ES2085656T3 - Forma de administracion peroral de medicamentos peptidicos, en particular insulina. - Google Patents

Forma de administracion peroral de medicamentos peptidicos, en particular insulina.

Info

Publication number
ES2085656T3
ES2085656T3 ES92924546T ES92924546T ES2085656T3 ES 2085656 T3 ES2085656 T3 ES 2085656T3 ES 92924546 T ES92924546 T ES 92924546T ES 92924546 T ES92924546 T ES 92924546T ES 2085656 T3 ES2085656 T3 ES 2085656T3
Authority
ES
Spain
Prior art keywords
peptidic
peroral administration
medicines
gelatine
particular insulin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92924546T
Other languages
English (en)
Inventor
Jens-Christian Wunderlich
Ursula Schick
Juergen Werry
Juergen Freidenreich
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alfatec Pharma GmbH
Original Assignee
Alfatec Pharma GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19914140178 external-priority patent/DE4140178C2/de
Priority claimed from DE19914140177 external-priority patent/DE4140177C2/de
Priority claimed from DE19914140195 external-priority patent/DE4140195C2/de
Priority claimed from DE19914140186 external-priority patent/DE4140186C2/de
Application filed by Alfatec Pharma GmbH filed Critical Alfatec Pharma GmbH
Application granted granted Critical
Publication of ES2085656T3 publication Critical patent/ES2085656T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5169—Proteins, e.g. albumin, gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1658—Proteins, e.g. albumin, gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2063—Proteins, e.g. gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A61K9/2846—Poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4891—Coated capsules; Multilayered drug free capsule shells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
    • G—PHYSICS
    • G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
    • G03C—PHOTOSENSITIVE MATERIALS FOR PHOTOGRAPHIC PURPOSES; PHOTOGRAPHIC PROCESSES, e.g. CINE, X-RAY, COLOUR, STEREO-PHOTOGRAPHIC PROCESSES; AUXILIARY PROCESSES IN PHOTOGRAPHY
    • G03C1/00—Photosensitive materials
    • G03C1/005—Silver halide emulsions; Preparation thereof; Physical treatment thereof; Incorporation of additives therein
    • G03C1/04—Silver halide emulsions; Preparation thereof; Physical treatment thereof; Incorporation of additives therein with macromolecular additives; with layer-forming substances
    • G03C1/047—Proteins, e.g. gelatine derivatives; Hydrolysis or extraction products of proteins
    • G03C2001/0471—Isoelectric point of gelatine

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)

Abstract

UNA FORMA DE ADMINISTRACION PERORAL PARA MEDICAMENTOS PEPTIDICOS CONTIENE EL MEDICAMENTO PEPTIDICO, EN PARTICULAR INSULINA, DISTRIBUIDO EN UNA GELATINA O MATRIZ DERIVADA DE GELATINA, JUNTO A LOS EXCIPIENTES Y ADITIVOS FARMACEUTICOS HABITUALES. MEDIANTE LA SELECCION DE UNA GELATINA APROPIADA, SE LIBERA EL MEDICAMENTO EN EL INTESTINO DELGADO O GRUESO, DE FORMA QUE NO SE DESCOMPONE ENZIMATICAMENTE POR PEPTIDASAS.
ES92924546T 1991-12-05 1992-12-04 Forma de administracion peroral de medicamentos peptidicos, en particular insulina. Expired - Lifetime ES2085656T3 (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DE19914140178 DE4140178C2 (de) 1991-12-05 1991-12-05 Akutform für ein Indolylessigsäurederivat enthaltendes Arzneimittel und seine Herstellung
DE19914140177 DE4140177C2 (de) 1991-12-05 1991-12-05 Nanosol-Akutform für Glibenclamid
DE19914140195 DE4140195C2 (de) 1991-12-05 1991-12-05 Pharmazeutisch applizierbares Nanosol und Verfahren zu seiner Herstellung
DE19914140186 DE4140186C2 (de) 1991-12-05 1991-12-05 Perorale Applikationsform für Peptidarzneistoffe, insbesondere Insulin
US87686792A 1992-04-30 1992-04-30

Publications (1)

Publication Number Publication Date
ES2085656T3 true ES2085656T3 (es) 1996-06-01

Family

ID=27511568

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92924546T Expired - Lifetime ES2085656T3 (es) 1991-12-05 1992-12-04 Forma de administracion peroral de medicamentos peptidicos, en particular insulina.

Country Status (9)

Country Link
EP (1) EP0615444B1 (es)
AT (1) ATE134875T1 (es)
AU (1) AU671964B2 (es)
CA (1) CA2125284C (es)
DE (1) DE59205625D1 (es)
DK (1) DK0615444T3 (es)
ES (1) ES2085656T3 (es)
GR (1) GR3019608T3 (es)
WO (1) WO1993010767A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2266542A3 (en) * 1998-10-01 2013-07-31 Elan Pharma International Limited Controlled release nanoparticulate compositions
AU763039B2 (en) 1999-04-08 2003-07-10 Genentech Inc. Composition based on oppositely-charged polypeptides
DE19951617A1 (de) * 1999-10-26 2001-05-03 Basf Ag Zubereitungen pharmazeutische Wirkstoffe
HUP0900482A2 (en) 2009-08-03 2011-03-28 Cera Med Kft Pharmaceutical formulation for oral administration
CN108309955B (zh) * 2018-04-27 2020-06-02 武昌理工学院 一种聚明胶肽结合型紫杉醇纳米颗粒的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3312594A (en) * 1963-06-21 1967-04-04 Squibb & Sons Inc Longlasting troche
JPS5911563B2 (ja) * 1980-02-27 1984-03-16 日本原子力研究所 多層構造の徐放性複合体を製造する方法
EP0138216B1 (en) * 1983-10-14 1993-01-07 Sumitomo Pharmaceuticals Company, Limited Sustained-release ifn preparation for parenteral administration
WO1985005029A1 (en) * 1984-05-09 1985-11-21 Medaphore Inc. Oral insulin and a method of making the same
US5011692A (en) * 1985-12-28 1991-04-30 Sumitomo Pharmaceuticals Company, Limited Sustained pulsewise release pharmaceutical preparation
GB8723846D0 (en) * 1987-10-10 1987-11-11 Danbiosyst Ltd Bioadhesive microsphere drug delivery system

Also Published As

Publication number Publication date
EP0615444A1 (de) 1994-09-21
AU3080192A (en) 1993-06-28
CA2125284C (en) 2000-06-20
GR3019608T3 (en) 1996-07-31
ATE134875T1 (de) 1996-03-15
WO1993010767A1 (de) 1993-06-10
DK0615444T3 (da) 1996-07-08
AU671964B2 (en) 1996-09-19
CA2125284A1 (en) 1993-06-10
EP0615444B1 (de) 1996-03-06
DE59205625D1 (de) 1996-04-11

Similar Documents

Publication Publication Date Title
NO930604D0 (no) Doseringsform for medikamentavgivelse med tidsvarierende moenster
DE59406075D1 (de) Tramadolsalz enthaltende Arzneimittel mit verzögerter Wirkstofffreitsetzung
KR920019342A (ko) 골질환 치료제
MY111879A (en) Pharmaceutical formulations.
MX9203443A (es) Una forma de dosis para el suministro retardado de un farmaco.
KR930702022A (ko) 인슐린의 경구 투여에 의한 타잎 1 당뇨병의 치료 또는 예방법
DK0600079T3 (da) Oral 1alpha-hydroxyprævitamin D
ATE306266T1 (de) Verbesserte verabreichungstechnik für multiple medikamentengaben
ATE183387T1 (de) Pharmazeutische und andere darreichungsformen
MX9204776A (es) Forma de dosis para surtir farmaco en un periodo corto
PT957899E (pt) Forma de dosagem para proporcionar um medicamento numa dose crescente
ZA959367B (en) Melt-extrusion multiparticulates
ES2167609T3 (es) Formulaciones de quinolona inyectables.
MY119722A (en) Swallow tablet comprising paracetamol.
ES2010466A6 (es) Formas de administracion solidas, de rapida desintegracion.
ES2085656T3 (es) Forma de administracion peroral de medicamentos peptidicos, en particular insulina.
NO892764D0 (no) Medikamentell administreringsform for droevtyggere.
KR950013513A (ko) 약제 제조용 모에노마이신 및 이의 유도체, 및 모에노마이신 또는 이의 유도체를 함유하는 약제
AR034142A1 (es) Una composicion farmaceutica, metodo para fabricar un medicamento en base a dicha composicion y uso de la composicion
DE69120536D1 (de) Arzneimittel
KR960003718A (ko) 말초신경병 및 중추신경변성병의 치료에 유용한 의약의 제조를 위한 이펜프로딜 및 그 부분입체이성질체의 이용
IT1271354B (it) Preparazione di una forma farmaceutica atta a combattere l'iperinsulinismo contenente n-acetil cisteine e loro analoghi
ES2063079T3 (es) Una composicion farmaceutica que tiene efecto sinergico basada en sulbactam y metampicilina.
ES2082524T3 (es) Medicamento de liberacion retardada que contiene un derivado de dihidropiridina en forma de nanosol y su preparacion.
RU2002101613A (ru) Способ коррекции иммуно-и гепатотоксических эффектов циклофосфана

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 615444

Country of ref document: ES