ES2081989T3 - Tratamiento para reducir el edema en lesiones cerebrales y musculares. - Google Patents
Tratamiento para reducir el edema en lesiones cerebrales y musculares.Info
- Publication number
- ES2081989T3 ES2081989T3 ES90909011T ES90909011T ES2081989T3 ES 2081989 T3 ES2081989 T3 ES 2081989T3 ES 90909011 T ES90909011 T ES 90909011T ES 90909011 T ES90909011 T ES 90909011T ES 2081989 T3 ES2081989 T3 ES 2081989T3
- Authority
- ES
- Spain
- Prior art keywords
- brain
- edema
- treatment
- musculature
- analogue
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 210000004556 brain Anatomy 0.000 title abstract 3
- 208000029549 Muscle injury Diseases 0.000 title 1
- 208000029028 brain injury Diseases 0.000 title 1
- 208000027418 Wounds and injury Diseases 0.000 abstract 2
- IDLFZVILOHSSID-OVLDLUHVSA-N corticotropin Chemical compound C([C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)NC(=O)[C@@H](N)CO)C1=CC=C(O)C=C1 IDLFZVILOHSSID-OVLDLUHVSA-N 0.000 abstract 2
- 230000006378 damage Effects 0.000 abstract 2
- 208000014674 injury Diseases 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 102400000739 Corticotropin Human genes 0.000 abstract 1
- 101800000414 Corticotropin Proteins 0.000 abstract 1
- 239000012503 blood component Substances 0.000 abstract 1
- 210000005013 brain tissue Anatomy 0.000 abstract 1
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 229960000258 corticotropin Drugs 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 210000000653 nervous system Anatomy 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000001356 surgical procedure Methods 0.000 abstract 1
- 230000008728 vascular permeability Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/2228—Corticotropin releasing factor [CRF] (Urotensin)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/10—Preservation of living parts
- A01N1/12—Chemical aspects of preservation
- A01N1/122—Preservation or perfusion media
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/10—Preservation of living parts
- A01N1/12—Chemical aspects of preservation
- A01N1/122—Preservation or perfusion media
- A01N1/126—Physiologically active agents, e.g. antioxidants or nutrients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Wood Science & Technology (AREA)
- Dentistry (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Endocrinology (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Obesity (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Diaphragms For Electromechanical Transducers (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
LA ADMINISTRACION DE UN FACTOR DE LIBERACION DE LA CORTICOTROPINA (O UNA SAL O ANALOGO DEL MISMO) HACE QUE DISMINUYA EL DERRAME DE COMPONENTES SANGUINEOS EN EL TEJIDO CEREBRAL DEBIDO A VARIAS CONDICIONES MEDICAS ADVERSAS Y REDUCE EL SANGRADO CUANDO LOS TEJIDOS MUSCULARES SE CORTAN O MANEJAN, COMO POR EJEMPLO EN LA CIRUGIA PLASTICA O RECONSTITUYENTE. UN METODO PARA TRATAR A UN PACIENTE QUE SUFRE UNA LESION O UNA ENFERMEDAD EN EL CEREBRO, EN EL SISTEMA NERVIOSO CENTRAL O EN LA MUSCULATURA EN QUE UN EDEMA ES UN FACTOR CONSISTE EN ADMINISTRAR AL PACIENTE UN FACTOR DE LIBERACION DE LA CORTICOTROPINA (O UNA SAL O ANALOGO) EN UNA CANTIDAD EFECTIVA PARA DISMINUIR LA PERMEABILIDAD VASCULAR EN EL CEREBRO ENFERMO O LESIONADO, EN EL TEJIDO DEL SISTEMA NERVIOSO O EN LA MUSCULATURA PARA ASI REDUCIR EL EDEMA. SEGUN EL METODO LA ADMINISTRACION PUEDE TENER LUGAR UNAS DOS HORAS ANTES DE LA OPERACION Y SE PUEDE SEGUIR ADMINISTRANDO HASTA TRES DIAS DESPUES DE LA LESION.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/386,885 US5137871A (en) | 1989-07-28 | 1989-07-28 | Treatment to reduce edema for brain and musculature injuries |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2081989T3 true ES2081989T3 (es) | 1996-03-16 |
Family
ID=23527476
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES90909011T Expired - Lifetime ES2081989T3 (es) | 1989-07-28 | 1990-05-30 | Tratamiento para reducir el edema en lesiones cerebrales y musculares. |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US5137871A (es) |
| EP (1) | EP0484340B1 (es) |
| JP (1) | JP3012319B2 (es) |
| AT (1) | ATE131064T1 (es) |
| AU (1) | AU641166B2 (es) |
| CA (1) | CA2064039C (es) |
| DE (1) | DE69024053T2 (es) |
| DK (1) | DK0484340T3 (es) |
| ES (1) | ES2081989T3 (es) |
| IE (1) | IE63053B1 (es) |
| WO (1) | WO1991001997A1 (es) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5137871A (en) * | 1989-07-28 | 1992-08-11 | Regents Of The University Of California | Treatment to reduce edema for brain and musculature injuries |
| US5488033A (en) * | 1989-07-28 | 1996-01-30 | The Regents Of The University Of California | Treatment to reduce edema |
| US5374621A (en) * | 1991-09-13 | 1994-12-20 | Regents Of The University Of California | Neurotensin method for inhibiting vascular leakage |
| US6039956A (en) * | 1994-09-12 | 2000-03-21 | Pennsylvania, Trustees Of The University Of, The | Corticotropin release inhibiting factor and methods of using same for treating behavioral symptoms in an anxiety disorder |
| US5830866A (en) * | 1994-09-12 | 1998-11-03 | The Trustees Of The University Of Pennsylvania | Corticotropin release inhibiting factor and methods of using same |
| US5869450A (en) * | 1996-03-06 | 1999-02-09 | The Regents Of The University Of California | Anti-inflammatory compositions and method with corticotropin-releasing factor analogs |
| US6011066A (en) * | 1998-02-02 | 2000-01-04 | Veterans General Hospital-Taipei | Method for treating septic shock |
| EP2016953A3 (en) * | 1998-12-22 | 2009-04-15 | Genentech, Inc. | Vascular endothelial cell growth factor antagonists and uses thereof |
| US6849600B2 (en) * | 2002-03-25 | 2005-02-01 | The Regents Of The University Of California, Berkeley | Corticotropin-releasing hormone analogs |
| WO2006021814A2 (en) * | 2004-07-08 | 2006-03-02 | Aimsco Limited | Medicament |
| GB0415359D0 (en) * | 2004-07-08 | 2004-08-11 | Aimsco Ltd | Medicament |
| GB0600202D0 (en) * | 2006-01-06 | 2006-02-15 | Aimsco Ltd | Treatment of HIV |
| US7455447B2 (en) * | 2006-05-19 | 2008-11-25 | Mediatek Inc. | Method and apparatus for a portable device |
| EP2898900B1 (en) | 2008-09-19 | 2017-11-15 | Nektar Therapeutics | Polymer conjugates of ziconotide |
| CN104602682B (zh) | 2012-05-08 | 2018-12-14 | 埃罗米克斯公司 | 用于治疗水通道蛋白介导的疾病的化合物 |
| AU2014346682B2 (en) | 2013-11-06 | 2020-03-12 | Aeromics, Inc. | Novel formulations |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3980778A (en) * | 1973-10-25 | 1976-09-14 | The Upjohn Company | Anti-inflammatory steroid |
| US4579844A (en) * | 1976-05-13 | 1986-04-01 | Johnson & Johnson | Topical anti-inflammatory drug therapy |
| US4404198A (en) * | 1979-01-24 | 1983-09-13 | Beecham Inc. | Phenyl Salicylate as a topical anti-inflammatory |
| US4415558A (en) * | 1981-06-08 | 1983-11-15 | The Salk Institute For Biological Studies | CRF And analogs |
| US4517181A (en) * | 1982-09-15 | 1985-05-14 | The Salk Institute For Biological Studies | Mammalian PGRF |
| US4533654A (en) * | 1982-09-29 | 1985-08-06 | The Salk Institute For Biological Studies | Urotensin peptides |
| US4528189A (en) * | 1983-02-03 | 1985-07-09 | The Salk Institute For Biological Studies | Urotensin peptides |
| US4489163A (en) * | 1983-04-14 | 1984-12-18 | The Salk Institute For Biological Studies | rCRF and analogs |
| US4594329A (en) * | 1984-05-14 | 1986-06-10 | The Salk Institute For Biological Studies | CRF analogs |
| US4605642A (en) * | 1984-02-23 | 1986-08-12 | The Salk Institute For Biological Studies | CRF antagonists |
| US4801612A (en) * | 1986-07-03 | 1989-01-31 | Regents Of The University Of California | Method of inhibiting inflammatory response |
| US5137871A (en) * | 1989-07-28 | 1992-08-11 | Regents Of The University Of California | Treatment to reduce edema for brain and musculature injuries |
-
1989
- 1989-07-28 US US07/386,885 patent/US5137871A/en not_active Expired - Lifetime
-
1990
- 1990-05-30 ES ES90909011T patent/ES2081989T3/es not_active Expired - Lifetime
- 1990-05-30 AT AT90909011T patent/ATE131064T1/de not_active IP Right Cessation
- 1990-05-30 AU AU57492/90A patent/AU641166B2/en not_active Expired
- 1990-05-30 DK DK90909011.0T patent/DK0484340T3/da active
- 1990-05-30 JP JP2508553A patent/JP3012319B2/ja not_active Expired - Lifetime
- 1990-05-30 CA CA002064039A patent/CA2064039C/en not_active Expired - Lifetime
- 1990-05-30 WO PCT/US1990/003003 patent/WO1991001997A1/en not_active Ceased
- 1990-05-30 EP EP90909011A patent/EP0484340B1/en not_active Expired - Lifetime
- 1990-05-30 DE DE69024053T patent/DE69024053T2/de not_active Expired - Lifetime
- 1990-07-27 IE IE273790A patent/IE63053B1/en not_active IP Right Cessation
-
1992
- 1992-04-30 US US07/876,487 patent/US5306710A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP0484340B1 (en) | 1995-12-06 |
| JP3012319B2 (ja) | 2000-02-21 |
| AU5749290A (en) | 1991-03-11 |
| IE63053B1 (en) | 1995-03-22 |
| US5137871A (en) | 1992-08-11 |
| US5306710A (en) | 1994-04-26 |
| CA2064039A1 (en) | 1991-01-29 |
| EP0484340A4 (en) | 1993-02-17 |
| AU641166B2 (en) | 1993-09-16 |
| JPH05501856A (ja) | 1993-04-08 |
| DK0484340T3 (da) | 1996-04-22 |
| EP0484340A1 (en) | 1992-05-13 |
| WO1991001997A1 (en) | 1991-02-21 |
| DE69024053D1 (de) | 1996-01-18 |
| DE69024053T2 (de) | 1996-07-04 |
| CA2064039C (en) | 2001-01-02 |
| ATE131064T1 (de) | 1995-12-15 |
| IE902737A1 (en) | 1991-02-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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