ES2080700A1 - Nuevo procedimiento para la obtencion de loratadina. - Google Patents
Nuevo procedimiento para la obtencion de loratadina.Info
- Publication number
- ES2080700A1 ES2080700A1 ES09401648A ES9401648A ES2080700A1 ES 2080700 A1 ES2080700 A1 ES 2080700A1 ES 09401648 A ES09401648 A ES 09401648A ES 9401648 A ES9401648 A ES 9401648A ES 2080700 A1 ES2080700 A1 ES 2080700A1
- Authority
- ES
- Spain
- Prior art keywords
- loratadin
- obtaining
- new process
- piperidyliden
- ethoxycarbonyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 title abstract 2
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 abstract 2
- 239000003054 catalyst Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- QMECDISWKUXRHA-UHFFFAOYSA-N ethyl 4-(pyridin-2-ylmethylidene)piperidine-1-carboxylate Chemical compound C(C)OC(=O)N1CCC(CC1)=CC1=NC=CC=C1 QMECDISWKUXRHA-UHFFFAOYSA-N 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 150000007529 inorganic bases Chemical class 0.000 abstract 1
- 238000003402 intramolecular cyclocondensation reaction Methods 0.000 abstract 1
- 150000007530 organic bases Chemical class 0.000 abstract 1
- 229910052763 palladium Inorganic materials 0.000 abstract 1
Landscapes
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
SE DESCRIBE UN NUEVO PROCEDIMIENTO PARA LA OBTENCION DE LORATADINA CONSISTENTE EN SOMETER UNOS COMPUESTOS DERIVADOS DE 2-[(1-ETOXICARBONIL-4-PIPERIDILIDEN)METIL]PIRIDINA, DE FORMULA (II), EN LA QUE X SIGNIFICA HALOGENO, A UNA CICLACION INTRAMOLECULAR EN PRESENCIA DE UN CATALIZADOR DE PALADIO Y DE UNA BASE ORGANICA O INORGANICA.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES9401648A ES2080700B1 (es) | 1994-07-27 | 1994-07-27 | Nuevo procedimiento para la obtencion de loratadina. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES9401648A ES2080700B1 (es) | 1994-07-27 | 1994-07-27 | Nuevo procedimiento para la obtencion de loratadina. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES2080700A1 true ES2080700A1 (es) | 1996-02-01 |
| ES2080700B1 ES2080700B1 (es) | 1996-10-16 |
Family
ID=8287058
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES9401648A Expired - Fee Related ES2080700B1 (es) | 1994-07-27 | 1994-07-27 | Nuevo procedimiento para la obtencion de loratadina. |
Country Status (1)
| Country | Link |
|---|---|
| ES (1) | ES2080700B1 (es) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105566214A (zh) * | 2014-10-17 | 2016-05-11 | 上海医药工业研究院 | 3-[2-(3-氯苯基)乙基]-2-吡啶甲酸的制备工艺 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0208855A1 (en) * | 1985-05-13 | 1987-01-21 | Schering Corporation | Process for preparing piperidylidene dihydrodibenzo(a,d)cycloheptenes and aza derivatives thereof, compounds obtained by such process and the use of such compounds for preparing useful pharmaceutical compositions |
| EP0270818A1 (en) * | 1986-10-31 | 1988-06-15 | Schering Corporation | Benzo(5,6)cycloheptapyridines, compositions and method of use |
| EP0359499A2 (en) * | 1988-09-15 | 1990-03-21 | Schering Corporation | Fluoro substituted benzocycloheptapyridine compounds, compositions and methods of use as antihistaminic compounds |
| WO1990013548A1 (en) * | 1989-05-01 | 1990-11-15 | Schering Corporation | Heterocyclic n-oxide derivatives of substituted benzo[5,6]cycloheptapyridines, compositions and methods of use |
-
1994
- 1994-07-27 ES ES9401648A patent/ES2080700B1/es not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0208855A1 (en) * | 1985-05-13 | 1987-01-21 | Schering Corporation | Process for preparing piperidylidene dihydrodibenzo(a,d)cycloheptenes and aza derivatives thereof, compounds obtained by such process and the use of such compounds for preparing useful pharmaceutical compositions |
| EP0270818A1 (en) * | 1986-10-31 | 1988-06-15 | Schering Corporation | Benzo(5,6)cycloheptapyridines, compositions and method of use |
| EP0359499A2 (en) * | 1988-09-15 | 1990-03-21 | Schering Corporation | Fluoro substituted benzocycloheptapyridine compounds, compositions and methods of use as antihistaminic compounds |
| WO1990013548A1 (en) * | 1989-05-01 | 1990-11-15 | Schering Corporation | Heterocyclic n-oxide derivatives of substituted benzo[5,6]cycloheptapyridines, compositions and methods of use |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105566214A (zh) * | 2014-10-17 | 2016-05-11 | 上海医药工业研究院 | 3-[2-(3-氯苯基)乙基]-2-吡啶甲酸的制备工艺 |
| CN105566214B (zh) * | 2014-10-17 | 2020-05-15 | 上海医药工业研究院 | 3-[2-(3-氯苯基)乙基]-2-吡啶甲酸的制备工艺 |
Also Published As
| Publication number | Publication date |
|---|---|
| ES2080700B1 (es) | 1996-10-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EC2A | Search report published |
Date of ref document: 19940727 Kind code of ref document: B1 Effective date: 19940727 |
|
| PC2A | Transfer of patent | ||
| FD1A | Patent lapsed |
Effective date: 20040728 |