ES2068404T3 - Un metodo para aislar el factor viii. - Google Patents

Un metodo para aislar el factor viii.

Info

Publication number
ES2068404T3
ES2068404T3 ES90917201T ES90917201T ES2068404T3 ES 2068404 T3 ES2068404 T3 ES 2068404T3 ES 90917201 T ES90917201 T ES 90917201T ES 90917201 T ES90917201 T ES 90917201T ES 2068404 T3 ES2068404 T3 ES 2068404T3
Authority
ES
Spain
Prior art keywords
factor viii
isolating
proteins
plasma
practically
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90917201T
Other languages
English (en)
Inventor
Per Kaersgaard
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novo Nordisk AS
Original Assignee
Novo Nordisk AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk AS filed Critical Novo Nordisk AS
Application granted granted Critical
Publication of ES2068404T3 publication Critical patent/ES2068404T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Housing For Livestock And Birds (AREA)
  • Cephalosporin Compounds (AREA)
  • Networks Using Active Elements (AREA)
  • External Artificial Organs (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Separation By Low-Temperature Treatments (AREA)
  • Amplifiers (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

SE PRESENTA UN METODO PARA AISLAR EL FACTOR VIII DE OTRAS PROTEINAS DISUELTAS EN EL PLASMA SANGUINEO, EN DONDE EL PLASMA SE SOMETE A UNA FILTRACION EN GEL BAJO CONDICIONES DE SEPARACION DEL GRUPO CON LO QUE SE OBTIENE UNA FRACCION QUE CONTIENE EL FACTOR VIII EN UN RENDIMIENTO MUY ELEVADO Y PRACTICAMENTE SIN OTRAS PROTEINAS.
ES90917201T 1989-11-09 1990-11-05 Un metodo para aislar el factor viii. Expired - Lifetime ES2068404T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK562189A DK162233C (da) 1989-11-09 1989-11-09 Fremgangsmaade til isolering af faktor viii fra blodplasma og pharmaceutisk praeparat indeholdende den saaledes isolerede fator viii

Publications (1)

Publication Number Publication Date
ES2068404T3 true ES2068404T3 (es) 1995-04-16

Family

ID=8144000

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90917201T Expired - Lifetime ES2068404T3 (es) 1989-11-09 1990-11-05 Un metodo para aislar el factor viii.

Country Status (26)

Country Link
US (1) US5245014A (es)
EP (1) EP0524172B1 (es)
JP (1) JP2509407B2 (es)
CN (1) CN1044121C (es)
AT (1) ATE118508T1 (es)
AU (1) AU631471B2 (es)
BG (1) BG61231B1 (es)
CA (1) CA2073012C (es)
CZ (1) CZ537190A3 (es)
DE (1) DE69017050T2 (es)
DK (1) DK162233C (es)
ES (1) ES2068404T3 (es)
FI (1) FI103510B1 (es)
HU (1) HU214905B (es)
IE (1) IE66836B1 (es)
IL (1) IL96277A (es)
NO (1) NO180741C (es)
NZ (1) NZ236004A (es)
PL (1) PL164894B1 (es)
PT (1) PT95830B (es)
RU (1) RU2055593C1 (es)
SK (1) SK278640B6 (es)
UA (1) UA29421C2 (es)
WO (1) WO1991007438A1 (es)
YU (1) YU47524B (es)
ZA (1) ZA908599B (es)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69002033T2 (de) * 1989-05-24 1993-09-30 Miles Inc Gelfiltration von wärmebehandeltem Faktor VIII.
US5888974A (en) * 1992-04-07 1999-03-30 Emory University Hybrid human/animal factor VIII
US6180371B1 (en) 1996-06-26 2001-01-30 Emory University Modified factor VIII
US5859204A (en) * 1992-04-07 1999-01-12 Emory University Modified factor VIII
US5659017A (en) * 1995-11-07 1997-08-19 Alpha Therapeutic Corporation Anion exchange process for the purification of Factor VIII
US7560107B2 (en) 1996-06-26 2009-07-14 Emory University Modified factor VIII
US6458563B1 (en) 1996-06-26 2002-10-01 Emory University Modified factor VIII
US6531577B1 (en) * 1997-12-15 2003-03-11 Hemasure Denmark A/S von Willebrand factor (vWF)-containing preparation, process for preparing vWF-containing preparations, and use of such preparations
US6290527B1 (en) * 1998-07-03 2001-09-18 Nippon Telegraph And Telephone Corp. Nippon telegraph and telephone corporation
DK1820516T3 (da) 1999-02-22 2013-10-28 Univ Connecticut Nye albuminfrie faktor VIII-præparater
JP2002348300A (ja) * 1999-04-12 2002-12-04 Fujimori Kogyo Co Ltd 血液凝固第ｖｉｉｉ因子および血液凝固第ｖｉｉｉ因子／フォン・ビルブラント因子複合体の精製方法
BR0207007A (pt) * 2001-02-05 2004-02-17 Novo Nordisk Healthcare Ag Composição farmcêutica, kit, usos de uma preparação e de uma composição, e, métodos para tratar de episódios de hemorragia em um paciente, para reduzir o tempo de coagulação em um paciente, para intensificar a hemostasia em um paciente para reduzir o número de administrações da proteìna do fator de coagulação necessário para deter a hemorragia e manter a hemostasia em um paciente, para reduzir a quantidade de proteìna do fator de coagulação administrada necessária para deter a hemorragia e manter a hemostasia em um paciente, para prolongar o tempo de lise do coágulo em um paciente, para aumentar a resistência do coágulo em paciente e para intensificar a formação de coágulo de fibrina em um paciente
AUPR638801A0 (en) * 2001-07-13 2001-08-09 Life Therapeutics Limited Factor viii separation
RU2253475C1 (ru) * 2004-02-02 2005-06-10 Общество с ограниченной ответственностью "Гемоцентр" Способ получения препарата фактора viii
DK1750733T3 (da) 2004-05-03 2014-01-20 Univ Emory FREMGANGSMÅDE TIL INDGIVELSE AF SVINE-B-DOMÆNELØS fVIII
CN101010333B (zh) * 2004-08-27 2013-08-14 诺和诺德医疗保健公司 从生物材料中纯化凝血因子xⅲ多肽
US20060226086A1 (en) * 2005-04-08 2006-10-12 Robinson Thomas C Centrifuge for blood processing systems
RU2324495C1 (ru) * 2006-08-31 2008-05-20 Федеральное государственное унитарное предприятие "Научно-производственное объединение по медицинским иммунобиологическим препаратам "Микроген" Министерства здравоохранения Российской Федерации Способ получения препарата фактора свертывания viii крови человека
MX339060B (es) 2008-11-07 2016-05-09 Baxter Int Formulaciones del factor viii.
WO2011121020A1 (en) * 2010-03-30 2011-10-06 Octapharma Ag A process for purifying vitamin k dependent proteins such as coagulation factor ix
RU2445974C2 (ru) * 2010-04-26 2012-03-27 Учреждение Российской академии медицинских наук Гематологический научный центр ГНЦ РАМН Способ получения концентрата фактора viii из плазмы крови человека
DK2635297T3 (da) 2010-11-05 2019-05-06 Baxalta GmbH En ny variant af antihæmofil faktor viii, der har en øget specifik aktivitet
SG191186A1 (en) 2010-12-15 2013-07-31 Baxter Int Eluate collection using conductivity gradient
CN103506080A (zh) * 2012-06-19 2014-01-15 汪志友 一种用于分离纯化凝血因子viii的介质及其制备方法
BR112015006634B1 (pt) 2012-09-28 2022-06-14 Chugai Seiyaku Kabushiki Kaisha Método e kit para avaliação de reação de coagulação sanguínea
US9663553B2 (en) 2014-01-29 2017-05-30 Hemarus Therapeutics Limited Integrated process for the production of therapeutics (human albumin, immunoglobulins, clotting factor VIII and clotting factor IX) from human plasma

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4495175A (en) * 1982-08-05 1985-01-22 University Of Rochester Preparation of highly purified human antihemophilic factor
US4543210A (en) * 1984-10-04 1985-09-24 Miles Laboratories, Inc. Process for producing a high purity antihemophilic factor concentrate
DK525384D0 (da) * 1984-11-05 1984-11-05 Nordisk Insulinlab Praeparat paa basis af faktor viii til behandling af haemofili a inhibitorpatienter samt fremgangsmaade til fremstilling af et saadan praeparat
US4847362A (en) * 1985-02-01 1989-07-11 New York University Method for purifying antihemophilic factor
US4675385A (en) * 1985-03-27 1987-06-23 Alpha Therapeutic Corporation Isolation of human plasma procoagulant protein factor VIII from biological factors
US4758657A (en) * 1985-07-11 1988-07-19 Armour Pharmaceutical Company Method of purifying Factor VIII:C
AT391808B (de) * 1986-11-03 1990-12-10 Immuno Ag Verfahren zur herstellung einer faktor viii (ahf)-haeltigen fraktion
ATE112287T1 (de) * 1987-12-21 1994-10-15 Miles Inc Faktor viii- gelfiltration.
WO1989009784A1 (en) * 1988-04-08 1989-10-19 Commonwealth Serum Laboratories Commission Production of heat-stable factor viii concentrate
DE69002033T2 (de) * 1989-05-24 1993-09-30 Miles Inc Gelfiltration von wärmebehandeltem Faktor VIII.

Also Published As

Publication number Publication date
IL96277A (en) 1995-07-31
FI103510B (fi) 1999-07-15
FI103510B1 (fi) 1999-07-15
SK537190A3 (en) 1997-12-10
HUT60511A (en) 1992-09-28
IL96277A0 (en) 1991-08-16
CA2073012A1 (en) 1991-05-10
UA29421C2 (uk) 2000-11-15
BG61231B1 (en) 1997-03-31
PL287703A1 (en) 1991-12-02
DK162233C (da) 1992-03-16
RU2055593C1 (ru) 1996-03-10
AU631471B2 (en) 1992-11-26
PT95830A (pt) 1991-09-30
CN1044121C (zh) 1999-07-14
DK562189A (da) 1991-05-10
JP2509407B2 (ja) 1996-06-19
IE904022A1 (en) 1991-05-22
NZ236004A (en) 1991-11-26
CA2073012C (en) 1996-03-19
EP0524172A1 (en) 1993-01-27
WO1991007438A1 (en) 1991-05-30
HU214905B (hu) 1998-07-28
DK162233B (da) 1991-09-30
FI922105L (fi) 1992-05-08
YU210590A (sh) 1993-05-28
IE66836B1 (en) 1996-02-07
NO180741B (no) 1997-03-03
US5245014A (en) 1993-09-14
PL164894B1 (pl) 1994-10-31
JPH05501557A (ja) 1993-03-25
NO180741C (no) 1997-06-11
HU9201551D0 (en) 1992-08-28
ZA908599B (en) 1991-07-31
DE69017050T2 (de) 1995-06-14
BG96316A (bg) 1993-12-24
PT95830B (pt) 1997-11-28
CZ537190A3 (cs) 1998-05-13
SK278640B6 (en) 1997-12-10
DE69017050D1 (de) 1995-03-23
NO921839D0 (no) 1992-05-08
DK562189D0 (da) 1989-11-09
NO921839L (no) 1992-07-08
EP0524172B1 (en) 1995-02-15
ATE118508T1 (de) 1995-03-15
YU47524B (sh) 1995-10-03
CN1051732A (zh) 1991-05-29
AU6747090A (en) 1991-06-13
FI922105A0 (fi) 1992-05-08

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