ES2070925T3 - Procedimiento para la preparacion de 14beta-hidroxi-esteroides. - Google Patents

Procedimiento para la preparacion de 14beta-hidroxi-esteroides.

Info

Publication number
ES2070925T3
ES2070925T3 ES89730020T ES89730020T ES2070925T3 ES 2070925 T3 ES2070925 T3 ES 2070925T3 ES 89730020 T ES89730020 T ES 89730020T ES 89730020 T ES89730020 T ES 89730020T ES 2070925 T3 ES2070925 T3 ES 2070925T3
Authority
ES
Spain
Prior art keywords
image
preparation
general formula
14beta
steroids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89730020T
Other languages
English (en)
Inventor
Gerald Dr Kirsch
Roland Golde
Gunter Dr Neef
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Application granted granted Critical
Publication of ES2070925T3 publication Critical patent/ES2070925T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0059—Estrane derivatives substituted in position 17 by a keto group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0038—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 with an androstane skeleton, including 18- or 19-substituted derivatives, 18-nor derivatives and also derivatives where position 17-beta is substituted by a carbon atom not directly bonded to a further carbon atom and not being part of an amide group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0072—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the A ring of the steroid being aromatic

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)

Abstract

SE DESCRIBE UN PROCEDIMIENTO PARA LA OBTENCION DE 14 - BETA HIDROXI - ESTEROIDES DE LAS FORMULA(I), DONDE R1 ES UN H O UN GRUPO METILO Y A SIMBOLIZA EL RESTO DE LA MOLECULA DE ESTEROIDE, EL CUAL SE CARACTERIZA POR QUE SE UTILIZA UN ESTEROIDE DE LA FORMULA(I) DONDE, R1 Y A TIENEN LOS SIGNIFICADOS DADOS ARRIBA Y R2 SIGNIFICA UN RESTO 1 - OXOALQUILO CON DE 2 A 6 C O UN GRUPO BENZOILO, CONVERTIDO CON UN COMPUESTO NITROSO DE LA FORMULA(III). EL PRODUCTO ASI OBTENIDO SE CALIENTA EN PRESENCIA DE UN ALCOHOL QUE CONTIENE DE 1 A 4 C Y EL COMPUESTO ASI OBTENIDO SE HIDRATA PARCIALMENTE CON UN COMPUESTO DE LA FORMULA(IV) DONDE R1 Y A TIENEN LOS SIGNIFICADOS ARRIBA.
ES89730020T 1988-02-03 1989-01-31 Procedimiento para la preparacion de 14beta-hidroxi-esteroides. Expired - Lifetime ES2070925T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3803551A DE3803551A1 (de) 1988-02-03 1988-02-03 Verfahren zur herstellung von 14ss-hydroxysteroiden

Publications (1)

Publication Number Publication Date
ES2070925T3 true ES2070925T3 (es) 1995-06-16

Family

ID=6346749

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89730020T Expired - Lifetime ES2070925T3 (es) 1988-02-03 1989-01-31 Procedimiento para la preparacion de 14beta-hidroxi-esteroides.

Country Status (4)

Country Link
EP (1) EP0327489B1 (es)
AT (1) ATE118504T1 (es)
DE (2) DE3803551A1 (es)
ES (1) ES2070925T3 (es)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4380624A (en) * 1981-07-31 1983-04-19 Advance Biofactures Corp. Novel isomers of bufalin and resibufogenin and their preparation

Also Published As

Publication number Publication date
DE58908988D1 (de) 1995-03-23
ATE118504T1 (de) 1995-03-15
EP0327489A3 (de) 1991-03-13
EP0327489A2 (de) 1989-08-09
DE3803551A1 (de) 1989-08-17
EP0327489B1 (de) 1995-02-15

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