ES2087869T3 - Proteinas modificadas; interferones alfa y beta modificados, proteinas fosforiladas y analogos, secuencias de adn, y sus aplicaciones. - Google Patents

Proteinas modificadas; interferones alfa y beta modificados, proteinas fosforiladas y analogos, secuencias de adn, y sus aplicaciones.

Info

Publication number
ES2087869T3
ES2087869T3 ES89311108T ES89311108T ES2087869T3 ES 2087869 T3 ES2087869 T3 ES 2087869T3 ES 89311108 T ES89311108 T ES 89311108T ES 89311108 T ES89311108 T ES 89311108T ES 2087869 T3 ES2087869 T3 ES 2087869T3
Authority
ES
Spain
Prior art keywords
proteins
modified
phosphorilated
dna sequences
applications
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89311108T
Other languages
English (en)
Inventor
Sidney Pestka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
PESTKA BIOMEDICAL LAB Inc
Pestka Biomedical Laboratories Inc
Original Assignee
PESTKA BIOMEDICAL LAB Inc
Pestka Biomedical Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by PESTKA BIOMEDICAL LAB Inc, Pestka Biomedical Laboratories Inc filed Critical PESTKA BIOMEDICAL LAB Inc
Application granted granted Critical
Publication of ES2087869T3 publication Critical patent/ES2087869T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/56—IFN-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/565—IFN-beta
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/57—IFN-gamma
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/90—Fusion polypeptide containing a motif for post-translational modification

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Analytical Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

PROTEINAS MODIFICADAS, INTERFERONES MODIFICADOS A''S Y B''S, PROTEINAS MODIFICADAS FOSFORILATADAS Y SECUENCIAS DNA QUE CODIFICAN LO ANTERIOR, APLICACIONES Y USOS DE ELLO. LAS PROTEINAS COMO HU-IFN-A FOSFORILATADAS MODIFICADAS SON PROVISTAS QUE LLEVEN UNA ETIQUETA IDENTIFICABLE TAL COMO UNA ETIQUETA RADIO. LAS PROTEINAS COMO HU-IFN-A FOSFORILATADAS CORRESPONDIENTES QUE CONTIENEN UN SITIO DE FOSFORILACION PUTATIVO. LAS SECUENCIAS DNA QUE CODIFICAN LA PROTEINA COMO HU-IFN-A Y CONTIENE UNA SECUENCIA QUE CODIFICA UN LUGAR DE FOSFORILACION PUTATIVO. LOS VECTORES DE EXPRESION APROPIADA SON USADOS PARA TRANSFORMAR LAS CELULAS HUESPED COMPATIBLES DE VARIOS ORGANISMOS, TALES COMO E. COLI. SON DESCUBIERTOS NUMEROSOS USOS PARA LAS PROTEINAS FOSFORILATADAS.
ES89311108T 1988-10-28 1989-10-27 Proteinas modificadas; interferones alfa y beta modificados, proteinas fosforiladas y analogos, secuencias de adn, y sus aplicaciones. Expired - Lifetime ES2087869T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US26427188A 1988-10-28 1988-10-28

Publications (1)

Publication Number Publication Date
ES2087869T3 true ES2087869T3 (es) 1996-08-01

Family

ID=23005308

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89311108T Expired - Lifetime ES2087869T3 (es) 1988-10-28 1989-10-27 Proteinas modificadas; interferones alfa y beta modificados, proteinas fosforiladas y analogos, secuencias de adn, y sus aplicaciones.

Country Status (9)

Country Link
US (1) US6225455B1 (es)
EP (1) EP0372707B1 (es)
JP (2) JP3621948B2 (es)
AT (1) ATE135014T1 (es)
CA (1) CA2001719C (es)
DE (1) DE68925869T2 (es)
ES (1) ES2087869T3 (es)
GR (1) GR3020060T3 (es)
IL (1) IL92124A (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6747131B1 (en) 1988-10-28 2004-06-08 Pestka Biomedical Laboratories, Inc. Phosphorylated fusion proteins
US5545723A (en) * 1994-03-15 1996-08-13 Biogen Inc. Muteins of IFN-β
US6800747B1 (en) * 1995-06-07 2004-10-05 Pestka Biomedical Laboratories, Inc. Nucleic acids encoding phosphorylated fusion proteins
US5969102A (en) 1997-03-03 1999-10-19 St. Jude Children's Research Hospital Lymphocyte surface receptor that binds CAML, nucleic acids encoding the same and methods of use thereof
US8406498B2 (en) 1999-01-25 2013-03-26 Amnis Corporation Blood and cell analysis using an imaging flow cytometer
US8131053B2 (en) 1999-01-25 2012-03-06 Amnis Corporation Detection of circulating tumor cells using imaging flow cytometry
US7450229B2 (en) 1999-01-25 2008-11-11 Amnis Corporation Methods for analyzing inter-cellular phenomena
US8885913B2 (en) 1999-01-25 2014-11-11 Amnis Corporation Detection of circulating tumor cells using imaging flow cytometry
US6268178B1 (en) 1999-05-25 2001-07-31 Phage Biotechnology Corp. Phage-dependent super-production of biologically active protein and peptides
US7129331B2 (en) 2000-05-31 2006-10-31 Pestka Biomedical Laboratories, Inc. Phosphorylated polypeptides and uses related thereto
JP2003534790A (ja) * 2000-05-31 2003-11-25 ピービーエル バイオメディカル ラボラトリーズ リン酸化ポリペプチドおよび前記に関連する使用
AU2002211228A1 (en) 2000-09-14 2002-03-26 Mount Sinai School Of Medicine Screening methods to identify g-proteins and other compounds which modulate phosphodiesterase (pde) activity
AU2001297843A1 (en) 2000-10-12 2002-12-23 Amnis Corporation Imaging and analyzing parameters of small moving objects such as cells
US7803982B2 (en) 2001-04-20 2010-09-28 The Mount Sinai School Of Medicine Of New York University T1R3 transgenic animals, cells and related methods
US8103080B2 (en) 2004-03-16 2012-01-24 Amnis Corporation Method for imaging and differential analysis of cells
US8953866B2 (en) 2004-03-16 2015-02-10 Amnis Corporation Method for imaging and differential analysis of cells
WO2005098430A2 (en) 2004-03-16 2005-10-20 Amnis Corporation Image based quantitation of molecular translocation
WO2007067999A2 (en) 2005-12-09 2007-06-14 Amnis Corporation Extended depth of field imaging for high speed object analysis
US8001400B2 (en) * 2006-12-01 2011-08-16 Apple Inc. Power consumption management for functional preservation in a battery-powered electronic device
US8451524B2 (en) 2009-09-29 2013-05-28 Amnis Corporation Modifying the output of a laser to achieve a flat top in the laser's Gaussian beam intensity profile
US8817115B1 (en) 2010-05-05 2014-08-26 Amnis Corporation Spatial alignment of image data from a multichannel detector using a reference image

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE7811630L (sv) 1977-11-17 1979-05-18 Welsh Nat School Med Metod for uppteckt eller mengdbestemning av substanser med anvendning av merkningsteknik
WO1983002461A1 (en) 1982-01-19 1983-07-21 Cetus Corp Multiclass hybrid interferons
US6936694B1 (en) 1982-05-06 2005-08-30 Intermune, Inc. Manufacture and expression of large structural genes
US4591552A (en) 1982-09-29 1986-05-27 New York Blood Center, Inc. Detection of hepatitis B surface antigen (or antibody to same) with labeled synthetic peptide
US4739046A (en) 1985-08-19 1988-04-19 Luzio Nicholas R Di Soluble phosphorylated glucan
CA1338860C (en) * 1987-04-13 1997-01-21 Peter Parker Radiolabelling of proteins
US5001064A (en) 1988-06-20 1991-03-19 Washington University Phosphatidylinositol 4-kinase

Also Published As

Publication number Publication date
CA2001719C (en) 2002-01-15
CA2001719A1 (en) 1990-04-28
IL92124A (en) 1996-10-31
GR3020060T3 (en) 1996-08-31
US6225455B1 (en) 2001-05-01
JP2004089184A (ja) 2004-03-25
DE68925869T2 (de) 1996-11-14
ATE135014T1 (de) 1996-03-15
DE68925869D1 (de) 1996-04-11
EP0372707A3 (en) 1991-09-11
EP0372707B1 (en) 1996-03-06
EP0372707A2 (en) 1990-06-13
JPH02288900A (ja) 1990-11-28
JP3621948B2 (ja) 2005-02-23
IL92124A0 (en) 1990-07-12

Similar Documents

Publication Publication Date Title
MX9203379A (es) Proteinas producidas por los linfocitos humanos, secuencia de adn que codifica para estas proteinas y composiciones farmaceuticas que las contienen.
AR241314A1 (es) Aislado de adn, vector en base en dicho aislado cultivo de celulas tratadas con dicho vector y preparacion de factor viii humano funcional.
ES8401133A1 (es) Metodo para preparar albumina de suero humano o una proteina de fusion de la misma.
ES2068791T1 (es) Metodos y acido desoxirribonucleico para la preparacion de proteina de factor de tejido.
MX9302917A (es) Derivados de proteinas c humanas, procedimiento para su preparacion y formulacion famaceutica que los contiene.
MX9204685A (es) Secuencia de adn que codifica una proteina superficial externa (ospa) o derivado de la misma composicion de vacuna qe comprende tal proteina.
ES2038579T1 (es) Una celula de levadura del genero schwanniovices.
DK478786A (da) Cystein-forarmede muteiner af biologisk aktive humantumornekrosefaktorproteiner
DK369788D0 (da) Konstruktion af syntetisk dna og dens anvendelse til syntese af store polypeptider
IL92124A0 (en) Modified proteins,modified interferons,alpha and beta,phosphorylated proteins and analogues,dna sequences,applications and uses therefor
ES8402351A1 (es) Procedimiento para producir interferon inmune humano.
ES2193145T3 (es) Proteinas procoagulants quimericas.
ATE122397T1 (de) Fusionsproteine aus interleukin-2 und hirudin.
EP0689550A4 (en) NEW ANTIMICROBIAL PEPTIDE FROM BOVINE NEUTROPHILES
ES2142953T3 (es) Factor de crecimiento y diferenciacion de la familia del tgf-beta.
SV1997000018A (es) Proteinas inhibisoras (bikunin humano)
DOP1981004064A (es) Interferones leucocitarios hibridos para uso en el tratamiento de enfermedades neoplasticas virales.
SE9004010D0 (sv) Viralt medel
IT8224915A0 (it) Uso di peptidi come medicamenti.
DK491487D0 (da) Dna-sekvens til ekspressionering af biologisk aktivt faktor xiii og anvendelse af samme
ES2174835T3 (es) Carboxilasa dependiente de la vitamina k.
DE3584579D1 (de) Herstellung von polypeptiden mit human-gammainterferon-aktivitaet.
ES2115622T5 (es) Clones moleculares de hiv-1 y usos de los mismos.
ES2012940A6 (es) Un procedimiento para la preparacion de una celula de mamifero capaz de expresar interleukin-2 humana.
DE3881023D1 (de) Proteine, expressionsvektoren, die fuer solche proteine kodierende dna enthalten und zellen, die solche expressionsvektoren enthalten.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 372707

Country of ref document: ES