ES2075016T3 - THE ALPHA SUBUNIT OF THE RECEPTOR OF ADHERENCE TO LEUKOCYTES LFA-1. - Google Patents

THE ALPHA SUBUNIT OF THE RECEPTOR OF ADHERENCE TO LEUKOCYTES LFA-1.

Info

Publication number
ES2075016T3
ES2075016T3 ES89115160T ES89115160T ES2075016T3 ES 2075016 T3 ES2075016 T3 ES 2075016T3 ES 89115160 T ES89115160 T ES 89115160T ES 89115160 T ES89115160 T ES 89115160T ES 2075016 T3 ES2075016 T3 ES 2075016T3
Authority
ES
Spain
Prior art keywords
lfa
molecules
leukocytes
adherence
receptor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89115160T
Other languages
Spanish (es)
Inventor
Timothy Alan Springer
Richard Larson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dana Farber Cancer Institute Inc
Original Assignee
Dana Farber Cancer Institute Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dana Farber Cancer Institute Inc filed Critical Dana Farber Cancer Institute Inc
Application granted granted Critical
Publication of ES2075016T3 publication Critical patent/ES2075016T3/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70546—Integrin superfamily
    • C07K14/70553—Integrin beta2-subunit-containing molecules, e.g. CD11, CD18
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Materials For Medical Uses (AREA)

Abstract

EL PRESENTE INVENTO SE REFIERE A LA SUBUNIDAD - ALFA LFA - 1 QUE ESTA INVOLUCRADA EN EL PROCESO A TRAVES DEL CUAL LA CELULA RECONOCE Y MIGRA HACIA LUGARES DE INFLAMACION ASI COMO SE SUJETA A SUBSTRATOS CELULARES DURANTE LAS INFLAMACIONES. EL INVENTO SE DIRIGE HACIA TALES MOLECULAS, LOS DERIVADOS FUNCIONALES DE TALES MOLECULAS, ENSAYOS PARA IDENTIFICAR TALES MOLECULAS Y USOS TERAPEUTICOS Y DIAGNOSTICOS PARA TALES MOLECULAS.THE PRESENT INVENTION REFERS TO THE SUBUNIT - ALFA LFA - 1 THAT IS INVOLVED IN THE PROCESS THROUGH WHICH THE CELL RECOGNIZES AND MIGRATES TO PLACES OF INFLAMMATION AS WELL AS IT IS SUBJECTED TO CELLULAR SUBSTRATES DURING INFLAMMATION. THE INVENTION IS DIRECTED TOWARDS SUCH MOLECULES, THE FUNCTIONAL DERIVATIVES OF SUCH MOLECULES, TESTS TO IDENTIFY SUCH MOLECULES, AND THERAPEUTIC AND DIAGNOSTIC USES FOR SUCH MOLECULES.

ES89115160T 1988-08-23 1989-08-17 THE ALPHA SUBUNIT OF THE RECEPTOR OF ADHERENCE TO LEUKOCYTES LFA-1. Expired - Lifetime ES2075016T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23522788A 1988-08-23 1988-08-23
US32101789A 1989-03-09 1989-03-09

Publications (1)

Publication Number Publication Date
ES2075016T3 true ES2075016T3 (en) 1995-10-01

Family

ID=26928699

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89115160T Expired - Lifetime ES2075016T3 (en) 1988-08-23 1989-08-17 THE ALPHA SUBUNIT OF THE RECEPTOR OF ADHERENCE TO LEUKOCYTES LFA-1.

Country Status (14)

Country Link
EP (1) EP0362526B1 (en)
JP (1) JPH02306999A (en)
KR (1) KR900002796A (en)
AT (1) ATE123810T1 (en)
AU (1) AU634974B2 (en)
DE (1) DE68923048T2 (en)
DK (1) DK412589A (en)
ES (1) ES2075016T3 (en)
FI (1) FI893916L (en)
GR (1) GR3017303T3 (en)
HU (1) HUT53673A (en)
IL (1) IL91369A (en)
NO (1) NO893366L (en)
PT (1) PT91503B (en)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988006592A1 (en) * 1987-02-26 1988-09-07 Dana-Farber Cancer Institute, Inc. Cloning of lfa-1
US5395929A (en) * 1987-12-15 1995-03-07 Dana Farber Cancer Institute Isolated nucleic acid encoding the alpha subunit of the human leukocyte adhesion receptor
US6514936B1 (en) 1988-09-01 2003-02-04 Bayer Corporation Antiviral methods using human rhinovirus receptor (ICAM-1)
US6051231A (en) * 1988-09-01 2000-04-18 Bayer Corporation Antiviral methods and prepations
US6143298A (en) * 1988-09-01 2000-11-07 Bayer Corporation Soluble truncated forms of ICAM-1
ZA896668B (en) * 1988-09-01 1990-06-27 Molecular Therapeutics Inc A human rhinovirus receptor protein that inhibits virus infectivity
DE68929096T2 (en) 1988-09-01 2000-05-11 Bayer Corp., Pittsburgh Human rhinovirus receptor protein that inhibits susceptibility to virus infection
JPH04505613A (en) * 1989-03-09 1992-10-01 ダナ・ファーバー・キャンサー・インスティチュート leukocyte adhesion receptor
JPH04505009A (en) * 1989-03-09 1992-09-03 ダナ・ファーバー・キャンサー・インスティチュート Cloning LFA-1
ES2134762T3 (en) * 1990-07-20 1999-10-16 Bayer Ag MULTIMERICAL FORMS OF HUMAN RHINOVIRUS RECEPTOR PROTEINS.
US5686581A (en) * 1990-07-20 1997-11-11 Bayer Corporation Multimeric form of human rhinovirus receptor protein
US5686582A (en) * 1990-07-20 1997-11-11 Bayer Corporation Multimeric forms of human rhinovirus receptor protein
US6107461A (en) * 1990-07-20 2000-08-22 Bayer Corporation Multimeric forms of human rhinovirus receptor and fragments thereof, and method of use
US5120830A (en) * 1990-10-25 1992-06-09 Washington University Inhibitory peptides against α-2, β-1 mediated mg++ dependent adhesion of platelets to collagen
US5610148A (en) * 1991-01-18 1997-03-11 University College London Macroscopically oriented cell adhesion protein for wound treatment
US5629287A (en) * 1991-01-18 1997-05-13 University College London Depot formulations
CA2188287A1 (en) * 1994-04-19 1995-10-26 Stephen Benedict Icam-1/lfa-1 short-chain peptides and method of using same
US6017734A (en) * 1995-07-07 2000-01-25 The Texas A & M University System Unique nucleotide and amino acid sequence and uses thereof
US6075004A (en) * 1996-04-26 2000-06-13 The University Of Kansas Peptide compositions which induce immune tolerance and methods of use
AU4825699A (en) * 1998-06-19 2000-01-05 Genzyme Corporation Identification and use of differentially expressed genes and polynucleotide sequences
WO2000001841A2 (en) * 1998-07-06 2000-01-13 Prestwich Glenn D Hyaluronic acid mimics and methods related thereto
DE60324794D1 (en) * 2003-09-04 2009-01-02 Biomay Ag Hypoallergenic polypeptides based on fish-derived parvalbumin
AU2004287875B2 (en) 2003-11-05 2011-06-02 Bausch + Lomb Ireland Limited Modulators of cellular adhesion
AU2005214382B2 (en) 2004-02-19 2011-08-04 Genentech, Inc. CDR-repaired antibodies
DK2444079T3 (en) 2005-05-17 2017-01-30 Sarcode Bioscience Inc Compositions and Methods for the Treatment of Eye Diseases
ES2630406T3 (en) 2007-10-19 2017-08-21 Sarcode Bioscience Inc. Composition and procedures for the treatment of diabetic retinopathy
US8080562B2 (en) 2008-04-15 2011-12-20 Sarcode Bioscience Inc. Crystalline pharmaceutical and methods of preparation and use thereof
US8378105B2 (en) 2009-10-21 2013-02-19 Sarcode Bioscience Inc. Crystalline pharmaceutical and methods of preparation and use thereof
CA2879982C (en) 2012-07-25 2020-09-01 Sarcode Bioscience Inc. Lfa-1 inhibitor and polymorph thereof

Also Published As

Publication number Publication date
HUT53673A (en) 1990-11-28
FI893916A7 (en) 1990-02-24
IL91369A0 (en) 1990-04-29
DE68923048T2 (en) 1995-11-16
JPH02306999A (en) 1990-12-20
PT91503A (en) 1990-03-08
EP0362526B1 (en) 1995-06-14
GR3017303T3 (en) 1995-12-31
FI893916A0 (en) 1989-08-21
KR900002796A (en) 1990-03-23
ATE123810T1 (en) 1995-06-15
FI893916L (en) 1990-02-24
DE68923048D1 (en) 1995-07-20
DK412589A (en) 1990-02-24
DK412589D0 (en) 1989-08-22
AU634974B2 (en) 1993-03-11
IL91369A (en) 1994-08-26
AU4014589A (en) 1990-03-01
EP0362526A2 (en) 1990-04-11
EP0362526A3 (en) 1990-07-18
PT91503B (en) 1996-04-30
NO893366L (en) 1990-02-26
NO893366D0 (en) 1989-08-22

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