ES2082847T3 - Procedimiento mejorado para la preparacion de derivados de amidoximas. - Google Patents

Procedimiento mejorado para la preparacion de derivados de amidoximas.

Info

Publication number
ES2082847T3
ES2082847T3 ES90901653T ES90901653T ES2082847T3 ES 2082847 T3 ES2082847 T3 ES 2082847T3 ES 90901653 T ES90901653 T ES 90901653T ES 90901653 T ES90901653 T ES 90901653T ES 2082847 T3 ES2082847 T3 ES 2082847T3
Authority
ES
Spain
Prior art keywords
amidoxime
alkyl
group
branched
general formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90901653T
Other languages
English (en)
Inventor
Bela Bertok
Istvan Szekely
Angelika Thurner
Eva Somfai
Sandor Botar
Antal Gajary
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chinoin Private Co Ltd
Original Assignee
Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt filed Critical Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt
Application granted granted Critical
Publication of ES2082847T3 publication Critical patent/ES2082847T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/12—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. N-hydroxyamidines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Train Traffic Observation, Control, And Security (AREA)
  • Networks Using Active Elements (AREA)
  • Pyridine Compounds (AREA)

Abstract

LA INVENCION ES RELATIVA A UN PROCESO MEJORADO PARA PREPARAR DERIVADOS DE AMIDOXIMA DE FORMULA GENERAL (I), EN DONDE R1 SIGNIFICA UN GRUPO C2-15, EL CUAL PUEDE SER NO SATURADO Y/O ALQUILO CICLICO, GRUPO ARALQUILO U OPCIONALMENTE SUSTITUIDO Y/O AROMATICO CONDENSADO Y/O GRUPO HETEROAROMATICO; R2 REPRESENTA HIDROGENO O UNA CADENA LINEAL O RAMIFICADA OPCIONALMENTE SUSTITUIDA Y/O ALQUILO NO SATURADO C1-7 O GRUPO AROMATICO; R3 REPRESENTA UNA CADENA LINEAL O RAMIFICADA O CICLICA Y/O ALQUILO C1-7 NO SATURADO O GRUPO AROMATICO; R3 REPRESENTA UNA CADENA LINEAL O RAMIFICADA OPCIONALMENTE SUSTITUIDA O CADENA RAMIFICADA O CICLICA Y/O ALQUILO C1-7 NO SATURADO O GRUPO AROMATICO; O R2 Y R3 JUNTOS CON EL ATOMO DE NITROGENO ADYACENTE PUEDE FORMAR UN ANILLO DE 5 A 8 MIEMBROS CONTENIENDO OPCIONALMENTE OTRO(S) HETEROATOMO(S); Y X REPRESENTA HALOGENO Y SUS SALES POR REACCION DE UNA AMIDOXIMA DE FORMULA GENERAL (II), EN DONDE R1 ES COMO ANTES SE DEFINIO, EN PRESENCIA DE UNA SUBSTANCIA ALCALINA, TRANSFORMANDO EL PRODUCTO EN UNA SAL CON UN ACIDO O TRANSFORMANDO LA SAL EN UNA BASE; CUYO PROCESO COMPRENDE REACCIONAR LA AMIDOXIMA CON UN HIDROXIDO DE METAL ALCALINO O CON UN ALCOXIDO DE METAL ALCALINO Y DIMETILFORMAMIDA O 1,3-DIMETIL-2-IMIDAZOLIDINONA, PREFERIBLEMENTE EN PRESENCIA DE UNA FUENTE DE PROTONES, REACCIONAR EL COMPLEJO DE AMIDOXIMA ASI OBTENIDO PREFERIBLEMENTE SIN AISLAMIENTO CON UNA AMINA DE FORMULA GENERAL (III). LA INVENCION ES ADEMAS RELATIVA A HIDROCLORURO E HIDROBROMURO DE AMIDOXIMA DE O-(2-HIDROXI-PIPERIDINO-1-PROPILO) ACIDO NICOTINICO Y A AMIDOXIMA BASE DE O-(2-HIDROXI-3-PIPERIDINO-1-PROPILO) ACIDO NICOTINICO.
ES90901653T 1989-01-10 1990-01-10 Procedimiento mejorado para la preparacion de derivados de amidoximas. Expired - Lifetime ES2082847T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU8970A HUT54347A (en) 1989-01-10 1989-01-10 Improved process for producing amidoximes

Publications (1)

Publication Number Publication Date
ES2082847T3 true ES2082847T3 (es) 1996-04-01

Family

ID=10947753

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90901653T Expired - Lifetime ES2082847T3 (es) 1989-01-10 1990-01-10 Procedimiento mejorado para la preparacion de derivados de amidoximas.

Country Status (14)

Country Link
US (2) US5239077A (es)
EP (1) EP0406386B1 (es)
JP (1) JPH03504016A (es)
AT (1) ATE132485T1 (es)
AU (1) AU639223B2 (es)
BG (1) BG60267B2 (es)
CA (1) CA2024808A1 (es)
DE (1) DE69024546T2 (es)
ES (1) ES2082847T3 (es)
FI (1) FI904393A0 (es)
HU (1) HUT54347A (es)
NO (1) NO177821C (es)
RU (1) RU2074854C1 (es)
WO (1) WO1990008131A1 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU207988B (en) * 1988-10-20 1993-07-28 Biorex Kutato Fejlesztoe Kft Process for producing halogenides of o-/3-amino-2-hydroxy-propyl/hydroximic acid and pharmaceutical compositions containing them as active components
HU222994B1 (hu) * 1995-11-02 2004-01-28 BIOREX Kutató és Fejlesztő Rt. Hidroxilaminszármazékok és azok alkalmazása sejtek molekuláris chaperon-termelésének fokozására alkalmas gyógyszerkészítmények előállítására
US6458371B1 (en) * 1995-12-22 2002-10-01 Medgene, Limited Cosmetic composition and a method for the prevention and/or reduction of the photoaging processes of the skin
HUT78138A (hu) * 1995-12-22 2000-09-28 BIOREX Kutató és Fejlesztő Rt Hidroximsavszármazékot tartalmazó készítmény a növénytermesztés elősegítésére és alkalmazása
HU220971B1 (hu) * 1997-04-03 2002-07-29 BIOREX Kutató és Fejlesztő Rt. Eljárás 0-(3-amino-2-hidroxi-propil)-hidroximsav-halogenidek előállítására
HU9701081D0 (en) * 1997-06-23 1997-08-28 Gene Research Lab Inc N Pharmaceutical composition of antitumoral activity
UA65635C2 (uk) * 1998-09-03 2004-04-15 Н-Гене Кутато Кфт. НЕНАСИЧЕНІ ПОХІДНІ ГІДРОКСИМОВОЇ КИСЛОТИ, ЩО МАЮТЬ ВЛАСТИВОСТІ ІНГІБІТОРІВ NAD<sup>+</sup>-ADP-РИБОЗИЛТРАНСФЕРАЗИ
IL151669A0 (en) 2000-03-20 2003-04-10 N Gene Res Lab Inc Propenecarboxylic acid amidoxime derivatives, a process for the preparation thereof, and pharmaceutical compositions containing the same
CA2471752A1 (en) 2002-01-11 2003-07-17 Biorex Kutato Es Fejlesztoe Rt. Carboxamidine derivatives and their use in the treatment of vascular diseases
HUP0303584A3 (en) 2003-10-30 2009-12-28 Cytrx Corp Use of a hydroximic acid halide derivative in the treatment of neurodegenerative diseases
TW200831479A (en) * 2006-09-26 2008-08-01 Cytrx Corp Pharmaceutical compositions and methods for treating diseases
WO2022106614A1 (en) 2020-11-19 2022-05-27 Orphazyme A/S Processes for preparing arimoclomol citrate and intermediates thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7503311A (nl) * 1975-03-20 1976-09-22 Philips Nv Verbindingen met antidepressieve werking.
HU177578B (en) * 1976-08-27 1981-11-28 Chinoin Gyogyszer Es Vegyeszet Process for preparing new 0-/3-amino-2-hydroxy-propyl/-amidoxime derivatives
US4187220A (en) * 1977-08-30 1980-02-05 Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara R.T. New O-(3-amino-2-hydroxy-propyl)-amidoxime derivatives, process for the preparation thereof and pharmaceutical compositions containing same
US4308399A (en) * 1977-08-30 1981-12-29 Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt. O-(3-Amino-2-hydroxy-propyl)-amidoxime derivatives, process for the preparation thereof and pharmaceutical compositions containing same
DE2927117A1 (de) * 1979-07-05 1981-01-08 Basf Ag Verfahren zur herstellung von o-substituierten ketoximen
EP0121701B1 (en) * 1983-04-04 1988-08-24 Allied Corporation Process for the production of o-substituted oximes
DE3620166A1 (de) * 1986-06-14 1987-12-17 Bayer Ag Verfahren zur herstellung von hydroxybenzaldoxim-o-ethern

Also Published As

Publication number Publication date
RU2074854C1 (ru) 1997-03-10
EP0406386A1 (en) 1991-01-09
US5239077A (en) 1993-08-24
NO177821B (no) 1995-08-21
NO903921L (no) 1990-09-07
CA2024808A1 (en) 1990-07-11
EP0406386B1 (en) 1996-01-03
FI904393A7 (fi) 1990-09-06
US5278309A (en) 1994-01-11
BG60267B1 (bg) 1994-03-31
BG60267B2 (bg) 1994-03-31
NO903921D0 (no) 1990-09-07
DE69024546T2 (de) 1996-08-29
FI904393A0 (fi) 1990-09-06
JPH03504016A (ja) 1991-09-05
HUT54347A (en) 1991-02-28
AU639223B2 (en) 1993-07-22
NO177821C (no) 1995-11-29
ATE132485T1 (de) 1996-01-15
WO1990008131A1 (en) 1990-07-26
AU4823790A (en) 1990-08-13
DE69024546D1 (de) 1996-02-15

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