ES2082800T3 - Hidroxietilalmidon como diluyente del plasma y su procedimiento de preparacion. - Google Patents

Hidroxietilalmidon como diluyente del plasma y su procedimiento de preparacion.

Info

Publication number
ES2082800T3
ES2082800T3 ES90110531T ES90110531T ES2082800T3 ES 2082800 T3 ES2082800 T3 ES 2082800T3 ES 90110531 T ES90110531 T ES 90110531T ES 90110531 T ES90110531 T ES 90110531T ES 2082800 T3 ES2082800 T3 ES 2082800T3
Authority
ES
Spain
Prior art keywords
substitution
hydroxyethylation
value
substitution degree
plasma
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90110531T
Other languages
English (en)
Other versions
ES2082800T5 (es
Inventor
Klaus Dr Sommermeyer
Franz Dr Cech
Burghard Dr Weidler
Klaus Dr Henning
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fresenius SE and Co KGaA
Original Assignee
Fresenius SE and Co KGaA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6382894&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2082800(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Fresenius SE and Co KGaA filed Critical Fresenius SE and Co KGaA
Application granted granted Critical
Publication of ES2082800T3 publication Critical patent/ES2082800T3/es
Publication of ES2082800T5 publication Critical patent/ES2082800T5/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B31/00—Preparation of derivatives of starch
    • C08B31/08—Ethers
    • C08B31/12—Ethers having alkyl or cycloalkyl radicals substituted by heteroatoms, e.g. hydroxyalkyl or carboxyalkyl starch
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Materials Engineering (AREA)
  • Biochemistry (AREA)
  • Polymers & Plastics (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Dental Preparations (AREA)

Abstract

EL INVENTO SE REFIERE A UNA HIDROXIETILGLUCOSA QUE SE UTILIZA COMO EXPANSIONADOR DE PLASMA. PRESENTA UN PESO MOLECULAR MEDIO ENTRE 600 Y 600.000 Y UN GRADO DE SUSTITUCION (MS) ENTRE 0,15 Y 0,5; TIENE UNA RELACION DE SUSTITUCION DE LA UNIDAD ANHIDROGLUCOSA EN C2 Y C6 ENTRE 8 Y 20 Y EL GRADO DE SUSTITUCION (DS) VARIA ENTRE 0,15 Y 0,5 Y SE OBTIENE MEDIANTE LA PRESENTASIS HIDROLITICA DE UNA GLUCOSA RICA EN AMILOPECTINA, HIDROXIETILACION PARCIAL DEL COMPUESTO RESULTANTE, EN PRESENCIA DE UN ALCALI HASTA CONSEGUIR UN GRADO DE SUSTITUCION DETERMINADO Y SINTESIS HIDROELITICA HASTA CONSEGUIR UN PESO MOLECULAR DETERMINADO SE CARACTERIZA PORQUE LA HIDROXIETILACION SE REALIZA A TEMPERATURA AMBIENTE Y EN CONDICIONES ALCALINAS, PARA MANTENER EL PH A 12 Y A UNA TEMPERATURA DE 20 C Y EL PROCEDIMIENTO PARA LA PRODUCCION DE HIDROXIETILGLUCOSA SE EMPLEA COMO MEDIO DE HIDROXIETILACION DEL 2-CLORUETANOL.
ES90110531T 1989-06-16 1990-06-02 Hidroxietilalmidon como diluyente del plasma y su procedimiento de preparacion. Expired - Lifetime ES2082800T5 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3919729A DE3919729C3 (de) 1989-06-16 1989-06-16 Hydroxyethylstärke als Plasmaexpander, Verfahren zu ihrer Herstellung und Verwendung als kolloidales Plasmaersatzmittel

Publications (2)

Publication Number Publication Date
ES2082800T3 true ES2082800T3 (es) 1996-04-01
ES2082800T5 ES2082800T5 (es) 2001-06-16

Family

ID=6382894

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90110531T Expired - Lifetime ES2082800T5 (es) 1989-06-16 1990-06-02 Hidroxietilalmidon como diluyente del plasma y su procedimiento de preparacion.

Country Status (9)

Country Link
US (1) US5218108A (es)
EP (1) EP0402724B2 (es)
JP (1) JPH0326701A (es)
AT (1) ATE134196T1 (es)
DE (3) DE19975071I2 (es)
ES (1) ES2082800T5 (es)
GR (1) GR3019382T3 (es)
LU (1) LU90636I2 (es)
NL (1) NL300030I2 (es)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4242926C2 (de) 1992-12-18 1994-12-15 Fresenius Ag Dialyselösung für die Peritonealdialyse
DE4310974C2 (de) * 1993-04-03 1996-08-01 Fresenius Ag Verwendung von Hydroxyethylstärke zur Verbesserung der Mikrozirkulation
US6162642A (en) * 1997-01-23 2000-12-19 Fresenius Ag Agent for dehydrating corneas in organ culture
DE19702210C2 (de) * 1997-01-23 1999-01-14 Fresenius Ag Verwendung von HES zur Entquellung von Hornhäuten in der Organkultur
DE19744353C1 (de) * 1997-08-08 1999-02-11 Fresenius Ag Verfahren zur kontinuierlichen Herstellung von hydrolytisch abgebauter, ggfls. substituierter Stärke, Verwendung der hydrolytisch abgebauten Stärke und Vorrichtung zu ihrer Herstellung
DE19924773A1 (de) * 1999-05-29 2000-11-30 Buna Sow Leuna Olefinverb Gmbh Verfahren zur Herstellung pulverförmiger Hydroxyalkylstärkeether für den Einsatz als Sprühhilfsmittel
AT409928B (de) * 1999-08-10 2002-12-27 Tulln Zuckerforschung Gmbh Plasmaexpander, blutverdünnungsmittel und kryoprotektor, hergestellt unter verwendung von amylopektin-kartoffelstärke
US6746836B1 (en) * 2000-12-08 2004-06-08 Abe Widra Alpha-keratose as a blood plasma expander and use thereof
DE10112825A1 (de) * 2001-03-16 2002-10-02 Fresenius Kabi De Gmbh HESylierung von Wirkstoffen in wässriger Lösung
DE10209821A1 (de) 2002-03-06 2003-09-25 Biotechnologie Ges Mittelhesse Kopplung von Proteinen an ein modifiziertes Polysaccharid
DE10209822A1 (de) 2002-03-06 2003-09-25 Biotechnologie Ges Mittelhesse Kopplung niedermolekularer Substanzen an ein modifiziertes Polysaccharid
DE10237442B4 (de) * 2002-08-16 2004-08-19 Fresenius Kabi Deutschland Gmbh Hochverzweigte, niedrig substituierte Stärkeprodukte
BR0314106A (pt) 2002-09-11 2005-07-19 Fresenius Kabi De Gmbh Polipeptìdeos hasilados, especialmente eritropoietina hasilada
DE10242076A1 (de) * 2002-09-11 2004-03-25 Fresenius Kabi Deutschland Gmbh HAS-Allergen-Konjugate
ATE409048T1 (de) 2002-10-08 2008-10-15 Fresenius Kabi De Gmbh Pharmazeutisch aktive oligosaccharid-conjugate
US20080274948A1 (en) * 2003-08-08 2008-11-06 Fresenius Kabi Deutschland Gmbh Conjugates of Hydroxyalkyl Starch and G-Csf
EP1653991A2 (en) * 2003-08-08 2006-05-10 Fresenius Kabi Deutschland GmbH Conjugates of a polymer and a protein linked by an oxime linking group
WO2005014655A2 (en) 2003-08-08 2005-02-17 Fresenius Kabi Deutschland Gmbh Conjugates of hydroxyalkyl starch and a protein
DE502005001896D1 (en) 2004-03-01 2007-12-20 Braun Melsungen Ag Hydroxyethylstärke
WO2005092369A2 (en) * 2004-03-11 2005-10-06 Fresenius Kabi Deutschland Gmbh Conjugates of hydroxyethyl starch and erythropoietin
TWI417303B (zh) 2004-03-11 2013-12-01 Fresenius Kabi De Gmbh 經由還原胺化作用製得之羥烷基澱粉及蛋白質的接合物
AU2006222187A1 (en) * 2005-03-11 2006-09-14 Fresenius Kabi Deutschland Gmbh Production of bioactive glycoproteins from inactive starting material by conjugation with hydroxyalkylstarch
EP1762250A1 (en) * 2005-09-12 2007-03-14 Fresenius Kabi Deutschland GmbH Conjugates of hydroxyalkyl starch and an active substance, prepared by chemical ligation via thiazolidine
CN100453558C (zh) * 2005-12-29 2009-01-21 天津协和生物科技发展有限公司 用于不同分子量和不同替代度的羟乙基淀粉的制备方法
EP2070951A1 (en) * 2007-12-14 2009-06-17 Fresenius Kabi Deutschland GmbH Method for producing a hydroxyalkyl starch derivatives with two linkers
EP2070950A1 (en) 2007-12-14 2009-06-17 Fresenius Kabi Deutschland GmbH Hydroxyalkyl starch derivatives and process for their preparation
NZ598193A (en) 2007-12-27 2012-12-21 Baxter Int Chemically Modified Factor IX
EP2506858B1 (de) 2009-12-06 2017-05-10 B. Braun Melsungen AG Stärkederivatmischungen
RU2451691C2 (ru) * 2010-06-17 2012-05-27 Бревифолиа Лимитед Фармацевтическая субстанция, способ ее получения и лекарственное средство
CN102532330B (zh) * 2010-12-21 2014-02-05 北大方正集团有限公司 一种中分子量羟乙基淀粉的制备方法
WO2013113765A1 (en) 2012-01-30 2013-08-08 Fresenius Kabi Deutschland Gmbh Hydroxyalkyl starch for the treatment of head and neck cancers by reduction of tumor growth rates
CN105777920A (zh) * 2016-05-19 2016-07-20 郑桂富 一种羟乙基淀粉200/0.5的制备方法
DE202016102800U1 (de) 2016-05-25 2016-09-02 Joint-Stock Company "MEDPOLYMER" Plasma Ersatzlösung
CN106749579A (zh) * 2017-02-05 2017-05-31 河南康元生物科技股份有限公司 一种应用在血浆代用品的麦胚球蛋白

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB935339A (en) * 1960-10-27 1963-08-28 Staley Mfg Co A E Hydroxyalkyl amylose
GB1514720A (en) * 1974-10-07 1978-06-21 Secr Defence Preparation of hydroxyethyl starch
AT348548B (de) * 1977-04-08 1979-02-26 Laevosan Gmbh & Co Kg Verfahren zur herstellung von alsblutplasma- expander geeignerter hydroxyaethylstaerke
DE3313600A1 (de) * 1983-04-14 1984-10-18 Laevosan-Gesellschaft mbH & Co. KG, Linz Plasmastreckmittel auf staerkebasis und verfahren zu ihrer herstellung
US4474951A (en) * 1983-09-27 1984-10-02 The Dow Chemical Company Hydroxyalkylation of polysaccharides
US4716186A (en) * 1986-04-09 1987-12-29 A. E. Staley Manufacturing Company Starch derivatives and methods of making using same
US4837314A (en) * 1987-06-19 1989-06-06 A. E. Staley Manufacturing Company Etherified and esterified starch derivatives and processes for preparing same

Also Published As

Publication number Publication date
GR3019382T3 (en) 1996-06-30
DE19975071I2 (de) 2000-02-03
DE3919729C2 (es) 1992-03-26
JPH0326701A (ja) 1991-02-05
ES2082800T5 (es) 2001-06-16
NL300030I1 (nl) 2001-02-01
LU90636I2 (fr) 2000-12-15
ATE134196T1 (de) 1996-02-15
EP0402724B1 (de) 1996-02-14
DE3919729A1 (de) 1990-12-20
EP0402724A1 (de) 1990-12-19
DE3919729C3 (de) 1997-06-19
DE59010127D1 (de) 1996-03-28
EP0402724B2 (de) 2001-05-09
US5218108A (en) 1993-06-08
NL300030I2 (nl) 2006-05-01

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