ES2087812A1 - Derivados de decahidroisoquinolina utiles como antagonistas de los receptrores de los aminoacidos excitadores. - Google Patents
Derivados de decahidroisoquinolina utiles como antagonistas de los receptrores de los aminoacidos excitadores.Info
- Publication number
- ES2087812A1 ES2087812A1 ES09301493A ES9301493A ES2087812A1 ES 2087812 A1 ES2087812 A1 ES 2087812A1 ES 09301493 A ES09301493 A ES 09301493A ES 9301493 A ES9301493 A ES 9301493A ES 2087812 A1 ES2087812 A1 ES 2087812A1
- Authority
- ES
- Spain
- Prior art keywords
- exciter
- amino acid
- receptor antagonists
- acid receptor
- decahydroisoquinoline
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- NENLYAQPNATJSU-UHFFFAOYSA-N 1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline Chemical class C1NCCC2CCCCC21 NENLYAQPNATJSU-UHFFFAOYSA-N 0.000 title abstract 3
- 102000015404 Amino Acid Receptors Human genes 0.000 title abstract 2
- 108010025177 Amino Acid Receptors Proteins 0.000 title abstract 2
- 239000002464 receptor antagonist Substances 0.000 title abstract 2
- 229940044551 receptor antagonist Drugs 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 101100439663 Arabidopsis thaliana CHR7 gene Proteins 0.000 abstract 2
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 2
- 208000012902 Nervous system disease Diseases 0.000 abstract 1
- 208000025966 Neurological disease Diseases 0.000 abstract 1
- -1 R2 is H Chemical group 0.000 abstract 1
- 229910006069 SO3H Inorganic materials 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 230000036592 analgesia Effects 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 1
- 125000000020 sulfo group Chemical group O=S(=O)([*])O[H] 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
DERIVADOS DE DECAHIDROISOQUINOLINA UTILES COMO ANTAGONISTAS DE LOS RECEPTORES DE LOS AMINOACIDOS EXCITADORES. LOS DERIVADOS DE DECAHIDROISOQUINOLINA DE FORMULA (I) DONDE R1 ES H, ALQUILO, ARILALQUILO, ALCOXICARBONILO O ACILO, R2 ES H, ALQUILO, OPCIONALMENTE SUSTITUIDO, CICLOALQUILO O ARILAQUILO, R3 ES CO2H, SO3H, CONHSO2R8, O UN ANILLO DE 5 MIEMBROS QUE CONTIENE DE 1 A 4 ATOMOS DE N, Y, OPCIONALMENTE 1 ATOMO DE O O S, OPCIONALMENTE SUSTITUIDO, W ES (CH2)N, S, SO, SO2, Y ES CHR7, NR4, O, S, SO, O SO2, Z ES NR6, CHR7, CH, O W E Y JUNTOS SON HC=CH O CIGUC, O Y Y Z JUNTOS SON HC=CH O CIGUC, SON UTILES COMO ANTAGONISTAS DE LOS AMINOACIDOS EXCITADORES, POR LO QUE PUEDEN SER UTILIZADOS EN EL TRATAMIENTO DE DESORDENES NEUROLOGICOS Y EN LA PRODUCCION DE ANALGESIA.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES9301493A ES2087812B1 (es) | 1993-07-02 | 1993-07-02 | Derivados de decahidroisoquinolina utiles como antagonistas de los receptrores de los aminoacidos excitadores. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES9301493A ES2087812B1 (es) | 1993-07-02 | 1993-07-02 | Derivados de decahidroisoquinolina utiles como antagonistas de los receptrores de los aminoacidos excitadores. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES2087812A1 true ES2087812A1 (es) | 1996-07-16 |
| ES2087812B1 ES2087812B1 (es) | 1997-03-16 |
Family
ID=8282429
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES9301493A Expired - Fee Related ES2087812B1 (es) | 1993-07-02 | 1993-07-02 | Derivados de decahidroisoquinolina utiles como antagonistas de los receptrores de los aminoacidos excitadores. |
Country Status (1)
| Country | Link |
|---|---|
| ES (1) | ES2087812B1 (es) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4902695A (en) * | 1989-02-13 | 1990-02-20 | Eli Lilly And Company | Excitatory amino acid receptor antagonists |
| US5284957A (en) * | 1992-09-03 | 1994-02-08 | Eli Lilly And Company | Excitatory amino acid receptor antagonists |
-
1993
- 1993-07-02 ES ES9301493A patent/ES2087812B1/es not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4902695A (en) * | 1989-02-13 | 1990-02-20 | Eli Lilly And Company | Excitatory amino acid receptor antagonists |
| US5284957A (en) * | 1992-09-03 | 1994-02-08 | Eli Lilly And Company | Excitatory amino acid receptor antagonists |
Non-Patent Citations (1)
| Title |
|---|
| ORNSTEIN y col. 6-Substituted Decahydroisoquinolines-3-carboxylic Acids as Potent and Selective Conformationally Constrained NMDA Receptor Antagonists. J. Med. Chem. 1992, Vol. 35, pßginas 3547-3560 * |
Also Published As
| Publication number | Publication date |
|---|---|
| ES2087812B1 (es) | 1997-03-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EC2A | Search report published |
Effective date: 19960716 |
|
| FD1A | Patent lapsed |
Effective date: 20040503 |