ES2076837T3 - Dispositivo osmotico con activacion retardada de entrega de farmacos. - Google Patents
Dispositivo osmotico con activacion retardada de entrega de farmacos.Info
- Publication number
- ES2076837T3 ES2076837T3 ES93902985T ES93902985T ES2076837T3 ES 2076837 T3 ES2076837 T3 ES 2076837T3 ES 93902985 T ES93902985 T ES 93902985T ES 93902985 T ES93902985 T ES 93902985T ES 2076837 T3 ES2076837 T3 ES 2076837T3
- Authority
- ES
- Spain
- Prior art keywords
- drug delivery
- distribution
- osmotic device
- delayed activation
- period
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- External Artificial Organs (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
LA PRESENTE INVENCION ESTA DIRIGIDA A UN DISPOSITIVO (1) ABSORBEDOR DE FLUIDO DE DISTRIBUCION DE MEDICAMENTO QUE ES UTIL PARA LA DISTRIBUCION INICIAL RETARDADA DE UNA FORMULACION DE AGENTE ACTIVO (16) PARA USO EN UN ENTORNO FLUIDO, SIENDO EL PERIODO INICIAL DE RETARDO PARA EL COMIENZO O LA ACTIVACION DE UNA DURACION TEMPORAL PREDERTERMINADA. LA DISTRIBUCION DE LA FORMULACION (169 DESDE EL DISPOSITIVO APLICADOR (1) SE CONTINUA, UNA VEZ COMENZADA, A LO LARGO DE UN PERIODO PROLONGADO DE TIEMPO PREDETERMINADO.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/819,417 US5223265A (en) | 1992-01-10 | 1992-01-10 | Osmotic device with delayed activation of drug delivery |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2076837T3 true ES2076837T3 (es) | 1995-11-01 |
Family
ID=25228098
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES93902985T Expired - Lifetime ES2076837T3 (es) | 1992-01-10 | 1993-01-08 | Dispositivo osmotico con activacion retardada de entrega de farmacos. |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US5223265A (es) |
| EP (1) | EP0620729B1 (es) |
| JP (1) | JP3514756B2 (es) |
| KR (1) | KR100246157B1 (es) |
| AT (1) | ATE127338T1 (es) |
| AU (1) | AU659285B2 (es) |
| CA (1) | CA2124829C (es) |
| DE (1) | DE69300451T2 (es) |
| DK (1) | DK0620729T3 (es) |
| ES (1) | ES2076837T3 (es) |
| FI (1) | FI943280A7 (es) |
| MX (1) | MX9300101A (es) |
| NO (1) | NO942525D0 (es) |
| NZ (1) | NZ246796A (es) |
| WO (1) | WO1993013759A1 (es) |
| ZA (1) | ZA93133B (es) |
Families Citing this family (76)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5728088A (en) * | 1988-12-13 | 1998-03-17 | Alza Corporation | Osmotic system for delivery of fluid-sensitive somatotropins to bovine animals |
| EP0675739A1 (en) * | 1992-12-28 | 1995-10-11 | BAUSCH & LOMB INCORPORATED | Controlled release composition for active substances into an aqueous medium |
| US5290240A (en) * | 1993-02-03 | 1994-03-01 | Pharmetrix Corporation | Electrochemical controlled dispensing assembly and method for selective and controlled delivery of a dispensing fluid |
| US5540665A (en) * | 1994-01-31 | 1996-07-30 | Alza Corporation | Gas driven dispensing device and gas generating engine therefor |
| US5651979A (en) * | 1995-03-30 | 1997-07-29 | Gel Sciences, Inc. | Apparatus and method for delivering a biologically active compound into a biological environment |
| US5817335A (en) * | 1995-05-26 | 1998-10-06 | Alza Corporation | Osmotic device with high drug loading and delayed activation of drug delivery |
| CN1138527C (zh) * | 1995-06-02 | 2004-02-18 | 阿尔萨公司 | 延时启动药剂的发送并完全释放药剂的渗透装置 |
| US5800422A (en) * | 1995-06-02 | 1998-09-01 | Alza Corporation | Osmotic device with delayed activation of drug delivery and complete drug release |
| US5904935A (en) * | 1995-06-07 | 1999-05-18 | Alza Corporation | Peptide/protein suspending formulations |
| KR0124764Y1 (ko) * | 1995-09-23 | 1998-09-15 | 양주환 | 의약 및 식품용 하드 공 캅셀 |
| US5922736A (en) * | 1995-12-04 | 1999-07-13 | Celegene Corporation | Chronic, bolus administration of D-threo methylphenidate |
| US5837284A (en) | 1995-12-04 | 1998-11-17 | Mehta; Atul M. | Delivery of multiple doses of medications |
| US6486177B2 (en) * | 1995-12-04 | 2002-11-26 | Celgene Corporation | Methods for treatment of cognitive and menopausal disorders with D-threo methylphenidate |
| US5902605A (en) * | 1996-04-18 | 1999-05-11 | Alza Corporation | Drug delivery device with minimal residual drug retention |
| AU3590497A (en) * | 1996-07-15 | 1998-02-09 | Alza Corporation | Interlocking osmotic device |
| US6962997B1 (en) * | 1997-05-22 | 2005-11-08 | Celgene Corporation | Process and intermediates for resolving piperidyl acetamide steroisomers |
| US6994851B1 (en) | 1997-07-10 | 2006-02-07 | Mannkind Corporation | Method of inducing a CTL response |
| US6977074B2 (en) * | 1997-07-10 | 2005-12-20 | Mannkind Corporation | Method of inducing a CTL response |
| MY125849A (en) * | 1997-07-25 | 2006-08-30 | Alza Corp | Osmotic delivery system, osmotic delivery system semipermeable body assembly, and method for controlling delivery rate of beneficial agents from osmotic delivery systems |
| MY125870A (en) * | 1997-07-25 | 2006-08-30 | Alza Corp | Osmotic delivery system flow modulator apparatus and method |
| WO1999033446A1 (en) * | 1997-12-29 | 1999-07-08 | Alza Corporation | Osmotic delivery system with membrane plug retention mechanism |
| KR100568917B1 (ko) * | 1997-12-30 | 2006-04-07 | 알자 코포레이션 | 멤브레인 플러그를 갖는 익제 전달장치 |
| AU1937099A (en) | 1997-12-31 | 1999-07-19 | Alza Corporation | Osmotic drug delivery monitoring system and method |
| DE19835346A1 (de) * | 1998-08-05 | 2000-02-10 | Boehringer Ingelheim Pharma | Zweiteilige Kapsel zur Aufnahme von pharmazeutischen Zubereitungen für Pulverinhalatoren |
| US6551613B1 (en) * | 1998-09-08 | 2003-04-22 | Alza Corporation | Dosage form comprising therapeutic formulation |
| US6342249B1 (en) | 1998-12-23 | 2002-01-29 | Alza Corporation | Controlled release liquid active agent formulation dosage forms |
| WO2000059479A1 (en) * | 1999-04-06 | 2000-10-12 | Pharmaquest Ltd. | Pharmaceutical dosage form for pulsatile delivery of methylphenidate |
| US20030170181A1 (en) * | 1999-04-06 | 2003-09-11 | Midha Kamal K. | Method for preventing abuse of methylphenidate |
| ES2248156T3 (es) | 1999-12-21 | 2006-03-16 | Alza Corporation | Valvula para dispositivos osmoticos. |
| US6669954B2 (en) | 2000-01-25 | 2003-12-30 | John R. Crison | Controlled release of drugs |
| JP4248236B2 (ja) * | 2000-11-29 | 2009-04-02 | デュレクト コーポレイション | 薬物送達装置からの送達を制御するための装置および方法 |
| US6491684B1 (en) * | 2001-05-22 | 2002-12-10 | Durect Corporation | Fluid delivery device having a water generating electrochemical/chemical pump and associated method |
| EP1492509A1 (en) * | 2001-12-18 | 2005-01-05 | ALZA Corporation | Dosage form providing time-varying patterns of drug delivery |
| KR20050071376A (ko) * | 2002-06-28 | 2005-07-07 | 알자 코포레이션 | 액체 활성성분 제제를 포함하고 팽창성 삼투 조성물에의해 그의 방출을 제어하는 경구제형 |
| US7731947B2 (en) | 2003-11-17 | 2010-06-08 | Intarcia Therapeutics, Inc. | Composition and dosage form comprising an interferon particle formulation and suspending vehicle |
| US7485322B2 (en) * | 2002-12-24 | 2009-02-03 | Lek Pharmaceuticals D.D. | Modified release pharmaceutical composition |
| CA2534364A1 (en) * | 2003-08-07 | 2005-02-17 | Alveolus Inc. | Therapeutic medical appliance, delivery and method of use |
| US20050239830A1 (en) * | 2004-04-26 | 2005-10-27 | Vikram Khetani | Methods of diminishing co-abuse potential |
| EP1761265A2 (en) * | 2004-06-28 | 2007-03-14 | ALZA Corporation | A drug/polymer complex, preferably ciprofloxacin/hpmc, its method of manufacturing using lyophilization and its use in an osmotic device |
| WO2006023286A2 (en) * | 2004-08-19 | 2006-03-02 | Alza Corporation | Controlled release nanoparticle active agent formulation dosage forms and methods |
| US7350479B2 (en) * | 2004-09-10 | 2008-04-01 | United States Of America As Represented By The Secretary Of The Army | System and method for controlling growth of aquatic plants utilizing bio-eroding means implanted in triploid grass carp |
| US20060127421A1 (en) * | 2004-12-09 | 2006-06-15 | Celgene Corporation | Treatment using D-threo methylphenidate |
| EP1838338A2 (en) * | 2004-12-29 | 2007-10-03 | Mannkind Corporation | Methods to trigger, maintain and manipulate immune responses by targeted administration of biological response modifiers into lymphoid organs |
| DE102005001332A1 (de) * | 2005-01-11 | 2006-07-20 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Zweiteilige Kapsel mit Vorverschluss zur Aufnahme von pharmazeutischen Zubereitungen für Pulverinhalatoren |
| WO2006083761A2 (en) | 2005-02-03 | 2006-08-10 | Alza Corporation | Solvent/polymer solutions as suspension vehicles |
| US11246913B2 (en) | 2005-02-03 | 2022-02-15 | Intarcia Therapeutics, Inc. | Suspension formulation comprising an insulinotropic peptide |
| AU2006269944A1 (en) * | 2005-07-19 | 2007-01-25 | Inverseon, Inc. | Improved pharmacokinetic profile of beta-adrenergic inverse agonists for the treatment of pulmonary airway diseases |
| US7858609B2 (en) * | 2005-11-28 | 2010-12-28 | Marinus Pharmaceuticals | Solid ganaxolone formulations and methods for the making and use thereof |
| US7762426B2 (en) * | 2006-03-16 | 2010-07-27 | The Procter & Gamble Company | Seal for dispensing container having dispensing opening |
| KR101106510B1 (ko) | 2006-05-30 | 2012-01-20 | 인타르시아 세라퓨틱스 인코포레이티드 | 투피스, 내부채널 삼투압 전달 시스템 유동 조절기 |
| EP2359808B1 (en) | 2006-08-09 | 2013-05-22 | Intarcia Therapeutics, Inc | Osmotic delivery systems and piston assemblies |
| BRPI0717721A2 (pt) | 2006-11-28 | 2013-10-29 | Marinus Pharmaceuticals | "partículas complexadas de drogas, composição farmacêutica, uso de uma composição farmacêutica, partículas complexadas de droga estabilizadas no tamanho, método para a preparação de partículas estabilizadas da droga, composição farmacêutica sólida, comprimido oral ingerível e composição líquida em nanopartículas estabilizadas no tamanho" |
| WO2008133908A2 (en) | 2007-04-23 | 2008-11-06 | Intarcia Therapeutics, Inc. | Suspension formulations of insulinotropic peptides and uses thereof |
| CN101827573A (zh) * | 2007-10-15 | 2010-09-08 | 葛兰素集团有限公司 | 已装填的连接件的制造装置和方法 |
| EP2209456B1 (en) * | 2007-10-15 | 2013-03-06 | Capsugel Belgium NV | Linkers for multipart dosage forms for release of one or more pharmaceutical compositions, and the resulting dosage forms |
| US8454992B2 (en) * | 2007-10-15 | 2013-06-04 | Capsugel Belgium Nv | Paneled capsule shells for release of pharmaceutical compositions |
| CA2726861C (en) | 2008-02-13 | 2014-05-27 | Intarcia Therapeutics, Inc. | Devices, formulations, and methods for delivery of multiple beneficial agents |
| RU2547990C2 (ru) | 2009-09-28 | 2015-04-10 | Интарсия Терапьютикс, Инк. | Быстрое достижение и/или прекращение существенной стабильной доставки лекарственного средства |
| US20120208755A1 (en) | 2011-02-16 | 2012-08-16 | Intarcia Therapeutics, Inc. | Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers |
| CN103987357B (zh) | 2011-10-06 | 2017-12-12 | 康宝卡普股份有限公司 | 胶囊的制造方法和装置 |
| US9456987B2 (en) | 2013-04-03 | 2016-10-04 | Binutra, Inc. | Capsule with internal diaphragm |
| US9889085B1 (en) | 2014-09-30 | 2018-02-13 | Intarcia Therapeutics, Inc. | Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c |
| RU2730996C2 (ru) | 2015-06-03 | 2020-08-26 | Интарсия Терапьютикс, Инк. | Системы установки и извлечения имплантата |
| US11160759B1 (en) | 2015-10-09 | 2021-11-02 | Combocap, Inc. | Capsule with internal diaphragm for improved bioavailability |
| KR102574993B1 (ko) | 2016-05-16 | 2023-09-06 | 인타르시아 세라퓨틱스 인코포레이티드 | 글루카곤-수용체 선택적 폴리펩티드 및 이들의 이용 방법 |
| USD840030S1 (en) | 2016-06-02 | 2019-02-05 | Intarcia Therapeutics, Inc. | Implant placement guide |
| USD860451S1 (en) | 2016-06-02 | 2019-09-17 | Intarcia Therapeutics, Inc. | Implant removal tool |
| EP3481387A4 (en) | 2016-08-11 | 2020-04-08 | Ovid Therapeutics Inc | METHOD AND COMPOSITIONS FOR TREATING EPILEPTIC DISEASES |
| JP7286542B2 (ja) | 2017-01-03 | 2023-06-05 | インターシア セラピューティクス,インコーポレイティド | Glp-1受容体アゴニストの持続的投与及び薬物の同時投与を含む方法 |
| USD933219S1 (en) | 2018-07-13 | 2021-10-12 | Intarcia Therapeutics, Inc. | Implant removal tool and assembly |
| US11266662B2 (en) | 2018-12-07 | 2022-03-08 | Marinus Pharmaceuticals, Inc. | Ganaxolone for use in prophylaxis and treatment of postpartum depression |
| JP7754799B2 (ja) | 2019-08-05 | 2025-10-15 | マリナス ファーマシューティカルズ, インコーポレイテッド | てんかん重積状態の治療に使用するためのガナキソロン |
| WO2021113834A1 (en) | 2019-12-06 | 2021-06-10 | Marinus Pharmaceuticals, Inc. | Ganaxolone for use in treating tuberous sclerosis complex |
| JP2025176720A (ja) * | 2022-10-07 | 2025-12-05 | テルモ株式会社 | 薬剤投与装置 |
| WO2024202782A1 (ja) * | 2023-03-30 | 2024-10-03 | テルモ株式会社 | 投与装置、及び被投与物の投与状態の判断方法 |
| CN117138215A (zh) * | 2023-08-15 | 2023-12-01 | 浙江诺尔康神经电子科技股份有限公司 | 一种无源自驱动的微递送装置 |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3732865A (en) * | 1971-01-13 | 1973-05-15 | Alza Corp | Osmotic dispenser |
| US3995631A (en) * | 1971-01-13 | 1976-12-07 | Alza Corporation | Osmotic dispenser with means for dispensing active agent responsive to osmotic gradient |
| US4034756A (en) * | 1971-01-13 | 1977-07-12 | Alza Corporation | Osmotically driven fluid dispenser |
| US3865108A (en) * | 1971-05-17 | 1975-02-11 | Ortho Pharma Corp | Expandable drug delivery device |
| US3845770A (en) * | 1972-06-05 | 1974-11-05 | Alza Corp | Osmatic dispensing device for releasing beneficial agent |
| US3916899A (en) * | 1973-04-25 | 1975-11-04 | Alza Corp | Osmotic dispensing device with maximum and minimum sizes for the passageway |
| US3995632A (en) * | 1973-05-04 | 1976-12-07 | Alza Corporation | Osmotic dispenser |
| US4002173A (en) * | 1974-07-23 | 1977-01-11 | International Paper Company | Diester crosslinked polyglucan hydrogels and reticulated sponges thereof |
| GB1478759A (en) * | 1974-11-18 | 1977-07-06 | Alza Corp | Process for forming outlet passageways in pills using a laser |
| US4063064A (en) * | 1976-02-23 | 1977-12-13 | Coherent Radiation | Apparatus for tracking moving workpiece by a laser beam |
| US4111202A (en) * | 1976-11-22 | 1978-09-05 | Alza Corporation | Osmotic system for the controlled and delivery of agent over time |
| US4207893A (en) * | 1977-08-29 | 1980-06-17 | Alza Corporation | Device using hydrophilic polymer for delivering drug to biological environment |
| US4285987A (en) * | 1978-10-23 | 1981-08-25 | Alza Corporation | Process for manufacturing device with dispersion zone |
| US4200098A (en) * | 1978-10-23 | 1980-04-29 | Alza Corporation | Osmotic system with distribution zone for dispensing beneficial agent |
| US4265874A (en) * | 1980-04-25 | 1981-05-05 | Alza Corporation | Method of delivering drug with aid of effervescent activity generated in environment of use |
| US4320759A (en) * | 1980-04-28 | 1982-03-23 | Alza Corporation | Dispenser with diffuser |
| US4327725A (en) * | 1980-11-25 | 1982-05-04 | Alza Corporation | Osmotic device with hydrogel driving member |
| US4449983A (en) * | 1982-03-22 | 1984-05-22 | Alza Corporation | Simultaneous delivery of two drugs from unit delivery device |
| US4612008A (en) * | 1983-05-11 | 1986-09-16 | Alza Corporation | Osmotic device with dual thermodynamic activity |
| US4777049A (en) * | 1983-12-01 | 1988-10-11 | Alza Corporation | Constant release system with pulsed release |
| US4595583A (en) * | 1984-03-19 | 1986-06-17 | Alza Corporation | Delivery system controlled administration of beneficial agent to ruminants |
| US4601896A (en) * | 1984-03-21 | 1986-07-22 | Mark Nugent | Pharmaceutical capsule compositions and structures for gastric sensitive materials |
| US4643731A (en) * | 1985-08-16 | 1987-02-17 | Alza Corporation | Means for providing instant agent from agent dispensing system |
| US4955881A (en) * | 1985-08-16 | 1990-09-11 | Alza Corporation | Ruminant dispensing device |
| US5023088A (en) * | 1987-06-25 | 1991-06-11 | Alza Corporation | Multi-unit delivery system |
| US4874388A (en) * | 1987-06-25 | 1989-10-17 | Alza Corporation | Multi-layer delivery system |
| US4872873A (en) * | 1987-12-14 | 1989-10-10 | Merck & Co., Inc. | Controlled release bolus device |
| US5034229A (en) * | 1988-12-13 | 1991-07-23 | Alza Corporation | Dispenser for increasing feed conversion of hog |
| US4976966A (en) * | 1988-12-29 | 1990-12-11 | Alza Corporation | Delayed release osmotically driven fluid dispenser |
| GB8903564D0 (en) * | 1989-02-16 | 1989-04-05 | Rashid Abdul | Drug dispensing device |
| US5178866A (en) * | 1990-03-23 | 1993-01-12 | Alza Corporation | Dosage form for delivering drug to the intestine |
| US5017381A (en) * | 1990-05-02 | 1991-05-21 | Alza Corporation | Multi-unit pulsatile delivery system |
| FI933397A7 (fi) * | 1991-01-30 | 1993-07-29 | Alza Corp | Osmoottinen laite aineen viivästettyyn vapauttamiseen |
-
1992
- 1992-01-10 US US07/819,417 patent/US5223265A/en not_active Expired - Lifetime
-
1993
- 1993-01-08 AT AT93902985T patent/ATE127338T1/de not_active IP Right Cessation
- 1993-01-08 NZ NZ246796A patent/NZ246796A/en not_active IP Right Cessation
- 1993-01-08 DE DE69300451T patent/DE69300451T2/de not_active Expired - Fee Related
- 1993-01-08 EP EP93902985A patent/EP0620729B1/en not_active Expired - Lifetime
- 1993-01-08 KR KR1019940702383A patent/KR100246157B1/ko not_active Expired - Fee Related
- 1993-01-08 ZA ZA93133A patent/ZA93133B/xx unknown
- 1993-01-08 FI FI943280A patent/FI943280A7/fi not_active Application Discontinuation
- 1993-01-08 ES ES93902985T patent/ES2076837T3/es not_active Expired - Lifetime
- 1993-01-08 DK DK93902985.6T patent/DK0620729T3/da active
- 1993-01-08 WO PCT/US1993/000110 patent/WO1993013759A1/en not_active Ceased
- 1993-01-08 AU AU34368/93A patent/AU659285B2/en not_active Ceased
- 1993-01-08 MX MX9300101A patent/MX9300101A/es not_active IP Right Cessation
- 1993-01-08 JP JP51256493A patent/JP3514756B2/ja not_active Expired - Fee Related
- 1993-01-08 CA CA002124829A patent/CA2124829C/en not_active Expired - Fee Related
- 1993-01-14 US US08/004,340 patent/US5312390A/en not_active Expired - Lifetime
-
1994
- 1994-07-05 NO NO942525A patent/NO942525D0/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JPH07504401A (ja) | 1995-05-18 |
| JP3514756B2 (ja) | 2004-03-31 |
| ZA93133B (en) | 1993-08-16 |
| US5223265A (en) | 1993-06-29 |
| EP0620729B1 (en) | 1995-09-06 |
| US5312390A (en) | 1994-05-17 |
| CA2124829A1 (en) | 1993-07-22 |
| NO942525L (no) | 1994-07-05 |
| MX9300101A (es) | 1994-01-31 |
| NO942525D0 (no) | 1994-07-05 |
| AU659285B2 (en) | 1995-05-11 |
| EP0620729A1 (en) | 1994-10-26 |
| FI943280A0 (fi) | 1994-07-08 |
| KR940703654A (ko) | 1994-12-12 |
| CA2124829C (en) | 2004-03-16 |
| DE69300451T2 (de) | 1996-05-02 |
| WO1993013759A1 (en) | 1993-07-22 |
| DK0620729T3 (da) | 1995-12-04 |
| DE69300451D1 (de) | 1995-10-12 |
| FI943280L (fi) | 1994-07-08 |
| FI943280A7 (fi) | 1994-07-08 |
| KR100246157B1 (ko) | 2000-04-01 |
| AU3436893A (en) | 1993-08-03 |
| NZ246796A (en) | 1995-10-26 |
| ATE127338T1 (de) | 1995-09-15 |
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