ES2070104T1 - Dna que codifica para un receptor (5-ht4b) de la serotonina humana y usos del mismo. - Google Patents

Dna que codifica para un receptor (5-ht4b) de la serotonina humana y usos del mismo.

Info

Publication number
ES2070104T1
ES2070104T1 ES94901252T ES94901252T ES2070104T1 ES 2070104 T1 ES2070104 T1 ES 2070104T1 ES 94901252 T ES94901252 T ES 94901252T ES 94901252 T ES94901252 T ES 94901252T ES 2070104 T1 ES2070104 T1 ES 2070104T1
Authority
ES
Spain
Prior art keywords
receiver
codes
nucleic acid
ht4b
isolated nucleic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
ES94901252T
Other languages
English (en)
Inventor
Jonathan A Bard
Theresa Branchek
Richard L Weinshank
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lundbeck Research USA Inc
Original Assignee
Synaptic Pharmaceutical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25518691&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2070104(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Synaptic Pharmaceutical Corp filed Critical Synaptic Pharmaceutical Corp
Publication of ES2070104T1 publication Critical patent/ES2070104T1/es
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70571—Receptors; Cell surface antigens; Cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/035—Animal model for multifactorial diseases
    • A01K2267/0356—Animal model for processes and diseases of the central nervous system, e.g. stress, learning, schizophrenia, pain, epilepsy
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/035—Animal model for multifactorial diseases
    • A01K2267/0375—Animal model for cardiovascular diseases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Neurology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

ESTA INVENCION PROPORCIONA UNA MOLECULA DE ACIDO NUCLEICO AISLADA QUE CODIFICA UN RECEPTOR 5 LECULA DE ACIDO NUCLEICO AISLADA QUE CODIFICA UN RECEPTOR 5 HT4B HUMANO, UNA PROTEINA AISLADA QUE ES RECEPTORA DE 5 -HT4B DE MAMIFERO, VECTORES QUE COMPRENDEN UNA MOLECULA DE ACIDO NUCLEICO AISLADA QUE CODIFICA UN RECEPTOR 5 ECTORES QUE COMPRENDEN UNA MOLECULA DE ACIDO NUCLEICO AISLADA QUE CODIFICA UN RECEPTOR 5 QUE COMPRENDEN DICHOS VECTORES, ANTICUERPOS DIRIGIDOS AL RECEPTOR 5 IDO NUCLEICO QUE CODIFIQUE UN RECEPTOR 5 HT4B HUMANO O DE MAMIFERO, OLIGONUCLEOTIDOS COMPLEMENTARIOS A CUALQUIER SECUENCIA DE UNA MOLECULA DE ACIDO NUCLEICO QUE CODIFICA UN RECEPTOR 5 T4B HUMANO O DE MAMIFERO, COMPUESTOS FARMACEUTICOS RELACIONADOS CON EL RECEPTOR 5 DEMAS METODOS PARA DETERMINAR UNIONES LIGANTES, DETECTAR EXPRESION, APANTALLAMIENTO DE DROGAS Y TRATAMIENTOS PARA ALIVIAR ANORMALIDADES ASOCIADAS CON UN RECEPTOR 5
ES94901252T 1992-11-03 1993-10-29 Dna que codifica para un receptor (5-ht4b) de la serotonina humana y usos del mismo. Pending ES2070104T1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US97169092A 1992-11-03 1992-11-03

Publications (1)

Publication Number Publication Date
ES2070104T1 true ES2070104T1 (es) 1995-06-01

Family

ID=25518691

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94901252T Pending ES2070104T1 (es) 1992-11-03 1993-10-29 Dna que codifica para un receptor (5-ht4b) de la serotonina humana y usos del mismo.

Country Status (15)

Country Link
US (4) US5985585A (es)
EP (1) EP0624100B1 (es)
JP (1) JPH08506240A (es)
KR (1) KR950704001A (es)
AT (1) ATE192490T1 (es)
AU (1) AU686580B2 (es)
CA (1) CA2127117C (es)
DE (2) DE624100T1 (es)
ES (1) ES2070104T1 (es)
FI (1) FI111337B (es)
GR (1) GR950300029T1 (es)
HU (1) HU221822B1 (es)
NO (1) NO951689L (es)
NZ (1) NZ258320A (es)
WO (1) WO1994009828A1 (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ258320A (en) 1992-11-03 1996-12-20 Synaptic Pharma Corp Dna encoding a human receptor 5-ht4b receptor and diagnostic use
US6300087B1 (en) * 1992-11-03 2001-10-09 Synaptic Pharmaceutical Corporation DNA encoding a human serotonin receptor (5-HT4B) and uses thereof
US6228864B1 (en) * 1997-10-28 2001-05-08 Vivus, Inc. Administration of 5-HT receptor agonists and antagonists, to treat premature ejaculation
FR2771741B1 (fr) * 1997-11-28 2001-07-13 Inst Nat Sante Rech Med Variants d'epissage du recepteur serotoninergique 5-ht4 humain et leurs applications, notamment pour le criblage
EP0998923A1 (en) * 1998-10-30 2000-05-10 Basf Aktiengesellschaft Use of 5-HT7 receptor agonists for the treatment or prophylaxis of ischemias
WO2000069437A1 (en) 1999-05-18 2000-11-23 Synaptic Pharmaceutical Corporation Use of agonists or antagonists of the 5-ht7 receptor to treat disorders of the bladder
DE60115847T2 (de) * 2000-02-17 2006-07-27 Glaxo Group Ltd., Greenford Polymorphismen des 5-hydroxytryptamintransportergens
WO2002036629A2 (en) * 2000-10-31 2002-05-10 Bayer Aktiengesellschaft Regulation of human serotonin receptor precursor
US6989239B2 (en) * 2001-06-20 2006-01-24 R.E.D. Laboratories, N.V./S.A. Methods for diagnosis and treatment of chronic immune diseases
AU2003211501A1 (en) * 2002-02-08 2003-09-02 Nakoshi, Hideo Peptides
US7463934B2 (en) * 2002-04-12 2008-12-09 Medtronic, Inc. Implantable medical device with captivation fixation
FR2846559B1 (fr) 2002-10-31 2007-06-15 Centre Nat Rech Scient Composition pharmaceutique pour la preparation d'un medicament destine a traiter et/ou a prevenir une pathologie liee a une conduite obsessionnelle
EP1634081A2 (en) * 2003-05-28 2006-03-15 Bayer HealthCare AG Diagnostics and therapeutics for diseases associated with 5-hydroxytryptamine (serotonin) receptor 7 (5-ht7)
US9395365B2 (en) * 2009-04-02 2016-07-19 Abbott Point Of Care, Inc. Detection of infectious disease in a human or animal by measuring specific phagocytosis in a thin film sample of their anticoagulated blood

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1208146A (en) * 1983-10-27 1986-07-22 Tai-Kin Wong Method of transferring genes into cells
US4985352A (en) * 1988-02-29 1991-01-15 The Trustees Of Columbia University In The City Of New York DNA encoding serotonin 1C (5HT1c) receptor, isolated 5HT1c receptor, mammalian cells expressing same and uses thereof
WO1991006648A1 (en) * 1989-10-27 1991-05-16 The Salk Institute For Biological Studies Glutamate receptor compositions and methods
WO1991013979A1 (en) * 1990-03-05 1991-09-19 President And Fellows Of Harvard College Transgenic mouse overexpressing il-4 and method of use
US5155218A (en) * 1990-05-08 1992-10-13 Neurogenetic Corporation Dna encoding human 5-ht1d receptors
US5225543A (en) * 1991-03-28 1993-07-06 American Cyanamid Company Receptors method for purification of g protein-linked
AU672768B2 (en) * 1991-12-02 1996-10-17 Lundbeck Research Usa, Inc. DNA encoding a human 5-HT-1E receptor and uses thereof
US5360735A (en) * 1992-01-08 1994-11-01 Synaptic Pharmaceutical Corporation DNA encoding a human 5-HT1F receptor, vectors, and host cells
FR2693200B1 (fr) * 1992-07-01 1994-08-19 Inst Nat Sante Rech Med Nouveaux polypeptides ayant une activité de récepteur sérotoninergique, acides nucléiques codant pour ces polypeptides et utilisations.
FR2693201B1 (fr) * 1992-07-01 1994-08-19 Inst Nat Sante Rech Med Nouveaux polypeptides ayant une activité de récepteur sérotoninergique, acides nucléiques codant pour ces polyptides et utilisations.
AU5588094A (en) 1992-10-26 1994-05-24 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The The pct-65 serotonin receptor
NZ258320A (en) 1992-11-03 1996-12-20 Synaptic Pharma Corp Dna encoding a human receptor 5-ht4b receptor and diagnostic use
FR2699922B1 (fr) * 1992-12-30 1995-02-10 Inst Nat Sante Rech Med Polypeptides à activité de récepteur sérotoninergique, médicaments les comprenant, séquences codant pour eux, sondes vecteurs et hôtes les exprimant, et application au criblage des médicaments.
US5968817A (en) * 1993-03-15 1999-10-19 The Scripps Research Institute DNA encoding serotonin receptors
US7980514B2 (en) * 2008-03-14 2011-07-19 Northrop Grumman Space & Mission Systems Corp. Solar array momentum control

Also Published As

Publication number Publication date
FI111337B (fi) 2003-07-15
AU5590994A (en) 1994-05-24
WO1994009828A1 (en) 1994-05-11
CA2127117A1 (en) 1994-05-11
KR950704001A (ko) 1995-11-17
CA2127117C (en) 2001-02-13
EP0624100A1 (en) 1994-11-17
US5985585A (en) 1999-11-16
NO951689L (no) 1995-06-21
US6432655B1 (en) 2002-08-13
DE624100T1 (de) 1995-11-09
US6083749A (en) 2000-07-04
EP0624100A4 (en) 1995-11-29
HUT72837A (en) 1996-05-28
JPH08506240A (ja) 1996-07-09
US6376243B1 (en) 2002-04-23
FI952094A0 (fi) 1995-05-02
DE69328549D1 (de) 2000-06-08
ATE192490T1 (de) 2000-05-15
HU221822B1 (hu) 2003-01-28
GR950300029T1 (en) 1995-06-30
AU686580B2 (en) 1998-02-12
NO951689D0 (no) 1995-05-02
EP0624100B1 (en) 2000-05-03
NZ258320A (en) 1996-12-20
DE69328549T2 (de) 2000-08-24
FI952094A7 (fi) 1995-06-29

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