ES2073063T3 - Formulaciones galenicas acuosas de eritropoyetina y su uso. - Google Patents

Formulaciones galenicas acuosas de eritropoyetina y su uso.

Info

Publication number
ES2073063T3
ES2073063T3 ES91107308T ES91107308T ES2073063T3 ES 2073063 T3 ES2073063 T3 ES 2073063T3 ES 91107308 T ES91107308 T ES 91107308T ES 91107308 T ES91107308 T ES 91107308T ES 2073063 T3 ES2073063 T3 ES 2073063T3
Authority
ES
Spain
Prior art keywords
erythropoietin
aqueous
physiologically tolerated
epo
aqueous pharmaceutical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91107308T
Other languages
English (en)
Inventor
Dieter Dr Brazel
Bernhard Dr Siebold
Dorothee Dr Krumwieh
Thomas Dr Brune
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Siemens Healthcare Diagnostics GmbH Germany
Original Assignee
Behringwerke AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Behringwerke AG filed Critical Behringwerke AG
Application granted granted Critical
Publication of ES2073063T3 publication Critical patent/ES2073063T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1816—Erythropoietin [EPO]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Zoology (AREA)
  • Inorganic Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Dermatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE DESCRIBEN FORMULACIONES ACUOSAS Y GALENICAS DE PROTEINAS CON EFECTOS DE ERTROPOIETIN, CONCRETAMENTE ERITROPOIETIN (EOP) DE HUMANEN NATIVEN Y DE HUMANEN RECOMBINANTEN. UN ALTO PODER DE LIMPIEZA DE LA EPO SIN PROTEINAS EXTRAÑAS Y OTROS ESTABILIZADORES MANTIENE EN UN REGULADOR DE FOSFORO Y ACUOSO COMPATIBLE FISIOLOGICO, EL CUAL CONTIENE UN HALOGENID DE METAL DE ALCALI COMPATIBLES FISIOLOGICAMENTE, PERO NINGUN ADITIVO ESTABILIZADOR Y TIENE UN VALOR PH DE 6 A 8, A UNA TEMPERATURA AMBIENTE CON AL MENOS UN AÑO DE ACTIVIDAD ORIGINARIAMENTE DEL 78%. EN ESTA FORMULACION ACUOSA Y GALANICA, LOS PREPARADOS SON ADECUADOS ESPECIALMENTE PARA EL TRATAMIENTO DE HIPODERMICOS O DE INTRAMUSCULAR.
ES91107308T 1990-05-08 1991-05-06 Formulaciones galenicas acuosas de eritropoyetina y su uso. Expired - Lifetime ES2073063T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4014654A DE4014654A1 (de) 1990-05-08 1990-05-08 Galenische waessrige formulierungen von erythropoietin und ihre verwendung

Publications (1)

Publication Number Publication Date
ES2073063T3 true ES2073063T3 (es) 1995-08-01

Family

ID=6405907

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91107308T Expired - Lifetime ES2073063T3 (es) 1990-05-08 1991-05-06 Formulaciones galenicas acuosas de eritropoyetina y su uso.

Country Status (13)

Country Link
EP (1) EP0456153B1 (es)
JP (1) JP2922331B2 (es)
KR (1) KR100203546B1 (es)
AT (1) ATE120646T1 (es)
AU (1) AU652361B2 (es)
CA (1) CA2041989C (es)
DE (2) DE4014654A1 (es)
DK (1) DK0456153T3 (es)
ES (1) ES2073063T3 (es)
IE (1) IE65925B1 (es)
NO (1) NO301805B1 (es)
PT (1) PT97584B (es)
ZA (1) ZA913435B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9917606A (pt) * 1998-11-06 2002-12-31 Bio Sidus S A Procedimento para a purificação de eritropoetina humana recombinante a partir de sobrenadantes de cultivo de células e eritropoetina humana recombinante obtida com tal procedimento
MEP90708A (hr) 2000-05-15 2011-12-20 Nova farmaceutska smješa
DE10234192B4 (de) 2002-07-26 2009-11-26 Epoplus Gmbh Co.Kg Verwendung von Erythropoetin
EP1537876A1 (en) * 2003-12-01 2005-06-08 BioGeneriX AG Erythropoietin solution formulation

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57149228A (en) * 1981-03-11 1982-09-14 Ajinomoto Co Inc Novel erythropoietin and its preparation
JPH0686480B2 (ja) * 1983-02-21 1994-11-02 雪印乳業株式会社 エリスロポエチン製造用モノクローナル抗体
JPS6191131A (ja) * 1984-10-09 1986-05-09 Chugai Pharmaceut Co Ltd 医薬品の吸着防止方法および組成物
JPS6197229A (ja) * 1984-10-18 1986-05-15 Chugai Pharmaceut Co Ltd 安定なエリトロポエチン製剤
DE3729863A1 (de) * 1987-09-05 1989-03-16 Boehringer Mannheim Gmbh Stabilisierte erythropoietin-lyophilisate

Also Published As

Publication number Publication date
PT97584B (pt) 1998-08-31
DE4014654A1 (de) 1991-11-14
NO301805B1 (no) 1997-12-15
PT97584A (pt) 1992-01-31
JP2922331B2 (ja) 1999-07-19
DK0456153T3 (da) 1995-08-07
DE59105075D1 (de) 1995-05-11
NO911788D0 (no) 1991-05-07
CA2041989C (en) 2001-07-31
AU7618391A (en) 1991-11-14
EP0456153A1 (de) 1991-11-13
JPH04225923A (ja) 1992-08-14
CA2041989A1 (en) 1991-11-09
AU652361B2 (en) 1994-08-25
ATE120646T1 (de) 1995-04-15
ZA913435B (en) 1992-02-26
NO911788L (no) 1991-11-11
IE911549A1 (en) 1991-11-20
KR910019636A (ko) 1991-12-19
EP0456153B1 (de) 1995-04-05
IE65925B1 (en) 1995-11-29
KR100203546B1 (ko) 1999-06-15

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