ES2078559T3 - Procedimiento para la preparacion de hidrocloruro de 3-amino-9,13b-dihidro-1h-dibenz(c,f)imidazo(1,5-a)azepina. - Google Patents

Procedimiento para la preparacion de hidrocloruro de 3-amino-9,13b-dihidro-1h-dibenz(c,f)imidazo(1,5-a)azepina.

Info

Publication number
ES2078559T3
ES2078559T3 ES92100798T ES92100798T ES2078559T3 ES 2078559 T3 ES2078559 T3 ES 2078559T3 ES 92100798 T ES92100798 T ES 92100798T ES 92100798 T ES92100798 T ES 92100798T ES 2078559 T3 ES2078559 T3 ES 2078559T3
Authority
ES
Spain
Prior art keywords
dibenz
dihydro
azepine
imidazo
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92100798T
Other languages
English (en)
Inventor
Heinrich Dr Schneider
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim GmbH
Original Assignee
Boehringer Ingelheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim GmbH filed Critical Boehringer Ingelheim GmbH
Application granted granted Critical
Publication of ES2078559T3 publication Critical patent/ES2078559T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

LA PRESENTE INVENCION TRATA DEL PROCESO PARA LA FABRICACION DE 3-AMINO -9,13B-DIHIDRO-1H-DIBENZ-(C, F)IMIDAZO(B,E)AZEPIN-HIDROCLORURO (I), MEDIANTE HIDROGENACION DE 6-FTALIMIDOMETILO-5H-DIBENZ(B, E)AZEPIN, HIDRACINOLISIS DEL PRODUCTO DE HIDROGENACION, TRANSFORMACION CON BROMOCIANURO Y PRECIPITACION COMO HIDROCLORURO DEL PRODUCTO DE REACCION.
ES92100798T 1991-01-25 1992-01-18 Procedimiento para la preparacion de hidrocloruro de 3-amino-9,13b-dihidro-1h-dibenz(c,f)imidazo(1,5-a)azepina. Expired - Lifetime ES2078559T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4102148A DE4102148A1 (de) 1991-01-25 1991-01-25 Verfahren zur herstellung von 3-amino-9,13b-dihydro-1h-dibenz-(c,f)imidazol(1,5-a)azepin-hydrochlorid

Publications (1)

Publication Number Publication Date
ES2078559T3 true ES2078559T3 (es) 1995-12-16

Family

ID=6423672

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92100798T Expired - Lifetime ES2078559T3 (es) 1991-01-25 1992-01-18 Procedimiento para la preparacion de hidrocloruro de 3-amino-9,13b-dihidro-1h-dibenz(c,f)imidazo(1,5-a)azepina.

Country Status (9)

Country Link
US (1) US5312916A (es)
EP (1) EP0496306B1 (es)
JP (1) JP3133448B2 (es)
KR (1) KR100196965B1 (es)
AT (1) ATE127802T1 (es)
DE (2) DE4102148A1 (es)
DK (1) DK0496306T3 (es)
ES (1) ES2078559T3 (es)
GR (1) GR3017693T3 (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001131177A (ja) * 1999-11-08 2001-05-15 Ohara Yakuhin Kogyo Kk ジベンズ［ｃ，ｆ］イミダゾ［１，５−ａ］アゼピンの製造方法及びその製造中間体
DE19954516A1 (de) * 1999-11-12 2001-05-17 Boehringer Ingelheim Int Epinastin-haltige Lösungen
DE19958460A1 (de) * 1999-12-03 2001-06-07 Boehringer Ingelheim Pharma Verfahren zur Herstellung von Epinastine-Hydrochlorid in der hochschmelzenden Kristallmodifikation
KR100392692B1 (ko) * 2001-05-31 2003-07-28 바이오네스트 주식회사 에피나스틴 및 그 약제학적으로 허용되는 염의 새로운제조방법
JP4298212B2 (ja) * 2002-03-29 2009-07-15 大日本印刷株式会社 塩酸エピナスチン高融点型結晶の製造法
US7196193B2 (en) * 2002-04-11 2007-03-27 Konica Minolta Chemical Co., Ltd. Method for preparing 6-aminomethyl-6, 11-dihydro-5h-dibenz[b,e]azepine
JP4514017B2 (ja) * 2003-03-27 2010-07-28 大日本印刷株式会社 塩酸エピナスチンの製造方法
KR101386530B1 (ko) 2006-12-29 2014-04-18 케이피엑스 라이프사이언스 주식회사 순도 및 수율이 향상된3-아미노-9,13ｂ디하이드로-1Ｈ-디벤즈-[ｃ,ｆ]이미다조[1,5-ａ]-아제핀 염산염의 제조방법
CN101130544B (zh) * 2007-09-26 2010-09-08 杭州龙山化工有限公司 依匹斯汀的化学合成方法
KR100909295B1 (ko) * 2007-11-15 2009-07-24 주식회사 참조아 6-아미노메틸- 6,11-디하이드로-5Ｈ-디벤즈[ｂ,ｅ]아제핀의 제조방법
JP2009102434A (ja) * 2009-02-09 2009-05-14 Dainippon Printing Co Ltd ６−アミノメチル−６，１１−ジヒドロ−５Ｈ−ジベンズ［ｂ，ｅ］アゼピンの製造方法
JP2010120960A (ja) * 2010-02-17 2010-06-03 Dainippon Printing Co Ltd 塩酸エピナスチンの製造方法
CN104098575B (zh) * 2013-04-15 2016-06-01 四川科瑞德凯华制药有限公司 一种盐酸依匹斯汀晶型及其制备方法和用途
CN104447757B (zh) * 2014-11-17 2017-03-22 合肥华方医药科技有限公司 依匹斯汀的合成方法
CN105153169B (zh) * 2014-11-27 2018-11-30 兆科药业（广州）有限公司 一种盐酸依匹斯汀的合成方法
CN107118216B (zh) * 2017-05-08 2019-03-08 宏冠生物药业有限公司 一种盐酸依匹斯汀杂质b的合成方法
CN107141297B (zh) * 2017-06-23 2019-07-02 合肥华方医药科技有限公司 一种盐酸依匹斯汀的合成方法
KR102080239B1 (ko) 2019-08-06 2020-02-21 한양대학교 에리카산학협력단 에피나스틴의 신규 제조방법
CN112028897A (zh) * 2020-11-06 2020-12-04 南京远淑医药科技有限公司 一种盐酸依匹斯汀的合成方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3008944A1 (de) * 1980-03-08 1981-09-24 C.H. Boehringer Sohn, 6507 Ingelheim Dibenzimidazoazepine, ihre herstellung und verwendung

Also Published As

Publication number Publication date
DE4102148A1 (de) 1992-07-30
KR100196965B1 (ko) 1999-06-15
DE59203611D1 (de) 1995-10-19
JP3133448B2 (ja) 2001-02-05
KR920014814A (ko) 1992-08-25
GR3017693T3 (en) 1996-01-31
ATE127802T1 (de) 1995-09-15
US5312916A (en) 1994-05-17
DK0496306T3 (da) 1996-01-22
EP0496306B1 (de) 1995-09-13
EP0496306A1 (de) 1992-07-29
JPH04346988A (ja) 1992-12-02

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