ES2094811T3 - Sintesis enzimatica de fosfatidos solubles a partir de fosfolipidos. - Google Patents

Sintesis enzimatica de fosfatidos solubles a partir de fosfolipidos.

Info

Publication number
ES2094811T3
ES2094811T3 ES91908298T ES91908298T ES2094811T3 ES 2094811 T3 ES2094811 T3 ES 2094811T3 ES 91908298 T ES91908298 T ES 91908298T ES 91908298 T ES91908298 T ES 91908298T ES 2094811 T3 ES2094811 T3 ES 2094811T3
Authority
ES
Spain
Prior art keywords
salt
soluble
monovalent
solution
enzyme
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91908298T
Other languages
English (en)
Inventor
Paul A Tremblay
Frank Marziani
John A F Tino
Frank G Pilkiewicz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Elan Pharmaceuticals LLC
Original Assignee
Liposome Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Liposome Co Inc filed Critical Liposome Co Inc
Application granted granted Critical
Publication of ES2094811T3 publication Critical patent/ES2094811T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/10—Phosphatides, e.g. lecithin
    • C07F9/106—Adducts, complexes, salts of phosphatides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6436—Fatty acid esters
    • C12P7/6445—Glycerides
    • C12P7/6481—Phosphoglycerides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P9/00—Preparation of organic compounds containing a metal or atom other than H, N, C, O, S or halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Dispersion Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Molecular Biology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Fodder In General (AREA)

Abstract

SE PRESENTA UN METODO PARA PREPARAR UNA SAL MONOVALENTE SOLUBLE DE UN ESTER DE FOSFATIDIL QUE COMPRENDE LA REACCION DE UN FOSFOLIPIDO CON UN ALCOHOL PRIMARIO EN LA PRESENCIA DE UN CATALIZADOR DE ENZIMAS EN UNA SOLUCION CATIONICA DIVALENTE AMORTIGUADA Y UN SOLVENTE INMISCIBLE EN AGUA QUE NO ACTIVE LA ENZIMA, PARA FORMAR UNA SAL CATIONICA DIVALENTE DEL ESTER DE FOSFATIDIL, Y LA SUSPENSION DEL PRODUCTO EN LA PRESENCIA DE UNA CANTIDAD ESTOICOMETRICA DE UNA SAL CATIONICA MONOVALENTE CUYO ANION FORME UNA SAL INSOLUBLE CON EL CATION DIVALENTE. EL USO DE LA CROMATOGRAFIA DE PARTICION CENTRIFUGA FACILITA LA REACCION DE LA ENZIMA. LA SAL MONOVALENTE ES PREFERIBLEMENTE UNA SAL MEZCLADA DE AMONIO / SODIO.
ES91908298T 1990-04-17 1991-04-16 Sintesis enzimatica de fosfatidos solubles a partir de fosfolipidos. Expired - Lifetime ES2094811T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US51328590A 1990-04-17 1990-04-17

Publications (1)

Publication Number Publication Date
ES2094811T3 true ES2094811T3 (es) 1997-02-01

Family

ID=24042616

Family Applications (2)

Application Number Title Priority Date Filing Date
ES91908298T Expired - Lifetime ES2094811T3 (es) 1990-04-17 1991-04-16 Sintesis enzimatica de fosfatidos solubles a partir de fosfolipidos.
ES96100985T Expired - Lifetime ES2132780T3 (es) 1990-04-17 1991-04-16 Sintesis enzimatica de fosfatidos solubles a partir de fosfolipidos.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES96100985T Expired - Lifetime ES2132780T3 (es) 1990-04-17 1991-04-16 Sintesis enzimatica de fosfatidos solubles a partir de fosfolipidos.

Country Status (15)

Country Link
EP (2) EP0727491B1 (es)
JP (1) JP3169132B2 (es)
AT (2) ATE145244T1 (es)
AU (1) AU646458B2 (es)
CA (1) CA2080907C (es)
DE (2) DE69131404T2 (es)
DK (2) DK0528834T3 (es)
ES (2) ES2094811T3 (es)
GR (2) GR3022375T3 (es)
HU (1) HU212928B (es)
IE (1) IE911264A1 (es)
NZ (1) NZ237845A (es)
PT (1) PT97391B (es)
WO (1) WO1991016444A1 (es)
ZA (1) ZA912877B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060165606A1 (en) 1997-09-29 2006-07-27 Nektar Therapeutics Pulmonary delivery particles comprising water insoluble or crystalline active agents
US6309623B1 (en) 1997-09-29 2001-10-30 Inhale Therapeutic Systems, Inc. Stabilized preparations for use in metered dose inhalers
US6565885B1 (en) 1997-09-29 2003-05-20 Inhale Therapeutic Systems, Inc. Methods of spray drying pharmaceutical compositions
US7871598B1 (en) * 2000-05-10 2011-01-18 Novartis Ag Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use
PT1280520E (pt) 2000-05-10 2014-12-16 Novartis Ag Pós à base de fosfolípidos para administração de fármacos
DE10142014B4 (de) 2001-08-28 2004-11-11 Degussa Bioactives Deutschland Gmbh & Co. Kg Verfahren zur Herstellung von Phosphatidylserin
TWI324518B (en) 2001-12-19 2010-05-11 Nektar Therapeutics Pulmonary delivery of aminoglycosides
US6878532B1 (en) 2003-04-28 2005-04-12 Sioux Biochemical, Inc. Method of producing phosphatidylserine

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1900959A1 (de) * 1969-01-09 1970-08-27 Unilever Nv Verfahren zur Herstellung von Pflanzenphosphatiden mit universeller Emulgierkraft
US4235792A (en) * 1977-04-14 1980-11-25 The Governing Council Of The University Of Toronto Immunological materials
SU831129A1 (ru) * 1979-07-24 1981-05-23 Дальневосточный Государственный Уни-Верситет Способ получени фосфатидилглицерина
US4485045A (en) * 1981-07-06 1984-11-27 Research Corporation Synthetic phosphatidyl cholines useful in forming liposomes
US4587055A (en) * 1982-05-26 1986-05-06 Research Corporation Polymerized vesicles and compounds for their preparation
DE3476770D1 (en) * 1983-04-11 1989-03-23 Meito Sangyo Kk Production of primary or secondary alcohol derivatives of phospholipids by the enzymatic technique
JPS62205788A (ja) * 1986-03-05 1987-09-10 Shoichi Shimizu ホスフアチジルグリセロ−ル又はその誘導体の製造法
WO1989001524A1 (en) * 1987-08-14 1989-02-23 Liposome Technology, Inc. Method of preparing phosphatidylglycerol
US4997761A (en) * 1987-10-06 1991-03-05 Houston Biotechnology Incorporated Phosphatidyl treatment of viral disease
DE69011739T2 (de) * 1989-05-26 1995-01-19 Kao Corp Verfahren zur Herstellung von Phosphatidsäure.

Also Published As

Publication number Publication date
AU646458B2 (en) 1994-02-24
ZA912877B (en) 1992-12-30
AU7699591A (en) 1991-11-11
GR3022375T3 (en) 1997-04-30
DK0727491T3 (da) 1999-11-22
HUT63198A (en) 1993-07-28
CA2080907C (en) 2001-08-14
HU9203258D0 (en) 1993-01-28
DE69131404D1 (de) 1999-08-05
PT97391A (pt) 1991-12-31
EP0727491A1 (en) 1996-08-21
GR3031059T3 (en) 1999-12-31
EP0528834A4 (en) 1993-06-02
ATE181747T1 (de) 1999-07-15
EP0528834A1 (en) 1993-03-03
JP3169132B2 (ja) 2001-05-21
DK0528834T3 (da) 1997-04-07
PT97391B (pt) 1999-04-30
IE911264A1 (en) 1991-10-23
DE69123145T2 (de) 1997-06-12
HU212928B (en) 1996-12-30
CA2080907A1 (en) 1991-10-18
ATE145244T1 (de) 1996-11-15
JPH05509222A (ja) 1993-12-22
WO1991016444A1 (en) 1991-10-31
ES2132780T3 (es) 1999-08-16
EP0528834B1 (en) 1996-11-13
NZ237845A (en) 1993-06-25
DE69123145D1 (en) 1996-12-19
EP0727491B1 (en) 1999-06-30
DE69131404T2 (de) 1999-11-25

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