ES2077070T3 - Intermedio de sintesis de 2-alquiniladenosina, produccion de dicho intermedio, produccion de 2-alquiniladenosina a partir de dicho intermedio, y derivado de 2-alquiniladenosina estable. - Google Patents

Intermedio de sintesis de 2-alquiniladenosina, produccion de dicho intermedio, produccion de 2-alquiniladenosina a partir de dicho intermedio, y derivado de 2-alquiniladenosina estable.

Info

Publication number
ES2077070T3
ES2077070T3 ES90909403T ES90909403T ES2077070T3 ES 2077070 T3 ES2077070 T3 ES 2077070T3 ES 90909403 T ES90909403 T ES 90909403T ES 90909403 T ES90909403 T ES 90909403T ES 2077070 T3 ES2077070 T3 ES 2077070T3
Authority
ES
Spain
Prior art keywords
production
alkynyladenosine
derivative
synthesis
alkylyledenosine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90909403T
Other languages
English (en)
Inventor
Toyofumi Yamaguchi
Takanori Miyashita
Shinji Sakata
Toichi Abiru
Akira Matsuda
Tohru Ueda
Kentaro Kogi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Toa Eiyo Ltd
Yamasa Shoyu KK
Original Assignee
Toa Eiyo Ltd
Yamasa Shoyu KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toa Eiyo Ltd, Yamasa Shoyu KK filed Critical Toa Eiyo Ltd
Application granted granted Critical
Publication of ES2077070T3 publication Critical patent/ES2077070T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Ladders (AREA)

Abstract

UN NUEVO COMPUESTO DE LA FORMULA (I), DONDE A REPRESENTA UN GRUPO VIVO, UTIL COMO INTERMEDIARIO PARA LA SINTESIS DE 2-ALKINILADENOSINA; PRODUCCION DE DICHO COMPUESTO; PRODUCCION DE 2-ALKINILADENOSINA EN LA (IV), DONDE A = NH SUB 2 DEL COMPUESTO; 2-ALKINILADENOSINA DERIVADA DE LA FORMULA (V), DONDE A = NHR SUB 4; Y CONSERVACION DE 2-ALKINILADENOSINA EN FORMA DE DICHO DERIVADO. EN LA FORMULA ANTERIOR,R ELEVADO 1 A R ELEVADO 4 REPRESENTAN CADA PARTICULA DE HIDROGENO O UN GRUPO DE PROTECCION, Y N ES UN NUMERO ENTERO DE 1 A 15, SIEMPRE QUE SE EXCLUYAN LOS ATOMOS DE HIDROGENO R ELEVADO 1 A R ELEVADO 4.
ES90909403T 1989-06-20 1990-06-20 Intermedio de sintesis de 2-alquiniladenosina, produccion de dicho intermedio, produccion de 2-alquiniladenosina a partir de dicho intermedio, y derivado de 2-alquiniladenosina estable. Expired - Lifetime ES2077070T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP15751789 1989-06-20
JP472790 1990-01-13

Publications (1)

Publication Number Publication Date
ES2077070T3 true ES2077070T3 (es) 1995-11-16

Family

ID=26338545

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90909403T Expired - Lifetime ES2077070T3 (es) 1989-06-20 1990-06-20 Intermedio de sintesis de 2-alquiniladenosina, produccion de dicho intermedio, produccion de 2-alquiniladenosina a partir de dicho intermedio, y derivado de 2-alquiniladenosina estable.

Country Status (8)

Country Link
US (2) US5283327A (es)
EP (1) EP0429681B1 (es)
KR (1) KR920700218A (es)
AT (1) ATE127472T1 (es)
CA (1) CA2035038C (es)
DE (1) DE69022176T2 (es)
ES (1) ES2077070T3 (es)
WO (1) WO1990015812A1 (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5189027A (en) 1990-11-30 1993-02-23 Yamasa Shoyu Kabushiki Kaisha 2-substituted adenosine derivatives and pharmaceutical compositions for circulatory diseases
JP2740362B2 (ja) * 1991-02-12 1998-04-15 ヤマサ醤油株式会社 安定な固体状２‐オクチニルアデノシンおよびその製造法
EE05185B1 (et) * 1999-02-01 2009-06-15 University Of Virginia Patent Foundation Kompositsioonid p?letikuliste protsesside k„sitlemiseks
USRE47351E1 (en) 1999-06-22 2019-04-16 Gilead Sciences, Inc. 2-(N-pyrazolo)adenosines with application as adenosine A2A receptor agonists
US6403567B1 (en) * 1999-06-22 2002-06-11 Cv Therapeutics, Inc. N-pyrazole A2A adenosine receptor agonists
US6180615B1 (en) * 1999-06-22 2001-01-30 Cv Therapeutics, Inc. Propargyl phenyl ether A2A receptor agonists
US6214807B1 (en) * 1999-06-22 2001-04-10 Cv Therapeutics, Inc. C-pyrazole 2A A receptor agonists
CA2671940A1 (en) 2000-02-23 2001-08-30 Cv Therapeutics, Inc. Identification of partial agonists of the a2a adenosine receptor
WO2004011010A1 (en) * 2002-07-29 2004-02-05 Cv Therapeutics, Inc. Myocardial perfusion imaging using a2a receptor agonists
US8470801B2 (en) 2002-07-29 2013-06-25 Gilead Sciences, Inc. Myocardial perfusion imaging methods and compositions
US20050020915A1 (en) * 2002-07-29 2005-01-27 Cv Therapeutics, Inc. Myocardial perfusion imaging methods and compositions
EP1802317A2 (en) * 2004-10-20 2007-07-04 Cv Therapeutics, Inc. Use of a2a adenosine receptor agonists
CA2640089C (en) 2006-02-03 2013-07-23 Cv Therapeutics, Inc. Process for preparing an a2a-adenosine receptor agonist and its polymorphs
CA2655310A1 (en) * 2006-06-22 2008-05-29 Cv Therapeutics, Inc. Use of a2a adenosine receptor agonists in the treatment of ischemia
US20090081120A1 (en) * 2006-09-01 2009-03-26 Cv Therapeutics, Inc. Methods and Compositions for Increasing Patient Tolerability During Myocardial Imaging Methods
MX2009002299A (es) * 2006-09-01 2009-03-20 Cv Therapeutics Inc Metodos y composiciones para incrementar la tolerancia del paciente durante metodos de formacion de imagenes del miocardio.
WO2008042796A2 (en) * 2006-09-29 2008-04-10 Cv Therapeutics, Inc. Methods for myocardial imaging in patients having a history of pulmonary disease
EP2099360A2 (en) * 2007-01-03 2009-09-16 CV Therapeutics Inc. Myocardial perfusion imaging
KR20110063556A (ko) * 2008-09-29 2011-06-10 길리애드 사이언시즈, 인코포레이티드 다검출 전산화 단층 촬영법에 사용하기 위한 ａ-２-알파 수용체 길항제와 속도 조절제의 조합물
US9822141B2 (en) 2012-08-01 2017-11-21 Lewis And Clark Pharmaceuticals, Inc. N-alkyl 2-(disubstituted)alkynyladenosine-5-uronamides as A2A agonists
BR112015002249A2 (pt) 2012-08-01 2017-07-04 Lewis And Clark Pharmaceuticals Inc composto, um estereoisômero ou sal farmaceuticamente aceitável do mesmo; composição farmacêutica; método para tratar um estado associado a receptor de adenosina a2a em um indivíduo; método para diagnosticar anormalidades de perfusão de miocárdio em um mamífero; e método para reduzir a pressão interocular em um indivíduo

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6299395A (ja) * 1985-10-25 1987-05-08 Yamasa Shoyu Co Ltd ２−アルキニルアデノシンおよび抗高血圧剤
US5270304A (en) * 1988-11-15 1993-12-14 Yamasa Shoyu Kabushiki Kaisha Therapeutic 2-alkynyl adenosine agent for ischemic diseases of the heart or brain

Also Published As

Publication number Publication date
US5283327A (en) 1994-02-01
WO1990015812A1 (en) 1990-12-27
DE69022176D1 (de) 1995-10-12
DE69022176T2 (de) 1996-02-15
US5459254A (en) 1995-10-17
EP0429681B1 (en) 1995-09-06
KR920700218A (ko) 1992-02-19
CA2035038C (en) 1998-12-29
EP0429681A1 (en) 1991-06-05
EP0429681A4 (en) 1992-03-11
CA2035038A1 (en) 1990-12-21
ATE127472T1 (de) 1995-09-15

Similar Documents

Publication Publication Date Title
EP0429681A4 (en) Intermediate for 2-alkynyladenosine synthesis, production of said intermediate, production of 2-alkynyladenosine from said intermediate, and stable 2-alkynyladenosine derivative
DE69416306D1 (de) Sphingoglycolipid und verwendung davon
FI930991A0 (fi) Polymerer som innehaoller diesterenheter
KR950702221A (ko) 폴리와 그의 생산방법(poly(3-hydroxyalk anoates) and process for the production thereof)
DE69219221D1 (de) Vanadium Komplexe, ihre Herstellung und pharmazeutische Zusammensetzungen, die sie enthalten
EA199800768A1 (ru) Новые производные эритромицина, способ их получения и их применение в качестве медикаментов
FR2678930B1 (fr) Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii.
DE69226815D1 (de) 1-Methyl-carbapenemderivate, deren Herstellung und Verwendung als Antibiotika
DK0519673T3 (da) Præparat indeholdende dioxabicyclo{3,3,0}octanderivat
ZA9410181B (en) Arylacetic acid derivatives.
GR3019351T3 (en) Diaminoethylene compounds
CA2021733A1 (en) Azole-substituted cycloalkanol derivative, a process to produce the same and a use of the derivative as an agricultural and horticultural fungicide
ATE191915T1 (de) Herstellung von borester
DK0601191T3 (da) Hidtil ukendt tetracyklisk forbindelse
ZA891434B (en) Azolylmethyloxiranes and fungicides containing these compounds
FI951588A0 (fi) Öljykoostumuksia
ATE88471T1 (de) Azolylmethylcyloalkyloxirane, ihre herstellung und verwendung als pflanzenschutzmittel.
ATE102955T1 (de) Zyklisches tetrapeptid und verfahren zu dessen herstellung.
DE3882623D1 (de) Phosphorsaeurediester und salze davon.
GB2321459A (en) Synthesis of carboxylic acid derivatives
FI960588A0 (fi) Mikrobisideina käytettäviä tiokarbamoyyliyhdisteitä
DK0538517T3 (da) Nye organo-tinforbindelser med antitumoraktivitet og antitumormidler
EP0623608A4 (en) BENZOPYRANE DERIVATIVES, THE PRODUCTION THEREOF AND THE MEDICINAL PRODUCTS CONTAINING IT AS ACTIVE INGREDIENTS.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 429681

Country of ref document: ES