ES2071135T3 - Procedimientos selectivos para polimorfos de fosinopril. - Google Patents

Procedimientos selectivos para polimorfos de fosinopril.

Info

Publication number
ES2071135T3
ES2071135T3 ES91101663T ES91101663T ES2071135T3 ES 2071135 T3 ES2071135 T3 ES 2071135T3 ES 91101663 T ES91101663 T ES 91101663T ES 91101663 T ES91101663 T ES 91101663T ES 2071135 T3 ES2071135 T3 ES 2071135T3
Authority
ES
Spain
Prior art keywords
polymorph
fosinopril
water
polymorphes
exothermic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91101663T
Other languages
English (en)
Inventor
John A Grosso
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ER Squibb and Sons LLC
Original Assignee
ER Squibb and Sons LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ER Squibb and Sons LLC filed Critical ER Squibb and Sons LLC
Application granted granted Critical
Publication of ES2071135T3 publication Critical patent/ES2071135T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

SE DESCRIBE UN PROCESO PARA PREPARAR E INTERCONVERTIR SELECTIVAMENTE SALES POLIMORFAS DE FOSINOPRIL, AGENTE ANTIHIPERTENSIVO QUE INHIBE LA ENZIMA CONVERSORA DE LA ANGIOTENSINA. CADA POLIMORFO SE PREPARA MEZCLANDO UN PORTADOR DE METAL ALCALI, FOSINOCRIL, AGUA Y QUETO Y/O UN SOLVENTE HIDROXILICO Y AISLANDO EL POLIMORFO FORMADO A PARTIR DE LA MEZCLA DE REACCION. UN POLIMORFO A MENOS EXOTERMICO SE FORMA CUANDO EL AGUA COMPONE MAS DEL 0.2 % DEL AGUA Y LOS SOLVENTES; CUANDO COMPONE EL 0.2 % O MENOS, SE FORMA EL POLIMORFO B.
ES91101663T 1990-02-16 1991-02-07 Procedimientos selectivos para polimorfos de fosinopril. Expired - Lifetime ES2071135T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/481,009 US5162543A (en) 1990-02-16 1990-02-16 Selective processes for fosinopril polymorphs
AU75286/91A AU646032B2 (en) 1990-02-16 1991-04-23 Selective processes for fosinopril polymorphs

Publications (1)

Publication Number Publication Date
ES2071135T3 true ES2071135T3 (es) 1995-06-16

Family

ID=25637879

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91101663T Expired - Lifetime ES2071135T3 (es) 1990-02-16 1991-02-07 Procedimientos selectivos para polimorfos de fosinopril.

Country Status (9)

Country Link
US (1) US5162543A (es)
EP (1) EP0442378B1 (es)
JP (1) JP2938590B2 (es)
AT (1) ATE121411T1 (es)
AU (1) AU646032B2 (es)
CA (1) CA2034811C (es)
DE (1) DE69108953T2 (es)
DK (1) DK0442378T3 (es)
ES (1) ES2071135T3 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9206414D0 (en) * 1992-03-24 1992-05-06 Smithkline Beecham Corp N-t-butyl-androst-3,5-diene-17b-carboxamide-3-carboxylic acid polymorph b
JP2004520440A (ja) * 2001-04-30 2004-07-08 ルピン ラボラトリーズ リミティド フォシノプリルナトリウムの製造方法
ES2195752B1 (es) * 2001-11-30 2004-10-16 Quimica Sintetica, S.A. Procedimiento para la preparacion de polimorfos cristalinos de la sal sodica del fosinopril.
SI23149A (sl) 2009-09-21 2011-03-31 Silverstone Pharma Nove benzatinske soli ACE inhibitorjev, postopek za njihovo pripravo in njihova uporaba za zdravljenje kardiovaskularnih bolezni
CN107365268B (zh) * 2016-05-11 2021-02-05 常州制药厂有限公司 一种降压药福辛普利钠及其关键中间体的制备方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4337201A (en) * 1980-12-04 1982-06-29 E. R. Squibb & Sons, Inc. Phosphinylalkanoyl substituted prolines
US4734508A (en) * 1987-05-01 1988-03-29 E. R. Squibb & Sons, Inc. Process and intermediates for preparing 4-substituted proline derivatives

Also Published As

Publication number Publication date
CA2034811C (en) 2001-04-03
AU646032B2 (en) 1994-02-03
JPH04211093A (ja) 1992-08-03
AU7528691A (en) 1992-10-29
JP2938590B2 (ja) 1999-08-23
ATE121411T1 (de) 1995-05-15
CA2034811A1 (en) 1991-08-17
DE69108953T2 (de) 1995-10-19
DK0442378T3 (da) 1995-10-02
EP0442378B1 (en) 1995-04-19
US5162543A (en) 1992-11-10
EP0442378A1 (en) 1991-08-21
DE69108953D1 (de) 1995-05-24

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