ES2071310T3 - 2-yodo-3-ceto-delta4-esteroides, procedimiento para su preparacion asi como su elaboracion ulterior. - Google Patents
2-yodo-3-ceto-delta4-esteroides, procedimiento para su preparacion asi como su elaboracion ulterior.Info
- Publication number
- ES2071310T3 ES2071310T3 ES91909075T ES91909075T ES2071310T3 ES 2071310 T3 ES2071310 T3 ES 2071310T3 ES 91909075 T ES91909075 T ES 91909075T ES 91909075 T ES91909075 T ES 91909075T ES 2071310 T3 ES2071310 T3 ES 2071310T3
- Authority
- ES
- Spain
- Prior art keywords
- stands
- pct
- hydrogen atom
- preparation
- well
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000000034 method Methods 0.000 title abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 abstract 2
- 229910000043 hydrogen iodide Inorganic materials 0.000 abstract 2
- 239000013067 intermediate product Substances 0.000 abstract 2
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical group O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 abstract 1
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 238000003776 cleavage reaction Methods 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 230000007017 scission Effects 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 230000000707 stereoselective effect Effects 0.000 abstract 1
- 150000003431 steroids Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0059—Estrane derivatives substituted in position 17 by a keto group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0003—Androstane derivatives
- C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0003—Androstane derivatives
- C07J1/0018—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa
- C07J1/0022—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
- C07J1/0025—Esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
- C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
- C07J1/0074—Esters
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
LOS NUEVOS PRODUCTOS INTERMEDIOS DE LA FORMULA GENERAL (I), EN LA QUE: R1 ES UN ATOMO DE HIDROGENO O UN GRUPO ALQUILO ENCADENADO RECTO O RAMIFICADO CON 1 A 4 ATOMOS DE CARBONO; R2 ES UN ATOMO DE HIDROGENO O UN GRUPO METILO; R3 ES UN ATOMO DE HIDROGENO Y R4 ES UN GRUPO ACILOXILO CON 1 HASTA 4 ATOMOS DE CARBONO EN EL RADICAL ACILO; O R3 Y R4 JUNTOS REPRESENTAN UN ATOMO CETO-OXIGENO, SON MUY APROPIADOS PARA LA INTRODUCCION DE UN ENLACE DOBLE ANEA DE UN ENLACE DOBLE OS POR LA DISOCIACION DEL YODURO DE HIDROGENO CON UNA BASE EN UN DISOLVENTE AMIDICO A ELEVADA TEMPERATURA. SI EL R2 ES UN ATOMO DE HIDROGENO, EL ANILLO A ES AROMATIZADO DESPUES DE LA DISOCIACION DEL YODURO DE HIDROGENO. PARA LA FABRICACION DE NUEVOS PRODUCTOS INTERMEDIOS, SE EMPLEAN METODOS DE YODIZACION ESPECIALES, QUE EN PARTE TAMBIEN PERMITEN UN CONTROL ESTEREOSELECTIVO DE LA YODIZACION.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4015247A DE4015247A1 (de) | 1990-05-09 | 1990-05-09 | 2-jod-3-keto-(delta)(pfeil hoch)4(pfeil hoch)-steroide, verfahren zu ihrer herstellung sowie deren weiterverarbeitung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2071310T3 true ES2071310T3 (es) | 1995-06-16 |
Family
ID=6406240
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES91909075T Expired - Lifetime ES2071310T3 (es) | 1990-05-09 | 1991-05-08 | 2-yodo-3-ceto-delta4-esteroides, procedimiento para su preparacion asi como su elaboracion ulterior. |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US5391778A (es) |
| EP (1) | EP0528876B1 (es) |
| JP (1) | JPH05506438A (es) |
| AT (1) | ATE121098T1 (es) |
| CA (1) | CA2082503A1 (es) |
| DE (2) | DE4015247A1 (es) |
| DK (1) | DK0528876T3 (es) |
| ES (1) | ES2071310T3 (es) |
| GR (1) | GR3015778T3 (es) |
| HU (1) | HUT62913A (es) |
| WO (1) | WO1991017175A1 (es) |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3546259A (en) * | 1968-11-08 | 1970-12-08 | Du Pont | Selected 6beta- and 6alpha-trifluoromethoxyl androstane,estrane and pregnane derivatives |
| US3775404A (en) * | 1969-09-09 | 1973-11-27 | American Home Prod | Synthesis of 13-alkyl-6-chlorogona-4,6-dien-3-ones |
| JPS5655400A (en) * | 1979-10-12 | 1981-05-15 | Mitsubishi Chem Ind Ltd | Improved preparation process of 4,6-dien-3-one steroid |
| DE3715869A1 (de) * | 1987-05-07 | 1988-11-17 | Schering Ag | Verfahren zur herstellung von 1-methyl-androsta-1,4-dien-3,17-dion und die neuen zwischenprodukte fuer dieses verfahren |
-
1990
- 1990-05-09 DE DE4015247A patent/DE4015247A1/de not_active Withdrawn
-
1991
- 1991-05-08 DE DE59105193T patent/DE59105193D1/de not_active Expired - Fee Related
- 1991-05-08 AT AT91909075T patent/ATE121098T1/de active
- 1991-05-08 HU HU923497A patent/HUT62913A/hu unknown
- 1991-05-08 US US07/960,385 patent/US5391778A/en not_active Expired - Fee Related
- 1991-05-08 CA CA002082503A patent/CA2082503A1/en not_active Abandoned
- 1991-05-08 WO PCT/DE1991/000386 patent/WO1991017175A1/de not_active Ceased
- 1991-05-08 EP EP91909075A patent/EP0528876B1/de not_active Expired - Lifetime
- 1991-05-08 ES ES91909075T patent/ES2071310T3/es not_active Expired - Lifetime
- 1991-05-08 JP JP91508716A patent/JPH05506438A/ja active Pending
- 1991-05-08 DK DK91909075.3T patent/DK0528876T3/da active
-
1995
- 1995-04-13 GR GR950400875T patent/GR3015778T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| GR3015778T3 (en) | 1995-07-31 |
| DE4015247A1 (de) | 1991-11-14 |
| DE59105193D1 (de) | 1995-05-18 |
| HU9203497D0 (en) | 1993-01-28 |
| WO1991017175A1 (de) | 1991-11-14 |
| CA2082503A1 (en) | 1991-11-09 |
| US5391778A (en) | 1995-02-21 |
| EP0528876A1 (de) | 1993-03-03 |
| DK0528876T3 (da) | 1995-09-04 |
| EP0528876B1 (de) | 1995-04-12 |
| HUT62913A (en) | 1993-06-28 |
| ATE121098T1 (de) | 1995-04-15 |
| JPH05506438A (ja) | 1993-09-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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