ES2100151T3 - Nuevos derivados de benzopirano, procedimientos para su preparacion y su uso y composiciones que contienen los compuestos. - Google Patents

Nuevos derivados de benzopirano, procedimientos para su preparacion y su uso y composiciones que contienen los compuestos.

Info

Publication number
ES2100151T3
ES2100151T3 ES89112429T ES89112429T ES2100151T3 ES 2100151 T3 ES2100151 T3 ES 2100151T3 ES 89112429 T ES89112429 T ES 89112429T ES 89112429 T ES89112429 T ES 89112429T ES 2100151 T3 ES2100151 T3 ES 2100151T3
Authority
ES
Spain
Prior art keywords
compounds
procedures
preparation
compositions containing
benzopyran derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89112429T
Other languages
English (en)
Inventor
Wolfgang Dr Stenzel
Theo Dr Schotten
Ben Dr Armah
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beiersdorf Lilly GmbH
Original Assignee
Beiersdorf Lilly GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beiersdorf Lilly GmbH filed Critical Beiersdorf Lilly GmbH
Application granted granted Critical
Publication of ES2100151T3 publication Critical patent/ES2100151T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
    • C07D311/72—3,4-Dihydro derivatives having in position 2 at least one methyl radical and in position 6 one oxygen atom, e.g. tocopherols
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Vascular Medicine (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrane Compounds (AREA)

Abstract

DERIVADOS BENZOPYRAN, DE LA FORMULA GENERAL I EN LA QUE R1 Y R2, QUE PUEDEN SER IGUALES O DIFERENTES, SIGNIFICANTES HIDROGENO C1-6-ALQUIL, C3-6-RAMIFICADO-ALQUIL, C3-7-CICLOALQUIL O JUNTAMENTE CON LOS ATOMOS DE CARBONO EN ELLOS INCLUIDOS C3-7-SPIROALQUIL, R3 SIGNIFICA HIDROXI, C1-8-ALCOXI, FORMILOXI, C1-8-ALQUILCARBONILOXI, C1-8-ALCOXICARBONILOXI, C1-8-MONO-ALQUILAMINOCARBONILOXI O C1-8-DIALQUILAMINO-CARNBONILOXI, DE DONDE C1-8-ALQUIL O ALCOXIGRUPOS, PUEDEN SER LINEALES O RAMIFICADOS Y R4 VALE COMO HIDROGENO O R3 Y R4 FORMAN JUNTOS UNA IMAGEN; R5 SIGNIFICA UN HETEROCICLO DE LA FORMULA A DE DONDE N VALE 1, 2, 3 O 4 O UN HETEROCICLO DE LA FORMULA B DE DONDE Y VALE POR OXIGENO, SULFURO, AMINO NO SUBSTITUIDO-NH- AMINO SUSTITUIDO -NR7 Y R7 SIGNIFICA CA-9-ALQUIL DE ENCADENADO RECTO, C3-7-ALQUIL, C3-7-ALQUIL, C3-7-CICLOALQUIL RAMIFICADO, SUSTITUIDO POR C3-7-CICLOALQUIL, C1-8-ALCOXICARBONIL, BENZIL, TRIFENILMETILENO, FENIL BENZILOXICARBONIL, FENEILCARBONIL O BENZICARBONIL O R5 SIGNIFICAN UN HETEROCICLO DE LA FORMUAL C DE DONDE X VALE POR OXIGENO O SULFURICO Y N VALE POR 1, 2, 3, O 4 O UN HETEROCICLO DE LA FORMULA D, DE DONDE M VALE 0, 1 O 2 Y K 1, 2, O 3, NO OBSTANTE DE MANERA QUE (M+K) ES 1, 2 O 3 Y X E Y SIGUEN TENIENDO EL SIGNIFICADO DE LAS FORMULAS B Y C O SIGNIFICAN UN HETEROCICLO DE LA FORMULA E DE DONDE Z VALE POR CYANIMINO N-CN, CIS O TRANS NITROMEHILIDAS (C/T) CH-NO2 O NITROMINO N-NO2, Y TIENE EL SIGNIFICADO ANTERIORMENTE INDICADO Y P SIGNIFICAN 2 O 3 Y R6 EN DEPENDENCIA CON R5 VALE POR LAS DOS CLASES SUBSTITUIDAS R6 Y R6'''', DE DONDE EN CASO R5 SIGNIFICA UN HETEROCICLO A, B, C O D; R6 VALE POR LA CLASE SUBSTITUIDA R6'' Y R6 SIGNIFICA DIFLUOMETHOXI, TRIFLUORMETOXI, TRIFLUORETOXI, DIFLURMETHILTHIO, DIFLUORMETHYLSULFINYL, DIFLUORMETHILSULFONIL, TRIFLUORMETHYLTHIO, TRIFLUORMETHYLSULFONIL, TRIFLUORENTHYLTHIO, TRIFLUORRTHYLSULFINYL O TRIFLUORETHYLSULFONIL, O CASO DE QUE R5 SIGNIFIQUE HETEROCCICLO F, R6 VALE POR LA CLASE SUBSTITUIDA ANTES CITADA R6'' Y POR LA CLASE SUBSTITUIDAR6'''' Y R6'''' SIGNIFICA CIANO, NITRO, C1-6-ALQUIL, C3-8-CICLOALQUIL, FORMIL Y C1-6-ALQUILCARBONYL, DE DONDE EL HETEROCICLO R5 SE ENCUENTRA EN TRANSPOSICION AL RESTO R3, CUANDO R3 Y R4 NO SIGNIFICAN CONJUNTAMENTE UNA UNION, SINO R4 VALE POR HIDROGENO, ASI COMO SUS SALES Y SALES DE ACIDO ADICIONALES, TAUTOMEROS E ISOMEROS OPTICOS. LAS COMBINACIONES SON AGENTES TERAPEUTICOS.
ES89112429T 1988-07-12 1989-07-07 Nuevos derivados de benzopirano, procedimientos para su preparacion y su uso y composiciones que contienen los compuestos. Expired - Lifetime ES2100151T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3823533A DE3823533A1 (de) 1988-07-12 1988-07-12 Substituierte 4-heterocyclyl-2h-benzo(b)pyrane, verfahren und 4-hydroxy-3-brom-, 3,4-oxiranyl-3,4-dehydro-2h-benzo(b)pyrane als zwischenprodukte zu ihrer herstellung, sowie sie enthaltende pharmazeutsche praeparate

Publications (1)

Publication Number Publication Date
ES2100151T3 true ES2100151T3 (es) 1997-06-16

Family

ID=6358472

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89112429T Expired - Lifetime ES2100151T3 (es) 1988-07-12 1989-07-07 Nuevos derivados de benzopirano, procedimientos para su preparacion y su uso y composiciones que contienen los compuestos.

Country Status (11)

Country Link
US (2) US5028711A (es)
EP (1) EP0350805B1 (es)
JP (1) JP3075725B2 (es)
KR (1) KR0163169B1 (es)
AT (1) ATE151764T1 (es)
AU (1) AU632755B2 (es)
CA (1) CA1336835C (es)
DE (2) DE3823533A1 (es)
ES (1) ES2100151T3 (es)
GR (1) GR3023825T3 (es)
ZA (1) ZA895090B (es)

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Also Published As

Publication number Publication date
DE58909793D1 (de) 1997-05-22
JPH0272171A (ja) 1990-03-12
EP0350805A1 (de) 1990-01-17
US5096914A (en) 1992-03-17
AU632755B2 (en) 1993-01-14
GR3023825T3 (en) 1997-09-30
ATE151764T1 (de) 1997-05-15
EP0350805B1 (de) 1997-04-16
CA1336835C (en) 1995-08-29
AU3799789A (en) 1990-01-18
US5028711A (en) 1991-07-02
JP3075725B2 (ja) 2000-08-14
ZA895090B (en) 1990-05-30
KR900001689A (ko) 1990-02-27
KR0163169B1 (ko) 1998-12-01
DE3823533A1 (de) 1990-02-08

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