ES2070829T3 - Dipirazoles utiles como broncodilatadores. - Google Patents

Dipirazoles utiles como broncodilatadores.

Info

Publication number
ES2070829T3
ES2070829T3 ES88101180T ES88101180T ES2070829T3 ES 2070829 T3 ES2070829 T3 ES 2070829T3 ES 88101180 T ES88101180 T ES 88101180T ES 88101180 T ES88101180 T ES 88101180T ES 2070829 T3 ES2070829 T3 ES 2070829T3
Authority
ES
Spain
Prior art keywords
dipyrazoles
useful
broncodilatadores
dipirazoles
hydrazine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES88101180T
Other languages
English (en)
Inventor
Tourneau Michael E Le
Norton P Peet
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Merrell Dow Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharmaceuticals Inc filed Critical Merrell Dow Pharmaceuticals Inc
Application granted granted Critical
Publication of ES2070829T3 publication Critical patent/ES2070829T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pulmonology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Steroid Compounds (AREA)
  • Paper (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

SE DESCRIBE UN GRUPO DE [1,2-C:3,4-C''] DIPIRAZOLES SUSTITUIDOS, CICLOHEPTA [1,2-C:3,4-C''] DIPIRAZOLES Y CICLOPENTA [1,2-C:3,4-C''] DIPIRAZOLES UTILES COMO BRONCODILATADORES. LOS COMPUESTOS SE PREPARAN POR REACCION DE UNA 1,3-DICETONA CON HIDRAZINA O METILHIDRAZINA PARA DAR PRODUCTOS TRICICLICOS, OPCIONALMENTE SEGUIDA POR DESHIDROGENACION CATALITICA Y/O ALQUILACION CON UNA BASE FUERTE Y YODURO DE METILO PARA DAR OTROS VARIOS COMPUESTOS PROTEGIDOS POR LA INVENCION.
ES88101180T 1987-01-27 1988-01-27 Dipirazoles utiles como broncodilatadores. Expired - Lifetime ES2070829T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/007,305 US4734430A (en) 1987-01-27 1987-01-27 Dipyrazoles and their use as bronchodilators

Publications (1)

Publication Number Publication Date
ES2070829T3 true ES2070829T3 (es) 1995-06-16

Family

ID=21725393

Family Applications (1)

Application Number Title Priority Date Filing Date
ES88101180T Expired - Lifetime ES2070829T3 (es) 1987-01-27 1988-01-27 Dipirazoles utiles como broncodilatadores.

Country Status (19)

Country Link
US (1) US4734430A (es)
EP (1) EP0276833B1 (es)
JP (1) JP2571411B2 (es)
KR (2) KR880009024A (es)
CN (1) CN88100343A (es)
AT (1) ATE118494T1 (es)
AU (1) AU600789B2 (es)
CA (1) CA1324607C (es)
DE (1) DE3853012T2 (es)
DK (1) DK35188A (es)
ES (1) ES2070829T3 (es)
FI (1) FI89357C (es)
HU (1) HU197906B (es)
IL (1) IL85188A (es)
NO (1) NO167288C (es)
NZ (1) NZ223259A (es)
PH (1) PH23496A (es)
PT (1) PT86625B (es)
ZA (1) ZA88526B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4734429A (en) * 1987-01-27 1988-03-29 Merrell Dow Pharmaceuticals Inc. Cycloalkane[1,2-c:4,3-c']dipyrazoles and their use as bronchodilators
DE4232544A1 (de) * 1992-09-29 1994-03-31 Thomae Gmbh Dr K Arzneimittel enthaltend 1,5,6,7-Tetrahydro-4H-indazol-4-one, neue 1,5,6,7-Tetrahydro-4H-indazol-4-one und Verfahren zu ihrer Herstellung
GB9911053D0 (en) * 1999-05-12 1999-07-14 Pharmacia & Upjohn Spa 4,5,6,7-tetrahydroindazole derivatives process for their preparation and their use as antitumour agents
US20050176796A1 (en) * 2002-02-19 2005-08-11 D'alessio Roberto Tricyclic pyrazole derivatives, process for their preparation and their use as antitumor agents

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3404157A (en) * 1965-02-24 1968-10-01 American Cyanamid Co Substituted pyrroloindazole compounds
US3787430A (en) * 1972-07-13 1974-01-22 Squibb & Sons Inc Derivatives of dipyrazolo(3,4-b;3',4'-d)pyridines
US4515948A (en) * 1973-09-12 1985-05-07 Hoffmann-La Roche Inc. 2,4-Diamino-5-(4-amino and 4-dimethylamino-3,5-dimethoxy benzyl)pyrimidines
US4135048A (en) * 1977-05-17 1979-01-16 Laboratorios Cosmos S.A. Anaphylactic inhibiting trans-octahydronaphto[1,2-c:5,6-c'] dipyrazoles

Also Published As

Publication number Publication date
ZA88526B (en) 1988-09-28
IL85188A (en) 1992-02-16
DK35188A (da) 1988-07-28
NO880339L (no) 1988-07-28
JP2571411B2 (ja) 1997-01-16
IL85188A0 (en) 1988-07-31
US4734430A (en) 1988-03-29
FI880283A0 (fi) 1988-01-22
JPS63192775A (ja) 1988-08-10
PH23496A (en) 1989-08-16
FI880283A7 (fi) 1988-07-28
EP0276833A3 (en) 1990-01-24
AU600789B2 (en) 1990-08-23
CA1324607C (en) 1993-11-23
KR880009024A (ko) 1988-09-13
CN88100343A (zh) 1988-08-31
AU1073088A (en) 1988-07-28
HU197906B (en) 1989-06-28
FI89357B (fi) 1993-06-15
DK35188D0 (da) 1988-01-26
EP0276833B1 (en) 1995-02-15
NO167288B (no) 1991-07-15
EP0276833A2 (en) 1988-08-03
FI89357C (fi) 1993-09-27
PT86625A (pt) 1988-02-01
DE3853012T2 (de) 1995-07-20
HUT47281A (en) 1989-02-28
NO167288C (no) 1991-10-23
KR960001476B1 (ko) 1996-01-31
PT86625B (pt) 1991-12-31
NZ223259A (en) 1990-03-27
ATE118494T1 (de) 1995-03-15
NO880339D0 (no) 1988-01-26
DE3853012D1 (de) 1995-03-23

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