ES2094479T3 - Uso de esteres de l-2-oxotiazolidina-4-carboxilato para la preparacion de un medicamento para estimular la sintesis intracelular de glutation. - Google Patents

Uso de esteres de l-2-oxotiazolidina-4-carboxilato para la preparacion de un medicamento para estimular la sintesis intracelular de glutation.

Info

Publication number
ES2094479T3
ES2094479T3 ES93303213T ES93303213T ES2094479T3 ES 2094479 T3 ES2094479 T3 ES 2094479T3 ES 93303213 T ES93303213 T ES 93303213T ES 93303213 T ES93303213 T ES 93303213T ES 2094479 T3 ES2094479 T3 ES 2094479T3
Authority
ES
Spain
Prior art keywords
glutation
oxotiazolidine
medication
stimulate
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93303213T
Other languages
English (en)
Inventor
W Bruce Rowe
Dennis L Goldberg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Transcend Therapeutics Inc
Original Assignee
Transcend Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25462874&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2094479(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Transcend Therapeutics Inc filed Critical Transcend Therapeutics Inc
Application granted granted Critical
Publication of ES2094479T3 publication Critical patent/ES2094479T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE PRESENTA UN METODO PARA ESTIMULAR LA SINTESIS INTRACELULAR DE GLUTATION QUE COMPRENDE LOS PASOS DE ADMINISTRAR A UN MAMIFERO UNA CANTIDAD TERAPEUTICAMENTE EFECTIVA DE UN ESTER DE 2 - OXOTIAZOLINA 4 - CARBOXILATO.
ES93303213T 1992-08-20 1993-04-23 Uso de esteres de l-2-oxotiazolidina-4-carboxilato para la preparacion de un medicamento para estimular la sintesis intracelular de glutation. Expired - Lifetime ES2094479T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/932,761 US5208249A (en) 1992-08-20 1992-08-20 Method for stimulating intracellular synthesis of glutathione using esters of L-2-oxothiazolidine-4-carboxylate

Publications (1)

Publication Number Publication Date
ES2094479T3 true ES2094479T3 (es) 1997-01-16

Family

ID=25462874

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93303213T Expired - Lifetime ES2094479T3 (es) 1992-08-20 1993-04-23 Uso de esteres de l-2-oxotiazolidina-4-carboxilato para la preparacion de un medicamento para estimular la sintesis intracelular de glutation.

Country Status (7)

Country Link
US (1) US5208249A (es)
EP (1) EP0583863B1 (es)
JP (1) JPH06183973A (es)
AU (1) AU666931B2 (es)
CA (1) CA2096036C (es)
DE (1) DE69306063T2 (es)
ES (1) ES2094479T3 (es)

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ES2092539T3 (es) * 1991-01-10 1996-12-01 Transcend Therapeutics Inc Uso de derivados de la tiazolidina-4-carboxilato para el tratamiento de enfermedades pulmonares.
US5747459A (en) * 1991-02-04 1998-05-05 Nestec, Ltd. Method for insuring adequate intracellular glutathione in tissue
US5430045A (en) * 1992-04-23 1995-07-04 Free Radical Sciences, Inc. Method of reducing or preventing bone marrow hypoplasia
EP0656201A1 (en) * 1993-11-09 1995-06-07 Transcend Therapeutics, Inc. Use of stimulators of glutathione synthesis as hait growth promotors
US5447712A (en) * 1993-12-09 1995-09-05 Free Radical Sciences Method of reducing cyclophosphamide induced hemorrhagic cystitis
US5596011A (en) * 1995-04-06 1997-01-21 Repine; Karen M. Method for the treatment of macular degeneration
FR2742750B1 (fr) * 1995-12-22 1998-01-30 Oreal Nouveaux derives de l'acide l-2-oxothiazolidine 4-carboxylique et leur utilisation pour le soin de la peau
FR2742658B1 (fr) * 1995-12-22 1998-01-30 Oreal Utilisation de la procysteine comme agent depigmentant
FR2751331A1 (fr) * 1996-07-18 1998-01-23 Oreal Nouveau derive de l'acide kojique et son utilisation comme agent depigmentant
US5780489A (en) * 1996-08-21 1998-07-14 Brooks; Benjamin Rix Method for treating amyotrophic lateral sclerosis
CA2277911C (en) * 1997-01-13 2010-09-14 Emory University Compounds and their combinations for the treatment of influenza infection
RU2144374C1 (ru) * 1998-11-23 2000-01-20 Закрытое акционерное общество "ВАМ" Способ получения композита окисленного глутатиона с cis-диаминодихлорплатиной и фармацевтических композиций на его основе, регулирующих метаболизм, пролиферацию, дифференцировку и механизмы апоптоза нормальных и трансформированных клеток
US20070142267A1 (en) * 1998-11-23 2007-06-21 Novelos Therapeutics, Inc. Methods for production of the oxidized glutathione composite with CIS-diamminedichloroplatinum and pharmaceutical compositions based thereof regulating metabolism, proliferation, differentiation and apoptotic mechanisms for normal and transformed cells
AU7330200A (en) * 1999-08-09 2001-05-10 Webb-Waring Institute For Biomedical Research A method for the treatment of ocular oxidative stress
CA2419845A1 (en) 1999-08-17 2002-02-22 Phyllis G. Paterson Improved treatment for acute physical insult to the central nervous system
FR2816838B1 (fr) * 2000-11-17 2004-12-03 Oreal Utilisation de derives de l'acide 2-oxothiazolidine- 4-carboxylique comme agents prodesquamants
US20020137779A1 (en) * 2001-02-14 2002-09-26 Advanced Biochemicals Inc. Use of L-2-oxothiazolidine-4-carboxylic acid for the treatment of type 2 diabetes
RU2301800C2 (ru) * 2002-04-19 2007-06-27 Аризона Боард Оф Ридженс Он Бихав Оф Зе Юниверсити Оф Аризона Способ модулирования фототоксичности
US7022317B2 (en) 2003-04-25 2006-04-04 L'oreal Heterocyclic derivatives of 2-oxothiazolidine-4-carboxylic acid, and use as active photoprotective agents
FR2854160B1 (fr) * 2003-04-25 2005-06-17 Oreal Nouveaux derives heterocycliques de l'acide 2-oxothiazolidine4-carboxylique, utilisation comme agent de photoprotection active
FR2877004B1 (fr) * 2004-10-21 2007-03-09 Oreal Esters et amides silaniques d'acide 2-oxothiazolidine-4- carboxylique et leurs utilisations cosmetiques.
CN100434062C (zh) * 2006-08-28 2008-11-19 卢小明 L-2-氧代硫氮杂戍环烷-4-羧酸及其酯类衍生物作为皮肤药妆品的应用
US20110064828A1 (en) * 2009-09-11 2011-03-17 Novelos Therapeutics, Incorporated Treatment of metastatic tumors and other conditions
US10273205B2 (en) 2011-01-03 2019-04-30 The William M. Yarbrough Foundation Isothiocyanate functional surfactants, formulations incorporating isothiocyanate functional surfactants and associated methods for treating biofilms
US10640464B2 (en) 2011-01-03 2020-05-05 The William M. Yarbrough Foundation Use of isothiocyanate functional surfactants as Nrf2 inducers to treat epidermolysis bullosa simplex and related diseases
US11279674B2 (en) 2011-01-03 2022-03-22 The William M. Yarbrough Foundation Isothiocyanate functional surfactant and associated method of use
US10647668B2 (en) 2011-01-03 2020-05-12 The William M. Yarbrough Foundation Isothiocyanate functional surfactant and associated method of use
US8933119B2 (en) 2011-01-03 2015-01-13 The William M. Yarbrough Foundation Method for treating phytophotodermatitis
US9962361B2 (en) 2011-01-03 2018-05-08 The William M. Yarbrough Foundation Isothiocyanate functional surfactants, formulations incorporating the same, and associated methods of use
US10308599B2 (en) 2011-01-03 2019-06-04 The William M. Yarbrough Foundation Isothiocyanate functional surfactants, formulations incorporating the same, and associated methods of use
US11407713B2 (en) 2011-01-03 2022-08-09 The William M. Yarbrough Foundation Isothiocyanate functional surfactants, formulations incorporating the same, and associated methods of use
US8865765B2 (en) 2011-01-12 2014-10-21 The William M. Yarbrough Foundation Method for treating eczema
US9532969B2 (en) 2011-02-08 2017-01-03 The William M. Yarbrough Foundation Method for treating psoriasis
US8865772B2 (en) 2012-07-26 2014-10-21 The William M. Yarbrough Foundation Method for treating skin cancer
US9839621B2 (en) 2012-07-26 2017-12-12 The William M. Yarbrough Foundation Method for treating bladder cancer
US9949943B2 (en) 2012-07-26 2018-04-24 The William M. Yarbrough Foundation Method for treating neurodegenerative diseases
US10335387B2 (en) 2012-07-26 2019-07-02 The William M. Yarbrough Foundation Method for treating infectious diseases with isothiocyanate functional compounds
US10434081B2 (en) 2012-07-26 2019-10-08 The William M. Yarbrough Foundation Inhibitors of macrophage migration inhibitory factor
US10441561B2 (en) 2012-07-26 2019-10-15 The William M. Yanbrough Foundation Method for treating benign prostatic hyperplasia (BPH), prostatitis, and prostate cancer
US10080734B2 (en) 2012-07-26 2018-09-25 The William M. Yarbrough Foundation Method for treating autism and other neurodevelopmental disorders
US10434082B2 (en) 2012-07-26 2019-10-08 The William M. Yarbrough Foundation Isothiocyanate functional compounds augmented with secondary antineoplastic medicaments and associated methods for treating neoplasms
KR102601321B1 (ko) 2015-07-30 2023-11-10 메르크 파텐트 게엠베하 세포 내 글루타티온 수준을 증가시키는 방법

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4335210A (en) * 1981-02-11 1982-06-15 Cornell Research Foundation Method of producing L-cysteine
US4438124A (en) * 1981-02-11 1984-03-20 Cornell Research Foundation, Inc. Cysteine delivery system
US4434158A (en) * 1981-02-11 1984-02-28 Cornell Research Foundation Cysteine delivery system
US4647571A (en) * 1981-02-11 1987-03-03 Cornell Research Foundation Cysteine delivery composition
US4665082A (en) * 1981-02-11 1987-05-12 Cornell Research Foundation Cysteine delivery system
US4710489A (en) * 1985-04-22 1987-12-01 Cornell Research Foundation, Inc. Glutathione delivery system
JPH02202818A (ja) * 1988-12-09 1990-08-10 Allergan Inc 白内障の治療における２―置換―チアゾリジン―４―カルボン酸類の用途
US5095027A (en) * 1991-02-28 1992-03-10 Clintec Nutrition Co. Method for treating reperfusion injury employing L-2-oxothiazolidine-4-carboxylic acid
AU661379B2 (en) * 1992-04-23 1995-07-20 Transcend Therapeutics, Inc Method of reducing or preventing toxicity associated with antiretroviral therapy
US5306724A (en) * 1992-08-17 1994-04-26 Clintec Nutrition Company Method for preventing and treating atherosclerosis
AU5040493A (en) * 1992-11-30 1994-06-09 Transcend Therapeutics, Inc Method for treating systemic inflammatory response syndrome

Also Published As

Publication number Publication date
CA2096036C (en) 1999-04-27
DE69306063D1 (de) 1997-01-02
CA2096036A1 (en) 1994-02-21
EP0583863B1 (en) 1996-11-20
US5208249A (en) 1993-05-04
JPH06183973A (ja) 1994-07-05
AU3718193A (en) 1994-02-24
AU666931B2 (en) 1996-02-29
DE69306063T2 (de) 1997-05-22
EP0583863A1 (en) 1994-02-23

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