ES2071688T3 - Derivado bifenilico, agente reparador o protector de la degeneracion de las celulas nerviosas y proceso para preparar un derivado fenilico contenido en el agente. - Google Patents

Derivado bifenilico, agente reparador o protector de la degeneracion de las celulas nerviosas y proceso para preparar un derivado fenilico contenido en el agente.

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Publication number
ES2071688T3
ES2071688T3 ES90102488T ES90102488T ES2071688T3 ES 2071688 T3 ES2071688 T3 ES 2071688T3 ES 90102488 T ES90102488 T ES 90102488T ES 90102488 T ES90102488 T ES 90102488T ES 2071688 T3 ES2071688 T3 ES 2071688T3
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Spain
Prior art keywords
derivative
agent
protector
prepare
biphenylic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90102488T
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English (en)
Inventor
Tatsuyoshi - Nakanokosh Tanaka
Yoji - Aza Seicho Sakurai
Hiroshi - Aza Hachikam Okazaki
Takashi Hoji Aza Naga Hasegawa
Yoshiyasu Fukuyama
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
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Otsuka Pharmaceutical Co Ltd
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Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
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Publication of ES2071688T3 publication Critical patent/ES2071688T3/es
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    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D207/26—2-Pyrrolidones
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    • C07C35/21—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a non-condensed ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • C07C215/48—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups
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    • C07C215/66—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with quaternised amino groups bound to the carbon skeleton
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    • C07C217/18—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted
    • C07C217/20—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted by halogen atoms, by trihalomethyl, nitro or nitroso groups, or by singly-bound oxygen atoms
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    • C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
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    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/24—Radicals substituted by oxygen atoms
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    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
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    • C07D309/10—Oxygen atoms
    • C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers

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Abstract

SE DESCUBRE UN DERIVADO BIFENILO DE LA FORMULA (B): EN DONDE R1,R3,R4,R5 Y RC SON COMO SE DEFINEN EN LA MEMORIA O SUS SALES, UN AGENTE REPARADOR,O PROTECTOR, DE DEGENERACION DE CELULAS NERVIOSAS CONTENIENDO UN FENILO DERIVADO SELECCIONADO DE COMPUESTOS (1) A (4) Y (B) COMO SE DEFINE EN LA MEMORIA, Y UN PROCESO PARA PREPARAR UN FENILO DERIVADO CONTENIDO EN EL AGENTE.
ES90102488T 1989-02-08 1990-02-08 Derivado bifenilico, agente reparador o protector de la degeneracion de las celulas nerviosas y proceso para preparar un derivado fenilico contenido en el agente. Expired - Lifetime ES2071688T3 (es)

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JP2898389 1989-02-08
JP29941589 1989-11-16

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US (1) US5053548A (es)
EP (1) EP0382213B1 (es)
JP (1) JPH07103056B2 (es)
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CN (1) CN1029227C (es)
DE (1) DE69019185T2 (es)
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DE69019185D1 (de) 1995-06-14
US5053548A (en) 1991-10-01
JPH07103056B2 (ja) 1995-11-08
KR900012875A (ko) 1990-09-03
EP0382213A2 (en) 1990-08-16
CN1029227C (zh) 1995-07-05
DE69019185T2 (de) 1995-10-26
EP0382213B1 (en) 1995-05-10
JPH04154737A (ja) 1992-05-27
DK0382213T3 (da) 1995-07-10
EP0382213A3 (en) 1992-03-18
CN1044807A (zh) 1990-08-22

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