ES2079507T3 - Intermediarios para conjugados del acido difluoroglutamico con folatos y antifolatos para el tratamiento de enfermedades neoplasicas. - Google Patents

Intermediarios para conjugados del acido difluoroglutamico con folatos y antifolatos para el tratamiento de enfermedades neoplasicas.

Info

Publication number
ES2079507T3
ES2079507T3 ES91105767T ES91105767T ES2079507T3 ES 2079507 T3 ES2079507 T3 ES 2079507T3 ES 91105767 T ES91105767 T ES 91105767T ES 91105767 T ES91105767 T ES 91105767T ES 2079507 T3 ES2079507 T3 ES 2079507T3
Authority
ES
Spain
Prior art keywords
folates
antifolates
intermediaries
treatment
neoplastic diseases
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91105767T
Other languages
English (en)
Inventor
Philippe Bey
Michael H Kolb
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Merrell Dow Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharmaceuticals Inc filed Critical Merrell Dow Pharmaceuticals Inc
Application granted granted Critical
Publication of ES2079507T3 publication Critical patent/ES2079507T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
    • C07D475/08—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/24—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one carboxyl group bound to the carbon skeleton, e.g. aspartic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/36—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

LA INVENCION SE REFIERE A INTERMEDIARIOS PARA LA PREPARACION DE CIERTOS CONJUGADOS DE FOLATOS Y ANTIFOLATOS CON ACIDO DIFLOROGLUTAMICO QUE SON UTILES EN EL TRATAMIENTO DE PACIENTES QUE SUFREN CIERTAS ENFERMEDADES NEOPLASTICAS ENTRE LAS QUE SE ENCUENTRAN LA LEUCEMIA, MELANOMAS, CARCINOMAS, SARCOMAS Y NEOPLASIS MIXTAS.
ES91105767T 1990-04-12 1991-04-11 Intermediarios para conjugados del acido difluoroglutamico con folatos y antifolatos para el tratamiento de enfermedades neoplasicas. Expired - Lifetime ES2079507T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/508,874 US5066828A (en) 1990-04-12 1990-04-12 Difluoroglutamic acid conjugates with folates and anti-folates for the treatment of neoplastic diseases

Publications (1)

Publication Number Publication Date
ES2079507T3 true ES2079507T3 (es) 1996-01-16

Family

ID=24024432

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91105767T Expired - Lifetime ES2079507T3 (es) 1990-04-12 1991-04-11 Intermediarios para conjugados del acido difluoroglutamico con folatos y antifolatos para el tratamiento de enfermedades neoplasicas.

Country Status (18)

Country Link
US (1) US5066828A (es)
EP (1) EP0451835B1 (es)
JP (1) JP2970698B2 (es)
KR (1) KR910018344A (es)
CN (1) CN1055740A (es)
AT (1) ATE127778T1 (es)
AU (1) AU635628B2 (es)
CA (1) CA2040059A1 (es)
DE (1) DE69112885T2 (es)
ES (1) ES2079507T3 (es)
FI (1) FI911778L (es)
HU (1) HU911195D0 (es)
IE (1) IE911230A1 (es)
IL (1) IL97819A0 (es)
NO (1) NO911418L (es)
NZ (1) NZ237735A (es)
PT (1) PT97338A (es)
ZA (1) ZA912590B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5286726A (en) * 1990-04-12 1994-02-15 The Regents Of The University Of Michigan Difluoroglutamic acid conjugates with folates and anti-folates for the treatment of neoplastic diseases
DE69327312T2 (de) * 1992-04-29 2000-07-13 Sri International, Menlo Park Deazaaminopterine für behandlung von entzündungen
US6323205B1 (en) * 1996-07-17 2001-11-27 Sloan-Kettering Institute For Cancer Research Combinations of 10-propargyl-10-deazaaminopterin and taxols and methods of using same in the treatment of tumors
DE19904812A1 (de) * 1999-02-05 2000-08-10 Basf Ag Verfahren zur Herstellung von Folsäure
CN101646639A (zh) * 2007-04-11 2010-02-10 默克阿泼洛发股份公司 18f-标记的叶酸
WO2008125615A1 (en) * 2007-04-11 2008-10-23 Merck Eprova Ag 18 f-labelled folates
US9901578B2 (en) 2007-08-17 2018-02-27 Allos Therapeutics, Inc. Combination of 10-propargyl-10-deazaaminopterin and erlotinib for the treatment of non-small cell lung cancer
US20100248249A1 (en) * 2007-08-17 2010-09-30 Allos Therapeutics, Inc. Methods for Assessing Cancer for Increased Sensitivity to 10-Propargyl-10-Deazaaminopterin by Assessing Egfr Levels
US20090048262A1 (en) * 2007-08-17 2009-02-19 Allos Therapeutics, Inc. Combination of 10-propargyl-10-deazaaminopterin and erlotinib for the treatment of non-small cell lung cancer
SG195545A1 (en) 2008-10-10 2013-12-30 Merck & Cie 18f-labelled folates as pet radiotracers
AU2010345065B2 (en) 2010-02-02 2014-06-05 Allos Therapeutics, Inc. Optically pure diastereomers of 10-propargyl-10-deazaaminopterin and methods of using same

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH630380A5 (de) * 1977-08-12 1982-06-15 Lonza Ag Verfahren zur herstellung von l-methotrexat.
US4136101A (en) * 1978-02-03 1979-01-23 American Cyanamid Company Process for preparing dialkyl (p-aminobenzoyl) glutamates
US4247453A (en) * 1978-09-13 1981-01-27 Abbott Laboratories Folic acid derivatives for use in radioimmunoassay
IT1215169B (it) * 1985-12-17 1990-01-31 Rotta Research Lab Derivati alchil ossigenati degli acidi glutammico ed aspartico ad attivita antagonista su polipeptidi bioattivi e procedimento per la loro preparazione
NZ219971A (en) * 1986-06-06 1989-08-29 Univ Princeton Tetrahydropyrido (2,3-d pyrimidine derivatives and pharmaceutical compositions
EP0341837A3 (en) * 1988-04-15 1990-08-16 The Wellcome Foundation Limited Glutamic acid derivatives

Also Published As

Publication number Publication date
NO911418L (no) 1991-10-14
IL97819A0 (en) 1992-06-21
DE69112885T2 (de) 1996-02-15
JPH04235144A (ja) 1992-08-24
NO911418D0 (no) 1991-04-11
AU7416591A (en) 1991-10-17
IE911230A1 (en) 1991-10-23
FI911778A7 (fi) 1991-10-13
ATE127778T1 (de) 1995-09-15
AU635628B2 (en) 1993-03-25
FI911778A0 (fi) 1991-04-12
KR910018344A (ko) 1991-11-30
PT97338A (pt) 1992-01-31
ZA912590B (en) 1992-01-29
CA2040059A1 (en) 1991-10-13
JP2970698B2 (ja) 1999-11-02
US5066828A (en) 1991-11-19
EP0451835B1 (en) 1995-09-13
EP0451835A1 (en) 1991-10-16
FI911778L (fi) 1991-10-13
NZ237735A (en) 1993-08-26
CN1055740A (zh) 1991-10-30
HU911195D0 (en) 1991-10-28
DE69112885D1 (de) 1995-10-19

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