ES2097089A1 - Procedimiento para la preparacion de 2-hidroximetil-3,5-dimetil-4-metoxipiridina. - Google Patents

Procedimiento para la preparacion de 2-hidroximetil-3,5-dimetil-4-metoxipiridina.

Info

Publication number
ES2097089A1
ES2097089A1 ES09500182A ES9500182A ES2097089A1 ES 2097089 A1 ES2097089 A1 ES 2097089A1 ES 09500182 A ES09500182 A ES 09500182A ES 9500182 A ES9500182 A ES 9500182A ES 2097089 A1 ES2097089 A1 ES 2097089A1
Authority
ES
Spain
Prior art keywords
dimethyl
hydroxymethyl
trityloxymethylpyridine
methoxypyridine
heating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES09500182A
Other languages
English (en)
Other versions
ES2097089B1 (es
Inventor
Guillen Yolanda Gasanz
Torres Salvador Puig
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Esteve Quimica SA
Original Assignee
Esteve Quimica SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Esteve Quimica SA filed Critical Esteve Quimica SA
Priority to ES9500182A priority Critical patent/ES2097089B1/es
Publication of ES2097089A1 publication Critical patent/ES2097089A1/es
Application granted granted Critical
Publication of ES2097089B1 publication Critical patent/ES2097089B1/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

COMPRENDE LAS OPERACIONES DE HACER REACCIONAR 2-HIDROXIMETIL-3,5- DIMETIL -4-NITROPIRIDINA (IV) CON CLORURO DE TRITILO EN PRESENCIA DE TRIETILAMINA Y EN TOLUENO, OBTENIENDOSE EN CALIENTE 3,5- DIMETIL-4-NITRO-2- TRITILOXIMETILPIRIDINA (VI); DE HACER REACCIONAR 3,5-DIMETIL-4-NITRO-2- TRITILOXIMETILPIRIDINA (VI) CON METOXIDO SODICO EN TOLUENO Y METANOL, CALENTANDO A REFLUJO, OBTENIENDOSE 3,5-DIMETIL-4-METOXI- 2-TRITILOXIMETIL-PIRIDINA (VII); Y DE CALENTAR LIGERAMENTE 3,5-DIMETRIL-4-METOXI-2- TRITILOXIMETILPIRIDINA (VII) EN DISOLUCION DE METANOL CON UNA PEQUE¥A CANTIDAD DE ACIDO CLORHIDRICO CONCENTRADO, OBTENIENDOSE 2-HIDROXIMETIL-3,5-DIMETIL -4-METOXIPIRIDINA (I).
ES9500182A 1995-02-01 1995-02-01 Procedimiento para la preparacion de 2-hidroximetil-3,5-dimetil-4-metoxipiridina. Expired - Fee Related ES2097089B1 (es)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES9500182A ES2097089B1 (es) 1995-02-01 1995-02-01 Procedimiento para la preparacion de 2-hidroximetil-3,5-dimetil-4-metoxipiridina.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9500182A ES2097089B1 (es) 1995-02-01 1995-02-01 Procedimiento para la preparacion de 2-hidroximetil-3,5-dimetil-4-metoxipiridina.

Publications (2)

Publication Number Publication Date
ES2097089A1 true ES2097089A1 (es) 1997-03-16
ES2097089B1 ES2097089B1 (es) 1997-12-16

Family

ID=8289324

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9500182A Expired - Fee Related ES2097089B1 (es) 1995-02-01 1995-02-01 Procedimiento para la preparacion de 2-hidroximetil-3,5-dimetil-4-metoxipiridina.

Country Status (1)

Country Link
ES (1) ES2097089B1 (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999010326A1 (en) * 1997-08-23 1999-03-04 Seal Sands Chemicals Limited Preparation of pyridine derivatives

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0103553A1 (en) * 1982-08-26 1984-03-21 Aktiebolaget Hässle Intermediates for the preparation of omeprazole
EP0369208A1 (de) * 1988-11-15 1990-05-23 Hafslund Nycomed Pharma Aktiengesellschaft Verfahren zur Herstellung von 3,5-Dimethyl-4-methoxypyridinderivaten sowie neues Zwischenprodukt hierfür
JPH0559004A (ja) * 1991-08-28 1993-03-09 Tokyo Tanabe Co Ltd 新規なメトキシ基導入法による２−ヒドロキシメチル−４−メトキシ−３，５−ジメチルピリジンの製造法
JPH0570432A (ja) * 1991-07-17 1993-03-23 Tokyo Tanabe Co Ltd 新規な４−メトキシ−２−（２−テトラヒドロピラニルオキシメチル）ピリジン化合物及びその製造中間体ならびにそれらの製造方法
JPH0570434A (ja) * 1991-09-17 1993-03-23 Tokyo Tanabe Co Ltd 新規な２−ヒドロキシメチル−４−メトキシ−３，５−ジメチルピリジンの製造方法及びその製造中間体ならびにそれらの製造法
ES2035767A1 (es) * 1991-04-05 1993-04-16 Genesis Para La Investigacion Procedimiento de obtencion de 2-hidroximetil-3,5-dimetilpiridinas 4-sustituidas.

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0103553A1 (en) * 1982-08-26 1984-03-21 Aktiebolaget Hässle Intermediates for the preparation of omeprazole
EP0369208A1 (de) * 1988-11-15 1990-05-23 Hafslund Nycomed Pharma Aktiengesellschaft Verfahren zur Herstellung von 3,5-Dimethyl-4-methoxypyridinderivaten sowie neues Zwischenprodukt hierfür
ES2035767A1 (es) * 1991-04-05 1993-04-16 Genesis Para La Investigacion Procedimiento de obtencion de 2-hidroximetil-3,5-dimetilpiridinas 4-sustituidas.
JPH0570432A (ja) * 1991-07-17 1993-03-23 Tokyo Tanabe Co Ltd 新規な４−メトキシ−２−（２−テトラヒドロピラニルオキシメチル）ピリジン化合物及びその製造中間体ならびにそれらの製造方法
JPH0559004A (ja) * 1991-08-28 1993-03-09 Tokyo Tanabe Co Ltd 新規なメトキシ基導入法による２−ヒドロキシメチル−４−メトキシ−３，５−ジメチルピリジンの製造法
JPH0570434A (ja) * 1991-09-17 1993-03-23 Tokyo Tanabe Co Ltd 新規な２−ヒドロキシメチル−４−メトキシ−３，５−ジメチルピリジンの製造方法及びその製造中間体ならびにそれらの製造法

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
PATENT ABSTRACTS OF JAPAN, Vol. 14, N‘ 373 (C-1083), 1993, & JP 5059004 A (TOKYO TANABE CO LTD) *
PATENT ABSTRACTS OF JAPAN, Vol. 17, N‘ 391 (C-1087), 1993, & JP 5070432 A (TOKYO TANABE CO LTD) *
PATENT ABSTRACTS OF JAPAN, Vol. 17, N‘ 391 (C-1087), 1993, & JP 5070434 A (TOKYO TANABE CO LTD) *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999010326A1 (en) * 1997-08-23 1999-03-04 Seal Sands Chemicals Limited Preparation of pyridine derivatives

Also Published As

Publication number Publication date
ES2097089B1 (es) 1997-12-16

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