ES2072856T3 - Nuevo acido 7-(2-(2-aminotiazol-4-il)-2-hidroxiiminoacetamido)-3-vinil-3-cefem-4-carboxilico(isomero sin). - Google Patents

Nuevo acido 7-(2-(2-aminotiazol-4-il)-2-hidroxiiminoacetamido)-3-vinil-3-cefem-4-carboxilico(isomero sin).

Info

Publication number
ES2072856T3
ES2072856T3 ES88113311T ES88113311T ES2072856T3 ES 2072856 T3 ES2072856 T3 ES 2072856T3 ES 88113311 T ES88113311 T ES 88113311T ES 88113311 T ES88113311 T ES 88113311T ES 2072856 T3 ES2072856 T3 ES 2072856T3
Authority
ES
Spain
Prior art keywords
hidroxiiminoacetamido
aminotiazol
isomero
carboxilico
vinil
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES88113311T
Other languages
English (en)
Inventor
Takao Takaya
Fumiyuki Shirai
Hitoshi Nakamura
Yasunobu Inaba
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujisawa Pharmaceutical Co Ltd
Original Assignee
Fujisawa Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=16519432&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2072856(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Fujisawa Pharmaceutical Co Ltd filed Critical Fujisawa Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ES2072856T3 publication Critical patent/ES2072856T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/22—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with radicals containing only hydrogen and carbon atoms, attached in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

ACIDO CRISTALINO 7 - (2 - (2 - AMINOTIAZOL - 4 - IL) - 2 HIDROXIAMINOACETAMIDO) - 3 - VINIL - 3 - CEFEM - 4 - CARBOXILICO (SYN ISOMERO) QUE ES OBTENIDO ACIDULANDO UNA SOLUCION CONTENIENDO ACIDO 7 - (2 - (2 AMINOTIAZOL - 4 - IL) - 2 - HIDROXIAMINOACETAMIDO - 3 - VINIL - 3 - CEFEM - 4 - CARBOXILICO (SYN ISOMERO) A TEMPERATURA AMBIENTE O TEMPLADA. TAL COMPUESTO CRISTALINO MUESTRA UN DIBUJO CARACTERISTICO EN LA DIFRACCION DE LOS RAYOS X. EL INVENTO COMPRENDE TAMBIEN PROCESOS PARA PREPARAR TAL COMPUESTO CRISTALINO Y COMPOSICIONES FARMACEUTICAS CONTENIENDOLO COMO INGREDIENTE ACTIVO.
ES88113311T 1987-08-19 1988-08-17 Nuevo acido 7-(2-(2-aminotiazol-4-il)-2-hidroxiiminoacetamido)-3-vinil-3-cefem-4-carboxilico(isomero sin). Expired - Lifetime ES2072856T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP20619987 1987-08-19

Publications (1)

Publication Number Publication Date
ES2072856T3 true ES2072856T3 (es) 1995-08-01

Family

ID=16519432

Family Applications (1)

Application Number Title Priority Date Filing Date
ES88113311T Expired - Lifetime ES2072856T3 (es) 1987-08-19 1988-08-17 Nuevo acido 7-(2-(2-aminotiazol-4-il)-2-hidroxiiminoacetamido)-3-vinil-3-cefem-4-carboxilico(isomero sin).

Country Status (11)

Country Link
US (1) US4935507A (es)
EP (1) EP0304019B1 (es)
KR (1) KR970008126B1 (es)
AT (1) ATE123221T1 (es)
AU (1) AU617347B2 (es)
CA (1) CA1297096C (es)
DE (1) DE3853901T2 (es)
ES (1) ES2072856T3 (es)
HK (1) HK18496A (es)
IE (1) IE67348B1 (es)
ZA (1) ZA885709B (es)

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT405283B (de) * 1997-04-04 1999-06-25 Biochemie Gmbh Neues kristallines 7-(z)-(2-(2-aminothiazol-4-yl) -2-hydroxyiminoacetamido)-3-vinyl-3-cephem-4- carbonsäure dicyclohexylammoniumsalz und verfahren zu dessen herstellung
US6888124B1 (en) 1999-03-24 2005-05-03 Shell Oil Company Method to monitor internal parameters of electrical motor systems
EP1389187A4 (en) * 2001-04-17 2005-03-16 Ranbaxy Lab Ltd PROCESS FOR THE PREPARATION OF CEFPODOXIMIC ACID
KR100451672B1 (ko) 2001-06-05 2004-10-08 한미약품 주식회사 결정성 세프디니르 산부가염, 이의 제조방법 및 이를이용한 세프디니르의 제조방법
KR20030018536A (ko) * 2001-08-30 2003-03-06 임득수 유리제품의 표면처리방법
EP1458728A1 (en) * 2001-12-13 2004-09-22 Ranbaxy Laboratories Limited Crystalline cefdinir potassium dihydrate
US7297800B2 (en) * 2001-12-27 2007-11-20 Ajinomoto Co., Inc. Process of producing glutamate derivatives
IL163666A0 (en) 2002-02-22 2005-12-18 New River Pharmaceuticals Inc Active agent delivery systems and methods for protecting and administering active agents
TWI353979B (en) * 2002-04-10 2011-12-11 Nippon Zoki Pharmaceutical Co Novel crystal form of 5-hydroxy-1-methylhydantoin
ITMI20020913A0 (it) * 2002-04-29 2002-04-29 Acs Dobfar Spa Nuova forma cristallina del cefdinir
US6800756B2 (en) * 2002-05-03 2004-10-05 Orchid Chemicals And Pharmaceuticals, Ltd. Method for the preparation of ceftiofur sodium and its intermediates
EP1842852A1 (en) * 2002-08-13 2007-10-10 Sandoz AG A cefdinir intermediate
DK1533376T3 (da) 2002-08-26 2010-07-19 Ajinomoto Kk Nye aldolaser og fremgangsmåde til fremstilling af substitueret alfa-ketosyre
WO2004046154A1 (en) * 2002-11-15 2004-06-03 Orchid Chemicals & Pharmaceuticals Ltd Novel amorphous hydrate of a cephalosporin antibiotic
CN1723281B (zh) 2002-12-09 2012-08-15 味之素株式会社 突变的d-氨基转移酶和使用它们生产旋光性谷氨酸衍生物的方法
ITMI20022724A1 (it) 2002-12-20 2004-06-21 Antibioticos Spa Sali cristallini del cefdinir.
EA015145B1 (ru) 2003-01-14 2011-06-30 Джилид Сайэнс, Инк. Фармацевтическая композиция и пероральная фармацевтическая дозированная форма (варианты), проявляющие активность в отношении вич-инфекций, лечебный набор и таблетка и способ лечения или предотвращения симптомов или эффектов вич-инфекции
US20070106073A1 (en) * 2003-03-24 2007-05-10 Eiji Imai Novel crystal of 7-[2-[(2-aminothiazol-4-yl)-2-hydroxyiminoacetamide-3-vinyl-3-cephem-4-carboxylic acid (syn isomer) and method for preparation thereof
WO2004104010A1 (en) * 2003-05-20 2004-12-02 Ranbaxy Laboratories Limited Crystalline form of cefdinir
US20050137182A1 (en) * 2003-06-02 2005-06-23 Ramesh Dandala Novel crystalline form of cefdinir
US20040242556A1 (en) * 2003-06-02 2004-12-02 Ramesh Dandala Novel crystalline form of cefdinir
US7098329B2 (en) * 2003-06-19 2006-08-29 Orchid Chemicals & Pharmaceuticals Ltd. Process for the preparation of a cephalosporin antibiotic
US20050059819A1 (en) * 2003-09-12 2005-03-17 Duerst Richard W. Cefdinir pyridine salt
US20050059818A1 (en) * 2003-09-12 2005-03-17 Duerst Richard W. Polymorph of a pharmaceutical
US20050113355A1 (en) * 2003-09-12 2005-05-26 Duerst Richard W. Cefdinir pyridine salt
US20080139528A1 (en) * 2003-12-10 2008-06-12 Pujara Chetan P Cefdinir oral suspension
US20050131079A1 (en) * 2003-12-10 2005-06-16 Pujara Chetan P. Cefdinir oral suspension
US20060142261A1 (en) * 2004-03-16 2006-06-29 Devalina Law Crystalline anhydrous cefdinir and crystalline cefdinir hydrates
US20060211676A1 (en) * 2004-03-16 2006-09-21 Devalina Law Crystalline anhydrous cefdinir and crystalline cefdinir hydrates
US20050209211A1 (en) * 2004-03-16 2005-09-22 Devalina Law Trihemihydrate, anhydrate and novel hydrate forms of Cefdinir
US20060142563A1 (en) * 2004-03-16 2006-06-29 Devalina Law Crystalline anhydrous cefdinir and crystalline cefdinir hydrates
US20060069079A1 (en) * 2004-09-27 2006-03-30 Sever Nancy E Stable amorphous cefdinir
US20050245738A1 (en) * 2004-05-03 2005-11-03 Lupin Ltd Stable bioavailable crystalline form or cefdinir and a process for the preparation thereof
WO2006018807A1 (en) * 2004-08-16 2006-02-23 Ranbaxy Laboratories Limited Crystalline forms of cefdinir
MX2007006018A (es) * 2004-11-30 2007-06-07 Astellas Pharma Inc Suspension farmaceutica oral novedosa de cristal de cefdinir.
GB2421024A (en) * 2004-12-07 2006-06-14 Sandoz Ag Cefdinir crystalline form C
WO2006117794A1 (en) * 2005-05-02 2006-11-09 Hetero Drugs Limited A novel crystalline form of cefdinir
TWI375560B (en) 2005-06-13 2012-11-01 Gilead Sciences Inc Composition comprising dry granulated emtricitabine and tenofovir df and method for making the same
TWI471145B (zh) 2005-06-13 2015-02-01 Bristol Myers Squibb & Gilead Sciences Llc 單一式藥學劑量型
EP1848724A2 (en) * 2005-10-31 2007-10-31 Teva Pharmaceutical Industries Ltd Process for the preparation of cefdinir
WO2007053722A2 (en) * 2005-10-31 2007-05-10 Teva Pharmaceutical Industries Ltd. Crystalline form of cefdinir cesium salt
US20070128268A1 (en) * 2005-12-07 2007-06-07 Herwig Jennewein Pharmaceutical compositions comprising an antibiotic
ITMI20071628A1 (it) 2007-08-06 2007-11-05 Acs Dobfar Spa Sintesi di 3-alchenilcefalosporine e nuovi intermedi utili ad esse correlati
CN101481383B (zh) * 2008-12-31 2012-01-11 杭州奥默医药技术有限公司 头孢地尼酸式复盐化合物及制备方法
TR201000686A1 (tr) 2010-01-29 2011-08-22 B�Lg�� Mahmut Bakteriyel enfeksiyonların tedavisinde suda çözünebilir sefdinir ve klavulanik asit formülasyonları.@
PT3616695T (pt) 2011-09-09 2024-11-18 Merck Sharp & Dohme Ceftolozano/tazobactam para tratar infeções intrapulmonares
CN102643293A (zh) * 2012-03-30 2012-08-22 石药集团中诺药业（石家庄）有限公司 头孢地尼三元复合物及其用于制备头孢地尼的方法
US8809314B1 (en) 2012-09-07 2014-08-19 Cubist Pharmacueticals, Inc. Cephalosporin compound
US8476425B1 (en) 2012-09-27 2013-07-02 Cubist Pharmaceuticals, Inc. Tazobactam arginine compositions
CN103012433B (zh) * 2012-12-13 2015-06-24 珠海保税区丽珠合成制药有限公司 头孢地尼晶型b的制备方法
US20140274996A1 (en) 2013-03-15 2014-09-18 Cubist Pharmaceuticals, Inc. Tazobactam and ceftolozane antibiotic compositions
PE20160048A1 (es) 2013-03-15 2016-02-12 Merck Sharp & Dohme Composiciones antibioticas de ceftolozano
US9872906B2 (en) 2013-03-15 2018-01-23 Merck Sharp & Dohme Corp. Ceftolozane antibiotic compositions
WO2015035376A2 (en) 2013-09-09 2015-03-12 Calixa Therapeutics, Inc. Treating infections with ceftolozane/tazobactam in subjects having impaired renal function
US8906898B1 (en) 2013-09-27 2014-12-09 Calixa Therapeutics, Inc. Solid forms of ceftolozane
CN103622933B (zh) * 2013-12-19 2015-04-08 石家庄市华新药业有限责任公司 一种头孢地尼胶囊及其制备方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8323034D0 (en) * 1983-08-26 1983-09-28 Fujisawo Pharmaceutical Co Ltd 7-substituted-3-vinyl-3-cephem compounds

Also Published As

Publication number Publication date
KR890003778A (ko) 1989-04-18
AU617347B2 (en) 1991-11-28
HK18496A (en) 1996-02-09
DE3853901D1 (de) 1995-07-06
IE67348B1 (en) 1996-03-20
ZA885709B (en) 1989-04-26
EP0304019A2 (en) 1989-02-22
CA1297096C (en) 1992-03-10
DE3853901T2 (de) 1995-10-12
KR970008126B1 (ko) 1997-05-21
AU2099888A (en) 1989-02-23
IE882411L (en) 1989-02-19
ATE123221T1 (de) 1995-06-15
EP0304019B1 (en) 1995-05-31
EP0304019A3 (en) 1990-12-27
US4935507A (en) 1990-06-19

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