ES2079758T3 - Procedimiento y dispositivo para separar la sangre en sus componentes. - Google Patents

Procedimiento y dispositivo para separar la sangre en sus componentes.

Info

Publication number
ES2079758T3
ES2079758T3 ES92114687T ES92114687T ES2079758T3 ES 2079758 T3 ES2079758 T3 ES 2079758T3 ES 92114687 T ES92114687 T ES 92114687T ES 92114687 T ES92114687 T ES 92114687T ES 2079758 T3 ES2079758 T3 ES 2079758T3
Authority
ES
Spain
Prior art keywords
stage
separation
plasma
thrombocits
concentrate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92114687T
Other languages
English (en)
Inventor
Wolfgang Dr Biesel
Johannes Geibel
Henning Brass
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fresenius SE and Co KGaA
Original Assignee
Fresenius SE and Co KGaA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fresenius SE and Co KGaA filed Critical Fresenius SE and Co KGaA
Application granted granted Critical
Publication of ES2079758T3 publication Critical patent/ES2079758T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D43/00—Separating particles from liquids, or liquids from solids, otherwise than by sedimentation or filtration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3693—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/04—Liquids
    • A61M2202/0413—Blood
    • A61M2202/0427—Platelets; Thrombocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/04—Liquids
    • A61M2202/0413—Blood
    • A61M2202/0429—Red blood cells; Erythrocytes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S210/00—Liquid purification or separation
    • Y10S210/929—Hemoultrafiltrate volume measurement or control processes

Landscapes

  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • External Artificial Organs (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

LA INVENCION SE REFIERE A UN PROCESO Y A UN DISPOSITIVO PARA LA OBTENCION MAS EFECTIVA DE UNA FRACCION DE TROMBOCITOS MUY PURA EN LA CENTRIFUGACION POR DENSIDAD DE SANGRE, QUE, ANTES DE QUE SE INYECTE A UN PACIENTE, YA NO SE DEBA FILTRAR MAS RESPECTO A LOS LEUCOCITOS CONTENIDOS EN ELLA, CON EL FIN DE EVITAR UNA INMUNIZACION DEL RECEPTOR. LA INVENCION PARTE DE UNA SEPARACION POR DENSIDADES EN DOS ETAPAS, EN DONDE EN UNA PRIMERA ETAPA SE HACE UNA SEPARACION ENTRE CELULAS Y PLASMA RICO EN TROMBOCITOS, Y SOLO EN UNA SEGUNDA ETAPA EL PLASMA RICO EN TROMBOCITOS, EN CONCENTRADO DE TROMBOCITOS Y PLASMA POBRE EN TROMBOCITOS. DURANTE LA PRIMERA SEPARACION SE VARIA CICLICAMENTE LA POSICION DEL LIMITE DE FASES EN LA PRIMERA ETAPA DE SEPARACION. POR EL ALTERNADO DE LOS LIMITES DE FASES EN LA PRIMERA ETAPA, SERA POSIBLE EN LA SEGUNDA ETAPA OBTENER CONCENTRADO DE TROMBOCIDOS MUY PURO CON CONTAMINACION POR LEUCOCITOS BAJA MINIMA A PARTIR DEL PLASMA RICO EN TROMBOCITOS CONDUCIDO SIN PERDIDA DE EFICACIA.
ES92114687T 1991-09-06 1992-08-28 Procedimiento y dispositivo para separar la sangre en sus componentes. Expired - Lifetime ES2079758T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4129516A DE4129516C2 (de) 1991-09-06 1991-09-06 Verfahren und Vorrichtung zum Trennen von Blut in seine Bestandteile

Publications (1)

Publication Number Publication Date
ES2079758T3 true ES2079758T3 (es) 1996-01-16

Family

ID=6439916

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92114687T Expired - Lifetime ES2079758T3 (es) 1991-09-06 1992-08-28 Procedimiento y dispositivo para separar la sangre en sus componentes.

Country Status (5)

Country Link
US (1) US5281342A (es)
EP (1) EP0530688B1 (es)
JP (1) JP2618793B2 (es)
DE (2) DE4129516C2 (es)
ES (1) ES2079758T3 (es)

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US5804079A (en) 1991-12-23 1998-09-08 Baxter International Inc. Systems and methods for reducing the number of leukocytes in cellular products like platelets harvested for therapeutic purposes
US5437598A (en) * 1994-01-21 1995-08-01 Cobe Laboratories, Inc. Automation of plasma sequestration
US5545339A (en) * 1994-02-25 1996-08-13 Pall Corporation Method for processing biological fluid and treating separated component
US5585007A (en) * 1994-12-07 1996-12-17 Plasmaseal Corporation Plasma concentrate and tissue sealant methods and apparatuses for making concentrated plasma and/or tissue sealant
US5704888A (en) * 1995-04-14 1998-01-06 Cobe Laboratories, Inc. Intermittent collection of mononuclear cells in a centrifuge apparatus
US5704889A (en) * 1995-04-14 1998-01-06 Cobe Laboratories, Inc. Spillover collection of sparse components such as mononuclear cells in a centrifuge apparatus
AU725669B2 (en) * 1995-12-04 2000-10-19 Puget Sound Blood Center Non-immunogenic and toleragenic platelet and red blood cell compositions
US5964724A (en) * 1996-01-31 1999-10-12 Medtronic Electromedics, Inc. Apparatus and method for blood separation
DE19728089A1 (de) * 1997-07-02 1999-01-07 Fresenius Ag Verfahren zum Separieren einer Zellsuspension durch Zentrifugieren, insbesondere zum Trennen von Vollblut in seine Blutkomponenten
US6524231B1 (en) * 1999-09-03 2003-02-25 Baxter International Inc. Blood separation chamber with constricted interior channel and recessed passage
US7651474B2 (en) 1999-10-01 2010-01-26 Caridianbct, Inc. Method and apparatus for leukoreduction of red blood cells
US7686779B1 (en) 1999-10-01 2010-03-30 Caridian BCT, Inc Extracorporeal blood processing methods and apparatus
WO2002062482A2 (en) * 2000-11-02 2002-08-15 Gambro, Inc. Fluid separation devices, systems and methods
US6890291B2 (en) * 2001-06-25 2005-05-10 Mission Medical, Inc. Integrated automatic blood collection and processing unit
EP1455860B1 (en) * 2001-12-10 2011-08-31 CaridianBCT, Inc. Method for the leukoreduction of red blood cells
US7211037B2 (en) * 2002-03-04 2007-05-01 Therakos, Inc. Apparatus for the continuous separation of biological fluids into components and method of using same
US7479123B2 (en) 2002-03-04 2009-01-20 Therakos, Inc. Method for collecting a desired blood component and performing a photopheresis treatment
US7037428B1 (en) * 2002-04-19 2006-05-02 Mission Medical, Inc. Integrated automatic blood processing unit
US7992725B2 (en) 2002-05-03 2011-08-09 Biomet Biologics, Llc Buoy suspension fractionation system
US20030205538A1 (en) * 2002-05-03 2003-11-06 Randel Dorian Methods and apparatus for isolating platelets from blood
US7832566B2 (en) 2002-05-24 2010-11-16 Biomet Biologics, Llc Method and apparatus for separating and concentrating a component from a multi-component material including macroparticles
US7374678B2 (en) * 2002-05-24 2008-05-20 Biomet Biologics, Inc. Apparatus and method for separating and concentrating fluids containing multiple components
WO2003099412A1 (en) 2002-05-24 2003-12-04 Biomet Manufacturing Corp. Apparatus and method for separating and concentrating fluids containing multiple components
US7845499B2 (en) * 2002-05-24 2010-12-07 Biomet Biologics, Llc Apparatus and method for separating and concentrating fluids containing multiple components
US20060278588A1 (en) 2002-05-24 2006-12-14 Woodell-May Jennifer E Apparatus and method for separating and concentrating fluids containing multiple components
US7297272B2 (en) * 2002-10-24 2007-11-20 Fenwal, Inc. Separation apparatus and method
US20050049539A1 (en) * 2003-09-03 2005-03-03 O'hara Gerald P. Control system for driving fluids through an extracorporeal blood circuit
US7087177B2 (en) * 2004-04-16 2006-08-08 Baxter International Inc. Methods for determining flow rates of biological fluids
US7476209B2 (en) * 2004-12-21 2009-01-13 Therakos, Inc. Method and apparatus for collecting a blood component and performing a photopheresis treatment
ES2426941T3 (es) * 2005-02-07 2013-10-25 Hanuman Llc Aparato y procedimiento de concentrados de plasma rico en plaquetas
US7708152B2 (en) * 2005-02-07 2010-05-04 Hanuman Llc Method and apparatus for preparing platelet rich plasma and concentrates thereof
US7866485B2 (en) 2005-02-07 2011-01-11 Hanuman, Llc Apparatus and method for preparing platelet rich plasma and concentrates thereof
WO2007041716A1 (en) * 2005-10-05 2007-04-12 Gambro Bct, Inc. Method and apparatus for leukoreduction of red blood cells
US8567609B2 (en) 2006-05-25 2013-10-29 Biomet Biologics, Llc Apparatus and method for separating and concentrating fluids containing multiple components
US8430813B2 (en) * 2006-05-26 2013-04-30 Depuy Spine, Inc. Illuminated surgical access system including a surgical access device and integrated light emitter
JP5479319B2 (ja) 2007-04-12 2014-04-23 バイオメット・バイオロジックス・リミテッド・ライアビリティ・カンパニー ブイ式懸濁液分画システム
US8328024B2 (en) 2007-04-12 2012-12-11 Hanuman, Llc Buoy suspension fractionation system
US8685258B2 (en) * 2008-02-27 2014-04-01 Fenwal, Inc. Systems and methods for conveying multiple blood components to a recipient
US8075468B2 (en) * 2008-02-27 2011-12-13 Fenwal, Inc. Systems and methods for mid-processing calculation of blood composition
EP2567692B1 (en) 2008-02-27 2016-04-06 Biomet Biologics, LLC Use of a device for obtaining interleukin-1 receptor antagonist rich solutions
WO2009111338A1 (en) 2008-02-29 2009-09-11 Biomet Manufacturing Corp. A system and process for separating a material
US8012077B2 (en) * 2008-05-23 2011-09-06 Biomet Biologics, Llc Blood separating device
US8187475B2 (en) 2009-03-06 2012-05-29 Biomet Biologics, Llc Method and apparatus for producing autologous thrombin
US8313954B2 (en) 2009-04-03 2012-11-20 Biomet Biologics, Llc All-in-one means of separating blood components
US9011800B2 (en) * 2009-07-16 2015-04-21 Biomet Biologics, Llc Method and apparatus for separating biological materials
US8591391B2 (en) 2010-04-12 2013-11-26 Biomet Biologics, Llc Method and apparatus for separating a material
WO2012064754A2 (en) 2010-11-08 2012-05-18 New York Blood Center, Inc. Component preparation system
US9642956B2 (en) 2012-08-27 2017-05-09 Biomet Biologics, Llc Apparatus and method for separating and concentrating fluids containing multiple components
US20140271589A1 (en) 2013-03-15 2014-09-18 Biomet Biologics, Llc Treatment of collagen defects using protein solutions
US9950035B2 (en) 2013-03-15 2018-04-24 Biomet Biologics, Llc Methods and non-immunogenic compositions for treating inflammatory disorders
US10143725B2 (en) 2013-03-15 2018-12-04 Biomet Biologics, Llc Treatment of pain using protein solutions
US10208095B2 (en) 2013-03-15 2019-02-19 Biomet Manufacturing, Llc Methods for making cytokine compositions from tissues using non-centrifugal methods
US9895418B2 (en) 2013-03-15 2018-02-20 Biomet Biologics, Llc Treatment of peripheral vascular disease using protein solutions
US9713810B2 (en) 2015-03-30 2017-07-25 Biomet Biologics, Llc Cell washing plunger using centrifugal force
US9757721B2 (en) 2015-05-11 2017-09-12 Biomet Biologics, Llc Cell washing plunger using centrifugal force

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4185629A (en) * 1977-10-18 1980-01-29 Baxter Travenol Laboratories, Inc. Method and apparatus for processing blood
US4151844A (en) * 1977-11-11 1979-05-01 Baxter Travenol Laboratories, Inc. Method and apparatus for separating whole blood into its components and for automatically collecting one component
JPS5749461A (en) * 1980-09-10 1982-03-23 Asahi Chemical Ind Blood treating vessel, device and method for separating platelet
US4344560A (en) * 1979-11-02 1982-08-17 Asahi Kasei Kogyo Kabushiki Kaisha Container, apparatus and method for separating platelets
US4464167A (en) * 1981-09-03 1984-08-07 Haemonetics Corporation Pheresis apparatus
DE3410286C2 (de) * 1984-03-21 1986-01-23 Fresenius AG, 6380 Bad Homburg Verfahren zur Trennung von Blut sowie Vorrichtung zur Durchführung des Verfahrens
US4806252A (en) * 1987-01-30 1989-02-21 Baxter International Inc. Plasma collection set and method
US5104526A (en) * 1987-01-30 1992-04-14 Baxter International Inc. Centrifugation system having an interface detection system

Also Published As

Publication number Publication date
JP2618793B2 (ja) 1997-06-11
JPH05203639A (ja) 1993-08-10
EP0530688B1 (de) 1995-11-29
DE59204481D1 (de) 1996-01-11
EP0530688A1 (de) 1993-03-10
DE4129516A1 (de) 1993-03-18
US5281342A (en) 1994-01-25
DE4129516C2 (de) 2000-03-09

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