ES2088936T3 - Compuestos fenoxi-heterociclicos. - Google Patents
Compuestos fenoxi-heterociclicos.Info
- Publication number
- ES2088936T3 ES2088936T3 ES90120052T ES90120052T ES2088936T3 ES 2088936 T3 ES2088936 T3 ES 2088936T3 ES 90120052 T ES90120052 T ES 90120052T ES 90120052 T ES90120052 T ES 90120052T ES 2088936 T3 ES2088936 T3 ES 2088936T3
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- represented
- benzo
- alcoxyl
- halogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- -1 ETHYLENE DIOXY Chemical class 0.000 abstract 3
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 150000002367 halogens Chemical class 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical class [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 230000001430 anti-depressive effect Effects 0.000 abstract 1
- 239000000935 antidepressant agent Substances 0.000 abstract 1
- 239000002220 antihypertensive agent Substances 0.000 abstract 1
- 229940030600 antihypertensive agent Drugs 0.000 abstract 1
- 239000002249 anxiolytic agent Substances 0.000 abstract 1
- 230000000949 anxiolytic effect Effects 0.000 abstract 1
- HZVOZRGWRWCICA-UHFFFAOYSA-N methanediyl Chemical class [CH2] HZVOZRGWRWCICA-UHFFFAOYSA-N 0.000 abstract 1
- KHUXNRRPPZOJPT-UHFFFAOYSA-N phenoxy radical Chemical class O=C1C=C[CH]C=C1 KHUXNRRPPZOJPT-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D233/22—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
LA PRESENTE INVENCION SE DIRIGE A UNA CLASE DE COMPUESTOS HETEROCICLICOS FENOXI DE LA FORMULA I: EN LA CUAL R1 SE REPRESENTA POR HIDROGENO, HALOGENO, ALQUILO, ALCOXILO, OH, CF3, CN, METILENODIOXI, ETILENODIOXI, METILENO, 2,3-BENZO, 3,4-BENZO, ALQUILTIO, ALQUILSULFONILO, ALQUILSULFINILO, CICLOALQUILO, CICLOALCOXILO O CICLOALQUILTIO; R2 SE REPRESENTA POR HALOGENO, ALQUILO, ALCOXILO, OH, CF3, CN, ALQUILTIO, ALQUILSULFINILO, CICLOALQUILO, CICLOALCOXILO O CICLOALQUILTIO; R3 SE REPRESENTA POR HIDROGENO, HALOGENO, ALQUILO, ALCOXILO, OH, CF3, CN, METILENODIOXI, ETILENODIOXI, METILENO, 2,3-BENZO, 4,5-BENZO, 5,6-BENZO, ALQUILTIO, ALQUILSULFONILO, ALQUILSULFINILO, CICLOALQUILO, CICLOALCOXILO O CICLOALQUILTIO; M SE REPRESENTA POR UN ENTERO 1 O 2; P SE REPRESENTA POR UN ENTERO DE 0 A 4. TAMBIEN SE DIRIGE A LAS SALES DE ADICION ACIDA FARMACEUTICAMENTE ACEPTABLES, Y A SU USO COMO AGENTES ANTI-DEPRESIVOS, ANXIOLITICOS Y ANTI-HIPERTENSIVOS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US42442989A | 1989-10-20 | 1989-10-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2088936T3 true ES2088936T3 (es) | 1996-10-01 |
Family
ID=23682608
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES90120052T Expired - Lifetime ES2088936T3 (es) | 1989-10-20 | 1990-10-19 | Compuestos fenoxi-heterociclicos. |
Country Status (21)
| Country | Link |
|---|---|
| EP (1) | EP0423802B1 (es) |
| JP (1) | JP3097696B2 (es) |
| KR (1) | KR0182808B1 (es) |
| CN (1) | CN1028099C (es) |
| AR (1) | AR248400A1 (es) |
| AT (1) | ATE126217T1 (es) |
| AU (1) | AU627627B2 (es) |
| CA (1) | CA2027530C (es) |
| DE (1) | DE69021490T2 (es) |
| DK (1) | DK0423802T3 (es) |
| ES (1) | ES2088936T3 (es) |
| FI (1) | FI104717B (es) |
| GR (1) | GR3017775T3 (es) |
| HU (1) | HU207300B (es) |
| IE (1) | IE67049B1 (es) |
| IL (1) | IL96064A (es) |
| NO (1) | NO179367C (es) |
| NZ (1) | NZ235688A (es) |
| PH (1) | PH27290A (es) |
| PT (1) | PT95637B (es) |
| ZA (1) | ZA908234B (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE199547T1 (de) * | 1992-02-06 | 2001-03-15 | Merrell Pharma Inc | Arylalkoxyphenoxyimidazolinverbindungen |
| KR100693139B1 (ko) * | 2001-04-19 | 2007-03-13 | 엘지전자 주식회사 | 디스크 드라이브의 트레이 진동방지구조 |
| KR100482010B1 (ko) | 2002-11-05 | 2005-04-14 | 삼성전자주식회사 | 모니터장치 |
| EP1958507A1 (en) | 2007-02-15 | 2008-08-20 | Syngeta Participations AG | Chemical compounds |
| CN101687812A (zh) * | 2007-07-02 | 2010-03-31 | 弗·哈夫曼-拉罗切有限公司 | 对痕量胺相关受体(taar)具有良好亲和性的2-咪唑啉化合物 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE614596C (de) * | 1931-07-10 | 1935-06-13 | I G Farbenindustrie Akt Ges | Verfahren zur Darstellung von ?-Glyoxalidinarylmethylolen |
| US2893993A (en) * | 1958-06-17 | 1959-07-07 | Searle & Co | 2-aryloxyaralkyl-1, 4, 5, 6-tetrahydropyrimidines |
| US3897431A (en) * | 1969-04-24 | 1975-07-29 | Sterling Drug Inc | 2-{8 {60 -Alkoxy-arylmethyl{9 -2-imidazolines and -1,4,5,6-tetrahydropyrimidines |
| AU3546478A (en) * | 1977-04-29 | 1979-11-01 | Ciba Geigy Ag | Ectoparasiticides |
| EP0011596B1 (de) * | 1978-10-09 | 1981-12-30 | Ciba-Geigy Ag | Neue 2-(alpha-Phenoxy-alkyl)-imidazoline und ihre Salze, deren Herstellung und Verwendung sowie sie enthaltende Mittel zur Bekämpfung von pflanzenschädlichen und tierparasitären Milben |
| US4260626A (en) * | 1979-03-26 | 1981-04-07 | Richardson-Merrell Inc. | Tetrahydro and imidazoline antisecretory compounds |
| IT1231237B (it) * | 1987-09-21 | 1991-11-26 | Angeli Inst Spa | Derivati eterociclici |
-
1990
- 1990-10-12 CA CA002027530A patent/CA2027530C/en not_active Expired - Lifetime
- 1990-10-15 AU AU64565/90A patent/AU627627B2/en not_active Ceased
- 1990-10-15 NZ NZ235688A patent/NZ235688A/en unknown
- 1990-10-15 ZA ZA908234A patent/ZA908234B/xx unknown
- 1990-10-17 AR AR90318103A patent/AR248400A1/es active
- 1990-10-17 PH PH41397A patent/PH27290A/en unknown
- 1990-10-18 KR KR1019900016591A patent/KR0182808B1/ko not_active Expired - Fee Related
- 1990-10-19 HU HU906514A patent/HU207300B/hu not_active IP Right Cessation
- 1990-10-19 PT PT95637A patent/PT95637B/pt not_active IP Right Cessation
- 1990-10-19 CN CN90108492A patent/CN1028099C/zh not_active Expired - Lifetime
- 1990-10-19 FI FI905168A patent/FI104717B/fi not_active IP Right Cessation
- 1990-10-19 EP EP90120052A patent/EP0423802B1/en not_active Expired - Lifetime
- 1990-10-19 ES ES90120052T patent/ES2088936T3/es not_active Expired - Lifetime
- 1990-10-19 DE DE69021490T patent/DE69021490T2/de not_active Expired - Lifetime
- 1990-10-19 DK DK90120052.7T patent/DK0423802T3/da active
- 1990-10-19 IE IE376590A patent/IE67049B1/en not_active IP Right Cessation
- 1990-10-19 JP JP02279518A patent/JP3097696B2/ja not_active Expired - Lifetime
- 1990-10-19 IL IL9606490A patent/IL96064A/en not_active IP Right Cessation
- 1990-10-19 AT AT90120052T patent/ATE126217T1/de not_active IP Right Cessation
- 1990-10-19 NO NO904535A patent/NO179367C/no not_active IP Right Cessation
-
1995
- 1995-10-18 GR GR950402877T patent/GR3017775T3/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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