ES2092957A1 - Procedimiento de preparacion de intermedios para la sintesis de derivados dicloro-substituidos con actividad antifungica. - Google Patents
Procedimiento de preparacion de intermedios para la sintesis de derivados dicloro-substituidos con actividad antifungica.Info
- Publication number
- ES2092957A1 ES2092957A1 ES09402436A ES9402436A ES2092957A1 ES 2092957 A1 ES2092957 A1 ES 2092957A1 ES 09402436 A ES09402436 A ES 09402436A ES 9402436 A ES9402436 A ES 9402436A ES 2092957 A1 ES2092957 A1 ES 2092957A1
- Authority
- ES
- Spain
- Prior art keywords
- dichloro
- antifungal activity
- synthesis
- substituted derivatives
- preparing intermediates
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000000843 anti-fungal effect Effects 0.000 title abstract 3
- 239000000543 intermediate Substances 0.000 title abstract 3
- 230000015572 biosynthetic process Effects 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 238000003786 synthesis reaction Methods 0.000 title abstract 2
- PEZPGYVJQOXHEF-UHFFFAOYSA-N 1,3-dichloro-5,6-dihydrodibenzo[2,1-b:4',1'-f][7]annulen-11-one Chemical compound C1CC2=CC=CC=C2C(=O)C2=C(Cl)C=C(Cl)C=C12 PEZPGYVJQOXHEF-UHFFFAOYSA-N 0.000 abstract 3
- ZWLPBLYKEWSWPD-UHFFFAOYSA-N o-toluic acid Chemical compound CC1=CC=CC=C1C(O)=O ZWLPBLYKEWSWPD-UHFFFAOYSA-N 0.000 abstract 2
- 238000002360 preparation method Methods 0.000 abstract 2
- MPTJIDOGFUQSQH-UHFFFAOYSA-N 1-(2,4-dichloro-10,11-dihydrodibenzo[a,d][7]annulen-5-yl)imidazole Chemical compound C12=CC=CC=C2CCC2=CC(Cl)=CC(Cl)=C2C1N1C=CN=C1 MPTJIDOGFUQSQH-UHFFFAOYSA-N 0.000 abstract 1
- MNGSCJCRQAQXSF-UHFFFAOYSA-N 2-[2-(3,5-dichlorophenyl)ethyl]benzoic acid Chemical compound OC(=O)C1=CC=CC=C1CCC1=CC(Cl)=CC(Cl)=C1 MNGSCJCRQAQXSF-UHFFFAOYSA-N 0.000 abstract 1
- -1 3,5-dichlorobenzyl halide Chemical class 0.000 abstract 1
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 230000029936 alkylation Effects 0.000 abstract 1
- 238000005804 alkylation reaction Methods 0.000 abstract 1
- 238000003402 intramolecular cyclocondensation reaction Methods 0.000 abstract 1
- 229910052744 lithium Inorganic materials 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 229920000137 polyphosphoric acid Polymers 0.000 abstract 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PROCEDIMIENTO DE PREPARACION DE INTERMEDIOS PARA LA SINTESIS DE DERIVADOS DICLORO-SUSTITUIDOS CON ACTIVIDAD ANTIFUNGICA.NUEVO PROCEDIMIENTO PARA PREPARAR EL ACIDO 2-[2-(3,5-DICLOROFENIL)ETIL]BENZOICO (II), Y LA 2,4-DICLORO-10,11-DIHIDRO-5H-DIBENZO[A,D]CICLOHEPTEN-5-ONA (III), QUE COMPRENDE LA ALQUILACION DEL DIANION CON LITIO DEL ACIDO 2-METIL-BENZOICO POR UN HALOGENURO DE 3,5-DICLOROBENZILO (I) Y LA CICLACION INTRAMOLECULAR DEL ACIDO (II) ASI OBTENIDO, UTILIZANDO ACIDO POLIFOSFORICO. LA 2,4-DICLORO-10,11-DIHIDRO-5H-DIBENZO[A,D]CICLOHEPTEN-5-ONA (III) ES UTIL COMO INTERMEDIO EN LA PREPARACION DEL 1-(2,4-DICLORO-10,11-DIHIDRO-5H-DIBENZO[A,D]CICLOHEPTEN-5-I1)-1H-IMIDAZOL QUE TIENE ACTIVIDAD ANTIFUNGICA.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES9402436A ES2092957B1 (es) | 1994-11-28 | 1994-11-28 | Procedimiento de preparacion de intermedios para la sintesis de derivados dicloro-substituidos con actividad antifungica. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES9402436A ES2092957B1 (es) | 1994-11-28 | 1994-11-28 | Procedimiento de preparacion de intermedios para la sintesis de derivados dicloro-substituidos con actividad antifungica. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES2092957A1 true ES2092957A1 (es) | 1996-12-01 |
| ES2092957B1 ES2092957B1 (es) | 1997-08-01 |
Family
ID=8288108
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES9402436A Expired - Fee Related ES2092957B1 (es) | 1994-11-28 | 1994-11-28 | Procedimiento de preparacion de intermedios para la sintesis de derivados dicloro-substituidos con actividad antifungica. |
Country Status (1)
| Country | Link |
|---|---|
| ES (1) | ES2092957B1 (es) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999021838A1 (es) * | 1997-10-28 | 1999-05-06 | Laboratorios S.A.L.V.A.T., S.A. | Procedimiento de preparacion del eberconazol e intermedios para el mismo |
| RU2560727C1 (ru) * | 2014-09-22 | 2015-08-20 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Кубанский государственный университет" (ФГБОУ ВПО "КубГУ") | Способ получения 1,3-дикарбонильных соединений, содержащих дибензосуберенильный фрагмент |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104030908B (zh) * | 2014-05-28 | 2016-01-20 | 健雄职业技术学院 | 一种2,4-二氯-10,11-二氢-5H-二苯并[a,d]环庚烯-5-酮的制备方法 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2012297A6 (es) * | 1989-04-10 | 1990-03-01 | Espnola De Especialidades Farm | Procedimiento para la obtencion de nuevos derivados imidazolicos diclorados con actividad antifungica. |
-
1994
- 1994-11-28 ES ES9402436A patent/ES2092957B1/es not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2012297A6 (es) * | 1989-04-10 | 1990-03-01 | Espnola De Especialidades Farm | Procedimiento para la obtencion de nuevos derivados imidazolicos diclorados con actividad antifungica. |
Non-Patent Citations (1)
| Title |
|---|
| X. CIRERA. Tesis doctoral. Instituto Químico Sarriá, Barcelona, 1983, páginas 165-167 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999021838A1 (es) * | 1997-10-28 | 1999-05-06 | Laboratorios S.A.L.V.A.T., S.A. | Procedimiento de preparacion del eberconazol e intermedios para el mismo |
| RU2560727C1 (ru) * | 2014-09-22 | 2015-08-20 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Кубанский государственный университет" (ФГБОУ ВПО "КубГУ") | Способ получения 1,3-дикарбонильных соединений, содержащих дибензосуберенильный фрагмент |
Also Published As
| Publication number | Publication date |
|---|---|
| ES2092957B1 (es) | 1997-08-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EC2A | Search report published |
Date of ref document: 19961201 Kind code of ref document: A1 Effective date: 19961201 |
|
| PC2A | Transfer of patent | ||
| FD2A | Announcement of lapse in spain |
Effective date: 20150826 |