ES2098193A1 - Nueva formulacion farmaceutica de dehidroepiandrosterona para aplicacion topica percutanea. - Google Patents

Nueva formulacion farmaceutica de dehidroepiandrosterona para aplicacion topica percutanea.

Info

Publication number
ES2098193A1
ES2098193A1 ES09501471A ES9501471A ES2098193A1 ES 2098193 A1 ES2098193 A1 ES 2098193A1 ES 09501471 A ES09501471 A ES 09501471A ES 9501471 A ES9501471 A ES 9501471A ES 2098193 A1 ES2098193 A1 ES 2098193A1
Authority
ES
Spain
Prior art keywords
dehydroepiandrosterone
pharmaceutical formulation
topical application
novel pharmaceutical
formulation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES09501471A
Other languages
English (en)
Other versions
ES2098193B1 (es
Inventor
Gomez Jesus Calderon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to ES9501471A priority Critical patent/ES2098193B1/es
Priority to PCT/ES1996/000153 priority patent/WO1997003676A1/es
Priority to AU64196/96A priority patent/AU6419696A/en
Publication of ES2098193A1 publication Critical patent/ES2098193A1/es
Application granted granted Critical
Publication of ES2098193B1 publication Critical patent/ES2098193B1/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/06—Preparations for care of the skin for countering cellulitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
    • A61K31/5685—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone having an oxo group in position 17, e.g. androsterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/02—Algae
    • A61K36/03—Phaeophycota or phaeophyta (brown algae), e.g. Fucus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/16—Ginkgophyta, e.g. Ginkgoaceae (Ginkgo family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/042—Gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/63—Steroids; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • Birds (AREA)
  • Dispersion Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

NUEVA FORMULACION FARMACEUTICA DE DEHIDROEPIANDROSTERONA PARA APLICACION TOPICA PERCUTANEA. COMPRENDE: (A) 0,1 A 5 POR CIENTO EN PESO DE DEHIDROEPIANDROSTERONA; (B) 0,5-3 POR CIENTO DE UN GEL ACRILICO, 1-3 POR CIENTO DE GOMA-GUAR O 1-3 POR CIENTO DE UN GEL DERIVADO DE CELULOSA; Y OPCIONALMENTE OTROS INGREDIENTES TALES COMO GELES HIDROFILOS, ESTRADIOL, VITAMINAS, PROGESTERONA, MINOXIDIL, BASES XANTICAS, HIALURONIDASA, VASOPROTECTORES, EXTRACTOS VEGETALES, ETC. LA FORMULACION TIENE DIVERSAS APLICACIONES FARMACOLOGICAS, POR EJEMPLO, EN DESARREGLOS DEL CICLO MENSTRUAL FEMENINO, NEOPLASIAS DE MAMAS Y GINECOLOGICAS, LIPODISTROFIAS, PANICULOPATIAS Y TRASTORNOS CIRCULATORIOS, CONTUSIONES, DOLORES MUSCULARES, OBESIDAD, DIABETES, OSTEOPOROSIS, ENVEJECIMIENTO, ETC.
ES9501471A 1995-07-21 1995-07-21 Nueva formulacion farmaceutica de dehidroepiandrosterona para aplicacion topica percutanea. Expired - Fee Related ES2098193B1 (es)

Priority Applications (3)

Application Number Priority Date Filing Date Title
ES9501471A ES2098193B1 (es) 1995-07-21 1995-07-21 Nueva formulacion farmaceutica de dehidroepiandrosterona para aplicacion topica percutanea.
PCT/ES1996/000153 WO1997003676A1 (es) 1995-07-21 1996-07-19 Nueva formulacion farmaceutica de dehidroepiandrosterona para aplicacion topica percutanea
AU64196/96A AU6419696A (en) 1995-07-21 1996-07-19 Novel pharmaceutical formulation of dehydroepiandrosterone for percutaneous topical application

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9501471A ES2098193B1 (es) 1995-07-21 1995-07-21 Nueva formulacion farmaceutica de dehidroepiandrosterona para aplicacion topica percutanea.

Publications (2)

Publication Number Publication Date
ES2098193A1 true ES2098193A1 (es) 1997-04-16
ES2098193B1 ES2098193B1 (es) 1997-12-01

Family

ID=8291123

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9501471A Expired - Fee Related ES2098193B1 (es) 1995-07-21 1995-07-21 Nueva formulacion farmaceutica de dehidroepiandrosterona para aplicacion topica percutanea.

Country Status (3)

Country Link
AU (1) AU6419696A (es)
ES (1) ES2098193B1 (es)
WO (1) WO1997003676A1 (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013098592A1 (es) 2011-12-29 2013-07-04 Universidad De Chile Anillo vaginal que comprende dhea o dhea sulfato y opcionalmente un agente modulador de la liberación del principio activo, útil para aumentar la reserva ovárica en mujeres y para aliviar síntomas asociados a la menopausia

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6228852B1 (en) 1996-07-12 2001-05-08 Carolyn V. Shaak Transdermal application of naturally occurring steroid hormones
ES2135353B1 (es) * 1998-03-24 2000-08-16 Univ Miguel Hernandez Utilizacion del 17beta-estradiol, sus analogos y derivados en el tratamiento de la diabetes mellitus y sus manifestaciones.
KR20060098399A (ko) 1998-06-11 2006-09-18 앙도르쉐르슈 인코포레이티드 안드로스트-5-엔-3β,17β-디올을 포함하는 약학 조성물 및그 용도
KR20020011437A (ko) 1999-06-11 2002-02-08 추후보정 여성에 비-경구 안드로겐형 스테로이드의 투여
WO2001019365A1 (en) * 1999-09-15 2001-03-22 Roche Consumer Health Ag Pharmaceutical and/or cosmetical compositions
FR2799645B1 (fr) * 1999-10-13 2004-04-30 Oreal Utilisation de la dhea ou de ses precurseurs ou derives metaboliques comme depigmentant
FR2811562B1 (fr) * 2000-07-13 2003-03-07 Oreal Composition, notamment cosmetique, renfermant la dhea et un isoflavonoide
FR2811567B1 (fr) * 2000-07-13 2003-01-17 Oreal Composition, notamment cosmetique, comprenant la dhea et/ou un precurseur ou derive de celle-ci, en association avec au moins un inhibiteur de no-synthase
FR2811563B1 (fr) * 2000-07-13 2003-06-20 Oreal Composition, notamment cosmetique, comprenant la dhea et/ou un precurseur ou derive, et au moins un compose augmentant la synthese des glycosaminoglycanes
US8980290B2 (en) 2000-08-03 2015-03-17 Antares Pharma Ipl Ag Transdermal compositions for anticholinergic agents
US7198801B2 (en) 2000-08-03 2007-04-03 Antares Pharma Ipl Ag Formulations for transdermal or transmucosal application
WO2005039531A1 (en) 2003-10-10 2005-05-06 Antares Pharma Ipl Ag Transdermal pharmaceutical formulation for minimizing skin residues
WO2002011768A1 (en) 2000-08-03 2002-02-14 Antares Pharma Ipl Ag Novel composition for transdermal and/or transmucosal administration of active compounds that ensures adequate therapeutic levels
US7442369B1 (en) 2000-08-09 2008-10-28 Mcneil Ab Compositions of minoxidil
FR2815858B1 (fr) * 2000-10-26 2003-12-12 Oreal Composition, notamment cosmetique, renfermant la dhea et/ou ses precurseurs ou derives, et un agent susceptible d'inhiber l'irritation d'origine neurogene
FR2818138B1 (fr) * 2000-12-15 2003-02-14 Oreal Composition, notamment cosmetique, renfermant la 7-hydroxy dhea et/ou la 7-ceto dhea et au moins un agent depigmentant
FR2818136B1 (fr) * 2000-12-15 2004-10-15 Oreal Composition, notamment cosmetique, comprenant la 7-hydroxy dhea et/ou la 7-ceto dhea et au moins un inhibiteur de no-synthase
FR2818135B1 (fr) 2000-12-15 2003-02-14 Oreal Composition, notamment cosmetique, renfermant la 7-hydroxy dhea et/ou la 7-ceto dhea et au moins un carotenoide
FR2818148B1 (fr) * 2000-12-15 2005-06-24 Oreal Composition,notamment cosmetique, renfermant, la 7-hydroxy dhea et/ou la 7-ceto dhea et au moins un isoflavonoide
AU4625901A (en) * 2001-03-19 2001-10-03 Topic Empreendimentos E Participacoes S/C Ltda. Pharmaceutical composition of carrier substance for products based on vitamin-E,bromeline and hyaluronidase
US7354956B2 (en) 2002-04-12 2008-04-08 L'oreal Composition containing a sapogenin and use thereof
FR2847475B1 (fr) * 2002-11-25 2006-06-23 Oreal COMPOSITION COSMETIQUE OU PHARMACEUTIQUE ASSOCIANT UN AGENT MODULATEUR DE L'EXPRESSION DE L'OXYSTEROL 7alpha-HYDROXYLASE ET UN SUBSTRAT BIOLOGIQUE DE LADITE ENZYME
RU2275930C2 (ru) * 2004-04-26 2006-05-10 ООО "РусГен" Композиция для коррекции возрастных изменений эндокринной системы человека (варианты) и способ получения фармацевтической формы на основе такой композиции
US7425340B2 (en) 2004-05-07 2008-09-16 Antares Pharma Ipl Ag Permeation enhancing compositions for anticholinergic agents
WO2006125642A1 (en) 2005-05-27 2006-11-30 Antares Pharma Ipl Ag Methods and apparatus for transdermal or transmucosal application of testosterone
NZ571460A (en) 2006-04-21 2010-10-29 Antares Pharma Ipl Ag Methods of treating hot flashes with formulations for transdermal or transmucosal application
US9320744B2 (en) 2011-10-19 2016-04-26 Dhea Llc DHEA bioadhesive controlled release gel
US11324690B2 (en) 2019-02-12 2022-05-10 Dawn Marie Cutillo Composition for restorative vaginal lubrication and a method of use thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60161912A (ja) * 1984-02-01 1985-08-23 Kanebo Ltd 皮膚化粧料
US4542129A (en) * 1982-08-16 1985-09-17 Norman Orentreich DHEA Formulations and methods for treating dry skin
US4628052A (en) * 1985-05-28 1986-12-09 Peat Raymond F Pharmaceutical compositions containing dehydroepiandrosterone and other anesthetic steroids in the treatment of arthritis and other joint disabilities
WO1994016709A2 (en) * 1993-01-19 1994-08-04 Endorecherche Inc. Therapeutic uses and delivery systems of dehydroepiandrosterone

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4542129A (en) * 1982-08-16 1985-09-17 Norman Orentreich DHEA Formulations and methods for treating dry skin
JPS60161912A (ja) * 1984-02-01 1985-08-23 Kanebo Ltd 皮膚化粧料
US4628052A (en) * 1985-05-28 1986-12-09 Peat Raymond F Pharmaceutical compositions containing dehydroepiandrosterone and other anesthetic steroids in the treatment of arthritis and other joint disabilities
WO1994016709A2 (en) * 1993-01-19 1994-08-04 Endorecherche Inc. Therapeutic uses and delivery systems of dehydroepiandrosterone

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CHEM. ABS., Vol. 104, N‘ 2, 13 Enero 1986 (Columbus, Ohio, USA); pßgina 302, columna 1, resumen n‘ 103995 & JP 60161912 A (KANEBO, LTD) 23.08.85 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013098592A1 (es) 2011-12-29 2013-07-04 Universidad De Chile Anillo vaginal que comprende dhea o dhea sulfato y opcionalmente un agente modulador de la liberación del principio activo, útil para aumentar la reserva ovárica en mujeres y para aliviar síntomas asociados a la menopausia

Also Published As

Publication number Publication date
AU6419696A (en) 1997-02-18
ES2098193B1 (es) 1997-12-01
WO1997003676A1 (es) 1997-02-06

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