ES209285A1 - A procedure for the preparation of compounds of the pregnan series (Machine-translation by Google Translate, not legally binding) - Google Patents
A procedure for the preparation of compounds of the pregnan series (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES209285A1 ES209285A1 ES0209285A ES209285A ES209285A1 ES 209285 A1 ES209285 A1 ES 209285A1 ES 0209285 A ES0209285 A ES 0209285A ES 209285 A ES209285 A ES 209285A ES 209285 A1 ES209285 A1 ES 209285A1
- Authority
- ES
- Spain
- Prior art keywords
- translation
- compounds
- preparation
- hydroxyl group
- machine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- JWMFYGXQPXQEEM-WZBAXQLOSA-N pregnane Chemical class C1CC2CCCC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](CC)[C@@]1(C)CC2 JWMFYGXQPXQEEM-WZBAXQLOSA-N 0.000 title 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 150000001721 carbon Chemical group 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- LELOWRISYMNNSU-UHFFFAOYSA-N hydrogen cyanide Chemical compound N#C LELOWRISYMNNSU-UHFFFAOYSA-N 0.000 abstract 2
- XFXPMWWXUTWYJX-UHFFFAOYSA-N Cyanide Chemical compound N#[C-] XFXPMWWXUTWYJX-UHFFFAOYSA-N 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 238000000354 decomposition reaction Methods 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 230000000640 hydroxylating effect Effects 0.000 abstract 1
- 125000000468 ketone group Chemical group 0.000 abstract 1
- 229910000489 osmium tetroxide Inorganic materials 0.000 abstract 1
- 239000012285 osmium tetroxide Substances 0.000 abstract 1
- 230000001590 oxidative effect Effects 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 150000003128 pregnanes Chemical class 0.000 abstract 1
- 230000002829 reductive effect Effects 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 150000005691 triesters Chemical class 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
A process for the preparation of compounds of the pregnane series that possess a group containing oxygen in position 11 characterized by the addition of hydrocyanic acid or trihydroxy-3 beta 11 alpha 21-pregnanone-20 triesters and because water is separated as leads to the formation of a double bond cyanide between the carbon atoms 17 and 20 because this compound is then subjected to a saponificiation after which the free hydroxyl group is partially esterified on the carbon atom 21 then a hydroxylating people such as osmium tetroxide on the ester formed and the resulting product is subjected to oxidative and reductive decomposition in any order from which it results that the free hydroxyl group (s) is oxidized to a keto group or a hydroxyl group respectively is introduced into the carbon atom 17 after which a double bond is introduced in a manner known per se into itself and the carbon atoms 4 and 5 and the resulting substance is saponified and re-esterified if desired. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL169598 | 1952-05-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES209285A1 true ES209285A1 (en) | 1953-07-16 |
Family
ID=38466695
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES0209285A Expired ES209285A1 (en) | 1952-05-15 | 1953-05-13 | A procedure for the preparation of compounds of the pregnan series (Machine-translation by Google Translate, not legally binding) |
Country Status (1)
| Country | Link |
|---|---|
| ES (1) | ES209285A1 (en) |
-
1953
- 1953-05-13 ES ES0209285A patent/ES209285A1/en not_active Expired
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