768A1 (de) * 1993-11-30 1995-06-01 Bayer Ag Vorrichtung zum Inhalieren
WO1995016483A1 (en) * 1993-12-18 1995-06-22 Merck Patent Gmbh Powder inhalator
GB9326574D0 (en) * 1993-12-31 1994-03-02 King S College London Dry power inhalers
PT101450B (pt) * 1994-02-02 1999-11-30 Hovione Produtos Farmaceuticos Novo dispositivo para inalacao
AU1752795A (en) * 1994-03-10 1995-09-25 Franco Del Bon Inhalator
FI942196L (fi) * 1994-05-11 1995-11-12 Orion Yhtymae Oy Jauheinhalaattori
FI95441C (fi) * 1994-05-31 1996-02-12 Leiras Oy Inhalointilaitteen lääkeainekammio
DE19581244T1 (de) * 1994-09-14 1996-11-14 Nippon Denso Co Deodorierungsfilter
AU730625B2 (en) * 1994-09-16 2001-03-08 Laboratoire Glaxo Wellcome S.A. Inhalation device
AU710027B2 (en) * 1994-09-16 1999-09-09 Laboratoire Glaxo Wellcome Inhalation device
SE9404140D0 (sv) * 1994-11-29 1994-11-29 Astra Ab Dose indicating device
US5612053A (en) * 1995-04-07 1997-03-18 Edward Mendell Co., Inc. Controlled release insufflation carrier for medicaments
MX9707862A (es) * 1995-04-14 1997-11-29 Glaxo Wellcome Inc Inhalador de dosis medida para el propionato de fluticasona.
DE69622166T2 (de) * 1995-04-14 2003-04-03 Smithkline Beecham Corp., Philadelphia Dosierinhalator für albuterol
US5622166A (en) * 1995-04-24 1997-04-22 Dura Pharmaceuticals, Inc. Dry powder inhaler delivery system
PL182198B1 (en) * 1995-06-21 2001-11-30 Asta Medica Ag Pharmaceutic powder holding container with integrated measuring device and powdered
FR2738152B1 (fr) * 1995-09-04 1998-01-23 Tebro Dispositif de pre-dosage de produit pulverulent pour un distributeur de produit
FR2738153B1 (fr) * 1995-09-04 1998-01-02 Valois Appareil d'inhalation destine a distribuer des doses precises et reproductibles de produit pulverulent
FI102875B1 (fi) * 1995-11-10 1999-03-15 Orion Yhtymae Oy Jauheinhalaattori
US6123070A (en) * 1996-06-07 2000-09-26 Valois S.A. Device for enhancing the emptying of an inhaler metering chamber
DE19647947A1 (de) * 1996-11-20 1998-05-28 Pfeiffer Erich Gmbh & Co Kg Austragvorrichtung für Medien
GB9626263D0 (en) 1996-12-18 1997-02-05 Innovata Biomed Ltd Powder inhaler
GB2320489A (en) 1996-12-20 1998-06-24 Norton Healthcare Ltd Inhaler dose counter
TW469832U (en) 1997-03-14 2001-12-21 Astra Ab Inhalation device
SE9700937D0 (sv) 1997-03-14 1997-03-14 Astra Ab Powder inhaler I
SE9700938D0 (sv) * 1997-03-14 1997-03-14 Astra Ab Powder inhaler II and a method of construction thereof
SE9700936D0 (sv) * 1997-03-14 1997-03-14 Astra Ab Inhalation device
NL1006058C2 (nl) * 1997-05-14 1998-11-17 R & D Injector Ag Doseerinrichting.
TW533865U (en) * 1997-06-10 2003-05-21 Glaxo Group Ltd Dispenser for dispensing medicament and actuation indicating device
JP4423457B2 (ja) 1998-01-16 2010-03-03 トルーデル メディカル インターナショナル ディスペンサおよび投与装置用表示装置
US6142339A (en) 1998-01-16 2000-11-07 1263152 Ontario Inc. Aerosol dispensing device
US7143764B1 (en) 1998-03-13 2006-12-05 Astrazeneca Ab Inhalation device
US6082358A (en) 1998-05-05 2000-07-04 1263152 Ontario Inc. Indicating device for aerosol container
US6336453B1 (en) 1999-04-30 2002-01-08 Trudell Medical International Indicating device for aerosol container
US6729330B2 (en) 1998-05-05 2004-05-04 Trudell Medical International Indicating device for aerosol container
DE19831525A1 (de) * 1998-07-14 2000-01-20 Pfeiffer Erich Gmbh & Co Kg Spender für Medien
FI107126B (fi) * 1999-04-23 2001-06-15 Orion Yhtymae Oyj Jauheinhalaattori yhdistelmälääkkeelle
FI108518B (fi) * 1999-04-23 2002-02-15 Orion Yhtymae Oyj Jauheinhalaattori yhdistelmälääkkeelle
PL352615A1 (en) * 1999-06-05 2003-08-25 Innovata Biomed Ltd Delivery system
US9006175B2 (en) 1999-06-29 2015-04-14 Mannkind Corporation Potentiation of glucose elimination
ES2165768B1 (es) 1999-07-14 2003-04-01 Almirall Prodesfarma Sa Nuevos derivados de quinuclidina y composiciones farmaceuticas que los contienen.
GB9920839D0 (en) 1999-09-04 1999-11-10 Innovata Biomed Ltd Inhaler
WO2001021238A2 (en) * 1999-09-17 2001-03-29 Orion Corporation Moisture protected powder inhaler
JP2003511107A (ja) * 1999-10-06 2003-03-25 ゴルデマン・ラウル 乾燥粉末の呼吸制御式吸入器と、乾燥粉末を空気に均一に分配混合する方法
GB9924949D0 (en) * 1999-10-22 1999-12-22 Innovata Biomed Ltd Inhaler
GB9928265D0 (en) * 1999-12-01 2000-01-26 Innovata Biomed Ltd Inhaler
CA2393428A1 (en) * 1999-12-07 2001-06-14 Kari Seppala Multidose powder inhaler
GB0003197D0 (en) * 2000-02-11 2000-04-05 Aid Medic Ltd Improvements in and relating to controlling drug delivery
PL204106B1 (pl) 2000-02-28 2009-12-31 Pharmakodex Ltd Zestaw do dostarczania środka terapeutycznego
GB0005201D0 (en) * 2000-03-04 2000-04-26 Innovata Biomed Ltd Tooling methods
FI20000810A0 (fi) 2000-04-06 2000-04-06 Orion Yhtymae Oyj Jauheinhalaattori
GB2364649A (en) * 2000-05-17 2002-02-06 Orion Corp Inhaler with Dose Counter
TWI224513B (en) * 2000-06-23 2004-12-01 Norton Healthcare Ltd Dose counter for medicament inhaler
GB0019429D0 (en) 2000-08-09 2000-09-27 Innovata Biomed Ltd Diaphragm
GB0024793D0 (en) 2000-10-10 2000-11-22 Innovata Biomed Ltd Diaphragm
JP2004512101A (ja) * 2000-10-20 2004-04-22 グラクソ　グループ　リミテッド 吸入器
FI20002363A0 (fi) * 2000-10-27 2000-10-27 Orion Yhtymae Oyj Jauheinhalaattori
DE60221640T2 (de) * 2001-02-06 2008-05-21 Innovata Biomed Ltd., St. Albans Bimodale trockenpulverzusammensetzung zur inhalation
GB0111337D0 (en) 2001-05-10 2001-07-04 Innovata Biomed Ltd Device
GB0111330D0 (en) 2001-05-10 2001-07-04 Innovata Biomed Ltd Device
GB0111336D0 (en) 2001-05-10 2001-07-04 Innovata Biomed Ltd Device
US6745760B2 (en) 2001-05-15 2004-06-08 Trudell Medical International Medicament applicator
FI20011317A0 (fi) 2001-06-20 2001-06-20 Orion Corp Jauheinhalaattori
US6681768B2 (en) 2001-06-22 2004-01-27 Sofotec Gmbh & Co. Kg Powder formulation disintegrating system and method for dry powder inhalers
AUPR695801A0 (en) * 2001-08-10 2001-09-06 Caroma Industries Limited An ultra-low volume gravity flushing toilet
EP1453743B1 (en) * 2001-11-17 2008-07-23 Aventis Pharma Limited Pharmaceutical product and method with an adsorbent
GB0128148D0 (en) 2001-11-23 2002-01-16 Innovata Biomed Ltd Assembly
GB0217199D0 (en) * 2002-07-25 2002-09-04 Glaxo Group Ltd Medicament dispenser
GB0201677D0 (en) * 2002-01-25 2002-03-13 Glaxo Group Ltd Medicament dispenser
JP4681231B2 (ja) 2002-03-20 2011-05-11 マンカインド コーポレイション 吸入装置
US7004164B2 (en) 2002-03-21 2006-02-28 Trudell Medical International Indicating device for aerosol container
US7025205B2 (en) * 2002-06-26 2006-04-11 Aventis Pharma Limited Method and packaging for pressurized containers
US20050268908A1 (en) * 2002-07-25 2005-12-08 Bonney Stanley G Medicament dispenser
GB0217196D0 (en) * 2002-07-25 2002-09-04 Glaxo Group Ltd Medicament dispenser
AU2003254590A1 (en) * 2002-07-25 2004-02-16 Glaxo Group Limited Medicament dispenser
GB0217198D0 (en) * 2002-07-25 2002-09-04 Glaxo Group Ltd Medicament dispenser
PT1386630E (pt) 2002-07-31 2006-09-29 Chiesi Farma Spa Inalador em po
EP1452198A4 (en) * 2002-10-11 2006-11-02 Otsuka Pharma Co Ltd INHALATION DEVICE FOR POWDER
GB0315509D0 (en) * 2003-07-02 2003-08-06 Meridica Ltd Dispensing device
US7621273B2 (en) 2003-10-28 2009-11-24 Trudell Medical International Indicating device with warning dosage indicator
US7100530B2 (en) 2003-12-15 2006-09-05 Trudell Medical International, Inc. Dose indicating device
US8113199B2 (en) * 2004-02-16 2012-02-14 Glaxo Group Limited Counter for use with a medicament dispenser
WO2005102429A1 (en) * 2004-04-21 2005-11-03 Innovata Biomed Limited Inhaler
GB0409197D0 (en) 2004-04-24 2004-05-26 Innovata Biomed Ltd Device
RU2385156C2 (ru) 2004-05-31 2010-03-27 Лабораториос Альмираль С.А. Комбинации, содержащие антимускариновые средства и кортикостероиды
ES2257152B1 (es) 2004-05-31 2007-07-01 Laboratorios Almirall S.A. Combinaciones que comprenden agentes antimuscarinicos y agonistas beta-adrenergicos.
EP1616592B9 (en) 2004-07-16 2011-02-02 Almirall, S.A. Inhaler for the administration of powdered pharmaceuticals, and a powder cartridge for use with this inhaler
DE602005019748D1 (de) * 2004-08-12 2010-04-15 Idec Corp Zählmechanismus für einen zuführer und zuführer mit zählmechanismus
GB0418278D0 (en) 2004-08-16 2004-09-15 Glaxo Group Ltd Medicament dispenser
ATE486064T1 (de) 2004-08-20 2010-11-15 Mannkind Corp Katalyse der diketopiperazinsynthese
HUE025151T2 (en) 2004-08-23 2016-01-28 Mannkind Corp Diceto-piperazine salts for drug delivery
US7543582B2 (en) 2004-09-20 2009-06-09 Trudell Medical International Dose indicating device with display elements attached to container
WO2006062448A1 (en) * 2004-12-10 2006-06-15 Ernst Hörlins Ingenjörsbyrå Ab Dose inhaler with a dose counter
US7886934B2 (en) 2005-01-20 2011-02-15 Trudell Medical International Dispensing device
FR2883400B1 (fr) 2005-03-16 2007-06-15 Valois Sas Dispositif d'indication de doses pour distribuer des produits fluides ou pulverulents
CN100431634C (zh) * 2005-04-04 2008-11-12 陈庆堂 干粉气溶胶化吸入器
US8546423B2 (en) 2005-05-18 2013-10-01 Mpex Pharmaceuticals, Inc. Aerosolized fluoroquinolones and uses thereof
HUE030419T2 (en) 2005-05-18 2017-05-29 Horizon Orphan Llc Aerosolized fluoroquinolones and their uses
ES2265276B1 (es) 2005-05-20 2008-02-01 Laboratorios Almirall S.A. Derivados de 4-(2-amino-1-hidroxietil)fenol como agonistas del receptor beta2 adrenergico.
MX373000B (es) 2005-09-14 2020-05-21 Mannkind Corp Metodo para formulacion de farmaco basado en el aumento de la afinidad de agentes activos hacia las superficies de microparticulas cristalinas.
US20070068524A1 (en) * 2005-09-28 2007-03-29 Microdrug Ag Inhaler for moisture sensitive drugs
JP4934678B2 (ja) * 2005-12-23 2012-05-16 アストラゼネカ・アクチエボラーグ 新規デバイス
US8865743B2 (en) 2006-01-06 2014-10-21 Acelrx Pharmaceuticals, Inc. Small volume oral transmucosal dosage forms containing sufentanil for treatment of pain
US8535714B2 (en) 2006-01-06 2013-09-17 Acelrx Pharmaceuticals, Inc. Small volume oral transmucosal dosage forms containing sufentanil for treatment of pain
US9289583B2 (en) 2006-01-06 2016-03-22 Acelrx Pharmaceuticals, Inc. Methods for administering small volume oral transmucosal dosage forms using a dispensing device
US8202535B2 (en) * 2006-01-06 2012-06-19 Acelrx Pharmaceuticals, Inc. Small-volume oral transmucosal dosage forms
US9066847B2 (en) * 2007-01-05 2015-06-30 Aceirx Pharmaceuticals, Inc. Storage and dispensing devices for administration of oral transmucosal dosage forms
US8753308B2 (en) 2006-01-06 2014-06-17 Acelrx Pharmaceuticals, Inc. Methods for administering small volume oral transmucosal dosage forms using a dispensing device
US8252328B2 (en) * 2006-01-06 2012-08-28 Acelrx Pharmaceuticals, Inc. Bioadhesive drug formulations for oral transmucosal delivery
US8357114B2 (en) 2006-01-06 2013-01-22 Acelrx Pharmaceuticals, Inc. Drug dispensing device with flexible push rod
US8252329B2 (en) * 2007-01-05 2012-08-28 Acelrx Pharmaceuticals, Inc. Bioadhesive drug formulations for oral transmucosal delivery
CN104383546B (zh) 2006-02-22 2021-03-02 曼金德公司 用于改善包含二酮哌嗪和活性剂的微粒的药物性质的方法
GB0605150D0 (en) * 2006-03-14 2006-04-26 Glaxo Group Ltd Counter For Use With A Medicament Dispenser
US8141550B2 (en) 2006-08-01 2012-03-27 Trudell Medical International Dispensing device
GB0622827D0 (en) 2006-11-15 2006-12-27 Glaxo Group Ltd Sheet driver for use in a drug dispenser
EP2086618A2 (en) * 2006-11-19 2009-08-12 Aespira Ltd. Dry-powder inhaler
CN101600469B (zh) 2006-12-22 2013-10-23 奥米罗有限公司 药粉吸入装置
ES2306595B1 (es) 2007-02-09 2009-09-11 Laboratorios Almirall S.A. Sal de napadisilato de 5-(2-((6-(2,2-difluoro-2-feniletoxi)hexil)amino)-1-hidroxietil)-8-hidroxiquinolin-2(1h)-ona como agonista del receptor adrenergico beta2.
ES2320955B1 (es) 2007-03-02 2010-03-16 Laboratorios Almirall S.A. Nuevos derivados de 3-((1,2,4)triazolo(4,3-a)piridin-7-il)benzamida.
CA2693771A1 (en) * 2007-07-13 2009-01-22 Abbott Biotechnology Ltd. Methods and compositions for pulmonary administration of a tnf.alpha. inhibitor
US20090084379A1 (en) * 2007-10-02 2009-04-02 Baxter International Inc. Dry powder inhaler
ES2320961B1 (es) 2007-11-28 2010-03-17 Laboratorios Almirall, S.A. Derivados de 4-(2-amino-1-hidroxietil)fenol como agonistas del receptor adrenergico beta2.
GB0800457D0 (en) 2008-01-11 2008-02-20 Innovata Biomed Ltd Improvements in or relating to inhalers
CA2716124A1 (en) * 2008-02-20 2009-08-27 Boehringer Ingelheim International Gmbh Powder inhalers
EP2096105A1 (en) 2008-02-28 2009-09-02 Laboratorios Almirall, S.A. Derivatives of 4-(2-amino-1-hydroxyethyl)phenol as agonists of the b2 adrenergic receptor
EP2100598A1 (en) 2008-03-13 2009-09-16 Laboratorios Almirall, S.A. Inhalation composition containing aclidinium for treatment of asthma and chronic obstructive pulmonary disease
EP2100599A1 (en) 2008-03-13 2009-09-16 Laboratorios Almirall, S.A. Inhalation composition containing aclidinium for treatment of asthma and chronic obstructive pulmonary disease
EP2108641A1 (en) 2008-04-11 2009-10-14 Laboratorios Almirall, S.A. New substituted spiro[cycloalkyl-1,3'-indo]-2'(1'H)-one derivatives and their use as p38 mitogen-activated kinase inhibitors
EP2113503A1 (en) 2008-04-28 2009-11-04 Laboratorios Almirall, S.A. New substituted indolin-2-one derivatives and their use as p39 mitogen-activated kinase inhibitors
US8082873B2 (en) 2008-05-05 2011-12-27 Trudell Medical International Drive mechanism for an indicating device
US8181591B1 (en) 2008-05-23 2012-05-22 Trudell Medical International Domed actuator for indicating device
USD613849S1 (en) * 2008-06-13 2010-04-13 Mannkind Corporation Cartridge for a dry powder inhaler
MY155524A (en) 2008-06-13 2015-10-30 Mannkind Corp A dry powder inhaler and system for drug delivery
USD605753S1 (en) * 2008-06-13 2009-12-08 Mannkind Corporation Cartridge for a dry powder inhaler
US8485180B2 (en) 2008-06-13 2013-07-16 Mannkind Corporation Dry powder drug delivery system
EP2609954B1 (en) 2008-06-20 2021-12-29 MannKind Corporation An interactive apparatus for real-time profiling of inhalation efforts
TWI494123B (zh) 2008-08-11 2015-08-01 Mannkind Corp 超快起作用胰島素之用途
CN102325532B (zh) 2008-10-07 2015-06-17 Mpex医药有限公司 用于减轻肺部炎症的左氧氟沙星吸入剂
AU2009302478B2 (en) 2008-10-07 2015-09-03 Horizon Orphan Llc Aerosol fluoroquinolone formulations for improved pharmacokinetics
CA2683353C (en) 2008-10-22 2015-12-15 Trudell Medical International Modular aerosol delivery system
US8945592B2 (en) 2008-11-21 2015-02-03 Acelrx Pharmaceuticals, Inc. Sufentanil solid dosage forms comprising oxygen scavengers and methods of using the same
EP2196465A1 (en) 2008-12-15 2010-06-16 Almirall, S.A. (3-oxo)pyridazin-4-ylurea derivatives as PDE4 inhibitors
UY32297A (es) 2008-12-22 2010-05-31 Almirall Sa Sal mesilato de 5-(2-{[6-(2,2-difluoro-2-fenilitoxi) hexil]amino}-1-hidroxietil)-8-hidroxiquinolin-2( 1h)-ona como agonista del receptor b(beta)2 acrenérgico
US8314106B2 (en) 2008-12-29 2012-11-20 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
EP2221055A1 (en) 2009-02-18 2010-08-25 Almirall, S.A. 5-(2-{[6-(2,2-difluoro-2-phenylethoxy)hexyl]amino}-1-hydroxyethyl)-8-hydroxyquinolin-2(1H)-one for the treatment of lung function
EP2221297A1 (en) 2009-02-18 2010-08-25 Almirall, S.A. 5-(2-{[6-(2,2-difluoro-2-phenylethoxy)hexyl]amino}-1-hydroxyethyl)-8-hydroxyquinolin-2(1h)-one and its use in the treatment of pulmonary diseases
EP2226323A1 (en) 2009-02-27 2010-09-08 Almirall, S.A. New tetrahydropyrazolo[3,4-c]isoquinolin-5-amine derivatives
US8538707B2 (en) 2009-03-11 2013-09-17 Mannkind Corporation Apparatus, system and method for measuring resistance of an inhaler
EP2228368A1 (en) 2009-03-12 2010-09-15 Almirall, S.A. Process for manufacturing 5-(2-{[6-(2,2-difluoro-2-phenylethoxy) hexyl]amino}-1-hydroxyethyl)-8-hydroxyquinolin-2(1H)-one
WO2010107761A1 (en) 2009-03-18 2010-09-23 Acelrx Pharmaceuticals, Inc. Improved storage and dispensing devices for administration of oral transmucosal dosage forms
WO2010135340A2 (en) 2009-05-18 2010-11-25 3M Innovative Properties Company Dry powder inhalers
AU2010259943C1 (en) 2009-06-12 2016-03-03 Mannkind Corporation Diketopiperazine microparticles with defined specific surface areas
LT2473170T (lt) 2009-09-04 2019-10-10 Horizon Orphan Llc Aerozolizuoto levofloksacino panaudojimas cistinės fibrozės gydymui
JP5784622B2 (ja) 2009-11-03 2015-09-24 マンカインド コーポレ−ション 吸入活動をシミュレートするための装置及び方法
EP2322176A1 (en) 2009-11-11 2011-05-18 Almirall, S.A. New 7-phenyl-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one derivatives
US9492625B2 (en) 2009-11-12 2016-11-15 Stc.Unm Dry powder inhaler with flutter dispersion member
EP2380890A1 (en) 2010-04-23 2011-10-26 Almirall, S.A. New 7,8-dihydro-1,6-naphthyridin-5(6h)-one-derivatives as PDE4 inhibitors
EP2386555A1 (en) 2010-05-13 2011-11-16 Almirall, S.A. New cyclohexylamine derivatives having beta2 adrenergic agonist and m3 muscarinic antagonist activities
EP2394998A1 (en) 2010-05-31 2011-12-14 Almirall, S.A. 3-(5-Amino-6-oxo-1,6-dihydropyridazin-3-yl)-biphenyl derivatives as PDE4 inhibitors
RU2531455C2 (ru) 2010-06-21 2014-10-20 Маннкайнд Корпорейшн Системы и способы доставки сухих порошковых лекарств
EP2441755A1 (en) 2010-09-30 2012-04-18 Almirall, S.A. Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors
EP2457900A1 (en) 2010-11-25 2012-05-30 Almirall, S.A. New pyrazole derivatives having CRTh2 antagonistic behaviour
EP2463289A1 (en) 2010-11-26 2012-06-13 Almirall, S.A. Imidazo[1,2-b]pyridazine derivatives as JAK inhibitors
WO2012078804A1 (en) 2010-12-07 2012-06-14 Respira Therapeutics, Inc. Dry powder inhaler
HUE058753T2 (hu) 2011-01-31 2022-09-28 Avalyn Pharma Inc Aeroszol formájú pirfenidon- és piridon-analóg vegyületek és alkalmazásaik
EP2489663A1 (en) 2011-02-16 2012-08-22 Almirall, S.A. Compounds as syk kinase inhibitors
MX353285B (es) 2011-04-01 2018-01-05 Mannkind Corp Paquete de blister para cartuchos farmaceuticos.
EP2510928A1 (en) 2011-04-15 2012-10-17 Almirall, S.A. Aclidinium for use in improving the quality of sleep in respiratory patients
EP2518070A1 (en) 2011-04-29 2012-10-31 Almirall, S.A. Pyrrolotriazinone derivatives as PI3K inhibitors
EP2518071A1 (en) 2011-04-29 2012-10-31 Almirall, S.A. Imidazopyridine derivatives as PI3K inhibitors
EP2526945A1 (en) 2011-05-25 2012-11-28 Almirall, S.A. New CRTH2 Antagonists
EP2527344A1 (en) 2011-05-25 2012-11-28 Almirall, S.A. Pyridin-2(1H)-one derivatives useful as medicaments for the treatment of myeloproliferative disorders, transplant rejection, immune-mediated and inflammatory diseases
WO2012174472A1 (en) 2011-06-17 2012-12-20 Mannkind Corporation High capacity diketopiperazine microparticles
EP2548863A1 (en) 2011-07-18 2013-01-23 Almirall, S.A. New CRTh2 antagonists.
EP2548876A1 (en) 2011-07-18 2013-01-23 Almirall, S.A. New CRTh2 antagonists
EP2554544A1 (en) 2011-08-01 2013-02-06 Almirall, S.A. Pyridin-2(1h)-one derivatives as jak inhibitors
EP2578570A1 (en) 2011-10-07 2013-04-10 Almirall, S.A. Novel process for preparing 5-(2-{[6-(2,2-difluoro-2-phenylethoxy)hexyl]amino}-1(r)-hydroxyethyl)-8-hydroxyquinolin-2(1h)-one via novel intermediates of synthesis.
HK1201475A1 (en) 2011-10-24 2015-09-04 Mannkind Corporation Methods and compositions for treating pain
EP2592078A1 (en) 2011-11-11 2013-05-15 Almirall, S.A. New cyclohexylamine derivatives having beta2 adrenergic agonist and M3 muscarinic antagonist activities
EP2592077A1 (en) 2011-11-11 2013-05-15 Almirall, S.A. New cyclohexylamine derivatives having beta2 adrenergic agonist and M3 muscarinic antagonist activities
GB2498746A (en) 2012-01-26 2013-07-31 Innovata Biomed Ltd Inhaler which locks when empty
WO2013114371A1 (en) 2012-02-01 2013-08-08 Protalix Ltd. Dry powder formulations of dnase i
US10463815B2 (en) 2012-02-21 2019-11-05 Respira Therapeutics, Inc. Inhaler to deliver substances for prophylaxis or prevention of disease or injury caused by the inhalation of biological or chemical agents
GB2499597A (en) * 2012-02-21 2013-08-28 Innovata Biomed Ltd Dry powder inhaler with stepped rotation of metering member
WO2013132497A1 (en) 2012-03-07 2013-09-12 Advanced Inhilation Therapies (Ait) Ltd. Inhalation of nitric oxide for treating respiratory diseases
EP2641900A1 (en) 2012-03-20 2013-09-25 Almirall, S.A. Novel polymorphic Crystal forms of 5-(2-{[6-(2,2-difluoro-2-phenylethoxy) hexyl]amino}-1-(R)-hydroxyethyl)-8-hydroxyquinolin-2(1h)-one, heminapadisylate as agonist of the ß2 adrenergic receptor.
EP2647627A1 (en) 2012-04-02 2013-10-09 Almirall, S.A. Salts of 5-[(1r)-2-({2-[4-(2,2-difluoro-2-phenylethoxy)phenyl] ethyl}amino)-1-hydroxyethyl]-8-hydroxyquinolin-2(1h)-one.
EP2666465A1 (en) 2012-05-25 2013-11-27 Almirall, S.A. Novel dosage and formulation
EP2668941A1 (en) 2012-05-31 2013-12-04 Almirall, S.A. Novel dosage form and formulation of abediterol
AU2013289957B2 (en) 2012-07-12 2017-02-23 Mannkind Corporation Dry powder drug delivery systems and methods
WO2014060431A1 (en) 2012-10-16 2014-04-24 Almirall, S.A. Pyrrolotriazinone derivatives as pi3k inhibitors
WO2014066856A1 (en) 2012-10-26 2014-05-01 Mannkind Corporation Inhalable influenza vaccine compositions and methods
EP2738172A1 (en) 2012-11-28 2014-06-04 Almirall, S.A. New bicyclic compounds as crac channel modulators
ES2750523T3 (es) 2012-12-18 2020-03-26 Almirall Sa Derivados de ciclohexil y quinuclidinil carbamato que tienen actividades de agonista beta2 adrenérgicos y antagonistas muscarínicos M3
TW201446767A (zh) 2013-02-15 2014-12-16 Almirall Sa 作為磷脂肌醇3-激酶抑製劑之吡咯並三嗪衍生物
BR112015023168B1 (pt) 2013-03-15 2021-08-10 Mannkind Corporation Composição de 3,6-bis(n-fumaril-4-aminobutil)-2,5-dicetopiperazina cristalina, método de produção de partículas de 3,6-bis(n-fumaril-4-aminobutil)-2,5-dicetopiperazina e uso de uma composição de dicetopiperazina cristalina
EP2848615A1 (en) 2013-07-03 2015-03-18 Almirall, S.A. New pyrazole derivatives as CRAC channel modulators
BR122019026637B1 (pt) 2013-07-18 2023-09-26 Mannkind Corporation Formulações farmacêuticas de pó seco e método para a fabricação de uma formulação de pó seco
CA3280124A1 (en) 2013-07-31 2025-10-31 Avalyn Pharma Inc. Aerosol imatinib compounds and uses thereof
CA2920488C (en) 2013-08-05 2022-04-26 Mannkind Corporation Insufflation apparatus and methods
WO2015091285A1 (en) 2013-12-19 2015-06-25 Almirall S.A. Dosage formulation comprising salmeterol and fluticasone propionate
JP7066321B2 (ja) 2014-01-10 2022-05-13 アヴァリン ファーマ インク． エアロゾルのピルフェニドン及びピリドンのアナログの化合物、及び、その使用
US10307464B2 (en) 2014-03-28 2019-06-04 Mannkind Corporation Use of ultrarapid acting insulin
US10561806B2 (en) 2014-10-02 2020-02-18 Mannkind Corporation Mouthpiece cover for an inhaler
US20170304459A1 (en) 2014-10-10 2017-10-26 Alnylam Pharmaceuticals, Inc. Methods and compositions for inhalation delivery of conjugated oligonucleotide
BR112017013311B1 (pt) 2014-12-23 2022-05-31 Acelrx Pharmaceuticals, Inc Aparelho para a dispensação de formas de dosagem via oral e transmucosal
CA2972826C (en) 2015-01-14 2023-09-12 Respira Therapeutics, Inc. Powder dispersion methods and devices
WO2016170009A1 (en) 2015-04-21 2016-10-27 Almirall, S.A. Amino-substituted heterocyclic derivatives as sodium channel inhibitors
WO2016202800A1 (en) 2015-06-16 2016-12-22 Almirall, S.A. Pyrrolotriazinone derivatives as pi3k inhibitors
WO2017076990A1 (en) 2015-11-05 2017-05-11 Almirall, S.A. Addition salts of n-[4-(4-{[(1s)-1-(5-methyl-4-oxo-3-phenyl-3,4-dihydropyrrolo[2,1-f][1,2,4]triazin-2-yl)ethyl]amino}-7h-pyrrolo[2,3-d]pyrimidin-5-yl)-1h-indol-6-yl]sulfamide
EP3458133B2 (en) 2016-05-19 2026-07-15 MannKind Corporation Apparatus, system and method for detecting and monitoring inhalations
TW201919682A (zh) 2017-08-08 2019-06-01 西班牙商阿爾米雷爾有限公司 活化Ｎｒｆ２路徑的新穎化合物
CN119632930A (zh) 2019-04-29 2025-03-18 英斯梅德股份有限公司 曲前列素前药的干粉组合物及其使用方法
BR112022009952A8 (pt) * 2019-11-28 2023-09-26 Chiesi Farm Spa Montagem de inalador de pó
BR112022009973A2 (pt) 2019-11-28 2022-08-09 Chiesi Farm Spa Módulo eletrônico para um inalador e montagem de inalador que compreende o módulo eletrônico
CN116437906B (zh) 2020-10-28 2026-07-03 英斯梅德股份有限公司 曲前列环素前药的干粉组合物和其使用方法
GB202102026D0 (en) * 2021-02-12 2021-03-31 Cambridge Healthcare Innovations Ltd Medical apparatus and method
WO2022240897A1 (en) 2021-05-10 2022-11-17 Sepelo Therapeutics, Llc Pharmaceutical composition comprising delafloxacin for administration into the lung
WO2023028364A1 (en) 2021-08-27 2023-03-02 Sepelo Therapeutics, Llc Targeted compositions and uses therof
WO2023150747A1 (en) 2022-02-07 2023-08-10 Insmed Incorporated Dry powder compositions of bedaquiline and salts and methods of use thereof
WO2026133157A1 (en) 2024-12-16 2026-06-25 Puretech Lyt 100, Inc. Deupirfenidone for use for treating idiopathic pulmonary fibrosis

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2587215A (en) * 1949-04-27 1952-02-26 Frank P Priestly Inhalator
DE2716323C2 (de) * 1977-04-07 1986-03-13 Schering AG, 1000 Berlin und 4709 Bergkamen Vorrichtung zur Inhalation von Arzneimitteln
IT7920688U1 (it) * 1979-02-05 1980-08-05 Chiesi Paolo Inalatore per sostanze medicamentose pulverulente, con combinata funzione di dosatore
US4274403A (en) * 1979-08-29 1981-06-23 Struve Roger L Inhaler
EP0069715B1 (en) * 1981-07-08 1986-11-05 Aktiebolaget Draco Powder inhalator
EP0079478A1 (en) * 1981-11-03 1983-05-25 Miles Laboratories, Inc. Medicament inhalation device
US4570630A (en) * 1983-08-03 1986-02-18 Miles Laboratories, Inc. Medicament inhalation device
SE448277B (sv) * 1985-04-12 1987-02-09 Draco Ab Indikeringsanordning vid en doseringsanordning for lekemedel
AU591152B2 (en) * 1985-07-30 1989-11-30 Glaxo Group Limited Devices for administering medicaments to patients
GB9015522D0 (en) * 1990-07-13 1990-08-29 Braithwaite Philip W Inhaler

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EP0573128A2 (en) 1993-12-08
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DE69108912T2 (de) 1995-08-31
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EP0573128A3 (es) 1994-03-02
AU8191691A (en) 1992-02-04
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GB9015522D0 (en) 1990-08-29
CA2086415C (en) 1996-05-07
EP0573128B1 (en) 1994-12-07
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