ES2094224T3 - Aparato de deteccion de un analito inmovilizado. - Google Patents

Aparato de deteccion de un analito inmovilizado.

Info

Publication number
ES2094224T3
ES2094224T3 ES91910056T ES91910056T ES2094224T3 ES 2094224 T3 ES2094224 T3 ES 2094224T3 ES 91910056 T ES91910056 T ES 91910056T ES 91910056 T ES91910056 T ES 91910056T ES 2094224 T3 ES2094224 T3 ES 2094224T3
Authority
ES
Spain
Prior art keywords
receptive
receptive material
technique
preformed surface
reaction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91910056T
Other languages
English (en)
Inventor
Jeffrey B Etter
Diana M Maul
Garret R Moddel
Timothy Starzl
H John Hanlin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Inverness Medical Biostar Inc
Original Assignee
Biostar Inc USA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biostar Inc USA filed Critical Biostar Inc USA
Application granted granted Critical
Publication of ES2094224T3 publication Critical patent/ES2094224T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N21/4738—Diffuse reflection, e.g. also for testing fluids, fibrous materials
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/21—Polarisation-affecting properties
    • G01N21/211—Ellipsometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/41—Refractivity; Phase-affecting properties, e.g. optical path length
    • G01N21/45—Refractivity; Phase-affecting properties, e.g. optical path length using interferometric methods; using Schlieren methods

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Nanotechnology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Materials Engineering (AREA)
  • Microbiology (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Composite Materials (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)

Abstract

UN APARATO Y TECNICA DE ENSAYO PARA LA DETECCION DE UNA REACCION ENTRE MATERIAL RECEPTIVO Y UN ANALITICO, DONDE LA REACCION EN SI GENERA UNA SEÑAL DE INTERFERENCIA OPTICA. LA TECNICA DE ENSAYO SE BASA EN LA AFINIDAD DEL ANALITICO PARA EL LIGANDO RECEPTIVO. LA REACCION RESULTANTE ENTRE LOS DOS PARTICIPES AGLOMERANTES PRODUCE DETECCION CUALITATIVA Y/O CUANTITATIVA DEL ANALITICO QUIMICO, BIOQUIMICO O BIOLOGICO EN EN UNA MUESTRA. UN APARATO DE ENSAYO PREFERIDO COMPRENDE (A) UN SUSTRATO CUYA SUPERFICIE REFLEJA DIFUSAMENTE Y ESTA RECUBIERTA CON CAPAS OPTICAS ANTI REFLECTANTES; (B) UNA FINA CAPA DE MATERIAL ANTI REFLECTANTE ACTIVADA PARA AGLOMERAR EL MATERIAL RECEPTIVO; (C) UNA CAPA DE MATERIAL RECEPTIVO CAPAZ DE INTERACTUAR CON LA ESPECIES QUE SE ENSAYARAN. LOS COMPONENTES A-C SE PRODUCEN EN UNA SUPERFICIE PREFORMADA ACTIVA OPTICAMENTE CON RESPECTO A LUZ AL MENOS EN UNA CIERTA BANDA DE LONGITUDES DE ONDA. LA TECNICA DE ENSAYO COMPRENDE LOS PASOS DE (D) CONTACTAR LA SUPERFICIE PREFORMADA CON LA MUESTRA; Y (E) OBSERVAR LAS PROPIEDADES OPTICAS DE LA SUPERFICIE PREFORMADA PARA DETECTAR VISUALMENTE UN CAMBIO EN LAS PROPIEDADES OPTICAS DE LA SUPERFICIE PREFORMADA COMO RESULTADO DE LA AGLOMERACION DEL ANALITICO DENTRO DEL EJEMPLO AL MATERIAL RECEPTIVO.
ES91910056T 1989-09-18 1991-03-20 Aparato de deteccion de un analito inmovilizado. Expired - Lifetime ES2094224T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US40829689A 1989-09-18 1989-09-18
PCT/US1991/001781 WO1992016826A1 (en) 1989-09-18 1991-03-20 Apparatus for detection of an immobilized analyte

Publications (1)

Publication Number Publication Date
ES2094224T3 true ES2094224T3 (es) 1997-01-16

Family

ID=23615684

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91910056T Expired - Lifetime ES2094224T3 (es) 1989-09-18 1991-03-20 Aparato de deteccion de un analito inmovilizado.

Country Status (6)

Country Link
EP (1) EP0539383B1 (es)
JP (1) JP3193373B2 (es)
AU (2) AU6513790A (es)
DE (1) DE69122252T2 (es)
ES (1) ES2094224T3 (es)
WO (2) WO1991004483A1 (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4200088C2 (de) * 1992-01-04 1997-06-19 Nahm Werner Verfahren und Vorrichtung zum optischen Nachweis einer An- oder Einlagerung mindestens einer stofflichen Spezies in oder an mindestens einer dünnen Schicht
EP1126278B1 (en) * 1992-07-31 2007-05-23 Inverness Medical - BioStar Inc. Devices and methods for detection of an analyte based upon light interference
US5413939A (en) * 1993-06-29 1995-05-09 First Medical, Inc. Solid-phase binding assay system for interferometrically measuring analytes bound to an active receptor
EP0787298A1 (en) * 1995-08-22 1997-08-06 Koninklijke Philips Electronics N.V. Method and device for investigating non-linear optical behavior of a layer formed from first and second reactants e.g. antibody and antigen
US7153651B1 (en) 1996-10-31 2006-12-26 Inverness Medical - Biostar, Inc. Flow-through optical assay devices providing laminar flow of fluid samples, and methods of construction thereof
WO2000058726A1 (fr) 1999-03-29 2000-10-05 Asahi Kasei Kabushiki Kaisha Procede de numeration des leucocytes dans un echantillon de sang complet
FR2818382B1 (fr) * 2000-12-20 2003-02-21 Commissariat Energie Atomique Support pour determiner un analyte tel qu'une cible adn ou arn, comportant un filtre spectral selectif
US7288405B2 (en) 2001-04-25 2007-10-30 Cornell Research Foundation, Inc. Devices and methods for pharmacokinetic-based cell culture system
US20030108726A1 (en) * 2001-10-18 2003-06-12 Schembri Carol T. Chemical arrays
US6841663B2 (en) 2001-10-18 2005-01-11 Agilent Technologies, Inc. Chemical arrays
FR2843634B1 (fr) * 2002-08-13 2004-10-22 Genewave Dispositif de support d'elements chromophores
US7384742B2 (en) * 2002-08-16 2008-06-10 Decision Biomarkers, Inc. Substrates for isolating reacting and microscopically analyzing materials
JP2006515065A (ja) † 2002-08-16 2006-05-18 ディシジョン バイオマーカーズ インコーポレイテッド 蛍光配列の読み取り
US7394547B2 (en) * 2003-11-06 2008-07-01 Fortebio, Inc. Fiber-optic assay apparatus based on phase-shift interferometry
US20100261288A1 (en) 2005-06-13 2010-10-14 Fortebio, Inc. Tip tray assembly for optical sensors
KR100869066B1 (ko) * 2006-04-17 2008-11-17 한국기술산업 (주) 일 방향으로 정렬된 패턴의 바이오 칩, 이를 제조하는방법, 및 바이오 칩에 구비되는 대상물을 검출하는 방법
CN104328050B (zh) 2008-07-16 2017-12-15 儿童医疗中心有限公司 具有微通道的器官模仿装置及其使用和制造方法
US9725687B2 (en) 2011-12-09 2017-08-08 President And Fellows Of Harvard College Integrated human organ-on-chip microphysiological systems

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE789090A (fr) * 1971-09-22 1973-01-15 Western Electric Co Procede et solution d'attaque de semi-conducteurs
US4054646A (en) * 1973-07-30 1977-10-18 General Electric Method and apparatus for detection of antibodies and antigens
US4090849A (en) * 1976-12-20 1978-05-23 General Electric Company Diagnostic device and manufacture thereof
JPS56144541A (en) * 1980-04-11 1981-11-10 Fujitsu Ltd Etching method
US4654300A (en) * 1982-04-02 1987-03-31 Syntex (U.S.A.) Inc. Fluorescent microbead quenching assay
DE3215484A1 (de) * 1982-04-26 1983-11-03 Sagax Instrument AB, 18302 Täby Aus mehreren schichten bestehender schichtkoerper und verfahren zum nachweis und/oder messen der konzentration einer chemischen substanz, insbesondere biologischer herkunft
AU570425B2 (en) * 1982-12-21 1988-03-17 Applied Research Systems Ars Holding N.V. Assay technique
US4647544A (en) * 1984-06-25 1987-03-03 Nicoli David F Immunoassay using optical interference detection
US4737464A (en) * 1985-09-26 1988-04-12 Molecular Devices Corporation Solid-state optical assay imaging apparatus
CA1317206C (en) * 1986-09-22 1993-05-04 Takeyuki Kawaguchi Method for detecting a component of a biological system and detection device and kit therefor
CA1305921C (en) * 1987-01-30 1992-08-04 Eric K. Gustafson Diffraction immunoassay and reagents
US4921878A (en) * 1987-06-05 1990-05-01 Pall Corporation Non-fluorescing, non-reflective polyamide for use in diagnostic testing
DE3852797T2 (de) * 1987-08-11 1995-06-29 Eiji Ishikawa Hoch empfindlicher Immunoassay.
EP0353895A1 (en) * 1988-07-18 1990-02-07 MITSUI TOATSU CHEMICALS, Inc. Immunoassay method

Also Published As

Publication number Publication date
AU653940B2 (en) 1994-10-20
HK1000735A1 (en) 1998-04-24
JPH05506936A (ja) 1993-10-07
DE69122252D1 (de) 1996-10-24
EP0539383A1 (en) 1993-05-05
AU6513790A (en) 1991-04-18
WO1992016826A1 (en) 1992-10-01
AU7900491A (en) 1992-10-21
JP3193373B2 (ja) 2001-07-30
DE69122252T2 (de) 1997-02-06
EP0539383B1 (en) 1996-09-18
WO1991004483A1 (en) 1991-04-04
EP0539383A4 (es) 1994-05-04

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