ES2083851T3 - Dispositivo para el tratamiento de cultivos de celulas. - Google Patents
Dispositivo para el tratamiento de cultivos de celulas.Info
- Publication number
- ES2083851T3 ES2083851T3 ES93906477T ES93906477T ES2083851T3 ES 2083851 T3 ES2083851 T3 ES 2083851T3 ES 93906477 T ES93906477 T ES 93906477T ES 93906477 T ES93906477 T ES 93906477T ES 2083851 T3 ES2083851 T3 ES 2083851T3
- Authority
- ES
- Spain
- Prior art keywords
- pct
- culture
- slides
- collagen
- coating
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 102000008186 Collagen Human genes 0.000 abstract 3
- 108010035532 Collagen Proteins 0.000 abstract 3
- 238000004113 cell culture Methods 0.000 abstract 3
- 239000011248 coating agent Substances 0.000 abstract 3
- 238000000576 coating method Methods 0.000 abstract 3
- 229920001436 collagen Polymers 0.000 abstract 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 239000007789 gas Substances 0.000 abstract 1
- 239000001963 growth medium Substances 0.000 abstract 1
- 210000003494 hepatocyte Anatomy 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/24—Gas permeable parts
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/02—Form or structure of the vessel
- C12M23/04—Flat or tray type, drawers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/34—Internal compartments or partitions
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
- C12M25/06—Plates; Walls; Drawers; Multilayer plates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
- C12M29/04—Filters; Permeable or porous membranes or plates, e.g. dialysis
Landscapes
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Sustainable Development (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Clinical Laboratory Science (AREA)
- Immunology (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Cultivation Receptacles Or Flower-Pots, Or Pots For Seedlings (AREA)
Abstract
EN UN DISPOSITIVO PARA TRATAMIENTO DE CULTIVOS CELULARES, EN PARTICULAR DE HEPATOCITOS, SOBRE SOPORTE DE CULTIVO EN FORMA DE PLACAS, AL MENOS UNA PARTE DE LA SUPERFICIE DEL SOPORTE (1) DE CULTIVO CELULAR ES PERMEABLE AL GAS. EN EL INTERIOR DEL SOPORTE (1) DEL CULTIVO CELULAR SE INTRODUCE OXIGENO. SOBRE EL SOPORTE (1) DE CULTIVO CELULAR SE APLICA UNA CAPA (5,7) DE COLAGENO, QUE ESTA DISPUESTA SOBRE, O BIEN EN EL CULTIVO (6) CELULAR. CON UNA DISTANCIA REDUCIDA SOBRE LA CAPA (5,7) DE COLAGENO SE ENCUENTRA EL SOPORTE (1) DE CULTIVO CELULAR PROXIMO. EN EL ESPACIO (9) INTERMEDIO ENTRE LA CAPA (5,7) DE COLAGENO Y EL SOPORTE (1) DE CULTIVO CELULAR PROXIMO ES INTRODUCIBLE EL MEDIO DE CULTIVO.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4206585A DE4206585C2 (de) | 1992-03-03 | 1992-03-03 | Vorrichtung zur Massenkultur von Zellen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2083851T3 true ES2083851T3 (es) | 1996-04-16 |
Family
ID=6453071
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES93906477T Expired - Lifetime ES2083851T3 (es) | 1992-03-03 | 1993-03-02 | Dispositivo para el tratamiento de cultivos de celulas. |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US5658797A (es) |
| EP (1) | EP0629237B1 (es) |
| JP (1) | JP3176628B2 (es) |
| AT (1) | ATE131867T1 (es) |
| AU (1) | AU668922B2 (es) |
| CA (1) | CA2129648C (es) |
| DE (2) | DE4206585C2 (es) |
| DK (1) | DK0629237T3 (es) |
| ES (1) | ES2083851T3 (es) |
| GR (1) | GR3019255T3 (es) |
| NO (1) | NO315005B1 (es) |
| WO (1) | WO1993018133A1 (es) |
Families Citing this family (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5595909A (en) * | 1988-05-23 | 1997-01-21 | Regents Of The University Of Minnesota | Filter device |
| EP0629236B1 (en) * | 1992-03-04 | 2002-10-09 | The Regents Of The University Of Michigan | Methods, compositions and devices for maintaining and growing human stem and/or hematopoietic cells |
| DE4222345A1 (de) * | 1992-07-08 | 1994-01-13 | Augustinus Dr Med Bader | Verfahren zum Züchten einer Zellart im Kokulturverfahren mit Leberzellen |
| DE4322746A1 (de) * | 1993-07-08 | 1995-01-12 | Augustinus Dr Med Bader | Verfahren und Vorrichtung zur Behandlung von Zellkulturen |
| DE4336399A1 (de) * | 1993-10-26 | 1995-04-27 | Augustinus Dr Med Bader | Verfahren zur Verbesserung der Matrixbedingungen bipolar adhärierter Hepatozyten und zur Herstellung eines entsprechend konfigurierten Zellkulturkits |
| BE1009306A5 (fr) * | 1995-04-28 | 1997-02-04 | Baxter Int | Bioreacteur. |
| US7266725B2 (en) | 2001-09-03 | 2007-09-04 | Pact Xpp Technologies Ag | Method for debugging reconfigurable architectures |
| DE19704728A1 (de) | 1997-02-08 | 1998-08-13 | Pact Inf Tech Gmbh | Verfahren zur Selbstsynchronisation von konfigurierbaren Elementen eines programmierbaren Bausteines |
| US5955353A (en) * | 1997-05-22 | 1999-09-21 | Excorp Medical, Inc. | Hollow fiber bioreactor with an extrafilament flow plug |
| US6107085A (en) * | 1997-07-11 | 2000-08-22 | Corning Incorporated | Self contained cell growth system |
| WO1999047922A2 (en) | 1998-03-18 | 1999-09-23 | Massachusetts Institute Of Technology | Vascularized perfused microtissue/micro-organ arrays |
| AT407047B (de) * | 1998-08-03 | 2000-11-27 | Pfaller Walter Dr | Zellkulturvorrichtung |
| DE19919242A1 (de) * | 1999-04-28 | 2000-11-02 | Creavis Tech & Innovation Gmbh | Modulare Zellträgersysteme für dreidimensionales Zellwachstum |
| DE19919241A1 (de) * | 1999-04-28 | 2000-11-02 | Creavis Tech & Innovation Gmbh | 3D Zellträgersystem für Zell-, Gewebe- und Organkulturen |
| IL147207A0 (en) * | 1999-06-21 | 2002-08-14 | Gen Hospital Corp | Methods and devices for culturing cells |
| WO2000078920A1 (en) * | 1999-06-21 | 2000-12-28 | The General Hospital Corporation | Methods and devices for cell culturing and organ assist systems |
| WO2001007069A1 (en) * | 1999-07-22 | 2001-02-01 | Organogenesis Inc. | In vivo induction for enhanced function of isolated hepatocytes |
| JP3865354B2 (ja) | 2000-03-02 | 2007-01-10 | 高木産業株式会社 | 細胞又は組織の培養方法 |
| KR100404296B1 (ko) * | 2000-06-26 | 2003-11-07 | 임승완 | 맥류 배지 조직 배양 방법 및 맥류 배지 조직 배양 장치 |
| DE60013585T2 (de) * | 2000-07-19 | 2005-09-15 | Technodop Ltd. (Société de Droit Irlandais) | Kulturraum und Bioreaktor zur ausserkörperlichen Tierzellenkultur |
| US7581076B2 (en) * | 2001-03-05 | 2009-08-25 | Pact Xpp Technologies Ag | Methods and devices for treating and/or processing data |
| EP1465979A4 (en) * | 2001-12-21 | 2007-11-14 | Organogenesis Inc | CHAMBER WITH ADJUSTABLE VOLUME FOR CELL CULTURE AND ORGAN SUPPORT |
| EP2043000B1 (de) | 2002-02-18 | 2011-12-21 | Richter, Thomas | Bussysteme und Rekonfigurationsverfahren |
| WO2003104439A2 (en) * | 2002-03-12 | 2003-12-18 | Surface Logix, Inc. | Assay device that analyzes the absorption, metabolism, permeability and/or toxicity of a candidate compound |
| US7160719B2 (en) * | 2002-06-07 | 2007-01-09 | Mayo Foundation For Medical Education And Research | Bioartificial liver system |
| CN101120083B (zh) | 2003-10-08 | 2013-03-27 | 威尔森沃尔夫制造公司 | 利用透气性材料进行细胞培养的方法及装置 |
| NZ551783A (en) * | 2004-05-18 | 2009-07-31 | Australian Nuclear Science Tec | Membrane bioreactor |
| PT1773978E (pt) * | 2004-05-19 | 2014-05-29 | Massachusetts Inst Technology | Modelo de doença com células/tecidos tri-dimensionais perfundidos |
| US7531351B2 (en) * | 2004-06-14 | 2009-05-12 | Probiogen Ag | Liquid-gas-phase exposure reactor for cell culturing |
| US9376658B2 (en) | 2008-01-03 | 2016-06-28 | Emd Millipore Corporation | Cell culture array system for automated assays and methods of operation and manufacture thereof |
| WO2007008609A2 (en) | 2005-07-07 | 2007-01-18 | The Regents Of The University Of California | Methods and apparatus for cell culture array |
| US8257964B2 (en) | 2006-01-04 | 2012-09-04 | Cell ASIC | Microwell cell-culture device and fabrication method |
| US9354156B2 (en) | 2007-02-08 | 2016-05-31 | Emd Millipore Corporation | Microfluidic particle analysis method, device and system |
| US9637715B2 (en) | 2005-07-07 | 2017-05-02 | Emd Millipore Corporation | Cell culture and invasion assay method and system |
| US9388374B2 (en) | 2005-07-07 | 2016-07-12 | Emd Millipore Corporation | Microfluidic cell culture systems |
| US7745209B2 (en) | 2005-07-26 | 2010-06-29 | Corning Incorporated | Multilayered cell culture apparatus |
| WO2007021919A1 (en) | 2005-08-12 | 2007-02-22 | Clemson University | Co-culture bioreactor system |
| US7745210B2 (en) * | 2006-06-30 | 2010-06-29 | Corning Incorporated | Fluid flow diverter for cell culture vessel |
| AU2007332869B2 (en) | 2006-12-07 | 2012-10-11 | Wilson Wolf Manufacturing, LLC | Highly efficient gas permeable devices and methods for culturing cells |
| US7897379B2 (en) * | 2007-02-26 | 2011-03-01 | Corning Incorporated | Device and method for reducing bubble formation in cell culture |
| US9309491B2 (en) * | 2007-05-29 | 2016-04-12 | Corning Incorporated | Cell culture apparatus for co-culture of cells |
| US20090215176A1 (en) * | 2008-02-25 | 2009-08-27 | Clemson University | Differential Pressure Pump System |
| WO2010105204A2 (en) | 2009-03-13 | 2010-09-16 | Mayo Foundation For Medical Education And Research | Bioartificial liver |
| US8778669B2 (en) * | 2009-07-22 | 2014-07-15 | Corning Incorporated | Multilayer tissue culture vessel |
| US9353342B2 (en) | 2010-01-21 | 2016-05-31 | Emd Millipore Corporation | Cell culture and gradient migration assay methods and devices |
| DE102010005415B4 (de) | 2010-01-22 | 2015-07-16 | Zellwerk Gmbh | Verfahren und Vorrichtung zur dynamischen Expansion und/oder Differenzierung von suspendierten primären Zellen oder Stammzellen humanen und tierischen Ursprungs |
| KR20130109000A (ko) * | 2010-05-11 | 2013-10-07 | 아르텔리스 에스에이 | 세포 배양 장치 및 방법 |
| DE102010064098B4 (de) | 2010-12-23 | 2014-02-13 | Hochschule Wismar | Zellreaktor |
| US10526572B2 (en) | 2011-04-01 | 2020-01-07 | EMD Millipore Corporaticn | Cell culture and invasion assay method and system |
| DE102011106914B4 (de) | 2011-07-08 | 2015-08-27 | Zellwerk Gmbh | Mäander- Bioreaktor und Verfahren zu dynamischen Expansion, Differenzierung und Ernte von hämatopoetischen Zellen |
| NL2007734C2 (nl) * | 2011-11-07 | 2013-05-08 | Tulip Life Science Products B V | Inrichting voor het kweken van cellen. |
| JP6232383B2 (ja) | 2011-12-03 | 2017-11-15 | イー・エム・デイー・ミリポア・コーポレイシヨン | マイクロ流体の細胞培養のためのマイクロインキュベーションシステムおよび方法 |
| US9005550B2 (en) | 2012-10-29 | 2015-04-14 | Corning Incorporated | Multi-layered cell culture vessel with manifold grips |
| CN108699502A (zh) | 2016-02-23 | 2018-10-23 | 康宁股份有限公司 | 灌注生物反应器及其用于进行连续细胞培养的方法 |
| CA3114117A1 (en) | 2018-10-01 | 2020-04-09 | Membio Inc. | Cell culture bioreactor |
| DE202019001093U1 (de) | 2019-03-06 | 2019-04-11 | Zellwerk Gmbh | Zellkulturträger für Bioreaktoren |
| DE102019001604B4 (de) | 2019-03-06 | 2020-12-24 | Zellwerk Gmbh | Zellkulturträger für Bioreaktoren |
| WO2020177789A1 (de) | 2019-03-06 | 2020-09-10 | Zellwerk Gmbh | Zellkulturträger für bioreaktoren |
| DE102022000456B3 (de) | 2022-02-05 | 2023-04-20 | Zellwerk Gmbh | Plattenmäander- Bioreaktor für die Isolierung und Vermehrung von Zellen, insbesondere von adhärent wachsenden mesenchymalen Stoma-Zellen |
| DE102023002232B3 (de) | 2023-06-01 | 2024-06-13 | Zellwerk Gmbh | Perfusions- Plattenmäander- Bioreaktor für die Expansion von Zellen |
| WO2025235426A1 (en) * | 2024-05-06 | 2025-11-13 | Sunflower Therapeutics, Pbc | Internal support system for a stirred tank reactor |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3948732A (en) * | 1973-05-31 | 1976-04-06 | Instrumentation Laboratory, Inc. | Cell culture assembly |
| US4201845A (en) * | 1976-04-12 | 1980-05-06 | Monsanto Company | Cell culture reactor |
| DE2726313C3 (de) * | 1977-06-10 | 1980-02-07 | Battelle-Institut E.V., 6000 Frankfurt | Verfahren zur in-vitro-Biosynthese von Hormonen, insbesondere von Insulin |
| US4661458A (en) * | 1983-08-31 | 1987-04-28 | Cell Environmental Systems, Ltd. | Cell culture system |
| US4748124A (en) * | 1984-10-30 | 1988-05-31 | E. I. Du Pont De Nemours And Company | Compartmentalized cell-culture device and method |
| US4661455A (en) * | 1986-01-16 | 1987-04-28 | Dorr-Oliver Incorporated | Membrane cell culturing device |
| US6022742A (en) * | 1986-11-26 | 2000-02-08 | Kopf; Henry B. | Culture device and method |
| US5037656A (en) * | 1986-12-04 | 1991-08-06 | Millipore Corporation | Porous membrane having hydrophilic and cell growth promotions surface and process |
| WO1989011529A1 (en) * | 1988-05-23 | 1989-11-30 | The Regents Of The University Of Minnesota | Bioreactor device |
| JPH0292270A (ja) * | 1988-09-30 | 1990-04-03 | Terumo Corp | 細胞培養装置 |
| DE69017820T2 (de) * | 1989-04-25 | 1995-10-05 | Children's Medical Center Corp., Boston, Mass. | Implantaten für grosse mengen von zellen auf polymerische matrizen. |
| US4996154A (en) * | 1989-05-04 | 1991-02-26 | Millipore Corporation | Method for growing cellular tissue |
| US5316945A (en) * | 1991-12-14 | 1994-05-31 | Will Minuth | Cell carrier arrangement |
| DE4200446C2 (de) * | 1991-12-14 | 1994-04-07 | Will Prof Dr Minuth | Zellträgeranordnung |
-
1992
- 1992-03-03 DE DE4206585A patent/DE4206585C2/de not_active Expired - Fee Related
-
1993
- 1993-03-02 DE DE59301218T patent/DE59301218D1/de not_active Expired - Fee Related
- 1993-03-02 WO PCT/EP1993/000468 patent/WO1993018133A1/de not_active Ceased
- 1993-03-02 US US08/295,732 patent/US5658797A/en not_active Expired - Lifetime
- 1993-03-02 AT AT93906477T patent/ATE131867T1/de not_active IP Right Cessation
- 1993-03-02 DK DK93906477.0T patent/DK0629237T3/da active
- 1993-03-02 JP JP51530693A patent/JP3176628B2/ja not_active Expired - Fee Related
- 1993-03-02 ES ES93906477T patent/ES2083851T3/es not_active Expired - Lifetime
- 1993-03-02 AU AU37456/93A patent/AU668922B2/en not_active Ceased
- 1993-03-02 EP EP93906477A patent/EP0629237B1/de not_active Expired - Lifetime
- 1993-03-02 CA CA002129648A patent/CA2129648C/en not_active Expired - Lifetime
-
1994
- 1994-09-01 NO NO19943242A patent/NO315005B1/no unknown
-
1996
- 1996-03-11 GR GR960400654T patent/GR3019255T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE4206585C2 (de) | 1994-11-24 |
| CA2129648A1 (en) | 1993-09-16 |
| EP0629237B1 (de) | 1995-12-20 |
| EP0629237A1 (de) | 1994-12-21 |
| NO943242L (no) | 1994-09-01 |
| AU668922B2 (en) | 1996-05-23 |
| ATE131867T1 (de) | 1996-01-15 |
| DE4206585A1 (de) | 1993-09-09 |
| US5658797A (en) | 1997-08-19 |
| JPH07504325A (ja) | 1995-05-18 |
| CA2129648C (en) | 2009-08-11 |
| AU3745693A (en) | 1993-10-05 |
| DK0629237T3 (da) | 1996-04-09 |
| NO943242D0 (no) | 1994-09-01 |
| JP3176628B2 (ja) | 2001-06-18 |
| WO1993018133A1 (de) | 1993-09-16 |
| NO315005B1 (no) | 2003-06-23 |
| GR3019255T3 (en) | 1996-06-30 |
| DE59301218D1 (de) | 1996-02-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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