ES2100212T3 - Procedimiento para la purificacion de mezclas que contienen ibuprofeno. - Google Patents

Procedimiento para la purificacion de mezclas que contienen ibuprofeno.

Info

Publication number
ES2100212T3
ES2100212T3 ES91308177T ES91308177T ES2100212T3 ES 2100212 T3 ES2100212 T3 ES 2100212T3 ES 91308177 T ES91308177 T ES 91308177T ES 91308177 T ES91308177 T ES 91308177T ES 2100212 T3 ES2100212 T3 ES 2100212T3
Authority
ES
Spain
Prior art keywords
ibuprofen
crystallization
purification
ibuprophen
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91308177T
Other languages
English (en)
Inventor
Edward G Zey
Thomas H Shockley
Debra A Ryan
Gary L Moss
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CNA Holdings LLC
Original Assignee
Hoechst Celanese Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Celanese Corp filed Critical Hoechst Celanese Corp
Application granted granted Critical
Publication of ES2100212T3 publication Critical patent/ES2100212T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/42—Separation; Purification; Stabilisation; Use of additives
    • C07C51/43—Separation; Purification; Stabilisation; Use of additives by change of the physical state, e.g. crystallisation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

ESTA INVENCION PERTENECE AL METODO DE PURIFICACION DE MEZCLAS DE PRODUCTOS DE REACCION QUE COMPRENDEN IBUPROFENO. EL METODO DE PURIFICACION SE BASA EN LA CRISTALIZACION DEL IBUPROFENO DESDE UN DISOLVENTE DE HIDROCARBUROS Y EL DESCUBRIMIENTO DE QUE EXISTEN COMPLEJOS IMPUROS EN LAS MEZCLAS DE PRODUCTOS DE REACCION QUE COMPRENDEN IBUPROFENO, QUE NO PUEDEN RETIRARSE POR LA CRISTALIZACION DESDE UN DISOLVENTE DE HIDROCARBUROS. EL METODO DE LA INVENCION INCLUYE AL MENOS UN PASO EN EL QUE EL COMPLEJO DE IMPUREZAS EN UNA PRIMERA MEZCLA QUE COMPRENDE IBUPROFENO SE DESESTABILIZA O SE ROMPE, SEGUIDO DE LA CRISTALIZACION DEL IBUPROFENO DESDE UNA SEGUNDA SOLUCION O MEZCLA QUE COMPRENDE LA PRIMERA MEZCLA DE IBUPROFENO, DONDE LAS IMPUREZAS QUE SE FORMARON EN COMPLEJOS PREVIAMENTE, PODRAN SER REMOVIDAS DEL IBUPROFENO POR LA CRISTALIZACION DEL MISMO POR UN DISOLVENTE.
ES91308177T 1990-09-06 1991-09-06 Procedimiento para la purificacion de mezclas que contienen ibuprofeno. Expired - Lifetime ES2100212T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/579,427 US5151551A (en) 1990-09-06 1990-09-06 Method for purification of ibuprofen comprising mixtures

Publications (1)

Publication Number Publication Date
ES2100212T3 true ES2100212T3 (es) 1997-06-16

Family

ID=24316864

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91308177T Expired - Lifetime ES2100212T3 (es) 1990-09-06 1991-09-06 Procedimiento para la purificacion de mezclas que contienen ibuprofeno.

Country Status (10)

Country Link
US (1) US5151551A (es)
EP (1) EP0474509B1 (es)
AT (1) ATE149995T1 (es)
BR (1) BR9103858A (es)
CA (1) CA2050709C (es)
DE (1) DE69125073T2 (es)
DK (1) DK0474509T3 (es)
ES (1) ES2100212T3 (es)
GR (1) GR3022805T3 (es)
MX (1) MX9100983A (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5300301A (en) * 1992-12-02 1994-04-05 Hoechst Celanese Corporation Isolation of ibuprofen from tablets
WO2004096747A1 (en) * 2003-04-28 2004-11-11 Basf Aktiengesellschaft Process for the separation of palladium catalyst from crude reaction mixtures of aryl acetic acids obtained by carbonylation
WO2015163832A1 (en) 2014-04-25 2015-10-29 Pharmacti̇ve İlaç Sanayi̇ Ve Ti̇caret A.Ş. An ibuprofen and famotidine combined composition having improved stability
CN112433016A (zh) * 2020-12-11 2021-03-02 青岛科技大学 检测重排酯含量的液相色谱分析方法
CN114195633A (zh) * 2021-12-24 2022-03-18 浙江新和成股份有限公司 一种布洛芬杂质f的合成方法
CN115286501A (zh) * 2022-08-10 2022-11-04 浙江新和成股份有限公司 一种布洛芬结晶母液的综合利用方法
WO2026078180A1 (en) 2024-10-11 2026-04-16 Basf Se An efficient way to make ibuprofen

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2646792C2 (de) * 1975-10-23 1985-05-09 Mitsubishi Petrochemical Co., Ltd., Tokio/Tokyo Verfahren zur Herstellung einer α-(arylsubstituierten)-Propionsäure und/oder eines Esters derselben
US4476248A (en) * 1983-02-28 1984-10-09 The Upjohn Company Crystallization of ibuprofen
US4694100A (en) * 1984-07-14 1987-09-15 Nippon Petrochemicals Company, Ltd. Method for producing α-(p-isobutylphenyl)propionic acid or its alkyl esters
CA1286316C (en) * 1986-02-08 1991-07-16 Isoo Shimizu Method for refining 2-(aryl substituted)-propionic acid or its salt
JPH064560B2 (ja) * 1986-02-08 1994-01-19 日本石油化学株式会社 ２−（ｐ−イソブチルフエニル）プロピオン酸またはその塩の回収方法
JPH0657670B2 (ja) * 1986-06-14 1994-08-03 日本石油化学株式会社 粗イブプロフエンの精製方法
US4981995A (en) * 1987-03-20 1991-01-01 Varadaraj Elango Method for producing ibuprofen
DE3802619C1 (es) * 1988-01-29 1989-09-07 Hoechst Ag, 6230 Frankfurt, De
JPH02152945A (ja) * 1988-12-02 1990-06-12 Daicel Chem Ind Ltd ２−（４−ヒドロキシフェノキシ）プロピオン酸エステルの精製法

Also Published As

Publication number Publication date
MX9100983A (es) 1992-05-04
DE69125073D1 (de) 1997-04-17
GR3022805T3 (en) 1997-06-30
CA2050709A1 (en) 1992-03-07
EP0474509A3 (en) 1993-07-07
EP0474509B1 (en) 1997-03-12
DK0474509T3 (da) 1997-05-12
BR9103858A (pt) 1992-05-26
DE69125073T2 (de) 1997-06-19
US5151551A (en) 1992-09-29
EP0474509A2 (en) 1992-03-11
CA2050709C (en) 2002-08-20
ATE149995T1 (de) 1997-03-15

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