ES2090155T3 - Derivados de ciclopropacromen. - Google Patents
Derivados de ciclopropacromen.Info
- Publication number
- ES2090155T3 ES2090155T3 ES91103016T ES91103016T ES2090155T3 ES 2090155 T3 ES2090155 T3 ES 2090155T3 ES 91103016 T ES91103016 T ES 91103016T ES 91103016 T ES91103016 T ES 91103016T ES 2090155 T3 ES2090155 T3 ES 2090155T3
- Authority
- ES
- Spain
- Prior art keywords
- group
- hydrogen atom
- atom
- independently represent
- represent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 6
- 125000004432 carbon atom Chemical group C* 0.000 abstract 3
- 229910052757 nitrogen Inorganic materials 0.000 abstract 3
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- 125000005843 halogen group Chemical group 0.000 abstract 2
- -1 homopiperidinyl group Chemical group 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000005415 substituted alkoxy group Chemical group 0.000 abstract 2
- UGWHXVSKRXXIPL-UHFFFAOYSA-N C1=CC2=CC2=C2OC=CC=C21 Chemical class C1=CC2=CC2=C2OC=CC=C21 UGWHXVSKRXXIPL-UHFFFAOYSA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 230000002490 cerebral effect Effects 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 abstract 1
- 125000004193 piperazinyl group Chemical group 0.000 abstract 1
- 125000003386 piperidinyl group Chemical group 0.000 abstract 1
- 230000003236 psychic effect Effects 0.000 abstract 1
- 125000000719 pyrrolidinyl group Chemical group 0.000 abstract 1
- 125000004929 pyrrolidonyl group Chemical group N1(C(CCC1)=O)* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 125000005505 thiomorpholino group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/94—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyrane Compounds (AREA)
Abstract
UN DERIVADO DE CICLOPROPACROMO DE LA FORMULA (I) EN DONDE N REPRESENTA UN NUMERO ENTERO DE 2 A 5; R ELEVADO 1 Y R (AL CUADRADO) REPRESENTAN INDEPENDIENTEMENTE UN ATOMO DE HIDROGENO O UN GRUPO ALKIL QUE TIENE DE 1 A 5 ATOMOS DE CARBONO, UN GRUPO FENIL O GRUPO ARALKIL QUE TIENE DE 7 A 10 ATOMOS DE CARBONO, O ALTERNATIVAMENTE R ELEVADO 1 Y R (AL CUADRADO) FORMAN JUNTO CON EL ATOMO DE NITROGENO, AL CUAL ELLOS ESTAN LIGADOS, UN GRUPO MORFOLINO, UN GRUPO CIOMORFOLINO, UN GRUPO PIRROLIDINIL, UN GRUPO PIPERAZINIL, UN GRUPO HOMOPIPERAZINIL, UN GRUPO N-ALKILPIPERAZINIL, UN GRUPO N-ALKILHOMOPIPERAZINIL, UN GRUPO N-HIDROXIALKILPIPERAZINIL O UN GRUPO PIRROLIDINIL O ALTERNATIVAMENTE R ELEVADO 1 Y R (AL CUADRADO) FORMAN JUNTO AL ATOMO DE NITROGENO AL CUAL ESTAN LIGADOS, Y ADEMAS UN ATOMO DE CARBONO AL CUAL EL MENCIONADO ATOMO DE NITROGENO ESTA LIGADO, UN GRUPO PIRROLITIDINIL; A ELEVADO 1 Y A (AL CUADRADO) INDEPENDIENTEMENTE REPRESENTAN UN ATOMO DE HIDROGENO, UN GRUPO HIDROXIL, UN ATOMO HALOGENO O UN GRUPOALKOXI OPCIONALMENTE SUSTITUIDO; PROVISTO QUE DONDE R ELEVADO 1 Y R (AL CUADRADO) AMBOS REPRESENTAN UN ATOMO DE HIDROGENO; A ELEVADO 1, A (AL CUADRADO) , B ELEVADO 1 Y B (AL CUADRADO) SOBRE LOS DOS ANILLOS DE BENCENO REPRESENTAN TODOS UN ATOMO DE HIDROGENO, O DE OTRA MANERA, LOS DOS SUSTITUYENTES SOBRE AL MENOS UN ANILLO DE BENCENO TIENEN OTRO SIGNIFICADO QUE UN ATOMO DE HIDROGENO, Y SE DESCUBRE UNA SAL DE ESO FARMACOLOGICAMENTE ACEPTABLE. LOS COMPUESTOS PUEDEN USARSE PARA MEJORAR Y TRATAR AGENTES PARA DESORDENES CEREBRALES ORGANICOS Y DESORDENES FUNCIONALES PSIQUICOS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP14771090 | 1990-06-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2090155T3 true ES2090155T3 (es) | 1996-10-16 |
Family
ID=15436466
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES91103016T Expired - Lifetime ES2090155T3 (es) | 1990-06-06 | 1991-02-28 | Derivados de ciclopropacromen. |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP0461343B1 (es) |
| JP (1) | JP3054207B2 (es) |
| AT (1) | ATE139533T1 (es) |
| CA (1) | CA2037187A1 (es) |
| DE (2) | DE69120348D1 (es) |
| DK (1) | DK0461343T3 (es) |
| ES (1) | ES2090155T3 (es) |
| GR (1) | GR3020288T3 (es) |
| HU (1) | HUT57759A (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3993651B2 (ja) * | 1994-10-21 | 2007-10-17 | アスビオファーマ株式会社 | シクロプロパクロメンカルボン酸誘導体 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0723367B2 (ja) * | 1986-02-27 | 1995-03-15 | サントリー株式会社 | オキサビシクロヘプタン誘導体 |
-
1991
- 1991-02-27 JP JP03032922A patent/JP3054207B2/ja not_active Expired - Lifetime
- 1991-02-27 CA CA002037187A patent/CA2037187A1/en not_active Abandoned
- 1991-02-28 HU HU91676A patent/HUT57759A/hu unknown
- 1991-02-28 DK DK91103016.1T patent/DK0461343T3/da active
- 1991-02-28 AT AT91103016T patent/ATE139533T1/de not_active IP Right Cessation
- 1991-02-28 ES ES91103016T patent/ES2090155T3/es not_active Expired - Lifetime
- 1991-02-28 DE DE69120348A patent/DE69120348D1/de not_active Expired - Fee Related
- 1991-02-28 DE DE69120348T patent/DE69120348T4/de not_active Expired - Lifetime
- 1991-02-28 EP EP91103016A patent/EP0461343B1/en not_active Expired - Lifetime
-
1996
- 1996-06-20 GR GR960400235T patent/GR3020288T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP3054207B2 (ja) | 2000-06-19 |
| DE69120348D1 (de) | 1996-07-25 |
| ATE139533T1 (de) | 1996-07-15 |
| HUT57759A (en) | 1991-12-30 |
| JPH04235180A (ja) | 1992-08-24 |
| DE69120348T2 (de) | 1996-12-12 |
| HU910676D0 (en) | 1991-09-30 |
| DK0461343T3 (da) | 1996-08-05 |
| EP0461343B1 (en) | 1996-06-19 |
| CA2037187A1 (en) | 1991-12-07 |
| DE69120348T4 (de) | 1997-07-31 |
| EP0461343A1 (en) | 1991-12-18 |
| GR3020288T3 (en) | 1996-09-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
Ref document number: 461343 Country of ref document: ES |
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| FG2A | Definitive protection |
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