ES2075016T3 - THE ALPHA SUBUNIT OF THE RECEPTOR OF ADHERENCE TO LEUKOCYTES LFA-1. - Google Patents

THE ALPHA SUBUNIT OF THE RECEPTOR OF ADHERENCE TO LEUKOCYTES LFA-1.

Info

Publication number
ES2075016T3
ES2075016T3 ES89115160T ES89115160T ES2075016T3 ES 2075016 T3 ES2075016 T3 ES 2075016T3 ES 89115160 T ES89115160 T ES 89115160T ES 89115160 T ES89115160 T ES 89115160T ES 2075016 T3 ES2075016 T3 ES 2075016T3
Authority
ES
Spain
Prior art keywords
lfa
molecules
leukocytes
adherence
receptor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89115160T
Other languages
Spanish (es)
Inventor
Timothy Alan Springer
Richard Larson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dana Farber Cancer Institute Inc
Original Assignee
Dana Farber Cancer Institute Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dana Farber Cancer Institute Inc filed Critical Dana Farber Cancer Institute Inc
Application granted granted Critical
Publication of ES2075016T3 publication Critical patent/ES2075016T3/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70546—Integrin superfamily
    • C07K14/70553—Integrin beta2-subunit-containing molecules, e.g. CD11, CD18
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Materials For Medical Uses (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

EL PRESENTE INVENTO SE REFIERE A LA SUBUNIDAD - ALFA LFA - 1 QUE ESTA INVOLUCRADA EN EL PROCESO A TRAVES DEL CUAL LA CELULA RECONOCE Y MIGRA HACIA LUGARES DE INFLAMACION ASI COMO SE SUJETA A SUBSTRATOS CELULARES DURANTE LAS INFLAMACIONES. EL INVENTO SE DIRIGE HACIA TALES MOLECULAS, LOS DERIVADOS FUNCIONALES DE TALES MOLECULAS, ENSAYOS PARA IDENTIFICAR TALES MOLECULAS Y USOS TERAPEUTICOS Y DIAGNOSTICOS PARA TALES MOLECULAS.THE PRESENT INVENTION REFERS TO THE SUBUNIT - ALFA LFA - 1 THAT IS INVOLVED IN THE PROCESS THROUGH WHICH THE CELL RECOGNIZES AND MIGRATES TO PLACES OF INFLAMMATION AS WELL AS IT IS SUBJECTED TO CELLULAR SUBSTRATES DURING INFLAMMATION. THE INVENTION IS DIRECTED TOWARDS SUCH MOLECULES, THE FUNCTIONAL DERIVATIVES OF SUCH MOLECULES, TESTS TO IDENTIFY SUCH MOLECULES, AND THERAPEUTIC AND DIAGNOSTIC USES FOR SUCH MOLECULES.

ES89115160T 1988-08-23 1989-08-17 THE ALPHA SUBUNIT OF THE RECEPTOR OF ADHERENCE TO LEUKOCYTES LFA-1. Expired - Lifetime ES2075016T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23522788A 1988-08-23 1988-08-23
US32101789A 1989-03-09 1989-03-09

Publications (1)

Publication Number Publication Date
ES2075016T3 true ES2075016T3 (en) 1995-10-01

Family

ID=26928699

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89115160T Expired - Lifetime ES2075016T3 (en) 1988-08-23 1989-08-17 THE ALPHA SUBUNIT OF THE RECEPTOR OF ADHERENCE TO LEUKOCYTES LFA-1.

Country Status (14)

Country Link
EP (1) EP0362526B1 (en)
JP (1) JPH02306999A (en)
KR (1) KR900002796A (en)
AT (1) ATE123810T1 (en)
AU (1) AU634974B2 (en)
DE (1) DE68923048T2 (en)
DK (1) DK412589A (en)
ES (1) ES2075016T3 (en)
FI (1) FI893916L (en)
GR (1) GR3017303T3 (en)
HU (1) HUT53673A (en)
IL (1) IL91369A (en)
NO (1) NO893366L (en)
PT (1) PT91503B (en)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0303692A4 (en) * 1987-02-26 1990-12-05 Dana Farber Cancer Institute Cloning of lfa-1
US5395929A (en) * 1987-12-15 1995-03-07 Dana Farber Cancer Institute Isolated nucleic acid encoding the alpha subunit of the human leukocyte adhesion receptor
ZA896668B (en) * 1988-09-01 1990-06-27 Molecular Therapeutics Inc A human rhinovirus receptor protein that inhibits virus infectivity
US6514936B1 (en) 1988-09-01 2003-02-04 Bayer Corporation Antiviral methods using human rhinovirus receptor (ICAM-1)
US6051231A (en) * 1988-09-01 2000-04-18 Bayer Corporation Antiviral methods and prepations
US6143298A (en) * 1988-09-01 2000-11-07 Bayer Corporation Soluble truncated forms of ICAM-1
ES2141076T3 (en) 1988-09-01 2000-03-16 Bayer Ag HUMAN RHINOVIRUS RECEPTOR PROTEIN INHIBITING VIRUS INFECTIVITY.
JPH04505009A (en) * 1989-03-09 1992-09-03 ダナ・ファーバー・キャンサー・インスティチュート Cloning LFA-1
ZA901842B (en) * 1989-03-09 1990-12-28 Boehringer Ingelheim Pharma Use of intercellular adhesion molecules,and their binding ligans in the treatment of asthma
US5686581A (en) * 1990-07-20 1997-11-11 Bayer Corporation Multimeric form of human rhinovirus receptor protein
US6107461A (en) * 1990-07-20 2000-08-22 Bayer Corporation Multimeric forms of human rhinovirus receptor and fragments thereof, and method of use
US5871733A (en) * 1990-07-20 1999-02-16 Bayer Corporation Multimeric forms of human rhinovirus receptor protein
ES2134762T3 (en) * 1990-07-20 1999-10-16 Bayer Ag MULTIMERICAL FORMS OF HUMAN RHINOVIRUS RECEPTOR PROTEINS.
US5120830A (en) * 1990-10-25 1992-06-09 Washington University Inhibitory peptides against α-2, β-1 mediated mg++ dependent adhesion of platelets to collagen
US5610148A (en) * 1991-01-18 1997-03-11 University College London Macroscopically oriented cell adhesion protein for wound treatment
US5629287A (en) * 1991-01-18 1997-05-13 University College London Depot formulations
JPH09512021A (en) * 1994-04-19 1997-12-02 ザ ユニバーシティ オブ カンサス ICAM-1 / LFA-1 short chain peptides and methods of using the peptides
US6017734A (en) * 1995-07-07 2000-01-25 The Texas A & M University System Unique nucleotide and amino acid sequence and uses thereof
US6075004A (en) 1996-04-26 2000-06-13 The University Of Kansas Peptide compositions which induce immune tolerance and methods of use
AU4825699A (en) * 1998-06-19 2000-01-05 Genzyme Corporation Identification and use of differentially expressed genes and polynucleotide sequences
CA2346742A1 (en) * 1998-07-06 2000-01-13 University Of Utah Research Foundation Hyaluronic acid mimics and methods related thereto
ES2318077T3 (en) * 2003-09-04 2009-05-01 Biomay Ag HYPOALLERGENIC POLYPEPTIDES BASED ON FISH PARVALBUMINA.
JP5105578B2 (en) 2003-11-05 2012-12-26 サーコード バイオサイエンス インコーポレイテッド Cell adhesion modulator
CA2555820C (en) 2004-02-19 2016-01-19 Genentech, Inc. Cdr-repaired antibodies
US8168655B2 (en) 2005-05-17 2012-05-01 Sarcode Bioscience Inc. Compositions and methods for treatment of eye disorders
MX2010004281A (en) 2007-10-19 2010-09-10 Sarcode Corp Compositions and methods for treatment of diabetic retinopathy.
WO2009139817A2 (en) 2008-04-15 2009-11-19 Sarcode Corporation Crystalline pharmaceutical and methods of preparation and use thereof
US8378105B2 (en) 2009-10-21 2013-02-19 Sarcode Bioscience Inc. Crystalline pharmaceutical and methods of preparation and use thereof
SI3715345T1 (en) 2012-07-25 2024-07-31 Bausch + Lomb Ireland Limited PREPARATION OF THE LFA-1 INHIBITOR

Also Published As

Publication number Publication date
PT91503B (en) 1996-04-30
EP0362526B1 (en) 1995-06-14
GR3017303T3 (en) 1995-12-31
AU634974B2 (en) 1993-03-11
DE68923048D1 (en) 1995-07-20
ATE123810T1 (en) 1995-06-15
EP0362526A2 (en) 1990-04-11
JPH02306999A (en) 1990-12-20
NO893366D0 (en) 1989-08-22
FI893916A0 (en) 1989-08-21
FI893916A7 (en) 1990-02-24
PT91503A (en) 1990-03-08
DE68923048T2 (en) 1995-11-16
DK412589D0 (en) 1989-08-22
NO893366L (en) 1990-02-26
DK412589A (en) 1990-02-24
IL91369A (en) 1994-08-26
KR900002796A (en) 1990-03-23
IL91369A0 (en) 1990-04-29
HUT53673A (en) 1990-11-28
AU4014589A (en) 1990-03-01
EP0362526A3 (en) 1990-07-18
FI893916L (en) 1990-02-24

Similar Documents

Publication Publication Date Title
ES2077572T3 (en) MOLECULES OF INTERCELLULAR ADHESION, AND ITS BINDING LINKS.
DE68923048D1 (en) Alpha subunit of the LFA-1 leukocyte adhesion receptor.
ES2080044T3 (en) INTERCELLULAR ADHESION MOLECULES AND THEIR FIXATION LINKS.
ES2086313T3 (en) NEW XANTINA DERIVATIVES WITH ANTAGONIST EFFECT OF ADENOSINE.
DK135305B (en) N-Substituted-β-menthan-3-carboxamides for use as an agent for inducing a physiological cold effect on the skin or mucous membranes of the human body.
ES2058908T3 (en) PROCEDURE FOR THE SEPARATION AND PURIFICATION OF SIALIL-TRANSFERASAS.
ES2053555T3 (en) TEST PROCEDURE AND DIAGNOSTIC SYSTEM OF A MARKER OF ABNORMAL LIPID METABOLISM.
ES2054716T3 (en) BIS-NAFTALIMIDAS, ITS OBTAINING AND EMPLOYMENT.
DK0668933T3 (en) Use of methioninase as an antitumor agent in antimethionine chemotherapy
MX3400E (en) PROCEDURE FOR PRODUCING MANITOL FROM GLUCOSE
ES2072251T3 (en) COMPOSITIONS AND METHODS FOR THE SYNTHESIS AND TEST OF ENQUEFALINASA.
MX164854B (en) PROCEDURE FOR THE TREATMENT OF ETHYLENE COPOLYMER / CARBON MONOXIDE
ES2056184T3 (en) DERIVATIVES OF 2-AMINO-6-CHLORINE-4-NITRO-PHENOL, PROCEDURES FOR ITS PREPARATION AND HAIR DYES CONTAINING SUCH DERIVATIVES AS DIRECT NITRATED DYES.
ES544664A0 (en) PROCEDURE FOR IN VITRO DIAGNOSIS OF SEX
AR003438A1 (en) AMINOME METLROMANES REPLACED BY BENZOISOTIAZOLYL, PROCEDURE FOR THEIR PRODUCTION, MEDICINES CONTAINING THEM, PROCEDURE FOR THE PRODUCTION OF THE MEDICINAL PRODUCTS, USE OF THEM FOR TREATMENT OF THE CENTRAL NERVOUS SYSTEM.
ES556437A0 (en) PROCEDURE FOR PREPARING AN AGENT CONTAINING THYROSINE OR A TYROSINE DERIVATIVE AS AN ACTIVE SUBSTANCE TO IMPROVE THE FERTILITY OF MAMMALS.
ES2022865B3 (en) AZOIC COMPOUNDS CONTAINING CIANO GROUPS, PROCEDURES FOR THEIR OBTAINING AND APPLICATION OF THE SAME AS DYES.
ES2070202T3 (en) NEW DERIVATIVES OF SERINE, PROCEDURE FOR ITS PREPARATION AND USE IN HUMAN THERAPY.
MX9306032A (en) ADENOSINS 2-SUBSTITUTED WITH AFFINITY BY THE RECEIVER A-2.
ES2036523T3 (en) 4-AMINOARILDIHIDROPIRIDINLACTONAS, PROCEDURE FOR ITS OBTAINING AND ITS EMPLOYMENT IN MEDICINES.
GT197960582A (en) NEW DERIVATIVES OF AMINO ALKYLFURAN, PROCEDURE FOR ITS PREPARATION, AS WELL AS ITS USE IN THERAPEUTICS
ES2037657T3 (en) 4-TIENIL-DIHIDROPIRIDINAS, PROCEDURE FOR ITS PREPARATION AND ITS APPLICATION IN MEDICINES.
ES2026966T3 (en) PROCEDURE FOR THE OBTAINING OF 4-METHYL-4-PHENYL-1-PENTA - NALES AND ITS USE AS PERFUMANTS.
ES228022Y (en) DEVICE FOR THE ASSEMBLY BETWEEN THE PARTS OF AN ANTI-VIBRATION SUPPORT, AS WELL AS FOR THE FIXING OF THE SAME.
FR1323307A (en) Partial hydrogenation of cycloaliphatic compounds containing at least two olefinic double bonds

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 362526

Country of ref document: ES