ES2080079T3 - 13-alquil-11-beta-fenil-gonanos. - Google Patents

13-alquil-11-beta-fenil-gonanos.

Info

Publication number
ES2080079T3
ES2080079T3 ES89730155T ES89730155T ES2080079T3 ES 2080079 T3 ES2080079 T3 ES 2080079T3 ES 89730155 T ES89730155 T ES 89730155T ES 89730155 T ES89730155 T ES 89730155T ES 2080079 T3 ES2080079 T3 ES 2080079T3
Authority
ES
Spain
Prior art keywords
radicals
beta
gonanos
alquil
fenil
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89730155T
Other languages
English (en)
Inventor
Stefan Dr Scholz
Eckhard Dr Ottow
Gunter Dr Neef
Walter Dr Elger
Sybille Dr Beier
Krzysztof Dr Chwalisz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Application granted granted Critical
Publication of ES2080079T3 publication Critical patent/ES2080079T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/36—Antigestagens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0081—Substituted in position 17 alfa and 17 beta
    • C07J1/0088—Substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being an unsaturated hydrocarbon group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J15/00—Stereochemically pure steroids containing carbon, hydrogen, halogen or oxygen having a partially or totally inverted skeleton, e.g. retrosteroids, L-isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J33/00—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J33/002—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Macromonomer-Based Addition Polymer (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Lubricants (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Epoxy Compounds (AREA)

Abstract

SE DESCRIBEN 13- ALQUIL -11 BETA- FENIL -GONANOS DE LA FORMULA GENERAL I, DONDE: Z, R1, R2, R3 Y R4 TIENEN EL SIGNIFICADO DADO EN LA DESCRIPCION, PRODECIMIENTO PARA SU FABRICACION, PREPARADOS FARMACEUTICOS QUE CONTIENEN COMBINACIONES ASI COMO SU UTILIZACION PARA FABRICACION DE MEDICAMENTOS. LAS NUEVAS COMBINACIONES DE LA FORMULA GENERAL I TIENEN EXCELENTE EFECTIVIDAD ANTIGESTAGENA.
ES89730155T 1988-07-01 1989-07-03 13-alquil-11-beta-fenil-gonanos. Expired - Lifetime ES2080079T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3822770A DE3822770A1 (de) 1988-07-01 1988-07-01 13-alkyl-11ss-phenylgonane

Publications (1)

Publication Number Publication Date
ES2080079T3 true ES2080079T3 (es) 1996-02-01

Family

ID=6358021

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89730155T Expired - Lifetime ES2080079T3 (es) 1988-07-01 1989-07-03 13-alquil-11-beta-fenil-gonanos.

Country Status (17)

Country Link
US (2) US5273971A (es)
EP (1) EP0349481B1 (es)
JP (1) JP2956776B2 (es)
AT (1) ATE129717T1 (es)
AU (1) AU644060B2 (es)
CA (1) CA1334668C (es)
DD (2) DD287511A5 (es)
DE (2) DE3822770A1 (es)
ES (1) ES2080079T3 (es)
GR (1) GR3018069T3 (es)
HU (1) HU208021B (es)
IE (1) IE70664B1 (es)
IL (1) IL90826A (es)
NO (1) NO180451C (es)
PT (1) PT91031B (es)
WO (1) WO1990000174A1 (es)
ZA (1) ZA895058B (es)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3822770A1 (de) * 1988-07-01 1990-01-04 Schering Ag 13-alkyl-11ss-phenylgonane
US5707982A (en) * 1989-02-24 1998-01-13 Roussel Uclaf 19-nor-steroids
US6790971B1 (en) * 1989-02-24 2004-09-14 Aventis Pharma S.A. 19-Nor-steroids
DE4018168A1 (de) * 1990-06-01 1991-12-05 Schering Ag Ausgangsverbindungen fuer die herstellung von 10ss-h-steroiden und ein verfahren zur herstellung dieser ausgangsverbindungen
DE4042004A1 (de) * 1990-12-22 1992-06-25 Schering Ag 14(beta)-h-, 14- u. 15-en-11(beta)-aryl-4-estrene
DE69500542T2 (de) * 1994-05-19 1998-01-02 Akzo Nobel Nv 11,21-Bisphenyl-19-nor-pregnan Derivate
DE4434488A1 (de) * 1994-09-14 1996-03-21 Schering Ag Steroidester und -amide, Verfahren zu ihrer Herstellung und ihre pharmazeutische Verwendung
US5929262A (en) * 1995-03-30 1999-07-27 The United States Of America As Represented By The Department Of Health And Human Services Method for preparing 17α-acetoxy-11β-(4-N, N-dimethylaminophyl)-19-Norpregna-4,9-diene-3, 20-dione, intermediates useful in the method, and methods for the preparation of such intermediates
IL118974A (en) * 1995-08-17 2001-09-13 Akzo Nobel Nv History 11 - (Transformed Phenyl) - Astra - 4, 9 - Diane, their preparation and pharmaceutical preparations containing them
US6900193B1 (en) * 1996-05-01 2005-05-31 The United States Of America As Represented By The Department Of Health And Human Services Structural modification of 19-norprogesterone I: 17-α-substituted-11-β-substituted-4-aryl and 21-substituted 19-norpregnadienedione as new antiprogestational agents
AU710139B2 (en) * 1996-05-01 1999-09-16 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The 21-substituted progesterone derivatives as new antiprogestational agents
US6020328A (en) * 1998-03-06 2000-02-01 Research Triangle Institute 20-keto-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties
US6262042B1 (en) 1998-05-29 2001-07-17 Research Triangle Institute 17β-amino and hydroxylamino-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties
US5962444A (en) * 1998-05-29 1999-10-05 Research Triangle Institute 17β-nitro-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties
ATE294812T1 (de) * 2000-07-28 2005-05-15 Akzo Nobel Nv 16alpha-methyl oder ethyl substituierte oestrogene
AU2004217988C1 (en) * 2003-02-28 2010-06-03 Southwest Foundation For Biomedical Research Method for preparing 17 alpha-acetoxy-11beta-(4-N,N-dimethylaminophenyl)-19-norpregna-4,9-diene-3,20-dione, intermediates thereof, and methods for the preparation of such intermediates
TW200531977A (en) * 2004-03-25 2005-10-01 Akzo Nobel Nv Progesterone receptor modulators
US20060196449A1 (en) * 2004-09-17 2006-09-07 Mockry Eldon F Fluid heating system and method
US9517240B2 (en) 2006-09-26 2016-12-13 The Regents Of The University Of California Methods and compositions for cancer prevention and treatment
WO2008039482A2 (en) * 2006-09-26 2008-04-03 The Regents Of The University Of California Methods and compositions for cancer prevention and treatment
AU2007327707B2 (en) 2006-10-24 2012-07-12 Allergan pharmaceuticals International Ltd. Compositions and methods for suppressing endometrial proliferation
US7784843B2 (en) * 2008-01-08 2010-08-31 Toyota Motor Engineering & Manufacturing North America, Inc. Vehicle console with sliding panel
US8172293B2 (en) * 2008-01-09 2012-05-08 Toyota Motor Engineering & Manufacturing North America, Inc. Vehicle electronic device support systems
TWI539953B (zh) 2008-04-28 2016-07-01 瑞波若斯治療學公司 用於治療乳癌之組成物和方法
CN107260745A (zh) 2010-03-22 2017-10-20 利普生物药剂公司 用于抗孕酮的非毒性递送的组合物和方法
CN113201042A (zh) 2013-03-12 2021-08-03 康泰科思特生物制药公司 奥那司酮多晶型形式和使用方法
US9096641B2 (en) 2013-06-05 2015-08-04 Evestra, Inc. Imidazolyl progesterone antagonists
RU2017112748A (ru) 2014-11-17 2018-12-19 Арно Терапьютикс, Инк. Композиции онапристона пролонгированного действия и способы
CA2998924A1 (en) 2015-09-25 2017-03-30 Context Biopharma Inc. Methods of making onapristone intermediates
CA3008422A1 (en) 2015-12-15 2017-06-22 Context Biopharma Inc. Amorphous onapristone compositions and methods of making the same
US20180148471A1 (en) 2016-11-30 2018-05-31 Arno Therapeutics, Inc. Methods for onapristone synthesis dehydration and deprotection

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3971772A (en) * 1975-01-06 1976-07-27 E. R. Squibb & Sons, Inc. Steroidal[16α,17-b]1,4-dioxanes and Steroidal[16α,17-b]1,4-dioxins
ZA8231B (en) * 1981-01-09 1982-11-24 Roussel Uclaf New 11 -substituted steroid derivatives, their preparation, their use as medicaments, the compositions containing them and the new intermediates thus obtained
FR2522328B1 (fr) * 1982-03-01 1986-02-14 Roussel Uclaf Nouveaux produits derives de la structure 3-ceto 4,9 19-nor steroides, leur procede de preparation et leur application comme medicaments
ES533260A0 (es) * 1983-06-15 1985-02-01 Schering Ag Procedimiento para la preparacion de 13a-alquilgonanos
US4780461A (en) * 1983-06-15 1988-10-25 Schering Aktiengesellschaft 13α-alkyl-gonanes, their production, and pharmaceutical preparations containing same
FR2576025B1 (fr) * 1985-01-14 1987-01-23 Roussel Uclaf Nouveaux steroides substitues en position 10, leur procede et les intermediaires de preparation, leur application comme medicaments, les compositions pharmaceutiques les contenant
AU580843B2 (en) * 1985-02-07 1989-02-02 Schering Aktiengesellschaft 11``-phenyl-gonanes, their manufacture and pharmaceutical preparations containing them
DE3625315A1 (de) * 1986-07-25 1988-01-28 Schering Ag 11ss-(4-isopropenylphenyl)-estra-4,9-diene, deren herstellung und diese enthaltende pharmazeutische praeparate
DE3822770A1 (de) * 1988-07-01 1990-01-04 Schering Ag 13-alkyl-11ss-phenylgonane
DE3832303A1 (de) * 1988-09-20 1990-04-12 Schering Ag 11ss-phenyl-14ssh-steroide

Also Published As

Publication number Publication date
GR3018069T3 (en) 1996-02-29
PT91031B (pt) 1994-12-30
NO180451B (no) 1997-01-13
HU894130D0 (en) 1991-06-28
DD287511A5 (de) 1991-02-28
ATE129717T1 (de) 1995-11-15
DE58909476D1 (de) 1995-12-14
JPH03505727A (ja) 1991-12-12
IE70664B1 (en) 1996-12-11
HUT56114A (en) 1991-07-29
NO180451C (no) 1997-04-23
AU644060B2 (en) 1993-12-02
NO905609L (no) 1991-02-28
EP0349481A1 (de) 1990-01-03
PT91031A (pt) 1990-02-08
EP0349481B1 (de) 1995-11-02
HU208021B (en) 1993-07-28
IL90826A (en) 1994-06-24
AU3856889A (en) 1990-01-23
DE3822770A1 (de) 1990-01-04
NO905609D0 (no) 1990-12-27
WO1990000174A1 (de) 1990-01-11
JP2956776B2 (ja) 1999-10-04
ZA895058B (en) 1990-04-25
IE892141L (en) 1990-01-01
IL90826A0 (en) 1990-01-18
US5446036A (en) 1995-08-29
CA1334668C (en) 1995-03-07
US5273971A (en) 1993-12-28
DD295638A5 (de) 1991-11-07

Similar Documents

Publication Publication Date Title
ATE129717T1 (de) 13-alkyl-11beta-phenylgonane.
DK0673372T3 (da) Nye taxoider, deres fremstilling og farmaceutiske præparater indeholdende disse taxoider
FI845066A0 (fi) 11 -arylestradiener, deras framstaellning och dessa innehaollande farmaceutiska produkter.
DK148484A (da) Guanidin-derivater
NO179943C (no) Fremgangsmåte for enantioselektiv fremstilling av fenylisoserin-derivater
JPS51143674A (en) New derivatives of 4-oxopiperidines
NO952870D0 (no) Optisk aktivt
AU672448B2 (en) Antiretroviral hydrazine derivatives
ES484324A1 (es) Procedimiento para la obtencion de (n,n'-hidroxialquil)-ami-dinas de acido azo-di-isobutirico
IL92280A0 (en) Oxime ether derivatives,their preparation and fungicidal compositions containing them
SE7805863L (sv) Rifamycinforeningar
ES472263A1 (es) Procedimiento para preparar derivados de urea
DE3768469D1 (de) N-substituierte, estergruppen enthaltende acrylamide.
ATE74355T1 (de) Dihydrodibenzofuranderivate und diese verbindungen enthaltende fungizide.
MX9303753A (es) Dihidropiridinas anilladas y composiciones farmaceuticas que las contienen.
ES411563A1 (es) Procedimiento para la produccion de colorantes de camarina y de cumarinimida.
DE3864354D1 (de) Polyfunktionielle aethylenische monomere.
ATE155160T1 (de) Aminoverbindungen als verarbeitungsstabilisatoren für thermoplastische kunststoffe
DK0659814T3 (da) Anvendelse af antikernemisfarvningsmidler ved fremstillingen af skumstoffer på isocyanatbasis
ES440841A1 (es) Un procedimiento para preparar 1-tiadiazolil-6-aciloxitetra-hidropirimidinonas.
GR26076B (el) Αλκοξυμεθυλεναμιδια των 0, 0 - διαλκυλοθειο - και0, 0 - διαλκυλοδιθειο - φωσφορυλοξεικων οξεων.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 349481

Country of ref document: ES