ES2099304T3 - MYTHOGEN OF THE SMOOTH MUSCULATURE AND DNA THAT CODES IT. - Google Patents

MYTHOGEN OF THE SMOOTH MUSCULATURE AND DNA THAT CODES IT.

Info

Publication number
ES2099304T3
ES2099304T3 ES93101871T ES93101871T ES2099304T3 ES 2099304 T3 ES2099304 T3 ES 2099304T3 ES 93101871 T ES93101871 T ES 93101871T ES 93101871 T ES93101871 T ES 93101871T ES 2099304 T3 ES2099304 T3 ES 2099304T3
Authority
ES
Spain
Prior art keywords
btc
mythogen
dna
codes
amino acids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93101871T
Other languages
Spanish (es)
Inventor
Moses Judah Folkmann
Yuen Shing
Koichi Igarashi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Boston Childrens Hospital
Original Assignee
Takeda Chemical Industries Ltd
Boston Childrens Hospital
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd, Boston Childrens Hospital filed Critical Takeda Chemical Industries Ltd
Application granted granted Critical
Publication of ES2099304T3 publication Critical patent/ES2099304T3/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

A recombinant non-glycosylated mammalian growth factor (BTC-GF) stimulates proliferation of human smooth muscle cells. Especially, the amino acid sequence of the protein deduced from the nucleotide sequence coding for human BTC-GF is as that comprising the amino acids No. 1 to No. 147 of Figure 10 or the amino acids No. 1 to 80 of Figure 10, and the amino acid sequence of the protein deduced from the nucleotide sequence coding for mouse BTC-GF is as that comprising the amino acids No. 1 to No. 146 of Figure 9.
ES93101871T 1992-02-10 1993-02-06 MYTHOGEN OF THE SMOOTH MUSCULATURE AND DNA THAT CODES IT. Expired - Lifetime ES2099304T3 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US83355292A 1992-02-10 1992-02-10
US83293992A 1992-02-10 1992-02-10
US87259792A 1992-04-23 1992-04-23
US87279292A 1992-04-23 1992-04-23
US99477692A 1992-12-22 1992-12-22
US712693A 1993-01-21 1993-01-21

Publications (1)

Publication Number Publication Date
ES2099304T3 true ES2099304T3 (en) 1997-05-16

Family

ID=27555565

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93101871T Expired - Lifetime ES2099304T3 (en) 1992-02-10 1993-02-06 MYTHOGEN OF THE SMOOTH MUSCULATURE AND DNA THAT CODES IT.

Country Status (7)

Country Link
EP (1) EP0555785B1 (en)
JP (1) JP3621431B2 (en)
AT (1) ATE145939T1 (en)
CA (1) CA2089111C (en)
DE (1) DE69306273T2 (en)
DK (1) DK0555785T3 (en)
ES (1) ES2099304T3 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996030506A1 (en) * 1995-03-24 1996-10-03 Takeda Chemical Industries, Ltd. Antibody to human betacellulin and use thereof
US6232288B1 (en) 1995-11-09 2001-05-15 Takeda Chemical Industries, Ltd. Composition for improving pancreatic function
AUPP031897A0 (en) * 1997-11-12 1997-12-04 Gropep Pty Ltd Mammalian milk growth factor
PT1148129E (en) 1998-12-09 2007-09-05 Takeda Pharmaceutical Betacellulin modification
US20070054851A1 (en) * 2005-05-27 2007-03-08 Junyu Lin Methods of and compositions for stimulation of glucose uptake into muscle cells and treatment of diseases

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4801542A (en) * 1984-10-12 1989-01-31 Zymogenetics, Inc. Expression of biologically active PDGF analogs in eucaryotic cells
EP0482623B1 (en) * 1990-10-26 1995-05-10 Children's Medical Center Corporation Smooth muscle mitogen

Also Published As

Publication number Publication date
CA2089111A1 (en) 1993-08-11
EP0555785A1 (en) 1993-08-18
CA2089111C (en) 2004-08-03
JPH0687894A (en) 1994-03-29
DE69306273T2 (en) 1997-04-03
JP3621431B2 (en) 2005-02-16
DK0555785T3 (en) 1997-05-26
DE69306273D1 (en) 1997-01-16
ATE145939T1 (en) 1996-12-15
EP0555785B1 (en) 1996-12-04

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