ES2084972T3 - Compuestos de imidazol, su preparacion y su uso como bloqueadores de los canales de calcio. - Google Patents
Compuestos de imidazol, su preparacion y su uso como bloqueadores de los canales de calcio.Info
- Publication number
- ES2084972T3 ES2084972T3 ES92610081T ES92610081T ES2084972T3 ES 2084972 T3 ES2084972 T3 ES 2084972T3 ES 92610081 T ES92610081 T ES 92610081T ES 92610081 T ES92610081 T ES 92610081T ES 2084972 T3 ES2084972 T3 ES 2084972T3
- Authority
- ES
- Spain
- Prior art keywords
- blockers
- preparation
- calcium channels
- imidazole compounds
- alcoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- RAXXELZNTBOGNW-UHFFFAOYSA-N 1H-imidazole Chemical class C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 title 1
- 108090000312 Calcium Channels Proteins 0.000 title 1
- 102000003922 Calcium Channels Human genes 0.000 title 1
- -1 AMINO Chemical class 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical class [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 206010002660 Anoxia Diseases 0.000 abstract 1
- 241000976983 Anoxia Species 0.000 abstract 1
- 206010021143 Hypoxia Diseases 0.000 abstract 1
- 208000028017 Psychotic disease Diseases 0.000 abstract 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical group [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- 230000007953 anoxia Effects 0.000 abstract 1
- 239000002131 composite material Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 208000028867 ischemia Diseases 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/30—Nitrogen atoms not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epoxy Resins (AREA)
- Developing Agents For Electrophotography (AREA)
- Dental Preparations (AREA)
- Optical Fibers, Optical Fiber Cores, And Optical Fiber Bundles (AREA)
Abstract
EL PRESENTE INVENTO COMPRENDE COMPUESTO DE LA FORMULA DONDE R Y R'' SON INDEPENDIENTEMENTE ENTRE SI HIDROGENO O ALQUILO, O R Y R'' CONJUNTAMENTE FORMAN UN CADENA DE ALQUILENO DE 3 A 6 ELEMENTOS; N ES 1 O 2; R1 ES FENILO QUE PUEDE ESTAR SUSTITUIDO UNA O MAS VECES CON HALOGENO, CF3, ALCOXI, ALQUILO O AMINO; Y R4,R5,R6 Y R7 INDEPENDIENTEMENTE ENTRE SI SON HIDROGENO, HALOGENO, AMINO, CF3, ALQUILO O ALCOXI; O UNA SAL DE ADICION FARMACEUTICAMENTE ACEPTABLE CONSIGUIENTE. LOS COMPUESTOS SON UTILES COMO FARMACOS, POR EJEMPLO EN EL TRATAMIENTO DE ISQUEMIA, ANOXIA, MIGRAÑA Y PSICOSIS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US80175491A | 1991-12-03 | 1991-12-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2084972T3 true ES2084972T3 (es) | 1996-05-16 |
Family
ID=25181970
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES92610081T Expired - Lifetime ES2084972T3 (es) | 1991-12-03 | 1992-11-20 | Compuestos de imidazol, su preparacion y su uso como bloqueadores de los canales de calcio. |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US5314903A (es) |
| EP (1) | EP0545845B1 (es) |
| JP (1) | JPH072796A (es) |
| KR (1) | KR100220303B1 (es) |
| AT (1) | ATE134622T1 (es) |
| AU (1) | AU649899B2 (es) |
| CA (1) | CA2084233A1 (es) |
| DE (1) | DE69208604T2 (es) |
| DK (1) | DK0545845T3 (es) |
| ES (1) | ES2084972T3 (es) |
| FI (1) | FI925501L (es) |
| GR (1) | GR3019439T3 (es) |
| NO (1) | NO300832B1 (es) |
| NZ (1) | NZ245287A (es) |
| ZA (1) | ZA929268B (es) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK154092D0 (da) * | 1992-12-23 | 1992-12-23 | Neurosearch As | Imidazolforbindelser, deres fremstilling og anvendelse |
| GB9413724D0 (en) * | 1994-07-07 | 1994-08-24 | Wellcome Found | Therapeutic nucleosides |
| DE69924493T2 (de) * | 1998-07-02 | 2005-09-15 | Neurosearch A/S | Kaliumkanal-blockierende mittel |
| US6194447B1 (en) | 1998-07-02 | 2001-02-27 | Neurosearch A/S | Bis (benzimidazole) derivatives serving as potassium blocking agents |
| AU760250B2 (en) | 1998-12-04 | 2003-05-08 | Neurosearch A/S | New benzimidazolone-, benzoxazolone-, or benzothiazolone derivatives as ion channel modulating agents |
| WO2004064835A1 (en) * | 2003-01-17 | 2004-08-05 | Neurosearch A/S | Use of ion channel modulating agents for treating pain |
| US20060135506A1 (en) * | 2003-04-22 | 2006-06-22 | Pharmacia Corporation | Compositions of a cyclooxygenase-2 selective inhibitor and a calcium modulating agent for the treatment of pain, inflammation or inflammation mediated disorders |
| US20050159403A1 (en) * | 2003-04-22 | 2005-07-21 | Pharmacia Corporation | Compositions of a cyclooxygenase-2 selective inhibitor and a calcium modulating agent for the treatment of central nervous system damage |
| US7166603B2 (en) | 2003-07-23 | 2007-01-23 | Bristol-Myers Squibb Co. | Dihydropyrimidone inhibitors of calcium channel function |
| WO2005007124A2 (en) | 2003-07-23 | 2005-01-27 | Bristol-Myers Squibb Company | Substituted dihydropyrimidine inhibitors of calcium channel function |
| DE10342503A1 (de) * | 2003-09-12 | 2005-04-14 | Merck Patent Gmbh | Benzyl-Benzimidazolylderivate |
| US7504431B2 (en) | 2004-04-16 | 2009-03-17 | Bristol-Myers Squibb Company | Sulfonyl amide inhibitors of calcium channel function |
| US8921406B2 (en) | 2005-08-21 | 2014-12-30 | AbbVie Deutschland GmbH & Co. KG | 5-ring heteroaromatic compounds and their use as binding partners for 5-HT5 receptors |
| GB0715103D0 (en) * | 2007-08-03 | 2007-09-12 | Lectus Therapeutics Ltd | Calcium ion channel modulators and uses thereof |
| US10501421B1 (en) * | 2017-01-27 | 2019-12-10 | Vanderbilt University | Substituted benzimidazoles as modulators of Ras signaling |
| MX2023001758A (es) * | 2020-08-11 | 2023-04-11 | Univ Michigan State | Potenciadores de proteasoma y usos de los mismos. |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4004016A (en) * | 1975-08-11 | 1977-01-18 | E. R. Squibb & Sons, Inc. | Amino-benzimidazole derivatives |
| CA2009542C (en) * | 1989-02-10 | 2000-03-14 | Albert A. Carr | Cyclic guanidines as calcium antagonists |
| DE3928177A1 (de) * | 1989-04-08 | 1991-02-28 | Thomae Gmbh Dr K | Benzimidazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
| US5210091A (en) * | 1991-06-24 | 1993-05-11 | Neurosearch A/S | Imidazole compounds and their use |
-
1992
- 1992-11-18 US US07/978,131 patent/US5314903A/en not_active Expired - Lifetime
- 1992-11-20 DE DE69208604T patent/DE69208604T2/de not_active Expired - Lifetime
- 1992-11-20 ES ES92610081T patent/ES2084972T3/es not_active Expired - Lifetime
- 1992-11-20 AT AT92610081T patent/ATE134622T1/de not_active IP Right Cessation
- 1992-11-20 DK DK92610081.9T patent/DK0545845T3/da active
- 1992-11-20 EP EP92610081A patent/EP0545845B1/en not_active Expired - Lifetime
- 1992-11-26 NZ NZ245287A patent/NZ245287A/en not_active IP Right Cessation
- 1992-11-26 AU AU29651/92A patent/AU649899B2/en not_active Ceased
- 1992-11-30 ZA ZA929268A patent/ZA929268B/xx unknown
- 1992-12-01 KR KR1019920022960A patent/KR100220303B1/ko not_active Expired - Fee Related
- 1992-12-01 CA CA002084233A patent/CA2084233A1/en not_active Abandoned
- 1992-12-02 JP JP4323417A patent/JPH072796A/ja not_active Withdrawn
- 1992-12-02 NO NO924646A patent/NO300832B1/no unknown
- 1992-12-03 FI FI925501A patent/FI925501L/fi unknown
-
1996
- 1996-03-27 GR GR960400825T patent/GR3019439T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NO924646D0 (no) | 1992-12-02 |
| NZ245287A (en) | 1995-04-27 |
| AU649899B2 (en) | 1994-06-02 |
| NO924646L (no) | 1993-06-04 |
| ZA929268B (en) | 1993-06-29 |
| FI925501A7 (fi) | 1993-06-04 |
| KR100220303B1 (ko) | 1999-09-15 |
| AU2965192A (en) | 1993-06-10 |
| DK0545845T3 (da) | 1996-08-05 |
| NO300832B1 (no) | 1997-08-04 |
| JPH072796A (ja) | 1995-01-06 |
| US5314903A (en) | 1994-05-24 |
| GR3019439T3 (en) | 1996-06-30 |
| FI925501A0 (fi) | 1992-12-03 |
| ATE134622T1 (de) | 1996-03-15 |
| DE69208604T2 (de) | 1996-09-05 |
| EP0545845A1 (en) | 1993-06-09 |
| FI925501L (fi) | 1993-06-04 |
| CA2084233A1 (en) | 1993-06-04 |
| EP0545845B1 (en) | 1996-02-28 |
| DE69208604D1 (de) | 1996-04-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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