ES2074208T3 - Cepa aesporogena de bacillus subtilis y su uso como huesped para la preparacion de productos heterologos. - Google Patents

Cepa aesporogena de bacillus subtilis y su uso como huesped para la preparacion de productos heterologos.

Info

Publication number
ES2074208T3
ES2074208T3 ES91121211T ES91121211T ES2074208T3 ES 2074208 T3 ES2074208 T3 ES 2074208T3 ES 91121211 T ES91121211 T ES 91121211T ES 91121211 T ES91121211 T ES 91121211T ES 2074208 T3 ES2074208 T3 ES 2074208T3
Authority
ES
Spain
Prior art keywords
heterological
guest
products
preparation
bacillus subtilis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91121211T
Other languages
English (en)
Inventor
Gianni Frascotti
Paola Cosmina
Guido Grandi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pierrel SpA
Original Assignee
Pierrel SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pierrel SpA filed Critical Pierrel SpA
Application granted granted Critical
Publication of ES2074208T3 publication Critical patent/ES2074208T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/61—Growth hormone [GH], i.e. somatotropin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/75—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Bacillus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/07—Bacillus
    • C12R2001/125—Bacillus subtilis ; Hay bacillus; Grass bacillus

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

ESTA INVENCION SE REFIERE A UNA NUEVA CEPA ESPORAGENA DE BACILLUS SUBTILIS QUE SE HA DEPOSITADO EN EL CENTRAALBUREAU VOOR SCHIMMELCULTURES BAJO EL NOMBRE CBS 432.90. ESTA CEPA, QUE MUESTRA UNA FRECUENCIA DE REVERSION PARA LA FORMACION DE ESPORAS DE MENOS DE, APROXIMADAMENTE, 10 ELEVADO -8 Y BUENA ESTABILIDAD PLASMIDA, ES APTA COMO HUESPED EN UN SISTEMA DE VECTOR HUESPED PARA LA PREPARACION DE PRODUCTOS HETEROLOGOS DE INTERES.
ES91121211T 1990-12-21 1991-12-11 Cepa aesporogena de bacillus subtilis y su uso como huesped para la preparacion de productos heterologos. Expired - Lifetime ES2074208T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT02247690A IT1244477B (it) 1990-12-21 1990-12-21 Ceppo asporigeno di bacillus subtilis e suo impiego come ospite per la preparazione di prodotti eterologhi

Publications (1)

Publication Number Publication Date
ES2074208T3 true ES2074208T3 (es) 1995-09-01

Family

ID=11196787

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91121211T Expired - Lifetime ES2074208T3 (es) 1990-12-21 1991-12-11 Cepa aesporogena de bacillus subtilis y su uso como huesped para la preparacion de productos heterologos.

Country Status (9)

Country Link
US (1) US6284490B1 (es)
EP (1) EP0492274B1 (es)
JP (1) JP3013008B2 (es)
AT (1) ATE114171T1 (es)
DE (1) DE69105188T2 (es)
DK (1) DK0492274T3 (es)
ES (1) ES2074208T3 (es)
GR (1) GR3014979T3 (es)
IT (1) IT1244477B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2193597C1 (ru) * 2001-05-21 2002-11-27 Федеральное государственное учреждение Российский научно-исследовательский противочумный институт "Микроб" Способ получения аспорогенного штамма bacillus anthracis (варианты)
US7585674B2 (en) 2001-05-29 2009-09-08 Kao Corporation Host microorganisms
GB0116798D0 (en) * 2001-07-10 2001-08-29 Secr Defence Expression system
KR101176399B1 (ko) 2003-11-11 2012-08-28 히게따 쇼유 가부시키가이샤 신규한 브레비바실러스 초시넨시스 및 이 미생물을 숙주로 사용한 단백질 제조 방법
JP5140307B2 (ja) * 2007-04-10 2013-02-06 花王株式会社 組換え微生物
US8673290B2 (en) 2011-03-01 2014-03-18 MYGALAXY Limited Company Sporulation-deficient B. texasporus cells and methods for efficient and cost-effective inactivation and use thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4302544A (en) * 1979-10-15 1981-11-24 University Of Rochester Asporogenous mutant of B. subtilis for use as host component of HV1 system
US4450235A (en) * 1982-04-21 1984-05-22 Cpc International Inc. Asporogenic mutant of bacillus subtilis useful as a host in a host-vector system
US4465773A (en) * 1982-04-21 1984-08-14 Cpc International Inc. Amylase-negative, asporogenous mutant of Bacillus subtilis useful as a host in a host-vector system
US4450236A (en) * 1982-04-21 1984-05-22 Cpc International Inc. Asporogenic mutant of Bacillus subtilis useful as a host in a host-vector system
IE58099B1 (en) * 1984-06-06 1993-06-30 Cpc International Inc Amylase-negative, asporogenous mutant of bacillus subtilis useful as a host in a host-vector system
JPH0669377B2 (ja) * 1985-11-25 1994-09-07 工業技術院長 Ｄｎａ塩基配列およびベクタ−
GB8727772D0 (en) * 1987-11-27 1987-12-31 Celltech Ltd Host cells
IT1223577B (it) * 1987-12-22 1990-09-19 Eniricerche Spa Procedimento migliorato per la preparazione dell'ormone della crescita umano naturale in forma pura

Also Published As

Publication number Publication date
DE69105188D1 (de) 1994-12-22
DE69105188T2 (de) 1995-05-18
DK0492274T3 (da) 1995-04-18
JP3013008B2 (ja) 2000-02-28
US6284490B1 (en) 2001-09-04
EP0492274A2 (en) 1992-07-01
GR3014979T3 (en) 1995-05-31
IT9022476A1 (it) 1992-06-22
IT1244477B (it) 1994-07-15
ATE114171T1 (de) 1994-12-15
EP0492274B1 (en) 1994-11-17
EP0492274A3 (en) 1993-09-22
IT9022476A0 (it) 1990-12-21
JPH04287686A (ja) 1992-10-13

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