ES2090836T3 - Procedimiento para la preparacion de microcapsulas polimeras que contienen substancias biologicamente activas. - Google Patents

Procedimiento para la preparacion de microcapsulas polimeras que contienen substancias biologicamente activas.

Info

Publication number
ES2090836T3
ES2090836T3 ES93200438T ES93200438T ES2090836T3 ES 2090836 T3 ES2090836 T3 ES 2090836T3 ES 93200438 T ES93200438 T ES 93200438T ES 93200438 T ES93200438 T ES 93200438T ES 2090836 T3 ES2090836 T3 ES 2090836T3
Authority
ES
Spain
Prior art keywords
preparation
biologically active
procedure
microcapsules containing
active substances
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93200438T
Other languages
English (en)
Inventor
Cardina Anna Maria Chris Dirix
Hendrikus Johannes Maria Kamp
Anthonius Paulus Sam
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Akzo Nobel NV
Original Assignee
Akzo Nobel NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nobel NV filed Critical Akzo Nobel NV
Application granted granted Critical
Publication of ES2090836T3 publication Critical patent/ES2090836T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)

Abstract

SE PRESENTA UN PROCESO PARA LA PREPARACION DE MICROCAPSULAS QUE CONTIENEN UN MATERIAL BIOLOGICAMENTE ACTIVO. EL PROCESO COMPRENDE LA DISOLUCION DE UN POLIMERO EN UN SOLVENTE DENTRO DEL CUAL SE INTRODUCE EL MATERIAL ACTIVO; LA ATOMIZACION DE LA SUSPENSION O SOLUCION RESULTANTE Y LA RECOGIDA DE LAS GOTITAS EN UN MATERIAL NO SOLVENTE PARA LAS GOTITAS POLIMERICAS QUE CONTIENEN EL MATERIAL ACTIVO, DANDO COMO RESULTANDO LA COAGULACION. SUBSECUENTEMENTE, LAS GOTITAS COAGULADAS SE ENDURECEN EN UN SEGUNDO MATERIAL NO SOLVENTE.
ES93200438T 1992-02-18 1993-02-16 Procedimiento para la preparacion de microcapsulas polimeras que contienen substancias biologicamente activas. Expired - Lifetime ES2090836T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP92200466 1992-02-18

Publications (1)

Publication Number Publication Date
ES2090836T3 true ES2090836T3 (es) 1996-10-16

Family

ID=8210436

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93200438T Expired - Lifetime ES2090836T3 (es) 1992-02-18 1993-02-16 Procedimiento para la preparacion de microcapsulas polimeras que contienen substancias biologicamente activas.

Country Status (16)

Country Link
US (1) US5389379A (es)
EP (1) EP0556917B1 (es)
JP (1) JPH05337360A (es)
KR (1) KR930017574A (es)
AT (1) ATE138263T1 (es)
AU (1) AU658715B2 (es)
CA (1) CA2089354A1 (es)
DE (1) DE69302721T2 (es)
DK (1) DK0556917T3 (es)
ES (1) ES2090836T3 (es)
FI (1) FI930672L (es)
GR (1) GR3020417T3 (es)
MX (1) MX9300851A (es)
NO (1) NO930557L (es)
NZ (1) NZ245914A (es)
ZA (1) ZA93929B (es)

Families Citing this family (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6331318B1 (en) 1994-09-30 2001-12-18 Emisphere Technologies Inc. Carbon-substituted diketopiperazine delivery systems
US5714167A (en) 1992-06-15 1998-02-03 Emisphere Technologies, Inc. Active agent transport systems
US5578323A (en) 1992-06-15 1996-11-26 Emisphere Technologies, Inc. Proteinoid carriers and methods for preparation and use thereof
US6099856A (en) 1992-06-15 2000-08-08 Emisphere Technologies, Inc. Active agent transport systems
US5693338A (en) 1994-09-29 1997-12-02 Emisphere Technologies, Inc. Diketopiperazine-based delivery systems
US5629020A (en) * 1994-04-22 1997-05-13 Emisphere Technologies, Inc. Modified amino acids for drug delivery
US6221367B1 (en) 1992-06-15 2001-04-24 Emisphere Technologies, Inc. Active agent transport systems
US5443841A (en) 1992-06-15 1995-08-22 Emisphere Technologies, Inc. Proteinoid microspheres and methods for preparation and use thereof
US5541155A (en) 1994-04-22 1996-07-30 Emisphere Technologies, Inc. Acids and acid salts and their use in delivery systems
US5811127A (en) 1992-06-15 1998-09-22 Emisphere Technologies, Inc. Desferrioxamine oral delivery system
US5792451A (en) 1994-03-02 1998-08-11 Emisphere Technologies, Inc. Oral drug delivery compositions and methods
US6383470B1 (en) 1992-09-26 2002-05-07 Thomas Fritzsch Microparticle preparations made of biodegradable copolymers
US5401516A (en) 1992-12-21 1995-03-28 Emisphere Technologies, Inc. Modified hydrolyzed vegetable protein microspheres and methods for preparation and use thereof
US5958457A (en) 1993-04-22 1999-09-28 Emisphere Technologies, Inc. Compositions for the delivery of antigens
ES2244367T3 (es) 1993-04-22 2005-12-16 Emisphere Technologies, Inc. Composiciones para la administracion por via oral.
US20010003001A1 (en) * 1993-04-22 2001-06-07 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5709861A (en) 1993-04-22 1998-01-20 Emisphere Technologies, Inc. Compositions for the delivery of antigens
US5643957A (en) 1993-04-22 1997-07-01 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US6461643B2 (en) * 1993-04-22 2002-10-08 Emisphere Technologies, Inc. Oral drug delivery compositions and methods
US5650173A (en) * 1993-11-19 1997-07-22 Alkermes Controlled Therapeutics Inc. Ii Preparation of biodegradable microparticles containing a biologically active agent
US5965121A (en) 1995-03-31 1999-10-12 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US6090958A (en) 1995-03-31 2000-07-18 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5989539A (en) 1995-03-31 1999-11-23 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
BR9604880A (pt) 1995-03-31 1998-05-19 Emisphere Tech Inc Composto composição forma de unidade de dosagem métodos para administração de um agente biologicamente ativo para preparar uma composição para administração de um agente ativo e para preparar um composto e composição farmacológica
US5650386A (en) 1995-03-31 1997-07-22 Emisphere Technologies, Inc. Compositions for oral delivery of active agents
US5866536A (en) 1995-03-31 1999-02-02 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US6001347A (en) 1995-03-31 1999-12-14 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5820881A (en) 1995-04-28 1998-10-13 Emisphere Technologies, Inc. Microspheres of diamide-dicarboxylic acids
US6051258A (en) 1995-06-07 2000-04-18 Emisphere Technologies, Inc. Proteinoid emulsions and methods for preparation and use thereof
US5824345A (en) 1995-06-07 1998-10-20 Emisphere Technologies, Inc. Fragrances and flavorants
US5750147A (en) 1995-06-07 1998-05-12 Emisphere Technologies, Inc. Method of solubilizing and encapsulating itraconazole
US5667806A (en) * 1995-06-07 1997-09-16 Emisphere Technologies, Inc. Spray drying method and apparatus
CN1055417C (zh) * 1995-09-05 2000-08-16 中国科学院成都有机化学研究所 一种核-壳结构的蛋白高分子微球及其制法
WO1997010197A1 (en) 1995-09-11 1997-03-20 Emisphere Technologies, Inc. METHOD FOR PREPARING φ-AMINOALKANOIC ACID DERIVATIVES FROM CYCLOALKANONES
AU2595697A (en) * 1996-03-29 1997-10-22 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
IE960308A1 (en) 1996-04-23 1997-11-05 Kinerton Ltd Sustained release ionic conjugate
AU3828597A (en) 1996-06-14 1998-01-07 Emisphere Technologies, Inc. Microencapsulated fragrances and method for preparation
EP0886471A4 (en) 1996-11-18 2002-07-17 Emisphere Tech Inc METHODS AND COMPOSITIONS FOR INDUCING ORAL TOLERANCE IN MUZZLES
US6358504B1 (en) * 1997-02-07 2002-03-19 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5804688A (en) 1997-02-07 1998-09-08 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5990166A (en) 1997-02-07 1999-11-23 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5879681A (en) 1997-02-07 1999-03-09 Emisphere Technolgies Inc. Compounds and compositions for delivering active agents
US6060513A (en) 1997-02-07 2000-05-09 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5876710A (en) 1997-02-07 1999-03-02 Emisphere Technologies Inc. Compounds and compositions for delivering active agents
US6313088B1 (en) 1997-02-07 2001-11-06 Emisphere Technologies, Inc. 8-[(2-hydroxy-4-methoxy benzoyl) amino]-octanoic acid compositions for delivering active agents
US5939381A (en) 1997-02-07 1999-08-17 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5945126A (en) * 1997-02-13 1999-08-31 Oakwood Laboratories L.L.C. Continuous microsphere process
US5863944A (en) 1997-04-30 1999-01-26 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5962710A (en) 1997-05-09 1999-10-05 Emisphere Technologies, Inc. Method of preparing salicyloylamino acids
US5989463A (en) 1997-09-24 1999-11-23 Alkermes Controlled Therapeutics, Inc. Methods for fabricating polymer-based controlled release devices
US6270802B1 (en) 1998-10-28 2001-08-07 Oakwood Laboratories L.L.C. Method and apparatus for formulating microspheres and microcapsules
US6498153B1 (en) * 1998-12-31 2002-12-24 Akzo Nobel N.V. Extended release growth promoting two component composition
MXPA02004193A (es) * 1999-10-29 2002-12-13 Inhale Therapeutic Syst Composiciones de polvo seco que tienen caracteristicas de dispersion mejoradas.
US6767637B2 (en) * 2000-12-13 2004-07-27 Purdue Research Foundation Microencapsulation using ultrasonic atomizers
US9101949B2 (en) * 2005-08-04 2015-08-11 Eilaz Babaev Ultrasonic atomization and/or seperation system
US20070031611A1 (en) * 2005-08-04 2007-02-08 Babaev Eilaz P Ultrasound medical stent coating method and device
US7896539B2 (en) * 2005-08-16 2011-03-01 Bacoustics, Llc Ultrasound apparatus and methods for mixing liquids and coating stents
WO2007070957A1 (en) * 2005-12-21 2007-06-28 Monash University Process and apparatus for generating particles
TWI318894B (en) * 2006-08-07 2010-01-01 Ind Tech Res Inst System for fabricating nano particles
US20080142616A1 (en) * 2006-12-15 2008-06-19 Bacoustics Llc Method of Producing a Directed Spray
US7780095B2 (en) 2007-07-13 2010-08-24 Bacoustics, Llc Ultrasound pumping apparatus
US7753285B2 (en) 2007-07-13 2010-07-13 Bacoustics, Llc Echoing ultrasound atomization and/or mixing system
US10149826B2 (en) * 2015-01-20 2018-12-11 Hyalo Technologies, LLC Method of preparing microspheres

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4389330A (en) * 1980-10-06 1983-06-21 Stolle Research And Development Corporation Microencapsulation process
US4530840A (en) * 1982-07-29 1985-07-23 The Stolle Research And Development Corporation Injectable, long-acting microparticle formulation for the delivery of anti-inflammatory agents
FR2618674B1 (fr) * 1987-07-30 1990-06-15 Ire Celltarg Sa Microparticules comportant un polymere biodegradable controlant la liberation d'un principe actif antimalarique, compositions pharmaceutiques en comprenant et procede de preparation
US5019400A (en) * 1989-05-01 1991-05-28 Enzytech, Inc. Very low temperature casting of controlled release microspheres
ES2084698T5 (es) * 1989-05-04 2005-03-01 Southern Research Institute Procedimiento de encapsulacion.
US5091187A (en) * 1990-04-26 1992-02-25 Haynes Duncan H Phospholipid-coated microcrystals: injectable formulations of water-insoluble drugs

Also Published As

Publication number Publication date
US5389379A (en) 1995-02-14
CA2089354A1 (en) 1993-08-19
JPH05337360A (ja) 1993-12-21
FI930672A7 (fi) 1993-08-19
DE69302721D1 (de) 1996-06-27
GR3020417T3 (en) 1996-10-31
FI930672A0 (fi) 1993-02-16
EP0556917A1 (en) 1993-08-25
ATE138263T1 (de) 1996-06-15
FI930672L (fi) 1993-08-19
KR930017574A (ko) 1993-09-20
NO930557D0 (no) 1993-02-17
NZ245914A (en) 1995-02-24
EP0556917B1 (en) 1996-05-22
NO930557L (no) 1993-08-19
DK0556917T3 (da) 1996-09-16
AU658715B2 (en) 1995-04-27
DE69302721T2 (de) 1996-09-19
MX9300851A (es) 1994-08-31
ZA93929B (en) 1993-09-10
AU3313493A (en) 1993-08-19

Similar Documents

Publication Publication Date Title
MX9300851A (es) Un procedimiento para la preparacion de microcapsulas polimericas que contienen material biologicamente activo.
ATE221373T1 (de) Verfahren zur herstellung von präparaten mit kontrollierter wirkstofffreisetzung auf basis von polymeren
OA07419A (fr) Activateur de plamimogène de tissu humain, son procédé de production et composition pharmaceutique le contenant.
BR9908893A (pt) Composição polimérica lìquida para a liberação controlada de substâncias bioativas hidrofóbicas, e, processo para a liberação controlada de uma substância bioativa hidrofóbica em um animal, incluindo o ser humano
ES555277A0 (es) Procedimiento de obtencion de una composicion de injerto para la liberacion controlada de macromoleculas
ES2067873T3 (es) Composicion de champu.
DE3789956D1 (de) Polymere trägerzubereitungen, herstellung und verwendung.
NO931809L (no) Hemofilter
DK144382A (da) Latex til immobilisering af biologisk virksomme stoffer
SE8501111D0 (sv) Process for spinning hollow fiber membranes
ES2010960T3 (es) Polimeros con elevada velocidad de absorcion de liquidos acuosos.
DE69526787D1 (de) Biokompatibele und biodegradierbare Nanokapseln zur Absorption und Verabreichung von proteinischen Arzneimitteln
KR880002927A (ko) 폐색된 미소공 막
DE2326863A1 (de) Verfahren zur herstellung biokompatibler und biofunktioneller materialien
DE60238335D1 (de) Gerüstprodukt für die konstruktion von menschlichem knochengewebe, verfahren zu seiner herstellung
IL82197A (en) Wettable dry material in the form of an aqueous gel containing dispersed polymeric particles,process for preparation thereof and biological application thereof
ES2060715T3 (es) Medicamentos escasamente solubles inmovilizados en substancias polimericas de una manera adecuada para incrementar su grado de disolucion.
ATE78263T1 (de) Verfahren zur herstellung eines produkts von geliertem cellulosetriacetat und das so hergestellte produkt.
SE8601563D0 (sv) Matrismaterial, forfarande for framstellning derav och anvendning derav
DE69009784D1 (de) Verfahren zur Behandlung von Polyesterfasern, die so behandelten Polyesterfasern und Verbundmaterial aus diesen Polyesterfasern und Nitrilgruppen enthaltendes hochgesättigtes Kopolymergummi.
ATE50586T1 (de) Absorbierendes polymeres material und dessen herstellung.
JPS6440418A (en) Sustained release material for drug
DE69943225D1 (de) Flüssige Polymerlosung zur Kontrollierten freisetzung von bioaktiven substanzen
DE50113104D1 (de) Mit Blut und Gewebe verträgliche Membranen aus P(AN/NVP)-Misch-polymeren und deren Anwendung im medizinischen Bereich
MX171250B (es) Composicion de polimeros modificados en solucion

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 556917

Country of ref document: ES

FG2A Definitive protection

Ref document number: 556917

Country of ref document: ES