ES2096388T3 - Procedimiento para la hidrogenacion enantioselectiva de derivados de 2h-piran-2-ona. - Google Patents

Procedimiento para la hidrogenacion enantioselectiva de derivados de 2h-piran-2-ona.

Info

Publication number
ES2096388T3
ES2096388T3 ES94113871T ES94113871T ES2096388T3 ES 2096388 T3 ES2096388 T3 ES 2096388T3 ES 94113871 T ES94113871 T ES 94113871T ES 94113871 T ES94113871 T ES 94113871T ES 2096388 T3 ES2096388 T3 ES 2096388T3
Authority
ES
Spain
Prior art keywords
piran
procedure
general formula
image
optionally substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94113871T
Other languages
English (en)
Inventor
Emil Albin Broger
Martin Karpf
Ulrich Zutter
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Application granted granted Critical
Publication of ES2096388T3 publication Critical patent/ES2096388T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/32—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)
  • Pyrane Compounds (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A UN NUEVO PROCESO CATALITICO PARA LA ELABORACION DE COMPUESTOS ACTIVOS OPTICOS DE LA FORMULA GENERAL DONDE R1 Y R2 SIGNIFICAN ALQUIL INTERRUMPIDO EN UNA DE LAS POSICIONES ALFA OMO DE O O EVENTUALMENTE BENCIL SUSTITUIDO, R3 ES HIDROGENO, ALQUIL INFERIOR, BENCIL EVENTUALMENTE SUSTITUIDO, COOR4 O EN DONDE UN COMPUESTO DE LA FORMULA GENERAL DONDE R1, R2, R3 TIENEN EL SIGNIFICADO ANTES DADO, SE HIDROGENA ASIMETRICAMENTE EN PRESENCIA DE UN COMPLEJO DE UNA LIGANDURA DIFOSFINA ACTIVA, CON PREFERENCIA ATROPISOMERA CON UN METAL DEL GRUPO VIII.
ES94113871T 1993-09-13 1994-09-05 Procedimiento para la hidrogenacion enantioselectiva de derivados de 2h-piran-2-ona. Expired - Lifetime ES2096388T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH273893 1993-09-13

Publications (1)

Publication Number Publication Date
ES2096388T3 true ES2096388T3 (es) 1997-03-01

Family

ID=4240509

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94113871T Expired - Lifetime ES2096388T3 (es) 1993-09-13 1994-09-05 Procedimiento para la hidrogenacion enantioselectiva de derivados de 2h-piran-2-ona.

Country Status (9)

Country Link
US (1) US5481008A (es)
EP (1) EP0643052B1 (es)
JP (1) JP3598133B2 (es)
CN (1) CN1053902C (es)
AT (1) ATE146465T1 (es)
DE (1) DE59401319D1 (es)
DK (1) DK0643052T3 (es)
ES (1) ES2096388T3 (es)
RU (1) RU2127267C1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2693190B1 (fr) * 1992-07-02 1994-09-23 Elf Aquitaine Procédé d'hydrogénation énantiosélectif de la double liaison C=O OXO.
DE19532320A1 (de) * 1995-09-01 1997-03-06 Bayer Ag Verfahren zur Herstellung von optisch aktiven ortho-substituierten 4-Aryl-Dihydropyridinen
US5902882A (en) * 1996-04-17 1999-05-11 Hoffmann-La Roche Inc. Assymetric synthesis of azepines
US6914140B1 (en) 1996-04-17 2005-07-05 Hoffmann-La Roche Inc. Asymmetric synthesis process
US6222039B1 (en) 1998-07-13 2001-04-24 Hoffman-La Roche Inc. Process for the preparation of chiral lactones
EP0974590A1 (en) * 1998-07-13 2000-01-26 F. Hoffmann-La Roche Ag Process for the preparation of chiral lactones by asymetrical hydrogenation
DE60027734T2 (de) * 1999-09-20 2007-04-05 The Penn State Research Foundation Chirale phosphine, deren komplexe mit übergangsmetallen und deren verwendung in asymmetrischen synthesereaktionen
FR2978151B1 (fr) * 2011-07-22 2013-08-30 Centre Nat Rech Scient Composes organophosphores p-chirogeniques

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK350383A (da) * 1982-08-27 1984-02-28 Hoffmann La Roche Phosphorforbindelser
ATE128140T1 (de) * 1989-05-18 1995-10-15 Hoffmann La Roche Phosphorverbindungen.
CA2035972C (en) * 1990-02-23 2006-07-11 Martin Karpf Process for the preparation of oxetanones
US5274143A (en) * 1991-07-23 1993-12-28 Hoffmann-La Roche Inc. Process for the preparation of (R)-3-hexyl-5,6-dihydro-4-hydroxy-6-undecyl-2H-pyran-2-one and (R)-5,6-dihydro-6-undecyl-2H-pyran-2,4(3H)-dione
TW275630B (es) * 1991-11-19 1996-05-11 Hoffmann La Roche

Also Published As

Publication number Publication date
EP0643052B1 (de) 1996-12-18
EP0643052A2 (de) 1995-03-15
RU2127267C1 (ru) 1999-03-10
JPH07165747A (ja) 1995-06-27
ATE146465T1 (de) 1997-01-15
CN1053902C (zh) 2000-06-28
JP3598133B2 (ja) 2004-12-08
CN1106002A (zh) 1995-08-02
DK0643052T3 (da) 1997-03-17
EP0643052A3 (de) 1995-03-22
RU94033115A (ru) 1996-07-20
US5481008A (en) 1996-01-02
DE59401319D1 (de) 1997-01-30

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