ES2096062T3 - Derivados substituidos de la hidroquinona como productos intermedios para derivados de benzofurano. - Google Patents
Derivados substituidos de la hidroquinona como productos intermedios para derivados de benzofurano.Info
- Publication number
- ES2096062T3 ES2096062T3 ES92810768T ES92810768T ES2096062T3 ES 2096062 T3 ES2096062 T3 ES 2096062T3 ES 92810768 T ES92810768 T ES 92810768T ES 92810768 T ES92810768 T ES 92810768T ES 2096062 T3 ES2096062 T3 ES 2096062T3
- Authority
- ES
- Spain
- Prior art keywords
- precipitated
- substituted
- halogen
- hydrogen
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- IANQTJSKSUMEQM-UHFFFAOYSA-N 1-benzofuran Chemical class C1=CC=C2OC=CC2=C1 IANQTJSKSUMEQM-UHFFFAOYSA-N 0.000 title 1
- QIGBRXMKCJKVMJ-UHFFFAOYSA-N Hydroquinone Chemical class OC1=CC=C(O)C=C1 QIGBRXMKCJKVMJ-UHFFFAOYSA-N 0.000 title 1
- 239000013067 intermediate product Substances 0.000 title 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical group [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 7
- 229910052736 halogen Inorganic materials 0.000 abstract 7
- 150000002367 halogens Chemical class 0.000 abstract 7
- 229910052739 hydrogen Inorganic materials 0.000 abstract 7
- 239000001257 hydrogen Substances 0.000 abstract 7
- 150000001875 compounds Chemical class 0.000 abstract 4
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 abstract 3
- JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical class O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical group [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 abstract 3
- BDHFUVZGWQCTTF-UHFFFAOYSA-N sulfonic acid Chemical compound OS(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-N 0.000 abstract 3
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 abstract 2
- WURBFLDFSFBTLW-UHFFFAOYSA-N benzil Chemical class C=1C=CC=CC=1C(=O)C(=O)C1=CC=CC=C1 WURBFLDFSFBTLW-UHFFFAOYSA-N 0.000 abstract 2
- WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical group [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 abstract 2
- UGFAIRIUMAVXCW-UHFFFAOYSA-N Carbon monoxide Chemical group [O+]#[C-] UGFAIRIUMAVXCW-UHFFFAOYSA-N 0.000 abstract 1
- 150000001335 aliphatic alkanes Chemical class 0.000 abstract 1
- QUPDWYMUPZLYJZ-UHFFFAOYSA-N ethyl Chemical group C[CH2] QUPDWYMUPZLYJZ-UHFFFAOYSA-N 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 abstract 1
- SXPUVBFQXJHYNS-UHFFFAOYSA-N α-furil Chemical compound C=1C=COC=1C(=O)C(=O)C1=CC=CO1 SXPUVBFQXJHYNS-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
- C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
- C07C69/84—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring
- C07C69/92—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring with etherified hydroxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4056—Esters of arylalkanephosphonic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/54—Quaternary phosphonium compounds
- C07F9/5456—Arylalkanephosphonium compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/59—Hydrogenated pyridine rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Furan Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Inorganic Insulating Materials (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
COMPUESTOS DE LA FORMULA I DONDE R4 ES ALQUIL PRECIPITADO Y R1 O ES HIDROXI, HALOGENO, UN GRUPO DE LA FORMULA 5)R6 (LA), UN GRUPO DE LA FORMULA P+(R7)(R8)R9 X MENOS (LB) O UN GRUPO DE LA FORMULA R2 ES HIDROGENO O UN GRUPO DE LA FORMULA Y R3 ES HIDROGENO O HALOGENO O R1 ES HIDROXI O ALCOXI PRECIPITADO, M ES CARBONIL, R2 ES HIDROGENO Y R3 HALOGENO, R5 Y R6 DE FORMA RESPECTIVA INDEPENDIENTES UNOS DE OTROS SON ALQUIL PRECIPITADO, ALCOXI PRECIPITADO, N,N SUSTITUIDOS O SUSTITUIDOS BENZIL, BENZILOXI, FENIL, O FENILOXI EN ANILLO FENIL DE FORMA SENCILLA O DOBLE, DONDE LOS SUSTITUIDOS DE LOS ANILLOS FENIL PUEDEN SER ELEGIDOS DE FORMA RESPECTIVA A PARTIR DEL GRUPO, QUE SE COMPONE DE ALQUIL PRECIPITADO, ALCOXI PRECIPITADO, NITRO Y HALOGENO R7, R8 Y R9 INDEPENDIENTES UNOS DE OTROS PUEDEN SER ALQUIL PRECIPITADO, INSUSTITUIDO O FENIL SUSTITUIDO UNA O DOS VECES, DONDE LOS SUSTITUIDOS DE LOS ANILLOS FENIL PUEDEN SER ELEGIDOS A PARTIR DEL GRUPO, QUE SE COMPONE DE ALQUIL PRECIPITADO, ALCOXI PRECIPITADO, NITROY HALOGENO, O REPRESENTAR FURIL, X URO, UN ACIDO SULFONICO ALCANO PRECIPITADO, UN ACIDO SULFONICO ALCANO PRECIPITADO HALOGENO O UN INSUSTITUIDO O ACIDO SULFONICO BENZOL SUSTITUIDO POR MEDIO DE ALQUIL PRECIPITADO O HALOGENO DE FORMA SENCILLA Y DONDE O Y ES UN ENLACE DIRECTO Y R10 ES ALQUIL PRECIPITADO, ALIL, CIANO, ALCANSULFONIL PRECIPITADO, ALCANSULFONIL PRECIPITADO HALOGENO, INSUSTITUIDO O BENZIL SUSTITUIDO UNA O DOS VECES POR ANILLOS FENIL, DONDE LOS SUSTITUYENTES DE LOS ANILLOS FENIL PUEDEN SER ELEGIDOS A PARTIR DEL GRUPO, QUE SE COMPONE DE ALQUIL PRECIPITADO, ALCOXI PRECIPITADO, NITRO Y HALOGENO, O INSUSTITUIDOS O BENZOL SULFONIL SUSTITUIDOS DE FORMA SENCILLA A PARTIR DE ALQUIL PRECIPITADO O HALOGENO O DONDE Y ES UN GRUPO DE LA FORMULA FORMULA ALQUIL DIPRECIPITADO HALOGENO, ALCOXI PRECIPITADO, ALQUENOXI PRECIPITADO, ALCOXI PRECIPITADO FENIL, ALCOXI PRECIPITADO HALOGENO, ALQUILTIO PRECIPITADO O RESPECTIVAMENTE INSUSTITUIDOS O FENIL, FENILOXI, FENILTIO, FENIL, BENZILOXI O BENZILTIO SUSTITUIDOS POR ANILLOS FENIL UNA O DOS VECES, CON LO QUE LOS SUSTITUYENTES DE LOS ANILLOS BENZIL PUEDEN SER DE FORMA ELEGIBLE COMPUESTOS DEL GRUPO, QUE SE COMPONE DE ALQUIL PRECIPITADO, ALCOXI PRECIPITADO, NITRO Y HALOGENO, CON LA MEDIDA DE QUE UN COMPUESTO I, DONDE R1 ES UN GRUPO LB, DONDE R7, R8 Y R9 SIGNIFICAN DE FORMA RESPECTIVA FENIL SUSTITUIDO Y XMETILENO, R2 ES HIDROGENO Y R4 ES METIL, R3 ES DIFERENTE DE HIDROGENO Y CON OTRAS MEDIDAS DE FORMA QUE UN COMPUESTO I, DONDE R1 ES HIDROXI, M ES METILENO, R2 ES HIDROGENO Y R4 ES METIL O ETIL, R3 ES DIFERENTE DEL HIDROGENO, PUEDEN SER ADECUADOS PARA LA FABRICACION DE COMPUESTOS DE LA FORMULA, DONDE R3 ES HALOGENO Y R4 ES ALQUIL PRECIPITADO Y R10 E Y TIENEN LOS SIGNIFICADOS DADOS, Y SUS SALES QUE PUEDEN SER UTILIZADAS. SON FABRICADOS SEGUN UN METODO CONOCIDO.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH304291 | 1991-10-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2096062T3 true ES2096062T3 (es) | 1997-03-01 |
Family
ID=4247322
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES92810768T Expired - Lifetime ES2096062T3 (es) | 1991-10-17 | 1992-10-08 | Derivados substituidos de la hidroquinona como productos intermedios para derivados de benzofurano. |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US5290939A (es) |
| EP (1) | EP0542671B1 (es) |
| JP (1) | JPH05213808A (es) |
| KR (1) | KR930007940A (es) |
| AT (1) | ATE147059T1 (es) |
| AU (3) | AU661722B2 (es) |
| CA (1) | CA2080683A1 (es) |
| DE (1) | DE59207805D1 (es) |
| DK (1) | DK0542671T3 (es) |
| ES (1) | ES2096062T3 (es) |
| FI (1) | FI924651A7 (es) |
| GR (1) | GR3022221T3 (es) |
| HU (1) | HUT62250A (es) |
| IL (1) | IL103447A0 (es) |
| MX (1) | MX9205989A (es) |
| NO (1) | NO180441C (es) |
| NZ (1) | NZ244751A (es) |
| RU (1) | RU2095339C1 (es) |
| TW (1) | TW209869B (es) |
| ZA (1) | ZA928003B (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5693807A (en) * | 1992-10-14 | 1997-12-02 | Ciba-Geigy Corporation | Substituted hydroquinone derivatives |
| EP0637586B1 (en) * | 1993-08-05 | 1999-06-02 | HOECHST MARION ROUSSEL, Inc. | 2-(Piperidin-4-yl, pyridin-4-yl and tetrahydropyridin-4-yl)-benzofuran-7-carbamate derivatives, their preparation and their use as acetylcholinesterase inhibitors |
| CN100546970C (zh) * | 2006-05-18 | 2009-10-07 | 中国科学院广州化学研究所 | 一种溴代苯甲酸酯的合成方法 |
| CN104769006B (zh) | 2012-09-07 | 2017-03-08 | 英派尔科技开发有限公司 | 区域规则性共聚物及其制备方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4600719A (en) * | 1973-03-02 | 1986-07-15 | Ciba Geigy Corporation | Tetrahydropyridine and piperidine derivatives |
| CH592656A5 (es) * | 1973-03-02 | 1977-10-31 | Ciba Geigy Ag | |
| CH609054A5 (en) * | 1975-11-26 | 1979-02-15 | Ciba Geigy Ag | Process for the preparation of a novel piperidine derivative |
| JPS63139180A (ja) * | 1986-12-02 | 1988-06-10 | Tanabe Seiyaku Co Ltd | カルボン酸誘導体 |
| FR2619111B1 (fr) * | 1987-08-07 | 1991-01-11 | Synthelabo | Derives de (piperidinyl-4)methyl-2 tetrahydro-1,2,3,4 9h-pyrido (3,4-b) indole, leur preparation et leur application en therapeutique |
| FR2626877B1 (fr) * | 1988-02-05 | 1991-04-05 | Delalande Sa | Ethers alkyliques ou benzyliques du phenol, leurs procedes de preparation et leur application en therapeutique |
| EP0352581A3 (de) * | 1988-07-28 | 1990-07-04 | F. Hoffmann-La Roche Ag | Aethylendiaminmonoamid-Derivate |
-
1992
- 1992-09-03 RU SU925053216A patent/RU2095339C1/ru active
- 1992-10-08 ES ES92810768T patent/ES2096062T3/es not_active Expired - Lifetime
- 1992-10-08 DK DK92810768.9T patent/DK0542671T3/da active
- 1992-10-08 DE DE59207805T patent/DE59207805D1/de not_active Expired - Fee Related
- 1992-10-08 EP EP92810768A patent/EP0542671B1/de not_active Expired - Lifetime
- 1992-10-08 AT AT92810768T patent/ATE147059T1/de not_active IP Right Cessation
- 1992-10-09 TW TW081108038A patent/TW209869B/zh active
- 1992-10-14 FI FI924651A patent/FI924651A7/fi not_active Application Discontinuation
- 1992-10-14 HU HU9203233A patent/HUT62250A/hu unknown
- 1992-10-14 US US07/961,001 patent/US5290939A/en not_active Expired - Lifetime
- 1992-10-15 NZ NZ244751A patent/NZ244751A/en unknown
- 1992-10-15 AU AU27071/92A patent/AU661722B2/en not_active Ceased
- 1992-10-15 IL IL103447A patent/IL103447A0/xx unknown
- 1992-10-15 CA CA002080683A patent/CA2080683A1/en not_active Abandoned
- 1992-10-16 NO NO924024A patent/NO180441C/no unknown
- 1992-10-16 JP JP4278265A patent/JPH05213808A/ja active Pending
- 1992-10-16 ZA ZA928003A patent/ZA928003B/xx unknown
- 1992-10-16 MX MX9205989A patent/MX9205989A/es unknown
- 1992-10-16 KR KR1019920019147A patent/KR930007940A/ko not_active Ceased
-
1995
- 1995-11-02 AU AU36615/95A patent/AU691345B2/en not_active Expired - Fee Related
- 1995-11-02 AU AU36614/95A patent/AU691344B2/en not_active Expired - Fee Related
-
1997
- 1997-01-03 GR GR960403661T patent/GR3022221T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE59207805D1 (de) | 1997-02-13 |
| NO180441B (no) | 1997-01-13 |
| NZ244751A (en) | 1995-02-24 |
| KR930007940A (ko) | 1993-05-20 |
| AU2707192A (en) | 1993-04-22 |
| TW209869B (es) | 1993-07-21 |
| AU3661495A (en) | 1996-01-04 |
| AU661722B2 (en) | 1995-08-03 |
| AU691345B2 (en) | 1998-05-14 |
| EP0542671B1 (de) | 1997-01-02 |
| CA2080683A1 (en) | 1993-04-18 |
| ATE147059T1 (de) | 1997-01-15 |
| US5290939A (en) | 1994-03-01 |
| NO924024D0 (no) | 1992-10-16 |
| FI924651A7 (fi) | 1993-04-18 |
| HU9203233D0 (en) | 1992-12-28 |
| GR3022221T3 (en) | 1997-04-30 |
| DK0542671T3 (da) | 1997-01-20 |
| MX9205989A (es) | 1993-08-31 |
| RU2095339C1 (ru) | 1997-11-10 |
| FI924651A0 (fi) | 1992-10-14 |
| EP0542671A1 (de) | 1993-05-19 |
| JPH05213808A (ja) | 1993-08-24 |
| IL103447A0 (en) | 1993-03-15 |
| ZA928003B (en) | 1993-04-19 |
| AU691344B2 (en) | 1998-05-14 |
| NO180441C (no) | 1997-04-23 |
| NO924024L (no) | 1993-04-19 |
| HUT62250A (en) | 1993-04-28 |
| AU3661595A (en) | 1996-01-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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