ES2080945T3 - Sondas de hibridacion derivadas de la region espaciadora entre los genes 16s y 23s de arnr para la deteccion de microorganismos no viricos. - Google Patents
Sondas de hibridacion derivadas de la region espaciadora entre los genes 16s y 23s de arnr para la deteccion de microorganismos no viricos.Info
- Publication number
- ES2080945T3 ES2080945T3 ES91908755T ES91908755T ES2080945T3 ES 2080945 T3 ES2080945 T3 ES 2080945T3 ES 91908755 T ES91908755 T ES 91908755T ES 91908755 T ES91908755 T ES 91908755T ES 2080945 T3 ES2080945 T3 ES 2080945T3
- Authority
- ES
- Spain
- Prior art keywords
- genes
- arnr
- detection
- hybridization probes
- probes derived
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000000523 sample Substances 0.000 title abstract 2
- 238000001514 detection method Methods 0.000 title 1
- 238000009396 hybridization Methods 0.000 title 1
- 244000005700 microbiome Species 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
- 108091034117 Oligonucleotide Proteins 0.000 abstract 4
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 abstract 4
- 125000006850 spacer group Chemical group 0.000 abstract 2
- 241000894006 Bacteria Species 0.000 abstract 1
- 108700022487 rRNA Genes Proteins 0.000 abstract 1
- 230000003612 virological effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
- C12Q1/689—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Analytical Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Delivering By Means Of Belts And Rollers (AREA)
- Separation, Sorting, Adjustment, Or Bending Of Sheets To Be Conveyed (AREA)
- Sheets, Magazines, And Separation Thereof (AREA)
Abstract
SONDA QUE CONSTA DE AL MENOS DE ALREDEDOR DE 15 NUCLEOTIDOS DESDE LA REGION SEPARADORA ENTRE LOS GENES RRNA DE UN ORGANISMO NO VIRICO, PARTICULARMENTE UN ORGANISMO PROCARIOTICO Y MAS PARTICULARMENTE UNA BACTERIA, Y PREFERIBLEMENTE DESDE ALREDEDOR DE 15 NUCLEOTIDOS HASTA ALREDEDOR DEL NUMERO MAXIMO DE NUCLEOTIDOS DE LA REGION SEPARADORA Y MAS PREFERIBLEMENTE DESDE ALREDEDOR DE 15 HASTA ALREDEDOR DE 100 NUCLEOTIDOS PARA SER USADOS PARA LA DETECCION DE MICROORGANISMOS NO VIRICOS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP90401054A EP0452596A1 (en) | 1990-04-18 | 1990-04-18 | Hybridization probes derived from the spacer region between the 16S and 23S rRNA genes for the detection of non-viral microorganisms |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES2080945T3 true ES2080945T3 (es) | 1996-02-16 |
| ES2080945T5 ES2080945T5 (es) | 2003-02-01 |
Family
ID=8205701
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES91908755T Expired - Lifetime ES2080945T5 (es) | 1990-04-18 | 1991-04-18 | Sondas de hibridizacion derivadas de la region espaciadora entre los genes 16s y 23s de arnr para la deteccion de microorganismos no viricos. |
Country Status (12)
| Country | Link |
|---|---|
| US (4) | US5945282A (es) |
| EP (2) | EP0452596A1 (es) |
| JP (1) | JP3109599B2 (es) |
| AT (1) | ATE128189T1 (es) |
| AU (1) | AU658143B2 (es) |
| CA (1) | CA2080812C (es) |
| DE (1) | DE69113261T3 (es) |
| DK (1) | DK0525095T4 (es) |
| ES (1) | ES2080945T5 (es) |
| GR (1) | GR3018388T3 (es) |
| HU (1) | HU217804B (es) |
| WO (1) | WO1991016454A1 (es) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0452596A1 (en) | 1990-04-18 | 1991-10-23 | N.V. Innogenetics S.A. | Hybridization probes derived from the spacer region between the 16S and 23S rRNA genes for the detection of non-viral microorganisms |
| JP3107904B2 (ja) | 1992-04-07 | 2000-11-13 | 寳酒造株式会社 | ラクトバチルス属細菌の検出方法 |
| DE4219821A1 (de) * | 1992-06-17 | 1993-12-23 | Boehringer Mannheim Gmbh | Spezifischer Nachweis von Neisseria Gonorrhoeae |
| US5508168A (en) * | 1994-05-16 | 1996-04-16 | Hoffmann-La Roche Inc. | Methods and reagents for the detection of herpes simplex virus, treponema pallidum, and haemophilus ducreyi |
| US6025132A (en) * | 1994-06-24 | 2000-02-15 | Innogenetics N.V. | Probes targeted to rRNA spacer regions, methods and kits for using said probes, for the detection of respiratory tract pathogens |
| US20020055101A1 (en) | 1995-09-11 | 2002-05-09 | Michel G. Bergeron | Specific and universal probes and amplification primers to rapidly detect and identify common bacterial pathogens and antibiotic resistance genes from clinical specimens for routine diagnosis in microbiology laboratories |
| US6001564A (en) * | 1994-09-12 | 1999-12-14 | Infectio Diagnostic, Inc. | Species specific and universal DNA probes and amplification primers to rapidly detect and identify common bacterial pathogens and associated antibiotic resistance genes from clinical specimens for routine diagnosis in microbiology laboratories |
| AU1307595A (en) * | 1994-12-20 | 1996-07-10 | Heidelberg Repatriation Hospital | Typing of microorganisms |
| WO1996041017A2 (en) * | 1995-06-07 | 1996-12-19 | Gen-Probe Incorporated | Nucleic acid probes and amplification oligonucleotides for neisseria species |
| US5747252A (en) * | 1995-06-07 | 1998-05-05 | Gen-Probe Incorporated | Nucleic acid probes and amplification oligonucleotides for Neisseria species |
| FI102298B (fi) * | 1995-09-07 | 1998-11-13 | Oulutech Oy | Menetelmä maitohappobakteerilajien määrittämiseksi ja menetelmään sove ltuvia oligonukleotideja |
| US5994066A (en) * | 1995-09-11 | 1999-11-30 | Infectio Diagnostic, Inc. | Species-specific and universal DNA probes and amplification primers to rapidly detect and identify common bacterial pathogens and associated antibiotic resistance genes from clinical specimens for routine diagnosis in microbiology laboratories |
| US5849488A (en) * | 1996-02-27 | 1998-12-15 | Oulutech Ltd. | DNA-sequence-based diagnosis of mastitis from a milk sample |
| FR2751000B1 (fr) | 1996-07-12 | 1998-10-30 | Inst Nat Sante Rech Med | Adn specifiques des bacteries de l'espece neisseria meningitidis, leurs procedes d'obtention et leurs applications biologiques |
| DE19632041A1 (de) * | 1996-08-08 | 1998-02-12 | Boehringer Mannheim Gmbh | Verfahren zur Amplifikation von Neisseria gonorrhoeae Nukleinsäuresequenzen |
| EP0826778A1 (en) * | 1996-09-03 | 1998-03-04 | Peter Kaufmann | Oligonucleotide probes for the detection of bifidobacteria |
| US20030049636A1 (en) | 1999-05-03 | 2003-03-13 | Bergeron Michel G. | Species-specific, genus-specific and universal DNA probes and amplification primers to rapidly detect and identify common bacterial and fungal pathogens and associated antibiotic resistance genes from clinical specimens for diagnosis in microbiology laboratories |
| US20100267012A1 (en) | 1997-11-04 | 2010-10-21 | Bergeron Michel G | Highly conserved genes and their use to generate probes and primers for detection of microorganisms |
| US6465638B2 (en) | 1997-06-25 | 2002-10-15 | Ortho-Clinical Diagnostics, Inc. | Multiplexed PCR assay for detecting disseminated Mycobacterium avium complex infection |
| KR100436741B1 (ko) * | 1998-08-11 | 2004-06-22 | 아사히비루 가부시키가이샤 | 세균 검출용 유전자 및 이를 이용한 세균의 검출방법 |
| US6821770B1 (en) | 1999-05-03 | 2004-11-23 | Gen-Probe Incorporated | Polynucleotide matrix-based method of identifying microorganisms |
| EP1246935B1 (en) | 1999-09-28 | 2013-08-14 | Geneohm Sciences Canada Inc. | Highly conserved genes and their use to generate probes and primers for detection of microorganisms |
| US20030134293A1 (en) * | 1999-11-16 | 2003-07-17 | Zhiping Liu | Method for rapid and accurate identification of microorganisms |
| US6261785B1 (en) | 2000-07-27 | 2001-07-17 | Becton, Dickinson And Company | Amplification and detection of Bordetella pertussis |
| US7833779B2 (en) * | 2001-07-25 | 2010-11-16 | Jivan Biologies Inc. | Methods and systems for polynucleotide detection |
| KR100431586B1 (ko) * | 2002-03-25 | 2004-05-17 | 학교법인 한양학원 | 독소 생산 마이크로시스티스 검출방법 |
| US9126165B1 (en) | 2002-04-24 | 2015-09-08 | The University Of North Carolina At Greensboro | Nucleic acid arrays to monitor water and other ecosystems |
| US8383342B2 (en) | 2002-04-24 | 2013-02-26 | The University Of North Carolina At Greensboro | Compositions, products, methods and systems to monitor water and other ecosystems |
| US8048623B1 (en) | 2002-04-24 | 2011-11-01 | The University Of North Carolina At Greensboro | Compositions, products, methods and systems to monitor water and other ecosystems |
| JP4377375B2 (ja) | 2002-12-06 | 2009-12-02 | エフ.ホフマン−ラ ロシュ アーゲー | 病原性生物の多重分析検出 |
| US7718361B2 (en) | 2002-12-06 | 2010-05-18 | Roche Molecular Systems, Inc. | Quantitative test for bacterial pathogens |
| US20050050101A1 (en) * | 2003-01-23 | 2005-03-03 | Vockley Joseph G. | Identification and use of informative sequences |
| JP2004290171A (ja) * | 2003-02-07 | 2004-10-21 | Akira Hiraishi | 微生物の分子生物学的同定技術 |
| US20050017981A1 (en) * | 2003-03-17 | 2005-01-27 | Jonathan Bingham | Methods of representing gene product sequences and expression |
| JP5210634B2 (ja) * | 2004-09-30 | 2013-06-12 | イノジェネティックス・ナムローゼ・フェンノートシャップ | スペーサー領域を使用するセラチア(Serratia)種の検出、同定および鑑別 |
| US20070048764A1 (en) * | 2005-08-23 | 2007-03-01 | Jonathan Bingham | Indicator polynucleotide controls |
| RU2348695C2 (ru) | 2006-05-23 | 2009-03-10 | Закрытое акционерное общество "Молекулярно-медицинские технологии" | Дифференцирующий и специфический олигонуклеотиды для идентификации последовательностей днк инфекционных агентов в биологических материалах, способ видовой идентификации инфекционных агентов, биочип и набор для осуществления этого способа |
| DE102006062250A1 (de) * | 2006-12-22 | 2008-06-26 | Roland Saur-Brosch | Verwendung einer Zusammensetzung aus Mineralstoffen und/oder Vitaminen und gegebenenfalls acetogenen und/oder butyrogenen Bakterien zur oralen oder rektalen Verabreichung für die Behandlung und Vorbeugung von abdominalen Beschwerden |
| CN101627133A (zh) * | 2007-01-08 | 2010-01-13 | 株式会社美迪基尼斯 | 用于金黄色葡萄球菌检测的dna芯片 |
| US20100167956A1 (en) * | 2007-01-08 | 2010-07-01 | Medigenes Co., Ltd. | Dna chip for detection of escherichia coli |
| ITMI20071410A1 (it) * | 2007-07-13 | 2009-01-14 | Univ Firenze | Test in biologia molecolare su campioni biologici per la diagnosi e tipizzazione di germi causa di malattie invasive |
| US8835104B2 (en) | 2007-12-20 | 2014-09-16 | Fenwal, Inc. | Medium and methods for the storage of platelets |
| US9175353B2 (en) | 2008-11-14 | 2015-11-03 | Gen-Probe Incorporated | Compositions, kits and methods for detection of campylobacter nucleic acid |
| EP3662750A1 (en) | 2011-04-07 | 2020-06-10 | Fenwal, Inc. | Automated methods and systems for providing platelet concentrates with reduced residual plasma volumes and storage media for such platelet concentrates |
| CN106442997A (zh) * | 2015-12-14 | 2017-02-22 | 广西大学 | 检测无乳链球菌的双抗体夹心酶联免疫吸附测定试剂盒 |
| CN116254351A (zh) * | 2022-08-08 | 2023-06-13 | 领航基因科技(杭州)有限公司 | 同时检测草绿色链球菌、β溶血性链球菌和肺炎链球菌的试剂盒 |
| CN118441074A (zh) * | 2024-05-17 | 2024-08-06 | 伯杰(青岛)医疗科技有限公司 | 基于16SrRNA-23SrRNA连接区域的衣原体分型方法 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5288611A (en) * | 1983-01-10 | 1994-02-22 | Gen-Probe Incorporated | Method for detecting, identifying, and quantitating organisms and viruses |
| US5723597A (en) * | 1983-01-10 | 1998-03-03 | Gen-Probe Incorporated | Ribosomal nucleic acid probes for detecting organisms or groups of organisms |
| US4900659A (en) * | 1986-01-30 | 1990-02-13 | Enzo Biochem, Inc. | Nucleotide sequence composition and method for detection of Neisseria gonorrhoeae and method for screening for a nucleotide sequence that is specific for a genetically distinct group |
| FR2596774B1 (fr) * | 1986-04-04 | 1988-07-22 | Pasteur Institut | Sondes oligonucleotidiques et procedes pour la detection par hybridation des acides nucleiques de bacteries et autres etres vivants |
| AU1045588A (en) | 1986-11-21 | 1988-06-16 | Stanley Hochfeld | Device for opening a wrapped roll of coins |
| WO1988003957A1 (en) * | 1986-11-24 | 1988-06-02 | Gen-Probe Incorporated | Nucleic acid probes for detection and/or quantitation of non-viral organisms |
| JP2823566B2 (ja) * | 1987-08-14 | 1998-11-11 | アンスティテュ パストゥール | バクテリア診断プローブ |
| JPH02203800A (ja) * | 1988-04-15 | 1990-08-13 | Innogenetics Sa:Nv | ナイセリア菌株を検出するための交雑プローブ |
| IE81145B1 (en) * | 1989-04-20 | 2000-05-03 | Thomas Gerard Barry | Generation of specific probes for target nucleotide sequences |
| US5536638A (en) * | 1990-04-18 | 1996-07-16 | N.V. Innogenetics S.A. | Hybridization probes derived from the spacer region between the 16S and 23S rRNA genes for the detection of Neisseria gonorrhoeae |
| EP0452596A1 (en) * | 1990-04-18 | 1991-10-23 | N.V. Innogenetics S.A. | Hybridization probes derived from the spacer region between the 16S and 23S rRNA genes for the detection of non-viral microorganisms |
| DE4219821A1 (de) * | 1992-06-17 | 1993-12-23 | Boehringer Mannheim Gmbh | Spezifischer Nachweis von Neisseria Gonorrhoeae |
| US6025132A (en) * | 1994-06-24 | 2000-02-15 | Innogenetics N.V. | Probes targeted to rRNA spacer regions, methods and kits for using said probes, for the detection of respiratory tract pathogens |
| AU1307595A (en) * | 1994-12-20 | 1996-07-10 | Heidelberg Repatriation Hospital | Typing of microorganisms |
-
1990
- 1990-04-18 EP EP90401054A patent/EP0452596A1/en not_active Withdrawn
-
1991
- 1991-04-18 CA CA002080812A patent/CA2080812C/en not_active Expired - Lifetime
- 1991-04-18 AT AT91908755T patent/ATE128189T1/de not_active IP Right Cessation
- 1991-04-18 JP JP03508127A patent/JP3109599B2/ja not_active Expired - Lifetime
- 1991-04-18 HU HU9203267A patent/HU217804B/hu unknown
- 1991-04-18 DE DE69113261T patent/DE69113261T3/de not_active Expired - Lifetime
- 1991-04-18 AU AU77550/91A patent/AU658143B2/en not_active Expired
- 1991-04-18 WO PCT/EP1991/000743 patent/WO1991016454A1/en not_active Ceased
- 1991-04-18 EP EP91908755A patent/EP0525095B2/en not_active Expired - Lifetime
- 1991-04-18 ES ES91908755T patent/ES2080945T5/es not_active Expired - Lifetime
- 1991-04-18 DK DK91908755T patent/DK0525095T4/da active
-
1995
- 1995-12-13 GR GR950403524T patent/GR3018388T3/el unknown
-
1996
- 1996-04-22 US US08/635,761 patent/US5945282A/en not_active Expired - Lifetime
-
1999
- 1999-05-14 US US09/312,520 patent/US6277577B1/en not_active Expired - Fee Related
-
2001
- 2001-05-22 US US09/863,086 patent/US6656689B2/en not_active Expired - Fee Related
-
2003
- 2003-09-25 US US10/672,238 patent/US20040053320A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU658143B2 (en) | 1995-04-06 |
| US6277577B1 (en) | 2001-08-21 |
| EP0525095B1 (en) | 1995-09-20 |
| DE69113261T3 (de) | 2003-03-13 |
| CA2080812A1 (en) | 1991-10-19 |
| CA2080812C (en) | 2007-06-05 |
| GR3018388T3 (en) | 1996-03-31 |
| ATE128189T1 (de) | 1995-10-15 |
| WO1991016454A1 (en) | 1991-10-31 |
| AU7755091A (en) | 1991-11-11 |
| HUT63463A (en) | 1993-08-30 |
| US20040053320A1 (en) | 2004-03-18 |
| DK0525095T4 (da) | 2002-10-28 |
| US6656689B2 (en) | 2003-12-02 |
| ES2080945T5 (es) | 2003-02-01 |
| JP3109599B2 (ja) | 2000-11-20 |
| US5945282A (en) | 1999-08-31 |
| EP0452596A1 (en) | 1991-10-23 |
| EP0525095A1 (en) | 1993-02-03 |
| US20020048762A1 (en) | 2002-04-25 |
| JPH05504889A (ja) | 1993-07-29 |
| HU217804B (hu) | 2000-04-28 |
| EP0525095B2 (en) | 2002-07-10 |
| DE69113261T2 (de) | 1996-06-13 |
| DE69113261D1 (de) | 1995-10-26 |
| DK0525095T3 (da) | 1996-02-12 |
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