ES2085276T3 - Antibioticos peptidicos. - Google Patents

Antibioticos peptidicos.

Info

Publication number
ES2085276T3
ES2085276T3 ES89303568T ES89303568T ES2085276T3 ES 2085276 T3 ES2085276 T3 ES 2085276T3 ES 89303568 T ES89303568 T ES 89303568T ES 89303568 T ES89303568 T ES 89303568T ES 2085276 T3 ES2085276 T3 ES 2085276T3
Authority
ES
Spain
Prior art keywords
animals
antibiotics
hydrogen
growth
compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89303568T
Other languages
English (en)
Inventor
Laverne Dwaine Boeck
David Shuichi Fukuda
Marvin Martin Hoehn
Ralph Emil Kastner
Jon Stuart Mynderse
Harold Rudolf Papiska
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/179,773 external-priority patent/US4994270A/en
Priority claimed from US07/179,928 external-priority patent/US5039789A/en
Priority claimed from US07/179,930 external-priority patent/US4977083A/en
Priority claimed from US07/179,929 external-priority patent/US5028590A/en
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Application granted granted Critical
Publication of ES2085276T3 publication Critical patent/ES2085276T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces
    • C12R2001/54—Streptomyces fradiae
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Fodder In General (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

LA INVENCION TRATA DE UN NUEVO GRUPO DE ANTIBIOTICOS DE LIPOPEPTIDOS CICLICOS, LOS ANTIBIOTICOS A54145, QUE TIENEN LA FORMULA GENERAL (I), EN LA QUE R ES HIDROGENO, ALQUILO DE 8 A 18C, ALCANOILO O ALQUENOILO DE 8 A 18C OPCIONALMENTE SUSTITUIDOS; (LYS R EXP1) REPRESENTA UN GRUPO - NH(CH2)4 CH(NHR EXP1) CO -; R EXP1 Y R (AL CUADRADO) SON HIDROGENO O UN GRUPO AMINO - PROTECTOR; O R Y R (AL CUADRADO) JUNTOS REPRESENTAN UN GRUPO ALQUILIDENO DE 8 A 18C; X ES ILE O VAL; E Y ES GLU O 3 - MG Y DE SUS SALES QUE SON AGENTES ANTIBACTERIANOS O COMPUESTOS INTERMEDIOS PARA LA PREPARACION DE ESTOS. LOS COMPUESTOS A54145 MEJORAN EL COMPORTAMIENTO DE CRECIMIENTO DE ANIMALES. TAMBIEN SE INCLUYEN COMPOSICIONES DE PIENSOS PARA PROMOVER EL CRECIMIENTO DE ANIMALES, TALES COMO POLLOS, Y METODOS PARA AUMENTAR EL CRECIMIENTO DE ANIMALES USANDO ESTAS COMPOSICIONES.
ES89303568T 1988-04-11 1989-04-11 Antibioticos peptidicos. Expired - Lifetime ES2085276T3 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US07/179,773 US4994270A (en) 1988-04-11 1988-04-11 A54145 antibiotics and process for their production
US07/179,928 US5039789A (en) 1988-04-11 1988-04-11 A54145 cyclic peptides
US07/179,930 US4977083A (en) 1988-04-11 1988-04-11 Processes for preparing A54145 compounds
US07/179,929 US5028590A (en) 1988-04-11 1988-04-11 Derivatives of A54145 cyclic peptides

Publications (1)

Publication Number Publication Date
ES2085276T3 true ES2085276T3 (es) 1996-06-01

Family

ID=27497367

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89303568T Expired - Lifetime ES2085276T3 (es) 1988-04-11 1989-04-11 Antibioticos peptidicos.

Country Status (7)

Country Link
EP (1) EP0337731B1 (es)
JP (1) JPH0213392A (es)
AT (1) ATE133686T1 (es)
CA (1) CA1337758C (es)
DE (1) DE68925540T2 (es)
ES (1) ES2085276T3 (es)
GR (1) GR3019491T3 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4411025A1 (de) * 1994-03-30 1995-10-05 Hoechst Ag Lipopeptid-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung
DE19521938C2 (de) * 1995-06-07 1999-11-11 Dirk Vollenbroich Verwendung von cyklischen Lipopeptiden zur Inaktivierung von oder zum Schutz vor Infektionen durch Mikroorganismen der Klasse Mollicutes
US6696412B1 (en) * 2000-01-20 2004-02-24 Cubist Pharmaceuticals, Inc. High purity lipopeptides, Lipopeptide micelles and processes for preparing same
IL156394A0 (en) * 2000-12-18 2004-01-04 Cubist Pharm Inc Methods for preparing purified lipopeptides
US20060014674A1 (en) 2000-12-18 2006-01-19 Dennis Keith Methods for preparing purified lipopeptides
WO2003060128A2 (en) * 2001-12-26 2003-07-24 Ecopia Biosciences Inc. Compositions, methods and systems for discovery of lipopeptides
US7235651B2 (en) 2001-12-26 2007-06-26 Cubist Pharmaceuticals, Inc. Genes and proteins involved in the biosynthesis of lipopeptides
NO20045442L (no) * 2004-05-28 2005-11-29 Gunnar Hagelin Cykliske peptidiske antibiotika

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL68700A0 (en) * 1982-05-21 1983-09-30 Lilly Co Eli Improvements relating to a-21978c cyclic peptide derivatives and their production

Also Published As

Publication number Publication date
EP0337731A3 (en) 1991-07-17
DE68925540T2 (de) 1996-06-13
JPH0213392A (ja) 1990-01-17
ATE133686T1 (de) 1996-02-15
GR3019491T3 (en) 1996-07-31
DE68925540D1 (de) 1996-03-14
EP0337731A2 (en) 1989-10-18
CA1337758C (en) 1995-12-19
EP0337731B1 (en) 1996-01-31

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