ES2085350T3 - Analogos viia del factor de liberacion de la hormona de crecimiento. - Google Patents

Analogos viia del factor de liberacion de la hormona de crecimiento.

Info

Publication number
ES2085350T3
ES2085350T3 ES90907830T ES90907830T ES2085350T3 ES 2085350 T3 ES2085350 T3 ES 2085350T3 ES 90907830 T ES90907830 T ES 90907830T ES 90907830 T ES90907830 T ES 90907830T ES 2085350 T3 ES2085350 T3 ES 2085350T3
Authority
ES
Spain
Prior art keywords
arg
ala
leu
phe
ser
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90907830T
Other languages
English (en)
Inventor
Jean Edouard Frederic Rivier
Wylie Walker Vale Jr
Catherine Laure Rivier
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Salk Institute for Biological Studies
Original Assignee
Salk Institute for Biological Studies
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Salk Institute for Biological Studies filed Critical Salk Institute for Biological Studies
Application granted granted Critical
Publication of ES2085350T3 publication Critical patent/ES2085350T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/60—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Diaphragms For Electromechanical Transducers (AREA)
  • Oscillators With Electromechanical Resonators (AREA)
  • Amplifiers (AREA)
  • Electrophonic Musical Instruments (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

LA INVENCION PROVEE PEPTIDAS SINTETICAS, LAS CUALES SON EXTREMADAMENTE POTENTES ESTIMULANDO LA LIBERACION DE GH PITUITARIA EN ANIMALES, INCLUYENDO AL HOMBRE, Y TAMBIEN RESISTENCIA A LA DEGRADACION ENZIMATICA EN EL CUERPO. LAS PEPTIDAS TIENEN LA SECUENCIA: (B)R1-R2-R3-ALA....... ....... EN DONDE R1 ES TYR,.. ...., HIS O D-HIS; B ES H,...., DIETILESTILBESTROLAMINO, AC O FOR; R2 ES ALA, D-ALA, NMA O D-NMA; R3 ES ASP O D-ASP; R5 ES ILE O LEU; R8 ES SER, ASN, LYS, ARG, ASP O GLU; R10 ES TYR, D-TYR O PHE; R12 ES ARG O LYS; R13 ES ILE, VAL, LEU O ALA; R15 ES GLY O ALA; R18 ES SER O TYR; R21 ES LYS, D-LYS, ARG O D-ARG; R22 ES LEU, ILE, ALA O VAL;R24 ES GLN O HIS; R25 ES ASP O GLU; R26 ES ILE O LEU; R27 ES MET, D-MET, ALA, NLE, ILE, LEU, NVA O VAL; R28 ES ASN O SER; R34 ES SER O ARG; R38 ES ARG O GLN; R39 ES GLY O ARG; R40 ES ALA O SER; R42 ES PHE, ALA O VAL; R43 ES ASN O ARG; R44 ES UN AMINO ACIDO NATURAL; Q1-Q9 SON O H O CAME, PROVISTO NO OBSTANTE QUE UNO DE LOS Q1, Q4, Q7, Q8 Y Q9 SEA CAME. ESTASPEPTIDAS TAMBIEN SE PUEDEN USAR PARA DIAGNOSTICO, Y EL TERMINO C SE PUEDE REDUCIR AL RESIDUO 29.
ES90907830T 1989-04-25 1990-04-24 Analogos viia del factor de liberacion de la hormona de crecimiento. Expired - Lifetime ES2085350T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/342,751 US5098995A (en) 1987-05-22 1989-04-25 GRF Analogs VIIA

Publications (1)

Publication Number Publication Date
ES2085350T3 true ES2085350T3 (es) 1996-06-01

Family

ID=23343123

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90907830T Expired - Lifetime ES2085350T3 (es) 1989-04-25 1990-04-24 Analogos viia del factor de liberacion de la hormona de crecimiento.

Country Status (14)

Country Link
US (1) US5098995A (es)
EP (1) EP0423322B1 (es)
JP (1) JP2974254B2 (es)
KR (1) KR0163033B1 (es)
AT (1) ATE133687T1 (es)
AU (1) AU628558B2 (es)
CA (1) CA2030810C (es)
DE (1) DE69025123T2 (es)
DK (1) DK0423322T3 (es)
ES (1) ES2085350T3 (es)
FI (1) FI94356C (es)
IL (1) IL94171A (es)
NO (1) NO178031C (es)
WO (1) WO1990012810A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5756458A (en) * 1989-06-16 1998-05-26 Pharmacia & Upjohn Company Stabilized potent GRF analogs
WO1992019253A1 (en) * 1991-04-24 1992-11-12 Warner-Lambert Company CCK ANALOGS CONTAINING α-SUBSTITUTED AMINO ACIDS
CA2106764A1 (en) * 1991-04-24 1992-10-25 David C. Horwell Ó-substituted polypeptides having therapeutic activity
US5262519A (en) * 1991-05-15 1993-11-16 The Salk Institute For Biological Studies GRF analogs XI
CA2158782C (en) * 1994-09-23 2010-01-12 Pierrette Gaudreau Marker for growth hormone-releasing factor receptors
WO2003093294A2 (en) * 2002-04-29 2003-11-13 Euro-Celtique S.A. Conformationally constrained peptides that bind the orl-1 receptor
US9079974B2 (en) * 2011-12-21 2015-07-14 The University Of Miami GH-RH analogs with potent agonistic effects
US9855312B2 (en) 2012-12-21 2018-01-02 University Of Miami GHRH agonists for the treatment of ischemic disorders
WO2014100816A2 (en) 2012-12-21 2014-06-26 University Of Miami Ghrh agonists for islet cell transplantation and function and the treatment of diabetes

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4728726A (en) * 1982-10-04 1988-03-01 The Salk Institute For Biological Studies GRF analogs IIIb
US4594329A (en) * 1984-05-14 1986-06-10 The Salk Institute For Biological Studies CRF analogs
US4689318A (en) * 1985-08-29 1987-08-25 The Salk Institute For Biological Studies GRF analogs
US5002931A (en) * 1987-05-22 1991-03-26 The Salk Institute For Biological Studies GRF analogs VII

Also Published As

Publication number Publication date
KR920700225A (ko) 1992-02-19
EP0423322A1 (en) 1991-04-24
CA2030810C (en) 1999-12-14
EP0423322B1 (en) 1996-01-31
ATE133687T1 (de) 1996-02-15
AU5556990A (en) 1990-11-16
NO178031B (no) 1995-10-02
FI94356B (fi) 1995-05-15
NO905505D0 (no) 1990-12-20
KR0163033B1 (ko) 1998-11-16
IL94171A0 (en) 1991-01-31
DE69025123D1 (de) 1996-03-14
IL94171A (en) 1994-11-11
US5098995A (en) 1992-03-24
AU628558B2 (en) 1992-09-17
DK0423322T3 (da) 1996-06-24
JP2974254B2 (ja) 1999-11-10
CA2030810A1 (en) 1990-10-26
FI906240A0 (fi) 1990-12-18
WO1990012810A1 (en) 1990-11-01
JPH04500526A (ja) 1992-01-30
NO905505L (no) 1991-02-20
DE69025123T2 (de) 1996-09-19
FI94356C (fi) 1995-08-25
NO178031C (no) 1996-01-10

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ES2085350T3 (es) Analogos viia del factor de liberacion de la hormona de crecimiento.
TH1778A (th) สารคล้ายคลึง จี อาร์ เอฟ (grf)

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