ES2073448T3 - Procedimiento inmunometrico para la dosificacion de particulas de lipoproteina, anticuerpos monoclonales anti-lp(a) y aplicacion al diagnostico de la aterosclerosis. - Google Patents

Procedimiento inmunometrico para la dosificacion de particulas de lipoproteina, anticuerpos monoclonales anti-lp(a) y aplicacion al diagnostico de la aterosclerosis.

Info

Publication number
ES2073448T3
ES2073448T3 ES89400142T ES89400142T ES2073448T3 ES 2073448 T3 ES2073448 T3 ES 2073448T3 ES 89400142 T ES89400142 T ES 89400142T ES 89400142 T ES89400142 T ES 89400142T ES 2073448 T3 ES2073448 T3 ES 2073448T3
Authority
ES
Spain
Prior art keywords
lipoprotein
apob
particles
atherosclerosis
diagnosis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89400142T
Other languages
English (en)
Inventor
Jean-Charles Fruchart
Dac Ngoc Vu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Institut Pasteur de Lille
Institut Pasteur
Original Assignee
Institut Pasteur de Lille
Institut Pasteur
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR8802214A external-priority patent/FR2627589B1/fr
Application filed by Institut Pasteur de Lille, Institut Pasteur filed Critical Institut Pasteur de Lille
Application granted granted Critical
Publication of ES2073448T3 publication Critical patent/ES2073448T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

PROCESO INMUNOMETRICO PARA LA DOSIFICACION DE PARTICULAS DE LIPOPROTEINA COMPRENDIENDO ALGUNA APOLIPOPROTEINA B (APO B) Y AL MENOS OTRA APOLIPOPROTEINA, ANTICUERPOS MONOCLONICOS ANTILIPOPROTEINA (A) (ANTI-LP (A)), Y APLICACION DE ESTE PROCESO AL DIAGNOSTICO DE LA ARTERIOESCLEROSIS. ESTE METODO DE DOSIFICACION COMPRENDE LA PRESENCIA DE UN FLUIDO BIOLOGICO CONTENIENDO EVENTUALMENTE DICHAS PARTICULAS DE LIPOPROTEINA CON DOS ANTICUERPOS DIFERENTES, A SABER DE UN PRIMER ANTICUERPO ESCOGIDO ENTRE EL GRUPO QUE COMPRENDE LOS ANTICUERPOS DIRIGIDOS CONTRA OTRA APOLIPOPROTEINA QUE LA APO B COMPLETA Y LOS ANTICUERPOS DIRIGIDOS CONTRA UN FRAGMENTO O UN EPITOPE DEFINIDO DE LA APO B, QUE CAPTURA LA PARTICULA DE LIPOPROTEINA A DOSIFICAR Y DE UN SEGUNDO ANTICUERPO ANTI-APO B COMPLETO MARCADO DE MANERA APROPIADA, LA PRESENCIA DE LAS PARTICULAS DE LIPOPROTEINA SIENDO REVELADA POR UNA TECNICA APROPIADA, EN PARTICULAR EIA, RIA, REACCION DE AGLUTINACION, FLUORIMETRIA.
ES89400142T 1988-01-19 1989-01-18 Procedimiento inmunometrico para la dosificacion de particulas de lipoproteina, anticuerpos monoclonales anti-lp(a) y aplicacion al diagnostico de la aterosclerosis. Expired - Lifetime ES2073448T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14559788A 1988-01-19 1988-01-19
FR8802214A FR2627589B1 (fr) 1988-02-24 1988-02-24 Procede immunoenzymometrique selectif pour le dosage de lipoproteines contenant de l'apob ou un fragment de celle-ci, anticorps monoclonaux anti-lp(a) et application au diagnostic de l'atherosclerose

Publications (1)

Publication Number Publication Date
ES2073448T3 true ES2073448T3 (es) 1995-08-16

Family

ID=26226514

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89400142T Expired - Lifetime ES2073448T3 (es) 1988-01-19 1989-01-18 Procedimiento inmunometrico para la dosificacion de particulas de lipoproteina, anticuerpos monoclonales anti-lp(a) y aplicacion al diagnostico de la aterosclerosis.

Country Status (5)

Country Link
EP (1) EP0327418B1 (es)
JP (1) JPH026755A (es)
AT (1) ATE121197T1 (es)
DE (1) DE68922126T2 (es)
ES (1) ES2073448T3 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5196324A (en) * 1989-12-15 1993-03-23 Eli Lilly And Company Monoclonal antibodies reactive with a human atheroma associated antigen
US5783400A (en) * 1990-04-27 1998-07-21 Genzyme Corporation Method for the isolation of lipoprotein allowing for the subsequent quantification of its mass and cholesterol content
WO1994004563A1 (fr) * 1992-08-14 1994-03-03 Shino-Test Corporation PEPTIDES CONTENANT DES SEQUENCES D'ACIDES AMINES RESPECTIVES SELECTIONNEES PARMI CELLES DE LA LIPOPROTEINE(a) ET DE L'APOLIPOPROTEINE(a), ANTICORPS RECONNAISSANT CES SEQUENCES D'ACIDES AMINES ET PROCEDE D'ANALYSE UTILISANT CES ANTICORPS
DE59409345D1 (de) * 1993-02-09 2000-06-21 Roche Diagnostics Gmbh Lipoprotein (a)-Peptide und deren Verwendung
EP0614912B1 (de) * 1993-02-09 2000-05-17 Roche Diagnostics GmbH Lipoprotein (a)-Peptide und deren Verwendung
US6727102B1 (en) 1997-06-20 2004-04-27 Leuven Research & Development Vzw Assays, antibodies, and standards for detection of oxidized and MDA-modified low density lipoproteins
US6309888B1 (en) 1998-09-04 2001-10-30 Leuven Research & Development Vzw Detection and determination of the stages of coronary artery disease
US6620787B2 (en) 2001-04-30 2003-09-16 Syn X Pharma, Inc. Biopolymer marker indicative of disease state having a molecular weight of 2267 daltons
DE10353175A1 (de) * 2003-11-14 2005-06-16 Müller-Hermelink, Hans Konrad, Prof. Dr. Humaner monoklonaler Antikörper mit fettsenkender Wirkung
JP5298299B2 (ja) * 2007-09-28 2013-09-25 公益財団法人ヒューマンサイエンス振興財団 新規抗体、遺伝子、単鎖可変領域フラグメント、発現用ベクター、検出用キット、及び検出方法
TW202602930A (zh) * 2024-03-21 2026-01-16 美商美國禮來大藥廠 測量脂蛋白(a)之生物標記分析

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS56118671A (en) * 1980-02-22 1981-09-17 Amano Pharmaceut Co Ltd Measuring method of specific enzyme immunity of hybrid type protein

Also Published As

Publication number Publication date
DE68922126T2 (de) 1995-11-09
EP0327418A1 (fr) 1989-08-09
EP0327418B1 (fr) 1995-04-12
JPH026755A (ja) 1990-01-10
ATE121197T1 (de) 1995-04-15
DE68922126D1 (de) 1995-05-18

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