ES2076437T3 - ANALOGS OF PIG AND ITS USE. - Google Patents

ANALOGS OF PIG AND ITS USE.

Info

Publication number
ES2076437T3
ES2076437T3 ES91116704T ES91116704T ES2076437T3 ES 2076437 T3 ES2076437 T3 ES 2076437T3 ES 91116704 T ES91116704 T ES 91116704T ES 91116704 T ES91116704 T ES 91116704T ES 2076437 T3 ES2076437 T3 ES 2076437T3
Authority
ES
Spain
Prior art keywords
lys
asn
homoserine
gip
analogues
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91116704T
Other languages
Spanish (es)
Inventor
Masayasu Kurono
Takahiko Mitani
Haruo Takahashi
Ryoichi Unno
Tomoo Suzuki
Yuji Hayashi
Yohei Kobayashi
Yoko Ishii
Kiichi Sawai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanwa Kagaku Kenkyusho Co Ltd
Original Assignee
Sanwa Kagaku Kenkyusho Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanwa Kagaku Kenkyusho Co Ltd filed Critical Sanwa Kagaku Kenkyusho Co Ltd
Application granted granted Critical
Publication of ES2076437T3 publication Critical patent/ES2076437T3/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Obesity (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Lubrication Of Internal Combustion Engines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Holo Graphy (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Gastric inhibitory peptide (GIP) analogues and uses thereof are described. The GIP analogues codes an amino acid sequence shown by the formula of <IMAGE> wherein X is an amino acid residue other than Met, and Y is a) homoserine (inclusive of homoserine-lactone and indicated by a symbol of "Hse"), b) homoserine amide (HseNH2), c) Gly-Lys-Lys-Asn-Asp-Trp-Lys-His-Asn-Ile-Thr-Gln-Hse or d) Gly-Lys-Lys-Asn-Asp-Trp-Lys-His-Asn-Ile-Thr-Gln-HseNH2. Each of the GIP analogues is employed as an effective ingredient for medicines to cure diabetes.
ES91116704T 1990-10-05 1991-09-30 ANALOGS OF PIG AND ITS USE. Expired - Lifetime ES2076437T3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2266438A JPH04145099A (en) 1990-10-05 1990-10-05 Polypeptide derivative having gip-like activity and use thereof

Publications (1)

Publication Number Publication Date
ES2076437T3 true ES2076437T3 (en) 1995-11-01

Family

ID=17430941

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91116704T Expired - Lifetime ES2076437T3 (en) 1990-10-05 1991-09-30 ANALOGS OF PIG AND ITS USE.

Country Status (6)

Country Link
EP (1) EP0479210B1 (en)
JP (1) JPH04145099A (en)
AT (1) ATE123296T1 (en)
DE (1) DE69110101T2 (en)
DK (1) DK0479210T3 (en)
ES (1) ES2076437T3 (en)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE291624T1 (en) 1992-12-16 2005-04-15 Hexima Ltd A PROTEINASE INHIBITOR, PRECURSOR THEREOF AND GENETIC SEQUENCES CODING THEREOF
EP1119625B1 (en) * 1998-10-07 2005-06-29 Medical College Of Georgia Research Institute, Inc. Glucose-dependent insulinotropic peptide for use as an osteotropic hormone
US20050272652A1 (en) 1999-03-29 2005-12-08 Gault Victor A Peptide analogues of GIP for treatment of diabetes, insulin resistance and obesity
KR20020097236A (en) * 2000-04-27 2002-12-31 바이오네브라스카, 인코포레이티드 Gastric inhibitory polypeptide diagnostic test for detecting susceptibility to type-2 diabetes, impaired glucose tolerance, or impaired fasting glucose
WO2003103697A2 (en) * 2002-06-11 2003-12-18 Cell Therapeutics Scandinavia Ab Use of compounds having gip activity for the treatment of disorders associated with abnormal loss of cells and/or for the treatment of obesity
AU2005298689A1 (en) 2004-10-25 2006-05-04 Cytos Biotechnology Ag Gastric inhibitory polypeptide (GIP) antigen arrays and uses thereof
US8263545B2 (en) 2005-02-11 2012-09-11 Amylin Pharmaceuticals, Inc. GIP analog and hybrid polypeptides with selectable properties
KR20070115947A (en) 2005-02-11 2007-12-06 아밀린 파마슈티칼스, 인크. JP analogs and hybrid polypeptides with selectable properties
CA2913805A1 (en) 2005-11-07 2007-05-18 Indiana University Research And Technology Corporation Glucagon analogs exhibiting physiological solubility and stability
RU2477286C2 (en) 2007-01-05 2013-03-10 Индиана Юниверсити Рисерч Энд Текнолоджи Корпорейшн GLUCAGON ANALOGUES, HAVING HIGH SOLUBILITY IN PHYSIOLOGICAL pH BUFFERS
CA2677932A1 (en) 2007-02-15 2008-08-21 Indiana University Research And Technology Corporation Glucagon/glp-1 receptor co-agonists
MX2010004298A (en) 2007-10-30 2010-05-03 Univ Indiana Res & Tech Corp Compounds exhibiting glucagon antagonist and glp-1 agonist activity.
ES2509883T3 (en) 2007-10-30 2014-10-20 Indiana University Research And Technology Corporation Glucagon antagonists
CN102105159B (en) 2008-06-17 2015-07-08 印第安纳大学研究及科技有限公司 GIP-based mixed agonists for the treatment of metabolic disorders and obesity
US8450270B2 (en) 2008-06-17 2013-05-28 Indiana University Research And Technology Corporation Glucagon analogs exhibiting enhanced solubility and stability in physiological pH buffers
AR072160A1 (en) 2008-06-17 2010-08-11 Univ Indiana Res & Tech Corp GLUCAGON / GLP-1 RECEIVER CO-AGONISTS
ES2574835T3 (en) * 2008-08-07 2016-06-22 Ipsen Pharma S.A.S. Glucose-dependent insulinotropic polypeptide analogs
WO2010016940A2 (en) 2008-08-07 2010-02-11 Ipsen Pharma S.A.S. Analogues of glucose-dependent insulinotropic polypeptide
PE20120332A1 (en) 2008-12-19 2012-04-14 Univ Indiana Res & Tech Corp PEPTIDE PROPHARS FROM THE GLUCAGON SUPERFAMILY BASED ON AMIDA
EP2443146B1 (en) 2009-06-16 2016-10-05 Indiana University Research And Technology Corporation Gip receptor-active glucagon compounds
US8703701B2 (en) 2009-12-18 2014-04-22 Indiana University Research And Technology Corporation Glucagon/GLP-1 receptor co-agonists
KR20120123443A (en) 2010-01-27 2012-11-08 인디애나 유니버시티 리서치 앤드 테크놀로지 코퍼레이션 Glucagon antagonist - gip agonist conjugates and composition for the treatment of metabolic disorders and obesity
MX2012013001A (en) 2010-05-13 2013-02-26 Univ Indiana Res & Tech Corp Glucagon superfamily peptides exhibiting nuclear hormone receptor activity.
JP6050746B2 (en) 2010-05-13 2016-12-21 インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションIndiana University Research And Technology Corporation Glucagon superfamily of peptides exhibiting G protein-coupled receptor activity
EP2588126A4 (en) 2010-06-24 2015-07-08 Univ Indiana Res & Tech Corp GLUCAGON SUPERFAMILY AMIDE PEPTIDE PRODRUGS
US8507428B2 (en) 2010-12-22 2013-08-13 Indiana University Research And Technology Corporation Glucagon analogs exhibiting GIP receptor activity
US9453062B2 (en) 2011-06-10 2016-09-27 Beijing Hanmi Pharmaceutical Co., Ltd. Glucose dependent insulinotropic polypeptide analogs, pharmaceutical compositions and use thereof
RS56173B1 (en) 2011-06-22 2017-11-30 Univ Indiana Res & Tech Corp GLUCAGON / GLP-1 RECEPTOR RECEPTOR COAGONISTS
KR20140043793A (en) 2011-06-22 2014-04-10 인디애나 유니버시티 리서치 앤드 테크놀로지 코퍼레이션 Glucagon/glp-1 receptor co-agonists
JP6324315B2 (en) 2011-11-17 2018-05-16 インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションＩｎｄｉａｎａ Ｕｎｉｖｅｒｓｉｔｙ Ｒｅｓｅａｒｃｈ Ａｎｄ Ｔｅｃｈｎｏｌｏｇｙ Ｃｏｒｐｏｒａｔｉｏｎ Glucagon superfamily of peptides exhibiting glucocorticoid receptor activity
CN104583232B (en) 2012-06-21 2018-04-13 印第安纳大学研究及科技有限公司 Show the glucagon analogs of GIP receptor actives
FR2994848B1 (en) 2012-08-30 2014-08-22 Univ Paris Curie TREATMENT OF ARTHROSIS BY INCRETINED HORMONES OR THEIR ANALOGUES
JOP20190211A1 (en) 2017-03-31 2019-09-15 Takeda Pharmaceuticals Co Gip receptor activating peptide
EP4687947A1 (en) 2023-04-05 2026-02-11 Antag Therapeutics ApS Gip activity modulators and orthostatic intolerance

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01153092A (en) * 1986-11-27 1989-06-15 Sanwa Kagaku Kenkyusho Co Ltd Cdna clone of human gastric inhibitory polypeptide (gip) precursor

Also Published As

Publication number Publication date
DE69110101T2 (en) 1996-02-29
DK0479210T3 (en) 1995-07-31
ATE123296T1 (en) 1995-06-15
EP0479210B1 (en) 1995-05-31
EP0479210A3 (en) 1992-09-02
EP0479210A2 (en) 1992-04-08
JPH04145099A (en) 1992-05-19
DE69110101D1 (en) 1995-07-06

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